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  • Human
  • "Cloning and sequence analysis of cDNA for human cathepsin D" . Proceedings of the National Academy of Sciences of the United States of America . (wikipedia.org)
  • Human cathepsin D. (ebi.ac.uk)
  • Catalytically inactive human cathepsin D triggers fibroblast invasive growth. (ebi.ac.uk)
  • Human endometriosis lesions also exhibited greater cathepsin activity than adjacent peritoneum tissue, supporting the mouse results. (nih.gov)
  • IHC image of Cathepsin D staining in Human Lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. (abcam.com)
  • Human Cathepsin G purified from Human Neutrophil. (abcam.com)
  • Synthetic peptide within Human Cathepsin D aa 350 to the C-terminus (C terminal). (abcam.com)
  • induces
  • Cathepsin D enzymatic activity induces hydrolytic modification of apolipoprotein B-100-containing lipoproteins, including LDL, which means it may be involved in atherosclerosis as well. (wikipedia.org)
  • deficiency
  • Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. (nih.gov)
  • tumors
  • Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. (nih.gov)
  • Title: Expression of cathepsins V and S in thymic epithelial tumors. (nih.gov)
  • degrade
  • Researchers for the first time have shown that members of a family of enzymes known as cathepsins - which are implicated in many disease processes - may attack one another instead of the bodily proteins they normally degrade. (innovations-report.com)
  • cellular
  • Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. (genenames.org)
  • We saw that the cathepsin K was going away much faster when there was cathepsin S present than when it was by itself," said Platt, who is also a Georgia Cancer Coalition Distinguished Scholar and a Fellow of the Keystone Symposia on Molecular and Cellular Biology. (innovations-report.com)
  • lesions
  • To test this, we used an immunocompetent endometriosis mouse model and found that endometriotic lesions exhibited a greater than 5-fold increase in active cathepsins compared to tissue from peritoneal wall or eutopic endometrium, with cathepsins L and K specifically implicated. (nih.gov)
  • Mouse endometriotic lesions exhibit elevated cathepsin proteolytic activity. (nih.gov)