Catharanthus roseus is a plant of the Apocynaceae family. (intechopen.com)
The research team studied the biosynthesis of two alkaloids from the plant Catharanthus roseus that are used in human medicine as anti-cancer agents. (analytica-world.com)
The chemo drugs vincristine and vinblastine, vinca alkaloids, although they come from a different plant, Catharanthus roseus, aka the Madagascan Periwinkle, work in the same manner - inhibiting cell division. (acsh.org)
Left top) Catharanthus roseus, aka the Madagascan Periwinkle, a member of the Vinca plant family, is the source of the cancer drug vincristine (Right top) Nice structure, huh? (acsh.org)
Finding out endophytic fungi originated from Catharanthus roseus with antimicrobial, antioxidant and cytotoxicity activities is important for pharmaceutical development. (microbiologyjournal.org)
The study provided more interesting information about Fusarium oxysporum F01 isolated in Catharanthus roseus grown in Vietnam, contributing to pharmaceutical sources in the world. (microbiologyjournal.org)
Catharanthus roseus or Vinca rosea , which is also commonly known as the Madagascar periwinkle or rose periwinkle is a plant species belongs to Apocynaceae family. (microbiologyjournal.org)
Catharanthus roseus is well known for production of copper nanoparticle 15 , antibacterial activities 16 , anti-cancerous agents such as vinca alkaloids which have effect on pain-relieving or contain anticancer properties. (microbiologyjournal.org)
Vinblastine and vincristine of Catharanthus roseus have been developed and applied in anticancer drugs as prescriptions 17 . (microbiologyjournal.org)
As a matter of fact, an endophyte called Fusarium oxysporum of rosy periwinkle plant, Catharanthus roseus was discovered to produce vincristine - an anticancer drug 18-20 . (microbiologyjournal.org)
[9] It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus . (mdwiki.org)
Review of abiotic and biotic elicitors' roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn. (jmp.ir)
Amiri S, Fotovat R, Panahi B, Tarinezhad A, Mohammadi S A. Review of abiotic and biotic elicitors' roles in secondary metabolites biosynthesis of periwinkle ( Catharanthus roseus (Linn. (jmp.ir)
4. Dugede Bernonville T, Clastre M, Besseau S, Oudin A, Burlat V, Glévarec G, Lanoue A, Papon N, El-Sayed M. and Verpoorte R. Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators. (jmp.ir)
6. Amiri S, Fotovat R, Tarinejad A, Panahi B, Mohammadi S.. In vitro regeneration of periwinkle (Catharanthus roseus L.) and fidelity analysis of regenerated plants with ISSR Markers. (jmp.ir)
7. Chen Q, Lu X, Guo X, Guo Q and Li D. Metabolomics characterization of two apocynaceae plants, Catharanthus roseus and Vinca minor, using GC-MS and LC-MS methods in combination. (jmp.ir)
8. Sain M and Sharma V. Catharanthus roseus (An anti-cancerous drug yielding plant). (jmp.ir)
9. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P. Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. (jmp.ir)
Vincristine is a vinca alkaloid from the plant Cathar anthus roseus, and largely arrests mitosis in metaphase by binding to tubulin dimers. (plcsignaling.com)
The anticancer agents vinblastine and vincristine are bisindole alkaloids derived from coupling vindoline and catharanthine, monoterpenoid indole alkaloids produced exclusively by the Madagascar periwinkle (Catharanthus roseus). (uea.ac.uk)
Industrial production of vinblastine and vincristine currently relies on isolation from C. roseus leaves, a process that affords these compounds in 0.0003-0.01% yields. (uea.ac.uk)
Liscombe, DK & O'Connor, SE 2011, ' A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus ', Phytochemistry , vol. 72, no. 16, pp. 1969-1977. (uea.ac.uk)
Vincristine (also named leurocristine) is a natural alkaloid isolated from the leaves of the Catharanthus roseus (commonly known as the Madagascar periwinkle). (smpdb.ca)
One of the plants they studied was the Madagascar periwinkle (L. Catharanthus roseus), which has traditionally been used to treat diabetes. (martifarm.com)
This two-step process has previously never been observed, and the researchers also expect something similar is occurring in the synthesis of anti-cancer drugs vincristine and vinblastine from Madagascan periwinkle, Catharanthus roseus, and elsewhere in olive and snapdragon. (organicslant.com)
Catharanthus roseus has become a pantropical weed and is grown in temperate regions as an indoor plant or summer bedding plant for its attractive, periwinkle-like flowers. (prcupcc.org)
Led by Chenxin Li of UGA's Center for Applied Genetic Technologies in the College of Agricultural and Environmental Sciences, the research team studied the biosynthesis of two alkaloids from the Madagascar periwinkle (Catharanthus roseus) that are used as anti-cancer agents in human medicine. (hortidaily.com)
The research team is confident that the organization of biosynthetic pathways for medicinally relevant alkaloids in Catharanthus roseus is not an isolated phenomenon. (hortidaily.com)
A beautiful pink flower from the island of Madagascar off the coast of east Africa called the Madagascar periwinkle ( Catharanthus roseus ), also known as the rosy periwinkle, has long been used by traditional medicinal healers for treating diabetes. (rsc.org)
Catharanthus roseus (L.) G.Don is an accepted species. (stuartxchange.org)
The plant produces about 130 of these compounds, including vinblastine and vincristine, two drugs used to treat cancer. (wikipedia.org)
Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment. (jmp.ir)
Abiotic and biotic are induced the immune systems of periwinkle and subsequently increased the biosynthesis and accumulation of vinblastine and vincristine. (jmp.ir)
Based on our knowledge this is the first study on the reviewing of the different elicitors on vinblastine and vincristine and it will be more helpful in the future studies. (jmp.ir)
Among the indole alkaloids, vinblastine and vincristine are currently used to treat a wide variety of neoplasms and is recommended for treatment of Hodgkin's disease, acute leukemia and choriocarcinoma, which is resistant to other types of therapy. (supercriticalfluids.com)
The alkaloidsvinblastine and vincristine, which do not have an antidiabetic effect but act on murine leukaemia cells, were soon isolated. (martifarm.com)
Apocynaceae1
Catharanthus is a genus of flowering plants in the family Apocynaceae. (wikipedia.org)
naturalized in Italy, S Asia, Australia, S United States, Central America, India and various oceanic islands Catharanthus scitulus (Pichon) Pichon - Madagascar Catharanthus trichophyllus (Baker) Pichon - Madagascar. (wikipedia.org)
The Madagascar periwinkle was first named Vinca rosea by the great Swedish botanist Carolus Linnaeus in the 1750s, but was reclassified and placed in the genus Catharanthus in 1834. (rsc.org)
Indole2
the sole source of chemotherapy agents, vincristine and vinblastine (specialized metabolites, terpenoid indole alkaloids/TIAs). (bvsalud.org)
It contains more than 75 alkaloids, including vincristine and vinblastine, which have revolutionized cancer therapy, especially the treatment of acute leukemia in children. (prcupcc.org)
Chemotherapy6
Vincristine , also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer . (mdwiki.org)
Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens . (mdwiki.org)
The main side effects of vincristine are chemotherapy-induced peripheral neuropathy , hyponatremia , constipation , and hair loss . (mdwiki.org)
Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (mdwiki.org)
Re cently, cyclophosphamide, vincristine, and prednisone chemotherapy was applied to selleck Givinostat significantly enhance overall survival and progression no cost survival in key colonic lymphoma patients. (plcsignaling.com)
Vincristine are used as chemotherapy medication such as an antimitotic anticancer agent. (smpdb.ca)
Oncovin1
The medicinal products Velban and Oncovin (contain vincristine as the active substance) were registered in 1961 and 1963 to treat Hodgkin's disease, acute lymphocytic leukaemia, lymphoma, cervical and breast cancer. (martifarm.com)
When purified, derivatives of Vinca (vincristine sulfate, vinblastine sulfate) are used to treat cancer under rigidly controlled supervision. (prcupcc.org)
Isolated in 19611
Vincristine was first isolated in 1961. (mdwiki.org)
Clinically1
At lower clinically relevant concentrations, vincristine can block mitotic progression. (smpdb.ca)
Plant1
Further research led to isolation of two biologically active chemical substances produced naturally in the plant - vincristine and vinblastine - and to their identification as anti-cancer agents. (rsc.org)
Unlike the taxanes, which bind poorly to soluble tubulin, vincristine can bind both soluble and microtubule-associated tubulin. (smpdb.ca)
To be able stabilizing the kinetics of microtule, vincristine rapidly and reversibly bind to soluble tubulin which can increase the affinity of tublin by the induction of conformational changes of tubulin. (smpdb.ca)
Vincristine binds to β-tubulin subunits at the positive end of microtubules at a region called the _Vinca_-binding domain. (smpdb.ca)
Binding between vincristine and solubale tubulin decreases the rate of microtubule dynamics (lengthening and shortening) and increases the duration of attenuated state of microtubules. (smpdb.ca)
The mitotic spindle in the presence (at different concentrations) and absence of vinblastine (very similar to vincristine). (acsh.org)
As a microtubule destabilizing agent, Vincristine stimulates mitotic spindle destruction and microtubule depolymerization at high concentrations. (smpdb.ca)
Compounds1
In contrast, it is beneficial in form of endophytes - having a mutual relationship to plants, for example, some of these bioactive compounds have been found and extracted vincristine 18-20 . (microbiologyjournal.org)
Inhibition1
The mechanism of vincristine is the inhibition of microtubule dynamics that would cause mitotic arrest and eventual cell death. (smpdb.ca)
Leaves1
Therefore, 530 kg of dry leaves are necessary to produce 1 kg of vincristine and half a ton for getting 1 g of vinblastine. (intechopen.com)
Acute2
Vincristine is used to treat acute lymphocytic leukemia, lymphosarcoma, lympho-granulomatosis and in solid infant tumors. (intechopen.com)
Vincristine is used against various blood and solid cancers including acute lymphoblastic leukaemia and Hodgkin lymphoma. (rsc.org)
Family1
A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid the taking of vincristine. (mdwiki.org)
Yield1
5. Alam MM, Naeem M, Khan MMA and Uddin M. Vincristine and vinblastine anticancer catharanthus alkaloids: pharmacological applications and strategies for yield improvement. (jmp.ir)