Antimicrobial peptide genePeptideDefensinsPeptidesRegulation of cathelicidinCRAMPAMPsEpithelial CellsAbnormallyIntestinal barrierInhibitionAntiviralMembranesPathogenesisVitroHumanProteaseImmuneInfectionSignificantlyVitaminInnateRosaceaExpressionNuclearFoundMoleculesRoleStructuresFamilyMouse modelSuggestAdministration
Antimicrobial peptide gene5
- Our research aimed to use synthetized aroylated phenylenediamines (APDs) to induce the expression of cathelicidin antimicrobial peptide gene (CAMP) to minimize the necessity of antibiotic use during infection. (researchgate.net)
- 2014. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. . (oregonstate.edu)
- 2014. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. . (oregonstate.edu)
- 2013. Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. . (oregonstate.edu)
- 2020. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. . (oregonstate.edu)
Peptide14
- LL-37 is the only peptide in the Cathelicidin family found in the human body. (wikipedia.org)
- Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain. (wikipedia.org)
- The general rule of the mechanism triggering cathelicidin action, like that of other antimicrobial peptides, involves the disintegration (damaging and puncturing) of cell membranes of organisms toward which the peptide is active. (wikipedia.org)
- Cathelicidin-BF (C-BF), a new cathelicidin peptide purified from the venom of the snake Bungarus fasciatus, has been shown to have both antimicrobial and anti-inflammatory properties. (unboundmedicine.com)
- The manuscript demonstrates that a mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in the human bronchial epithelial cell line model VA10. (peerj.com)
- Zasloff M ( 2015 ) Peer Review #3 of 'Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells (v0.2)' . (peerj.com)
- and psoriasis, in which cathelicidin peptide converts self-DNA to a potent stimulus in an autoinflammatory cascade. (rosacea-support.org)
- Cathelicidin is a peptide. (irosacea.org)
- Here we found that levels of cathelicidin, an antimicrobial peptide, were increased in colon cancer tissues compared to noncancerous tissues. (oncotarget.com)
- The pleiotropic activity of individual cathelicidin LL-37 peptide includes an capability to reduce development of cancer of the colon cells. (biotech-angels.com)
- Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. (bvsalud.org)
- 2021. The Neutrophil Antimicrobial Peptide Cathelicidin Promotes TH17 Differentiation. (bu.edu)
- Binge alcohol also reduced levels of another key component of the immune system known as CRAMP (cathelicidin-related antimicrobial peptide). (news-medical.net)
- These substances include the protective cathelicidin antimicrobial peptide (CAMP) that speeds physical repair, but worsens rosacea symptoms. (rosacea.org)
Defensins6
- Whilst the defensins share common structural features, cathelicidin-related peptides are highly heterogeneous. (wikipedia.org)
- the defensins and cathelicidin. (biomedcentral.com)
- IntroductionThe antimicrobial peptides (AMPs) human -defensins and cathelicidin (LL-37) are key factors in innate and adaptive immune responses of the respiratory tract and play an important role in many respiratory diseases. (bezmialem.edu.tr)
- By now we know some human defensins and one human cathelicidin,named LL-37. (uni-wuerzburg.de)
- Defensins and cathelicidins constitute the two major groups of antimicrobial peptides in most mammalian species. (vin.com)
- This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
Peptides15
- Cathelicidin peptides are dual-natured molecules called amphiphiles: one end of the molecule is attracted to water and repelled by fats and proteins, and the other end is attracted to fat and proteins and repelled by water. (wikipedia.org)
- The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). (wikipedia.org)
- Cathelicidin peptides have been isolated from many different species of mammals. (wikipedia.org)
- Most cathelicidins are linear peptides with 23-37 amino acid residues, and fold into amphipathic α-helices. (wikipedia.org)
- Even larger cathelicidin peptides (39-80 amino acid residues) are also present. (wikipedia.org)
- Cathelicidin antimicrobial peptides, such as LL-37 and mCRAMP, can protect animals against intestinal barrier dysfunction. (unboundmedicine.com)
- Vit D3 has been shown to promote the production of the human antimicrobial peptides, cathelicidins (LL-37), and cathelicidins have been found to have broad spectrum antimicrobial activity. (rosacea-support.org)
- And while the jury is still out, there is more news worth mentioning that may be related to cathelicidin, peptides or antigenic proteins. (irosacea.org)
- Wikipedia in its article on Cathelcidin says, "Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes (PMNs), and keratinocytes. (irosacea.org)
- Cathelicidin related antimicrobial peptides ( CRAMPs ) enhance chemotactic responsiveness of BMSPCs to low SDF-1 gradients, suggesting a potential role in BMSPCs engraftment. (bvsalud.org)
- The serine proteases kallikrein 5 (KLK5) and kallikrein 7 (KLK7) control enzymatic processing of cathelicidin precursor in the skin and regulate the eventual function of the final forms of these peptides. (irosacea.org)
- In a previous study, we have also shown that the abundance of antimicrobial host defence peptides, specifically cathelicidin (CRAMP) and calprotectin (S100A8 and S100A9), is significantly increased in the joint tissues of CIA mice. (biomedcentral.com)
- We have also established a panel of proteins that are significantly elevated in the joint tissues of CIA mice, which includes cationic host defence peptides (CHDP), specifically cathelicidin CRAMP and calprotectin (S100A8 and S100A9) [ 4 ]. (biomedcentral.com)
- Overall, the results of this study demonstrates that the highly bioavailable CUR suppresses cathelicidin and calprotectin peptides in the joints of CIA mice to baseline levels and indicate that CUR can regulate both local and systemic inflammation in CIA mice. (biomedcentral.com)
- The cathelicidin family of antimicrobial peptides is an integral component of the innate immune response that exhibits activity against bacterial, fungal, and viral pathogens. (medscape.com)
Regulation of cathelicidin3
- Recent work identified vitamin D3 as a major factor involved in the regulation of cathelicidin. (rosacea-support.org)
- Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology? (rosacea-support.org)
- C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells. (oregonstate.edu)
CRAMP1
- Therefore, in this study, we examined the effects of CUR administration on the abundance of cathelicidin CRAMP and calprotectin (S100A8 and S100A9) in the joints of CIA mice. (biomedcentral.com)
AMPs2
- Cathelicidins are unique AMPs that protect the skin through 2 distinct pathways: (1) direct antimicrobial activity and (2) initiation of a host response resulting in cytokine release, inflammation, angiogenesis, and reepithelialization. (rosacea-support.org)
- Therapies targeting control of cathelicidin and other AMPs might provide new approaches in the management of infectious and inflammatory skin diseases. (rosacea-support.org)
Epithelial Cells1
- Cathelicidins are mostly found in neutrophils, monocytes, mast cells, dendritic cells and macrophages after activation by bacteria, viruses, fungi, parasites or the hormone 1,25-D, which is the hormonally active form of vitamin D. They have been found in some other cells, including epithelial cells and human keratinocytes. (wikipedia.org)
Abnormally1
- In the article in Nature magazine [3] the paper mentions that in rosacea patients the cathelicidin levels were abnormally high suggesting that the redness is caused by an abnormal immune system response. (irosacea.org)
Intestinal barrier2
- Cathelicidin inhibits NF-κB activity and ameliorates lipopolysaccharide-induced intestinal barrier disruption in rats. (tmu.edu.tw)
- Cathelicidin treatment attenuated intestinal injury as evidenced by lower intestinal injury scores and intestinal permeability and higher intestinal barrier protein expression. (tmu.edu.tw)
Inhibition3
- The cathelicidin family shares primary sequence homology with the cystatin family of cysteine proteinase inhibitors, although amino acid residues thought to be important in such protease inhibition are usually lacking. (wikipedia.org)
- Neutralization of cathelicidin, in vivo , significantly reduced the engraftment of macrophages into colon tumors, as well as proliferation of tumor cells, resulting in an inhibition of tumor growth. (oncotarget.com)
- Chou, HC & Chen, CM 2020, ' Cathelicidin attenuates hyperoxia-induced intestinal injury through inhibition of NF-κB activity in newborn rats ', Experimental and Molecular Pathology , vol. 113, 104269. (tmu.edu.tw)
Antiviral2
- The importance of cathelicidins in antiviral skin host defense was confirmed by the observation of higher levels of HSV-2 replication in cathelicidin-deficient mouse skin compared with that seen in skin from their wild-type counterparts. (medscape.com)
- Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection. (cdc.gov)
Membranes2
- citation needed] Cathelicidins rapidly destroy the lipoprotein membranes of microbes enveloped in phagosomes after fusion with lysosomes in macrophages. (wikipedia.org)
- 2017) Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. (birmingham.ac.uk)
Pathogenesis2
- These findings confirm the role of cathelicidin in skin inflammatory responses and suggest an explanation for the pathogenesis of rosacea by demonstrating that an exacerbated innate immune response can reproduce elements of this disease. (irosacea.org)
- Elevated levels of cathelicidin and calprotectin have been associated with the pathogenesis of rheumatoid arthritis. (biomedcentral.com)
Vitro1
- Furthermore, treatment with cathelicidin neutralizing antibody de-activated the Wnt/β-catenin signaling pathway in tumor cells both in vivo and in vitro . (oncotarget.com)
Human2
- Antibodies to the human LL-37/hCAP-18 have been used to find cathelicidin-like compounds in a marsupial. (wikipedia.org)
- We analyzed factors that control expression of KLK5 and KLK7 in normal human epidermal keratinocytes to better understand how these may influence cathelicidin processing and function. (irosacea.org)
Protease1
- Increased protease activity and differential processing of cathelicidin accompanied increased KLK expression. (irosacea.org)
Immune3
- Cathelicidins thus serve a critical role in mammalian innate immune defense against invasive bacterial infection. (wikipedia.org)
- Importantly, cathelicidin was mainly expressed in immune cells. (oncotarget.com)
- These data indicate that cathelicidin, expressed by immune cells in the tumor microenvironment, promotes colon cancer growth through activation of the PTEN/PI3K/Akt and Wnt/β-catenin signaling pathways. (oncotarget.com)
Infection1
- There are only a few publications regarding cathelicidin (LL-37) and a urinary tract infection (UTI). (biomedcentral.com)
Significantly1
- [ 9 ] Skin from patients with KVE exhibited significantly lower levels of cathelicidin protein expression than skin from patients with AD. (medscape.com)
Vitamin2
- Vitamin D3 is likely to increase the production of cathelicidins, which has been demonstrated to be a major inflammation factor for rosacea sufferers. (rosacea-support.org)
- Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D(3), and Retinoic Acid. (irosacea.org)
Innate1
- Cathelicidin has dual functions in the skin, acting as an innate antibiotic and as an immunomodulator in diseases such as rosacea and psoriasis. (irosacea.org)
Rosacea3
- Bac5, Bac7 Frogs: cathelicidin-AL (found in Amolops loloensis) Chickens: Four cathelicidins, fowlicidins 1,2,3 and cathelicidin Beta-1 Tasmanian Devil: Saha-CATH5 Salmonids: CATH1 and CATH2 Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). (wikipedia.org)
- Another paper stemming from the partly NRS funded research into the role of cathelicidins and its role in rosacea. (rosacea-support.org)
- What Does Cathelicidin Have To Do With Rosacea? (irosacea.org)
Expression1
- [ 10 ] An inverse correlation between cathelicidin expression and serum immunoglobulin E levels in patients with AD and patients with KVE has also been found. (medscape.com)
Nuclear1
- Cathelicidin activated Wnt/β-catenin signaling by inducing phosphorylation of PTEN, leading to activation of PI3K/Akt signaling and subsequent phosphorylation of GSK3β, resulting in stabilization and nuclear translocation of β-catenin. (oncotarget.com)
Found1
- The nutshell version is that Cathelicidin is a killer of microscopic organisms that is at the cellular level found in white blood cells and also found in cells on the skin. (irosacea.org)
Molecules1
- Additionally cathelicidins may also be small-sized molecules (12-18 residues) with beta-hairpin structures, stabilized by one or two disulphide bonds. (wikipedia.org)
Role1
- We discovered that both nanosystems had been effectively internalized by HT-29 cells and cathelicidin LL-37 and ceragenin CSA-13 might play an integral role as book homing substances. (biotech-angels.com)
Structures2
- citation needed] Cathelicidins range in size from 12 to 80 amino acid residues and have a wide range of structures. (wikipedia.org)
- These larger cathelicidins display repetitive proline motifs forming extended polyproline-type structures. (wikipedia.org)
Family1
- About 30 cathelicidin family members have been described in mammals. (wikipedia.org)
Mouse model1
- Therefore, in this study, we examined the effect CUR administration on the abundance of cathelicidin and calprotectin in the joints, in a CIA mouse model. (biomedcentral.com)
Suggest2
- Studies also suggest that it is unusual for bacteria to develop resistance to cathelicidins as they might from standard antibiotics. (rosacea-support.org)
- Overall, our results suggest that oral administration of a bioavailable CUR can suppress cathelicidin and calprotectin in the joints and regulate both local (joints) and systemic (serum) inflammation, in inflammatory arthritis. (biomedcentral.com)
Administration1
- Cathelicidins enhance BMMNC retention and recruitment after intramyocardial administration post-AMI resulting in improvements in heart physiology and recovery. (bvsalud.org)