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  • oxidative
  • Urine samples were analyzed for indole-catecholamines, their metabolites, and oxidative-stress marker, hydroxylpyrolline-2-one (HPL). (frontiersin.org)
  • Taurine/α-ketoglutarate (αKG) dioxygenase, or TauD, is a mononuclear non-heme iron hydroxylase that couples the oxidative decarboxylation of αKG to the decomposition of taurine, forming sulfite and aminoacetaldehyde. (pnas.org)
  • This Escherichia coli protein is a member of a rapidly expanding enzyme superfamily that utilizes mononuclear Fe(II) active sites to catalyze a diverse range of chemical transformations, usually coupled to the oxidative decarboxylation of an α-keto acid ( 2 - 4 ). (pnas.org)
  • The kinetics of the copper/N-methylimidazole catalysed oxidative coupling reaction with the C-O coupled dimer of 2,6- dimethylphenol (DMP or monomer), viz. (worldwidescience.org)
  • It was found that oxygen in air had little influence on the oxidative polymerization of 2,6- dimethylphenol (DMP) in the aqueous medium, and potassium ferricyanide was only an oxidant during the oxidative polymerization of DMP. (worldwidescience.org)
  • molecule
  • There are two chiral centers on the molecule on carbons 2 and 3. (wikipedia.org)
  • OTA is composed of a 7-carboxy-5-chloro-8-hydroxy-3,4-dihydro-3- R -methylisocoumarin (ochratoxin α) moiety and a L- β -phenylalanine molecule, which are linked through the 7‑carboxy group by an amide bond. (mdpi.com)
  • enzymes
  • Lipoxygenases (LOXs) comprise a family of non-heme iron-containing dioxygenases, representing the key enzymes in the biosynthesis of leukotrienes that have been postulated to play an important role in the pathophysiology of several inflammatory and allergic diseases. (biomedcentral.com)
  • This review covers the major phase II enzymes: UDP-glucuronosyltransferases, sulfotransferases, -acetyltransferases, glutathione S-transferases and methyltransferases (mainly thiopurine S-methyl transferase and catechol -methyl transferase). (docplayer.net)
  • The main enzymes in this phase are cytochromes P450 (CYPs) performing mainly hydroxylations and hence acting as monooxygenases, dioxygenases and hydrolases. (docplayer.net)
  • glutathione
  • Thiols such as glutathione react with TCBQ particularly rapidly ( 3 , 6 ). (pnas.org)
  • Accepted: April 20, 2010 Key words: Phase II biotransformation/udp-glucuronosyltransferases/sulfotransferases, -acetyltransferases/glutathione S-transferases/Thiopurine S-methyl transferase/catechol -methyl transferase Background. (docplayer.net)
  • aqueous
  • The effects of potassium ferricyanide, sodium n-dodecyl sulfate, sodium hydroxide and temperature on the molecular weight and the yield of poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) synthesized in an aqueous medium were studied. (worldwidescience.org)
  • carbon
  • The Sphingomonas macrogolitabida strain TFA is a gram-negative bacterium that is able to grow on tetralin (1,2,3,4-tetrahydronaphthalene) as the only carbon and energy source ( 14 ). (pubmedcentralcanada.ca)
  • flavonoid
  • Chalcone is then isomerized to naringenin by chalcone isomerase which is oxidized to eriodictyol by flavonoid 3'- hydroxylase and further oxidized to taxifolin by flavanone 3-hydroxylase. (wikipedia.org)
  • reaction
  • The oxidation of the catechol 3',4'-dihydroxyl electron-donating groups occurs first, at very low positive potentials, and is a reversible reaction. (wikipedia.org)
  • Prior studies revealed that taurine-free TauD catalyzes an O 2 - and αKG-dependent self-hydroxylation reaction involving Tyr-73, yielding an Fe(III)-catecholate chromophore with a λ max of 550 nm. (pnas.org)
  • acid
  • The conversion of nonhalogenated cinnamic acids to benzoic acids, such as the transformation of ferulic acid to vanillic acid, has been described previously ( 2 , 4 , 20 , 31 , 39 ). (asm.org)
  • Taurine/α-ketoglutarate (αKG) dioxygenase, or TauD, catalyzes the conversion of taurine (2-aminoethanesulfonic acid) to sulfite and aminoacetaldehyde in the presence of O 2 , αKG, and Fe(II) as shown in Scheme S1 ( 1 ). (pnas.org)
  • mechanism
  • The reactivity with 1,1-diphenyl-2-picryl-hydrazyl (DPPH), a free stable radical, was evaluated to elucidate the rate of possible lipid-derived radical scavenging in the mechanism of the enzyme inhibition. (biomedcentral.com)
  • Since the mechanism of the enzyme inhibition may include reduction of lipidperoxy- or lipidoxy-radicals, the effects of the samples tested on the 12-LOX activity were compared with their abilities to scavenge 1,1-diphenyl-2-picryl-hydrazyl (DPPH), a free stable radical. (biomedcentral.com)
  • Site
  • The ≈700-nm and 550-nm species are shown to interconvert by the addition or removal of bicarbonate, consistent with the αKG-derived CO 2 remaining tightly bound to the oxidized metal site as bicarbonate. (pnas.org)
  • effect
  • A kinetic model of NW doping, including the microscopic processes of (1) P incorporation into the liquid catalyst, (2) P evaporation from the catalyst, and (3) P crystallization in the Si NW, quantitatively explains the results and shows that suppression of the reservoir effect can be achieved when P evaporation is much faster than P crystallization. (jove.com)
  • known
  • On an evolutionary scale, they are some of the oldest molecules known, originating in the neighborhood of 3 BY ago. (bris.ac.uk)
  • shown
  • As shown in Fig. ​ Fig.1A, 1A , strain TFA metabolizes tetralin through a meta -cleavage pathway that involves an initial dioxygenation step (catalyzed by the enzymatic complex ThnA1A2A3A4), followed by a dehydrogenation step (catalyzed by ThnB) to produce 1,2-dihydroxytetralin ( 24 ). (pubmedcentralcanada.ca)
  • Here, a chromophore (λ max 720 nm) is described and shown to arise from O 2 -dependent self-hydroxylation of TauD in the absence of αKG, but requiring the product succinate. (pnas.org)
  • water
  • αKG chelates to the Fe(II) and displaces two water molecules, binding through the 1-carboxylate and 2-keto moieties. (pnas.org)