COMTPolymorphismEnzymeMethyltransferaseDioxygenase2019DopamineHydroxylation of phenolMoietyOxidasePhenolNorepinephrineSolubleNanoparticlesDerivativesPrecursorComplexesHydroquinoneCompoundsDerivative2023CatechinLevodopaCompoundPesticidesReversibleHumansFlavorsAcidOrganicAimsSearchReactionSensorExposurePresenceForm
COMT12
- In humans, catechol- O -methyltransferase protein is encoded by the COMT gene . (en-academic.com)
- Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. (en-academic.com)
- Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. (ox.ac.uk)
- Abstract: The cellular localization of the two forms of catechol‐O‐methyltransferase (COMT) was investigated by measuring their activities in rat striatum following unilateral stereotaxic injection of kainic acid, which causes degeneration of striatal neurons followed by proliferation of astroglial cells. (psu.edu)
- Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. (umn.edu)
- Stalevo, a combination drug consisting of levodopa (aromatic amino acid), carbidopa (aromatic amino acid decarboxylation inhibitor), and entacapone (catechol-O-methyltransferase (COMT) inhibitor) is indicated for the treatment of Parkinson's disease. (nih.gov)
- The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. (medlineplus.gov)
- The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. (medlineplus.gov)
- Other tissues, including the liver, kidneys, and blood, produce a shorter form of the enzyme called soluble catechol-O-methyltransferase (S-COMT). (medlineplus.gov)
- A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain. (medlineplus.gov)
- Aims: The catechol-O-methyltransferase (COMT) gene codes for synaptic enzyme degrading catecholamines, including dopamine, and has been extensively studied in mental health research. (frontiersin.org)
- Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. (cdc.gov)
Polymorphism1
- Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase. (medlineplus.gov)
Enzyme5
- Small amounts of catechol occur naturally in fruits and vegetables, along with the enzyme polyphenol oxidase (also known as catecholase, or catechol oxidase). (wikipedia.org)
- Upon mixing the enzyme with the substrate and exposure to oxygen (as when a potato or apple is cut and left out), the colorless catechol oxidizes to reddish-brown melanoid pigments, derivatives of benzoquinone. (wikipedia.org)
- An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (lookformedical.com)
- These results indicate that the K m membrane‐bound catechol‐O‐methyltransferase may be localized predominantly in neurons, whereas the high‐K m soluble enzyme is found in glial cells. (psu.edu)
- They synthesized catechol 1, 2 - dioxygense enzyme which is unique its properties to transform catechol to cis, cis - muconic acid. (researchbib.com)
Methyltransferase12
- TY - JOUR T1 - Catechol-O-methyltransferase inhibitors for levodopa-induced complications in Parkinson's disease. (unboundmedicine.com)
- Catechol-O-methyltransferase is shown in green boxes. (en-academic.com)
- Catechol- O -methyltransferase is involved in the inactivation of the catecholamine neurotransmitters ( dopamine , epinephrine , and norepinephrine ). (en-academic.com)
- Rivett, AJ , Francis, A & Roth, JA 1983, ' Distinct Cellular Localization of Membrane‐Bound and Soluble Forms of Catechol‐O‐Methyltransferase in Brain ', Journal of neurochemistry , vol. 40, no. 1, pp. 215-219. (psu.edu)
- Description: A sandwich ELISA for quantitative measurement of Rat Catechol O methyltransferase domain containing protein 1(COMTD1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (worldcarecouncil.org)
- Description: A sandwich ELISA for quantitative measurement of Human Catechol O methyltransferase domain containing protein 1(COMTD1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (worldcarecouncil.org)
- In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters. (medlineplus.gov)
- Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which organizes and coordinates information from other parts of the brain. (medlineplus.gov)
- Catechol-O-methyltransferase helps maintain appropriate levels of these neurotransmitters in this part of the brain. (medlineplus.gov)
- Little is known, however, about the relationship between catechol-O-methyltransferase activity and the specific mental and emotional problems characteristic of this condition. (medlineplus.gov)
- The change affects the stability and activity of catechol-O-methyltransferase, which alters the enzyme's ability to break down neurotransmitters in the prefrontal cortex. (medlineplus.gov)
- Variations in catechol-o-methyltransferase gene interact with parenting to influence attention in early development. (bvsalud.org)
Dioxygenase4
- Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. (wikipedia.org)
- The aim of the study was to purify, characterize and predict template-based three-dimensional structure of catechol 1,2-dioxygenase (C12O) from indigenous Pseudomonas chlororaphis strain UFB2 ( Pc UFB2). (preprints.org)
- Global transcriptomic analysis of a ΔsifR strain defines the SifR regulon as genes encoding a candidate catechol dioxygenase CatE, an uncharacterized oxidoreductase YwnB, a candidate flavin-dependent ferric reductase YhdA, a candidate heme -based ferric reductase domain-containing protein and the Piu ( pneumococcus iron uptake) Fe transporter (piuBCDA). (bvsalud.org)
- Consistent with this model, we show that CatE is an FeII-dependent 2,3-catechol dioxygenase with broad substrate specificity , YwnB is an NAD (P)H-dependent quinone reductase capable of reducing the oxidized and cyclized norepinephrine , adrenochrome , and YhdA is capable of reducing a number of FeIII complexes, including PiuA-binding transport substrates . (bvsalud.org)
20191
- Yabu, H 2019, Catechol-containing polymers: A biomimetic approach for creating novel adhesive and reducing polymers . (elsevierpure.com)
Dopamine1
- A comparison of Langmuirian binding constants for alizarin red S (1.4 x 10(5) mol(-1) dm(3)), catechol (8.4 x 10(4) mol(-1) dm(3)), caffeic acid (7.5 x 10(4) mol(-1) dm(3)), dopamine (1.0 x 10(4) mol(-1) dm(3)), and L-dopa (8 x 10(3) mol(-1) dm(3)) reveals that a combination of hydrophobicity and electrostatic interaction causes considerable selectivity effects. (bath.ac.uk)
Hydroxylation of phenol2
- Catechol is produced industrially by the hydroxylation of phenol using hydrogen peroxide. (wikipedia.org)
- Catechol is produced by hydroxylation of phenol with hydrogen peroxide in presence of Titanium Silicalite. (cfseuropespa.com)
Moiety1
- We describe the synthesis of conjugates between a catechol moiety and oxazolidinone antibiotics. (rsc.org)
Oxidase4
- Catechol oxidase. (lookformedical.com)
- Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (lookformedical.com)
- The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. (lookformedical.com)
- Substrates containing a -COOH group are inhibitors for catechol oxidase. (lookformedical.com)
Phenol1
Norepinephrine1
- Previous work established that membrane -anchored PiuA binds FeIII-bis-catechol or monocatechol complexes with high affinity, including the human catecholamine stress hormone , norepinephrine . (bvsalud.org)
Soluble1
- Catechol occurs as feathery white crystals that are very rapidly soluble in water. (wikipedia.org)
Nanoparticles1
- The experience and background of the team brings an important asset in the synthesis of "sticky" catechol based coatings and nanoparticles with bioadhesion properties in humid conditions. (polyphenols-site.com)
Derivatives2
- Like other difunctional benzene derivatives, catechol readily condenses to form heterocyclic compounds. (wikipedia.org)
- The N-hexadecyl-pyridinium-4-boronic acid hexafluorophosphate monolayer acts as an active receptor for 1,2-dihydroxy-benzene (catechol) derivatives in aqueous media. (bath.ac.uk)
Precursor2
- About 20,000 tonnes of catechol are now synthetically produced annually as a commodity organic chemical, mainly as a precursor to pesticides, flavors, and fragrances. (wikipedia.org)
- Catechol is used as a precursor to many of the chemicals that are used in the pharmaceutical and personal care product industries. (credenceresearch.com)
Complexes2
- Toughening elastomers using mussel-inspired iron-catechol complexes. (ucsb.edu)
- These findings are consistent with a model where FeIII-catechol complexes serve as significant nutritional Fe sources in the host. (bvsalud.org)
Hydroquinone1
- Orto - and para -dihydroxybenzene (DHB) compounds, such as catechol (CAT) and hydroquinone (HQ), have capacity to reduce iron(III) 9 9 Chen, R. (scielo.br)
Compounds1
- The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol. (planteome.org)
Derivative2
- Its methyl ether derivative, guaiacol, converts to catechol via hydrolysis of the CH3−O bond as promoted by hydroiodic acid (HI). (wikipedia.org)
- Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic. (lu.se)
20231
- The market for Catechol: Market is expected to reach XX Mn in 2023. (credenceresearch.com)
Catechin2
- Catechol was first isolated in 1839 by Edgar Hugo Emil Reinsch (1809-1884) by distilling it from the solid tannic preparation catechin, which is the residuum of catechu, the boiled or concentrated juice of Mimosa catechu (Acacia catechu). (wikipedia.org)
- Catechol was first discovered in a plant extract called catechin via destructive distillation. (credenceresearch.com)
Levodopa1
- To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydroxybenzoate, didox, levodopa, and nordihydroguaiaretic acid (NDGA), using novel luciferase-based reporters specific for the first step in HIF1 or Nrf2 protein stabilization. (elsevierpure.com)
Compound2
- Catechol (/ˈkætɪtʃɒl/ or /ˈkætɪkɒl/), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C6H4(OH)2. (wikipedia.org)
- Catechol, which is also known as 1,2-dihydroxybenzene or pyrocatechol, is an organic compound that is used for various applications in the global market. (credenceresearch.com)
Pesticides2
- More than 50% of catechol produced artificially, known as synthetic catechol, is used in the manufacture of pesticides. (credenceresearch.com)
- Rising demand for pesticides has led to the growth of the agrochemical industry, thereby boosting the growth of the catechol market worldwide. (credenceresearch.com)
Reversible1
- Inspired by cuticles of marine mussel byssi, we circumvent this inherent trade-off by incorporating sacrificial, reversible iron-catechol cross-links into a dry, loosely cross-linked epoxy network. (ucsb.edu)
Humans1
- Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to catechol. (cdc.gov)
Flavors1
- A large number of flavors and fragrances are produced using catechol as a starting material. (credenceresearch.com)
Acid2
- Catechol dioxygenases in microorganisms cleave catechol into cis - cis -muconic acid or 2-hydroxymuconic semialdehyde via the ortho- or meta- pathway, respectively. (preprints.org)
- It is shown that the immobilised boronic acid monolayer acts as sensor film for a wider range of catechols. (bath.ac.uk)
Organic1
- Background: Urushiol, the causative allergens in Toxicodendron plants such as poison ivy, is an oily mixture of organic catechols with alkyl-(C15-C17) side chains of varying degrees of saturation. (cdc.gov)
Aims1
- Objective: This study aims to determine whether urushiol-like catechols are present in consumer products labeled as containing Toxicodendron extracts. (cdc.gov)
Search1
- A literature search was conducted through February 2018 to identify catechol toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological ystem/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and ensitization. (cdc.gov)
Reaction1
- Upon reaction with catechol-derived quinones , we show that SifR dissociates from the DNA leading to regulon derepression, allowing the pneumococcus to access a catechol-derived source of Fe while minimizing reactive electrophile stress induced by quinones . (bvsalud.org)
Sensor1
- SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39. (bvsalud.org)
Exposure1
- The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to catechol and the potential for direct skin injuries from catechol. (cdc.gov)
Presence1
- By contrast, stabilization of Nrf2 requires the presence of 3,4-dihydroxy- (catechol) groups. (elsevierpure.com)
Form1
- Catechol has since been shown to occur in free form naturally in kino and in beechwood tar. (wikipedia.org)