• Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)
  • It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
  • Three-dimensional structure of the armadillo repeat region of beta-catenin. (embl.de)
  • Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)
  • A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)
  • The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. (embl.de)
  • Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)
  • Signal transduction of beta-catenin. (embl.de)
  • Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
  • The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
  • This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. (nih.gov)
  • beta-catenin is a target for the ubiquitin-proteasome pathway. (bioseek.eu)
  • beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)
  • In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)
  • Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)
  • beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)
  • Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)
  • This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)
  • We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)
  • ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
  • ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)
  • The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)
  • Recruitment of the adaptor protein MyD88 initiates early activation of NF-B, whereas MyD88-independent pathway leads to delayed NF-B activation (4) and rapid activation of IFN regulatory factor 3 (5, 6). (msi-sig.org)
  • Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. (uzh.ch)
  • In this context, β-catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. (oncotarget.com)
  • The encoded protein is a negative regulator of the Wnt signaling pathway. (modellab.cn)
  • Signaling genes necessary for orchestrating these processes (like the JNK pathway ( Rios-Barrera & Riesgo-Escovar, 2013 )) regulate cytoskeletal proteins, like the FERM-domain proteins Coracle ( Fehon, Dawson & Artavanis-Tsakonas, 1994 ) and Yurt ( Hoover & Bryant, 2002 ). (peerj.com)
  • The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
  • The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
  • This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
  • Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
  • We have shown in frogs (4), flies (7) and worms (11) that the TCF proteins constitute the effectors of the canonical Wnt pathway. (hubrecht.eu)
  • Proteins that contain armadillo repeats typically contain several tandemly repeated copies. (wikipedia.org)
  • Examples of proteins that contain armadillo repeats include β-catenin, Sarm1 (SARM1), α-importin, plakoglobin, adenomatous polyposis coli (APC), and many others. (wikipedia.org)
  • The 3-dimensional fold of an armadillo repeat was first observed in the crystal structure of β-catenin, where the 12 tandem repeats form a superhelix of alpha helices with three helices per unit. (wikipedia.org)
  • These proteins share common features including N-terminal (N-term) leucine-rich repeats and one to four PDZ domains, with the exception of lano that lacks a PDZ domain. (jneurosci.org)
  • Each member of the p120ctn family consists of a central domain consisting of nine armadillo (arm) repeats broken by a wedge between repeats 5 and 6 plus N- and C-terminal sequences that differ substantially between family members ( Pokutta and Weis, 2007 ). (jneurosci.org)
  • Domains and repeats with an ARM-like fold have been found in a number of proteins, including: ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins. (eu.org)
  • The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. (eu.org)
  • In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
  • Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. (nih.gov)
  • Although β-catenin was previously believed to be a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton, recent work indicates that β-catenin regulates the homodimerization of alpha-catenin, which in turn controls actin branching and bundling. (wikipedia.org)
  • δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)
  • Plakoglobin (also known as γ-catenin) is a member of the Armadillo family of proteins and a paralog of β-catenin. (oncotarget.com)
  • Similar to β-catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. (oncotarget.com)
  • How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. (oncotarget.com)
  • Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)
  • At the adherens junction in epithelia, the C-terminal domain of E-cadherin interacts, in a mutually exclusive manner, with β-catenin or γ-catenin (plakoglobin), which then interacts with α-catenin, an actin-binding protein. (oncotarget.com)
  • Also, the neck linker binds to the motor domain, which repositions the other head domain through the coiled-coil domain close to a second tubulin dimer, about 80 Angstroms along the microtubule. (unl.edu)
  • Meanwhile, ATP hydrolysis takes place, and when the second head domain binds to the microtubule, the first domain again replaces ADP with ATP, triggering a conformational change that pulls the first domain forward. (unl.edu)
  • The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. (modellab.cn)
  • Degradation of β-catenin is mediated by the β-catenin destruction complex, in which APC plays critical roles as it binds to AXIN1 and β-catenin [ 12 ]. (biomedcentral.com)
  • Upon Wnt signaling, ß-catenin binds and activates nuclear TCFs by providing a trans-activation domain. (hubrecht.eu)
  • The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. (hubrecht.eu)
  • Delta-catenin binds AMPA-binding protein (ABP), leading to the LTP-induced increase in AMPA channel content. (biomedcentral.com)
  • p120-Catenin (p120) is a member of the catenin subfamily of armadillo repeat domain-containing proteins that associates with the juxtamembrane domain of multiple types of the cadherin family (12). (msi-sig.org)
  • Plakophilins (PKPs) are members of subfamily p120ctn (p120-catenins) of the armadillo protein family, which mainly includes p120ctn (p120ctn, CTNND1), NPRAP/δ-catenin (CTNND2), ARVCF (armadillo repeat gene deleted in velocardio-facial syndrome), p0071/ plakophilin (PKP4), and plakophilin 1/2/3 (PKP1/2/3), while all members of the p120ctn family have characteristic armadillo repeat sequences (arm-repeats), which are flanked by N-terminal head domain and C-terminal tail domain. (biomedcentral.com)
  • Kaiso protein interacts exclusively with p120 catenin, a member in the armadillo household that owns B catenin. (alkpathway.com)
  • Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)
  • p120 protein is an important constituent of intercellular connections and a substrate of Src tyrosine kinase proteins. (biomedcentral.com)
  • Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. (nih.gov)
  • This domain has previously been shown to bind to the b-catenin homolog Armadillo (Arm), raising the possibility that Wg input, in addition to Hh input, modulates the activity of the hybrid CiD protein. (uzh.ch)
  • The term armadillo derives from the historical name of the β-catenin gene in the fruitfly Drosophila where the armadillo repeat was first discovered. (wikipedia.org)
  • The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
  • Here, we identify Pins-mediated planar cell polarized divisions in several of the mitotic domains of the early Drosophila embryo. (elifesciences.org)
  • kinesin-like protein [Drosophila melan. (nig.ac.jp)
  • The cylindrical structure features a positively charged groove, which presumably interacts with the acidic surfaces of the known interaction partners of β-catenin. (wikipedia.org)
  • The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
  • B catenin and p120ctn are extremely comparable mole cules possessing the 2 i. domains of Inhibitors,Modulators,Libraries interaction together with the cytosolic portion of cadherins and ii. (alkpathway.com)
  • Protein dephosphorylation by the PP2A phosphatase is mainly achieved through the interaction of its regulatory subunit with the associated proteins. (eu.org)
  • The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
  • Sec62 competitively disrupted the interaction between β-catenin and APC to inhibit the β-catenin destruction complex assembly. (biomedcentral.com)
  • However, the mechanisms by which the APC-β-catenin interaction is regulated in CRC are not fully understood. (biomedcentral.com)
  • An intramolecular interaction between the importin beta-binding (IBB) domain and the NLS-binding pocket of Importin subunit alpha (SRP1) prevents binding of NLS cargo (e.g. (eu.org)
  • This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
  • A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
  • Armadillo-related proteins regulate functions like cell-cell interaction and cytoskeleton maintenance by producing and transducing signals influencing gene expression [ 3 ]. (biomedcentral.com)
  • The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
  • The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing β-catenin to accumulate in the cytosol and nucleus and co-activate Wnt target genes. (silverchair.com)
  • In addition, δ-catenin, ARVCF, and p0071 also contain a PDZ binding motif at the C terminus. (jneurosci.org)
  • The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. (nih.gov)
  • Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. (nih.gov)
  • In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. (nih.gov)
  • In humans there exist five isoforms of the B56 type regulatory subunit and they bind to their interacting proteins through a conserved LxxIxE motif. (eu.org)
  • The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
  • Most of the B56 binding proteins contain a conserved motif LxxIxE which acts as a docking site for B56. (eu.org)
  • The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
  • A p120ctn is really a regulator from the kaiso perform and it is identified that while in the nucleus of the cell they straight modulate the action of canonical Wnt pathways and target genes of B catenin, which can be another indication in the importance of Kaiso while in the growth of cancer. (alkpathway.com)
  • Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
  • The expression of a dominant-negative (DN)allele of Lef1, or of a Lef1-engrailed fusion protein, led to the inhibition of expression of peripheral genes and iris hypoplasia, suggesting that canonical Wnt signaling is required for peripheral eye development. (biologists.com)
  • Based on known binding reactions, we suggest the first molecularly specific version of tag/capture hypothesis: that the CaMKII/NMDAR complex, once formed, serves as a tag, which then leads to a binding cascade involving densin, delta-catenin, and N-cadherin (some of which are newly synthesized). (biomedcentral.com)
  • Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. (thermofisher.com)
  • Plakophilin 3 (PKP3) is a recently described armadillo protein of the desmosomal plaque, which is synthesized in simple and stratified epithelia. (rupress.org)
  • This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. (nih.gov)
  • Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis. (nih.gov)
  • In higher organisms six conserved Gid proteins form the CTLH protein-complex with unknown function. (xenbase.org)
  • adaptor related protein complex 2 s. (gsea-msigdb.org)
  • Apical proteins recruit Inscuteable (Insc), which in turn recruits Pins/LGN and the spindle rotation complex. (elifesciences.org)
  • Evolution of the Cadherin-Catenin Complex. (brh.co.jp)
  • All the diversity of catenins forms a complex functional network. (chemdiv.com)
  • β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
  • MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)
  • Inhibition of nuclear import of Large T antigen by phosphorylation-dependent (T124) binding of BRCA1-associated protein (BRAP) . (eu.org)
  • Research reports implicate either dozens of genes in genomewide sweeps, or focus on a few genes that encode proteins that act at synapses, such as the neuroligins and neurexins . (plos.org)
  • So identifying genes that stand out in their exomes (the protein-encoding part of the genome) and that make physiological sense - that is, affect the brain - could reveal general steps in the beginnings of autism in the broader population. (plos.org)
  • This means that absence of CTNND2 protein would affect many genes, a broad stroke that could paint the many manifestations of autism. (plos.org)
  • Genetic analysis has uncovered that genes necessary for epithelial polarity code for cytoskeletal proteins and their regulators, like the par-3 protein Bazooka ( Kuchinke, Grawe & Knust, 1998 ) or the EGF and laminin domains-containing protein Crumbs ( Tepass, Theres & Knust, 1990 ). (peerj.com)
  • 120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
  • Alternatively, the interactions could be intra-molecular and be important in maintaining the structural integrity of the protein. (embl-heidelberg.de)
  • Thus, m 6 A modification-Sec62-β-catenin molecular axis might act as therapeutic targets in improving treatment of CRC. (biomedcentral.com)
  • However, it is unclear whether these molecular mechanisms pertain to the entire family of MLL-fusions or if they specifically affect the leukemogenicity of isolated MLL-fusion proteins. (nature.com)
  • The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
  • In APC-deficient colon carcinoma cells, we demonstrated that ß-catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5). (hubrecht.eu)
  • It has been proposed by Frey and Morris that late LTP involves the setting of a molecular tag during LTP induction, which subsequently allows the activated synapse to capture the proteins responsible for late LTP. (biomedcentral.com)
  • CTNND2 encodes a protein called delta-2 catenin. (plos.org)
  • A key part of the CTNND2 protein is the "armadillo domain," a 40-amino-acid repeat important in how an embryo passes signals from outside to inside the cell. (plos.org)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • PP2A-mediated protein dephosphorylation is involved in a broad range of cellular processes including cell-cycle progression, cytoskeletal dynamics, and growth factor signalling. (eu.org)
  • They include the usual suspects - proteins that act at synapses or in neural extensions, and in the actin cytoskeleton - but also a new role, chromatin modification. (plos.org)
  • Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. (wikipedia.org)
  • Binding of LPS to TLR4 results in loss of endothelial barrier and expression of cell-surface adhesion proteins such as ICAM-1 through MyD88-dependent and -independent signaling pathways (3). (msi-sig.org)
  • Sec62 promoted the stemness of CRC cells through activating Wnt/β-catenin signaling. (biomedcentral.com)
  • Wnt/β-catenin signaling plays crucial roles in the maintenance of CSCs [ 7 ]. (biomedcentral.com)
  • We further demonstrated that Sec62 activates β-catenin signaling to potentiate the stemness and attenuate the chemosensitivity in CRC. (biomedcentral.com)
  • β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
  • Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
  • Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
  • An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
  • In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). (hubrecht.eu)
  • Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). (thermofisher.com)
  • In symmetric epithelial cell divisions, spindle orientation also depends on Pins, which is recruited to the lateral cortex by the lateral domain protein, Discs large (Dlg). (elifesciences.org)
  • Hypothetical protein CBG01568 [Caeno. (nig.ac.jp)
  • hypothetical protein MGC66125 [Dani. (nig.ac.jp)
  • These are generally recognized and assessed by the presence of marker proteins ( Muller & Wieschaus, 1996 ). (peerj.com)
  • However, little is known about the biological significance of armadillo proteins in tumorigenesis and tumor progression. (biomedcentral.com)
  • Cadherins are single-pass transmembrane glycoproteins that form homotypic interactions with cadherin proteins on neighboring cells and interact intracellularly with proteins of the catenin family [ 4 , 5 ]. (oncotarget.com)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
  • C-type lectin domain family 2 membe. (gsea-msigdb.org)
  • DnaJ heat shock protein family (Hsp. (gsea-msigdb.org)
  • β-catenin belongs to the catenin molecule family. (chemdiv.com)
  • An armadillo repeat is a characteristic, repetitive amino acid sequence of about 42 residues in length that is found in many proteins. (wikipedia.org)
  • germin-like protein with N-terminal signal sequence that may target it to the vacuole, plasma membrane and/or outside the cell. (or.jp)
  • Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)
  • Armadillo and dTCF: a marriage made in the nucleus. (embl.de)
  • We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of δ-catenin severely impaired dendritic morphogenesis in hippocampal neurons. (jneurosci.org)
  • These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin. (jneurosci.org)
  • We found that disrupting forces through chemical inhibitors, depletion of an adherens junction protein, or blocking mesoderm invagination disrupted Pins planar polarity and spindle orientation. (elifesciences.org)
  • Protein phosphatase 2A (PP2A) belongs to the superfamily of phosphoprotein phosphatases (PPPs) and catalyzes protein dephosphorylation by hydrolyzing Ser/Thr-linked phosphate ester bonds ( Heroes,2013 ). (eu.org)
  • This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. (unl.edu)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
  • β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
  • The helical domain of phosphoinositide 3-kinase. (eu.org)
  • We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. (nature.com)
  • The expression level and prognosis of PKP1 showed little significance in ovarian cancer, and the expression of PKP2/3 mRNA and protein were upregulated in OC, showing significant correlations with poor prognosis of OC. (biomedcentral.com)
  • We found that the expression of Wnt2b or constitutively active (CA) β-catenin inhibited retinal progenitor gene(RPG) expression and the differentiation of retinal neurons. (biologists.com)
  • Mechanistically, Sec62 bound to β-catenin and inhibited the degradation of β-catenin. (biomedcentral.com)
  • Thus, the Hh and the Wg pathways are affected by the ciD mutation, and the CiD fusion protein integrates the activities of both. (uzh.ch)
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
  • Here, we used this innovative approach to identify further SMYD3-interacting proteins involved in crucial cancer pathways and found that the chromatin remodeling factors EP300 and TRRAP interact directly with SMYD3, thus linking SMYD3 to the emerging 'nonmutational epigenetic reprogramming' cancer hallmark. (bvsalud.org)
  • The PHD finger and the bromodomain are small protein domains that occur in many proteins associated with phenomena related to chromatin. (embl-heidelberg.de)
  • It has therefore been proposed that the oncogenic activity of MLL-fusion proteins depends on chromatin targeting functions exerted by the MLL N-terminus in combination with other functional properties encoded by the fusion partners 6 . (nature.com)