• Lander and his colleagues focused on an ion channel called the transient receptor potential vanilloid-2 (TRPV2), which resides within the membranes of cells throughout the body. (neurosciencenews.com)
  • Transient receptor potential vanilloid (TRPV) cation channels are polymodal sensors involved in a variety of physiological processes. (neurosciencenews.com)
  • Many transient receptor potential (TRP) channels respond to diverse stimuli and conditionally conduct small and large cations. (sdsc.edu)
  • First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the animal kingdom including the perception of light, temperature, pressure, and pain. (wustl.edu)
  • Transient receptor potential (TRP) channels appear to mediate these aspects of PEMF stimulation, serving as a conduit for extracellular calcium. (nature.com)
  • involve Transient Receptor Potential (TRP) channels. (freezingblue.com)
  • A strong applicant is certainly transient receptor potential isoform 4 (TRPV4), a polymodal non-selective cation route that was suggested to bind and/or functionally connect to multiple AQP isoforms (Liu et al. (californiaehealth.org)
  • Background Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli. (researchgate.net)
  • In this work, we explored the role of transient receptor potential vanilloid 2 (TRPV2), a non-selective cation channel in the context of neurite functions. (silverchair.com)
  • Here, we exploit cryoelectron microscopy (cryo-EM) to visualize conformational transitions of the capsaicin receptor, TRPV1, as a model to understand how dynamic transitions of the selectivity filter in response to algogenic agents, including protons, vanilloid agonists, and peptide toxins, permit permeation by small and large organic cations. (sdsc.edu)
  • The TRPV1 channel is a non-selective cation channel, with a high permeability to Ca2+. (wikipedia.org)
  • TRPM3 belongs to the melastatin sub-family of TRP channels and has been shown to function as a spontaneous calcium channel, with permeability to other cations influenced by alternative splicing and/or non-canonical channel activity. (wustl.edu)
  • Both Na + loading and cell swelling were dampened on inhibition of TRPV4 channels. (jneurosci.org)
  • Moreover, our experiments identified TRPV4 channels as hitherto unappreciated contributors to neuronal Na + loading on metabolic failure, suggesting this pathway as a possible target to ameliorate excitotoxic damage. (jneurosci.org)
  • It also allowed quantitative imaging independent from changes in cell volume, revealing a surprisingly strong and hitherto uncovered contribution of TRPV4 channels to Na + loading on energy failure. (jneurosci.org)
  • With the help of the CatSper channels as versatile and highly perceptive sensors, sperm can "read" the chemical milieu in the fallopian tube and find the ovum in this way. (mpg.de)
  • CatSper ( cat ion channels of sper m ) ion channels are responsible for the effect of the progesterone. (mpg.de)
  • The CatSper channels, which are found only in sperm, play an indispensable role in reproduction: men who carry a gene defect for CatSper are infertile. (mpg.de)
  • In a 2011 study, which was seen as a sensational breakthrough, scientists from the caesar research centre succeeded in showing that progesterone opens the CatSper channels directly and calcium flows through the channels into the sperm cell. (mpg.de)
  • Bourgeonal opens the CatSper channels directly - that is without deviation via olfactory receptors and complex biochemical signalling pathways as found in olfactory cells. (mpg.de)
  • Why are the CatSper channels so unselective, and even react to menthol if the concentration is high enough? (mpg.de)
  • If the scientists succeed in disrupting the effect of female factors on the CatSper channels, it could lead to the development of an innovative contraceptive: the pill for men. (mpg.de)
  • The CatSper channel: a polymodal chemosensor in human sperm. (mpg.de)
  • The sperm-specific ion channel CatSper is the principal calcium channel in sperm mediating the calcium influx into the sperm flagellum and acting as an essential modulator of downstream mechanisms involved in fertilization. (123dok.net)
  • This review aims to provide insights into the structure, localization, and function of the mammalian CatSper channel, primarily human and mice. (123dok.net)
  • The activation of CatSper by progesterone and prostaglandins, as well as the ligand-independent regulation of the channel by a change in the membrane voltage and intracellular pH are going to be addressed. (123dok.net)
  • When the researchers compared the structure of TRPV2 with TRPV1, a genetically similar ion channel found only in the nervous system, they noticed some significant differences. (neurosciencenews.com)
  • The other co-authors on the paper, "Cryo-electron microscopy structure of the TRPV2 ion channel," were Ben Chung and Zhirui Liu of the Duke University Medical Center. (neurosciencenews.com)
  • Abstract for "Cryo-electron microscopy structure of the TRPV2 ion channel" by Lejla Zubcevic, Mark A Herzik Jr, Ben C Chung, Zhirui Liu, Gabriel C Lander and Seok-Yong Lee in Nature Structural & Molecular Biology . (neurosciencenews.com)
  • Though researchers' attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of the more unusual suspects, such as G-protein coupled receptors. (stanford.edu)
  • Some of the receptors are cation channels, which can directly depolarize the nociceptor upon activation, while other receptors activate second messenger systems to change neuronal excitability by changing expression of, or modifying the function of, other cation channels. (frontiersin.org)
  • All these events are primarily regulated by an array of regulatory proteins that are present on the cell surface, such as ion channels, receptors and adhesion molecules which sense the different chemical signaling cues and allow the neurons to respond accordingly [ 8-10 ]. (silverchair.com)
  • RhTx binds to the outer pore region of the temperature regulated TRPV1 ion channel, preferably in activated state, causing a downwards shift in the activation threshold temperature, which leads to the immediate onset of heat pain. (wikipedia.org)
  • RhTx binds to the outer pore region of the polymodal TRPV1 ion channel. (wikipedia.org)
  • The toxin preferably binds to TRPV1 in the activated state of the channel. (wikipedia.org)
  • RhTx has a high affinity for the TRPV1 ion channel, which results in very rapid binding and slow unbinding. (wikipedia.org)
  • RhTx binding is expected to induce conformational changes to the outer pore, which are thought to be the cause of the drop of the activation threshold for the TRPV1 channel. (wikipedia.org)
  • These changes strongly promote the opening of the TRPV1 channel at the normal body temperature of the organism, resulting in intense burning pain. (wikipedia.org)
  • The method adds a large amount of genetic information as a basis for complete analysis of TRPV1 ion channel genetics and its functional consequences. (researchgate.net)
  • Preventing calcium entry during the repeated PEMF exposure with the co-administration of EGTA or TRP channel antagonists precluded the inhibition of differentiation. (nature.com)
  • This channel is activated by signalling molecules inside cells, called 'cyclic nucleotides', and its activity ultimately leads to calcium ions flowing into the sperm cell's tail. (elifesciences.org)
  • What is currently missing is a "photo series" of intermediate structural states that directly address this hypothesis and reveal specific mechanisms behind such dynamic channel regulation. (sdsc.edu)
  • Indeed, changes in the spatiotemporal Ca 2+ -levels and Ca 2+ -oscillation patterns have been correlated with most of these functions [ 2 , 8-10 ], which strongly suggest the importance of different Ca 2+ channels in the regulation of neuritogenesis. (silverchair.com)
  • The channel is also targeted by the active component of chilli peppers capsaicin, and the spider toxins Vanillotoxin and DkTx. (wikipedia.org)
  • These insights suggest a general framework for understanding how TRP channels function as polymodal signal integrators. (sdsc.edu)
  • In sea urchin sperm, a cyclic nucleotide-gated K + channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca 2+ influx. (elifesciences.org)
  • A picture is emerging of sperm channel orthologues that employ different activation mechanisms and serve different functions. (elifesciences.org)
  • In 2009, researchers identified a potassium ion channel, called CNGK, that starts the electrical signal in the sperm cells of sea urchins. (elifesciences.org)
  • including some of the researchers involved in the 2009 work - now report that the CNGK channel also exists in the sperm cells of a freshwater fish, the zebrafish. (elifesciences.org)
  • Unexpectedly, the CNGK channel is located in the heads of this fish's sperm cells rather than in the tails. (elifesciences.org)
  • These findings suggest that while channel proteins found in sperm cells from different species look similar and serve similar roles, they are activated in ways that can be very different. (elifesciences.org)
  • In a new study, researchers from The Scripps Research Institute (TSRI) and the Duke University Medical Center reveal the three-dimensional structure of a crucial ion channel. (neurosciencenews.com)
  • The general objective of our research group is to try to understand how the nervous system senses the environment, focusing on the role played by ion channels in mechanosensation, temperature sensing and pain. (painchannels.com)
  • We are also searching for novel ion channels involved in thermosenation and mechanosensation. (daktarprotidin.com)
  • Small molecule antagonists of TRPA1, one of the ion channels identified in the Patapoutian lab, are currently in phase I clinical studies. (daktarprotidin.com)
  • 2014). Benefiting from appearance program, leading us to summarize that both structurally extremely dissimilar channels type an operating symbiotic device that mediates swelling-induced signaling and quantity legislation in the retina. (californiaehealth.org)
  • Our ability to perceive our environment - which includes sensing temperature and pain - is heavily reliant on these channels. (neurosciencenews.com)
  • We recently identified Piezo1 and Piezo2, mechanically-activated cation channels that are expressed in many mechanosensitive cell types. (daktarprotidin.com)
  • We also perform behavioral characterization of animals lacking specific ion channels in different models of chronic pain. (painchannels.com)
  • The ultimate goal of our research program is to establish the contribution of particular ion channels to somatic and viscera sensations and their role in pathological conditions like chronic pain and inflammation. (painchannels.com)
  • The channel inventories probably reflect adaptations to species-specific challenges during fertilization. (elifesciences.org)
  • The expression of temperature-sensitive ion channels has been extensively investigated because thermal stimulation often evokes tooth pain. (mdpi.com)
  • This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the ion channels involved in tooth pain. (mdpi.com)
  • Their findings depict this channel in more detail than ever before, shedding light on the channel's possible role in immune functions such as detecting infection and inflammation. (neurosciencenews.com)
  • Together, this led the authors to propose that this configuration represents a 'desensitized' state, providing a new molecular snapshot of these ion channels at work. (neurosciencenews.com)
  • Our lab has identified and characterized ion channels activated by distinct changes in thermal energy (in the noxious to innocuous range), thus functioning as the molecular thermometers of our body. (daktarprotidin.com)
  • With the entire cycle imaged, researchers will have a better idea of how the ion channel works and how it might be manipulated therapeutically to treat autoimmune diseases. (neurosciencenews.com)
  • The voltage gated Na channels Nav1.7, Nav1.8 and Nav1.9 were found to be selectively up-regulated in rat DRG neurons treated with GM-CSF, which resulted in enhanced excitability. (iasp-pain.org)
  • It was previously thought that this CNGK channel is found only in animals without a backbone (i.e. in invertebrates). (elifesciences.org)
  • A new study from The Scripps Research Institute and Duke University Medical Center reveals the three-dimensional structure of a crucial ion channel, shedding light on its role in the immune system. (neurosciencenews.com)