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  • enzymes
  • Researchers for the first time have shown that members of a family of enzymes known as cathepsins - which are implicated in many disease processes - may attack one another instead of the bodily proteins they normally degrade. (innovations-report.com)
  • Because cathepsins have harmful effects on critical proteins such as collagen and elastin, pharmaceutical companies have been developing drugs to inhibit activity of the enzymes, but so far these compounds have had too many side effects to be useful and have failed clinical trials. (innovations-report.com)
  • Cathepsins are proteolytic enzymes with a broad spectrum of substrates. (springer.com)
  • Human
  • "Cloning and sequence analysis of cDNA for human cathepsin D" . Proceedings of the National Academy of Sciences of the United States of America . (wikipedia.org)
  • Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. (semanticscholar.org)
  • Human cathepsin D. (ebi.ac.uk)
  • Catalytically inactive human cathepsin D triggers fibroblast invasive growth. (ebi.ac.uk)
  • Human endometriosis lesions also exhibited greater cathepsin activity than adjacent peritoneum tissue, supporting the mouse results. (nih.gov)
  • IHC image of Cathepsin D staining in Human Lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. (abcam.com)
  • Human Cathepsin G purified from Human Neutrophil. (abcam.com)
  • Baici A, Müntener K, Willimann A, Zwicky R. Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death. (springer.com)
  • Synthetic peptide within Human Cathepsin D aa 350 to the C-terminus (C terminal). (abcam.com)
  • mammalian
  • Arampatzidou M, Rehders M, Dauth S, Yu DMT, Tedelind S, Brix K. Imaging of protease functions-current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues. (springer.com)
  • expression
  • Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. (nih.gov)
  • Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes. (nih.gov)
  • Title: Expression of cathepsins V and S in thymic epithelial tumors. (nih.gov)
  • Expression of cathepsins K, S and V within keratinocytes is reduced in photoprotected skin of aged women. (nih.gov)
  • Title: Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis. (nih.gov)
  • Arkona C, Wiederanders B. Expression, subcellular distribution and plasma membrane binding of cathepsin B and gelatinases in bone metastatic tissue. (springer.com)
  • A significantly elevated cathepsin S expression in gingival biopsies from rats with experimental periodontitis was found in vivo , as compared to that from control. (hindawi.com)
  • Gingival biopsies from periodontitis patients showed a significantly higher cathepsin S expression than those from healthy gingiva. (hindawi.com)
  • substrate
  • Like caspase and calpain activity, cathepsin activity can be easily detected in many cell types using a specific cathepsin substrate linked to a colorimetric or fluorogenic detection molecule, which will be released upon cleavage of the substrate. (abcam.com)
  • degradation
  • Using a combination of modeling and experiments, researchers from the Georgia Institute of Technology and Emory University have shown that one type of cathepsin preferentially attacks another, reducing the enzyme's degradation of collagen. (innovations-report.com)
  • That theoretical result led to additional experiments in which the researchers measured a direct correlation between an increase in the amount of cathepsin S added to the experiment and a reduction in the degradation of collagen. (innovations-report.com)
  • The experimental evidence indicates that a cathepsin B-like enzyme may be partly responsible for the autolytic degradation of cartilage matrix at pH5. (biochemj.org)