OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
CatecholsCatechol 2,3-DioxygenaseCatechol 1,2-DioxygenaseEstrogens, CatecholDioxygenasesOxygenasesCatechol O-Methyltransferase4-Hydroxyphenylpyruvate DioxygenaseProtocatechuate-3,4-DioxygenaseCysteine DioxygenaseTryptophan OxygenasePseudomonasBiodegradation, EnvironmentalHomogentisate 1,2-Dioxygenase3-Hydroxyanthranilate 3,4-DioxygenaseCatechol OxidasePhenolHydroxybenzoatesPseudomonas putidaKynurenineSorbic AcidRhodococcusBenzoatesChlorobenzenesTolueneEquileninChlorobenzoatesMixed Function OxygenasesBenzeneBenzoic AcidAdipatesSubstrate SpecificitySphingomonasPyrogallolTryptophanBurkholderiaAlcaligenesPhenolsGentisatesMolecular Sequence DataAcinetobacterHydroquinonesOxidation-ReductionPlanococcus BacteriaGenes, BacterialCresolsRalstoniaHydroxylationHydrocarbons, AromaticHydroxyestronesParabensBrevibacteriumGram-Negative Aerobic Rods and CocciIronSalicylatesToluidinesXylenesAmino Acid SequenceKineticsCloning, MolecularComamonasIntramolecular LyasesHomogentisic Acidortho-AminobenzoatesBiotransformationSiderophoresPseudomonas stutzeriAcinetobacter calcoaceticusQuinonesEscherichia coliMonophenol MonooxygenaseFerredoxinsPolychlorinated BiphenylsEnzyme InductionVanillic AcidBiphenyl CompoundsArthrobacterPseudomonas mendocinaFerrous Compounds3,4-Dihydroxyphenylacetic AcidChromatography, High Pressure LiquidBacterial ProteinsAdrenochromeBase SequenceBenzophenonesNaphthalenesNaphtholsChlorophenolsEnzyme ReactivatorsNormetanephrineSpectrophotometryBurkholderiaceae3-Hydroxyanthranilic Acidgamma-Butyrobetaine DioxygenaseAniline CompoundsCatecholaminesSequence Homology, Amino AcidAlkaptonuriaOxidoreductasesIsomerases
C23OCleavageGeneCytochrome P-450DegradationSubstratesDehydrogenasePseudomonasCharacterizationBeta-ketoadipate pathwaySuperfamilyBacteriaOxygenasesGenesTolueneCatalyzesInhibitorsPurified to homogeneityExtradiolRhodococcusAcinetobacterOxidation2023StructurallyAlcaligenesSurfactantEscherichiaProteinBRENDAAtomsNaphthaleneSemialdehydeTyrosinaseReactionExtractsSubstrate specificityBiosynthesisProteins
C23O3
  • The efficiency and regulatory properties of p ugp were measured using xylE and lacZ as reporter genes, which code for the corresponding enzymes catechol-2,3-dioxygenase (C23O) and β-galactosidase (βGal), respectively. (nau.edu)
  • Catechol 2,3-dioxygenase (C23O) gene was found andamplified with the designed primers from the total DNA of C-14-1. (researchgate.net)
  • The existence of catabolic and surfactant genes namely catechol dioxygenase ( C23O ), rhamnolipid enzyme ( rhlB ) and surfactin /lichenysin enzyme ( SrfA3 /LicA3 ) genes were detected in only four (4) out of the nine (9) marine aromatic degrading bacteria with 881 base pairs sizes. (journalarrb.com)
Cleavage7
  • The enzyme protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the ring cleavage of protocatechuate (PCA) in Acinetobacter baylyi. (uni-ulm.de)
  • An aromatic compound ring cleavage enzyme of catechol 1,2-dioxygenase was detected but catechol 2,3-dioxygenase was not detected in 2C6-43 T . A fatty acid profile with anteiso-C 15: 0 , iso-C 15: 0 and C 16: 0 as the major components supported the affiliation of strain 2C6-43 T to the genus Georgenia. (elsevierpure.com)
  • A novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC_JF8) catalyzing the meta-cleavage of the hydroxylated biphenyl ring was purified from the thermophilic biphenyl and naphthalene degrader, Bacillus sp. (muni.cz)
  • Dehydrogenation of phenanthrene-cis-9,10-dihydrodiol to produce the corresponding diol, followed by ortho-cleavage of the oxygenated ring, produced 2,2'-diphenic acid. (afpm.org.my)
  • David T. Gibson has included themes like Plasmid, DNA, Cleavage and Hydroquinone in his Enzyme study. (research.com)
  • In the convergent mode, structurally diverse aromatic compounds are converted to one of a few aromatic ring cleavage substrates such as catechol, gent sate, protocatechuate and their derivatives [ 5 ]. (biomedcentral.com)
  • In this divergent mode, a metal-dependent dioxygenase channels these dihydroxylated intermediates into one of the two possible pathways: the meta -cleavage pathway or the ortho -cleavage pathway [ 7 - 9 ] (Fig. 1 ). (biomedcentral.com)
Gene7
  • When the xylE gene was maximally expressed, the induced enzyme constituted approx. (nau.edu)
  • Moreover, a dioxygenase gene, nidA3B3, was detected in Mycobacterium vanbaalenii PYR-1 as an alternate degradation pathway which could catalyze both the initial dihydroxylation of pyrene [ 11 ] to be pyrene cis-4,5-dihydrodiol, and an alternate detoxification pyrene pathway to be pyrene cis-1,2-dihydrodiol [ 12 ]. (omicsonline.org)
  • 2006. Microbial dioxygenase gene population shifts during polycyclic aromatic hydrocarbon biodegradation. (nih.gov)
  • Each enzyme entry contains its common name and synonym, reaction in which enzyme is involved, family and subfamily, structure and gene link and literature citation. (biomedcentral.com)
  • For all significantly differentially expressed microRNAs inside of the 2 groups, we now have produced gene sets from their expressed target genes. (pdpksignaling.com)
  • Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia. (ouhsc.edu)
  • For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. (wakehealth.edu)
Cytochrome P-4503
  • Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • This graph shows the total number of publications written about "Cytochrome P-450 Enzyme System" by people in this website by year, and whether "Cytochrome P-450 Enzyme System" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles. (wakehealth.edu)
Degradation3
  • New metabolic pathways of phenanthrene and a better understanding of the phenoloxidases and dioxygenase mechanism involved in degradation of phenanthrene were explored in this research. (afpm.org.my)
  • A number of bacteria that can degrade a variety of aromatic compounds have been identified and the pathways involved in the degradation have been extensively characterized [ 3 , 4 ]. (biomedcentral.com)
  • Further, the centralized degradation pathways mean synthesis of fewer degradative enzymes requiring less metabolic energy. (biomedcentral.com)
Substrates7
  • The metal ligands and active site residues of extradiol dioxygenases are conserved although several amino acid residues found exclusively in enzymes which preferentially cleave bicyclic substrates are missing in BphC_JF8. (muni.cz)
  • The enzymes responsible for growth on these substrates are encoded by a large plasmid with properties similar to those of TOL plasmids isolated from other strains of Pseudomonas. (rhea-db.org)
  • p-Xylene-grown cells contained an inducible NAD+-dependent dehydrogenase which formed catechols from cis-p-toluate diol and the analogous acid diols formed from the other hydrocarbon substrates listed above. (rhea-db.org)
  • Oxygenases belong to the oxidoreductive group of enzymes (E.C. Class 1), which oxidize the substrates by transferring oxygen from molecular oxygen (O 2 ) and utilize FAD/NADH/NADPH as the co-substrate. (biomedcentral.com)
  • Peripheral enzymes, particularly oxygenases and dehydrogenases, were found to transform structurally diverse substrates into one of these central intermediates by bringing about the hydroxylation of the aromatic nucleus (Fig. 2A ), and hence it is thought that bacteria have developed these enzymes to extend their substrate range [ 5 ]. (biomedcentral.com)
  • 2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). (wakehealth.edu)
  • Substrates containing a -COOH group are inhibitors for catechol oxidase. (lookformedical.com)
Dehydrogenase2
Pseudomonas4
Characterization4
  • Cloning and characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a PCB and naphthalene degrading Bacillus sp. (muni.cz)
  • 2003. Characterization of a novel Acinetobacter species containing a toluene dioxygenase. (nih.gov)
  • 1. Fischer, D., Ebenau-Jehle, C. and Grisebach, H. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. (qmul.ac.uk)
  • Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (lookformedical.com)
Beta-ketoadipate pathway2
  • Dienelactone hydrolase (DLH), an enzyme from the beta-ketoadipate pathway, catalyzes the hydrolysis of dienelactone to maleylacetate. (inrae.fr)
  • The root-mean-square deviation from ideal bond distances for the model is 0.014 A and the error in atomic co-ordinates is estimated to be 0.15 A. DLH is a monomeric enzyme containing 236 amino acid residues and is a member of the beta-ketoadipate pathway found in bacteria and fungi. (inrae.fr)
Superfamily2
  • TIM barrel domain, Glyoxalase/fosfomycin resistance/dioxygenase domain, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily [InterProScan]. (ntu.edu.sg)
  • A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate. (bvsalud.org)
Bacteria2
  • PAHs could be degraded by bacteria under aerobic conditions through the initial oxidation of the aromatic ring, which is catalyzed by the dioxygenase enzyme. (omicsonline.org)
  • Enzymes induced in 4-fluorobenzoate-utilizing bacteria have been classified into three groups on the basis of their specificity towards cis- and trans-dienelactone. (inrae.fr)
Oxygenases2
Genes2
  • nidA and nidB genes are encoding genes for large and small subunits of napthalene-inducible dioxygenase [ 7 , 8 ]. (omicsonline.org)
  • B, solute carrier relatives six member 2, solute carrier relatives 18 member one, and transcription factors and homeobox genes involved in neural crest derived cell de velopment, paired like homeobox 2a and 2b, GATA binding protein two and 3, heart and neural crest derivatives expressed two. (pdpksignaling.com)
Toluene1
Catalyzes5
  • An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. (harvard.edu)
  • An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. (nih.gov)
  • An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. (uchicago.edu)
  • An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (lookformedical.com)
  • The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. (lookformedical.com)
Inhibitors1
  • The enzyme is resistant to denaturation by various chelators and inhibitors (EDTA, 1,10-phenanthroline, H2O2, 3-chlorocatechol) and did not exhibit substrate inhibition even at 3 mM 2,3-dihydroxybiphenyl. (muni.cz)
Purified to homogeneity2
  • The native and recombinant BphC enzyme was purified to homogeneity. (muni.cz)
  • Prophenoloxidase-activating enzyme (PPAE) was purified to homogeneity as judged by SDS-polyacrylamide gel electrophoresis from larval cuticles of the silkworm, Bombyx mori. (lookformedical.com)
Extradiol1
  • It exhibited a half life of 30 min at 80 C and 81 min at 75 C, making it the most thermostable extradiol dioxygenase studied. (muni.cz)
Rhodococcus1
  • An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. (brenda-enzymes.org)
Acinetobacter2
Oxidation1
  • Identification of metabolites from phenanthrene oxidation by phenoloxidases and dioxygenases of Polyporus sp. (afpm.org.my)
20234
  • 2023, 43(3): 297-309. (tea-science.com)
  • Analysis of Codon Usage Bias and Phylogenesis in the Chloroplast Genome of Ancient Tea Tree Camellia taliensis in Forest-tea Garden[J]. Journal of Tea Science, 2023, 43(3): 297-309. (tea-science.com)
  • 2023, 43(3): 310-324. (tea-science.com)
  • Thea bohea L.) Based on GBS-SNP[J]. Journal of Tea Science, 2023, 43(3): 310-324. (tea-science.com)
Structurally1
  • Catechol 1,2-dioxygenase is structurally similar to 3,4-PCD. (uni-ulm.de)
Alcaligenes2
  • Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. (wikipedia.org)
  • in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. (wikipedia.org)
Surfactant1
  • This nanocomposite was prepared with slight modification of nanocrystalline cellulose (NCC) with cationic surfactant of cetyltriammonium bromide (CTAB) and further decorated with 3-mercaptopropionic acid (3-MPA) capped CdS QDs. (afpm.org.my)
Escherichia3
  • The ugp promoter (p ugp ) responsible for expression of the binding-protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli was cloned into a small multicopy plasmid pTER5, a derivative of pBR322, between the transcription terminators rpoCt and t L1 . (nau.edu)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Protein2
  • This competitive enzyme-linked immunosorbent assay-like method, used competitive binding of free hyaluronan in the sample and biotin-labeled standard hyaluronan to hyaluronan binding protein in solid phase. (go.jp)
  • The enzyme contained 2 g-atoms of iron per mol of protein. (shengsci.com)
BRENDA1
  • The entries are also linked to several external database including BRENDA, KEGG, ENZYME and UM-BBD providing wide background information. (biomedcentral.com)
Atoms2
  • ICP-MS analysis confirmed the presence of 4.0 to 4.8 manganese atoms per enzyme molecule. (muni.cz)
  • Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. (nih.gov)
Naphthalene1
  • Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron. (research.com)
Semialdehyde1
  • This enzyme catalyses the following chemical reaction catechol + O2 ⇌ {\displaystyle \rightleftharpoons } 2-hydroxymuconate semialdehyde This enzyme contains Fe(II). (wikipedia.org)
Tyrosinase1
  • The nanocomposite material was then employed as scaffold for immobilization of tyrosinase enzyme (Tyr). (afpm.org.my)
Reaction1
  • In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. (qmul.ac.uk)
Extracts1
  • The identification of 2,2'-diphenic acid in culture extracts indicates that phenanthrene was initially attacked through dioxigenation at C9 and C10 to give cis-9,10-dihydrodiol. (afpm.org.my)
Substrate specificity3
Biosynthesis1
  • A survey of agricultural technologies influencing the biosynthesis and accumulation of phenolic compounds in crop plants is presented, including observations on the effects of light, temperature, mineral nutrition, water management, grafting, elevated atmospheric CO 2 , growth and differentiation of the plant and application of elicitors, stimulating agents and plant activators. (mdpi.com)
Proteins1