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CataractCataract ExtractionCarbacholPhacoemulsificationLens Implantation, IntraocularLenses, IntraocularVisual AcuityLens Capsule, CrystallinePseudophakiaEndophthalmitisLens, CrystallineAnesthesia, LocalCapsulorhexisOphthalmologyAphakia, PostcataractLens Nucleus, CrystallinePostoperative ComplicationsCholinergic AgonistsAnterior ChamberBlindnessPostoperative PeriodAstigmatismIris DiseasesMicrosurgeryTreatment OutcomeIntraoperative ComplicationsChoroid HemorrhageVitrectomyAqueous HumorEye Infections, BacterialProspective StudiesLens DiseasesReceptors, MuscarinicLens Cortex, CrystallineRefractive ErrorsCapsule OpacificationVision DisordersRetrospective StudiesEye DiseasesIntraocular PressureFollow-Up Studiesgamma-CrystallinsVisually Impaired PersonsMuscarinic AgonistsOphthalmic SolutionsOphthalmologic Surgical ProceduresPreoperative CareRefraction, OcularIrisLens SubluxationEyeglassesGlaucomaIridocyclitisTrabeculectomyAphakiaIndiaVision TestsTime FactorsViscoelastic SubstancesVitreous BodyCorneaRetinal DetachmentCrystallinsInjectionsCorneal Endothelial Cell LossPostoperative CareSuture TechniquesBariatric SurgeryAmbulatory Surgical ProceduresCorneal DiseasesMyopiaLaser TherapyAtropineContact LensesGlarePosterior Capsule of the LensLidocaineParasympathomimeticsVision, LowIntraoperative CarePolyhydroxyethyl MethacrylateAnesthetics, LocalIntraoperative PeriodConjunctival DiseasesRisk FactorsMacular DegenerationConjunctivaNepalHyphemaUveitis, AnteriorEye InjuriesUveitisGeneral SurgeryMuscle, SmoothPovidone-IodineCorneal OpacityEndothelium, CornealMuscarinic AntagonistsCorneal TopographyMydriatics

GlaucomaMiosis0.01Refractive SurgeryCholinergicCARBASTATCause of blindnessLowersSmall-incisionRetinalCapsular bagParasympathomimeticExtractionInjectionContact LensesChlorideImplantationConstrictSystemicPresbyopiaTopicalInduceProcedureLensComplicationMedicationsRapidlyPatientsHoursIncludeGroupSolutionEffectsDirectTechnologySECTIONTreatDrugRecommendExperienceYearsMeansVision

Glaucoma8

• It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. (wikipedia.org)
• Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery. (wikipedia.org)
• Carbachol eyedrops are used to decrease the pressure in the eye for people with glaucoma. (wikipedia.org)
• Used for adjunctive treatment of chronic simple (open-angle) glaucoma and secondary glaucoma and preoperatively in acute angle-closure glaucoma when delay of surgery desired to lower IOP. (medscape.com)
• Carbachol is also used to treat glaucoma. (rxwiki.com)
• Vision impairment can be related to eye diseases such as cataracts, glaucoma, retinal detachment or macular degeneration. (vinmec.com)
• Research advances have been made by the intramural staff and noted in this report in the areas of retinal biochemistry, cataracts, and glaucoma. (nih.gov)
• Carbachol and Echothiophate: These medications are very rarely used to treat IOP in patients with glaucoma due their significant side effect profiles. (optoprep.com)

Miosis4

• Intraocular use for obtaining miosis during surgery. (nih.gov)
• Intraocular administration is used to produce miosis after lens implantation during cataract surgery. (wikipedia.org)
• Summarizing our results we conclude that the effect of Healon on the postoperative intraocular pressure is successfully counteracted by its aspiration from the capsular bag and the anterior chamber, especially when carbachol is used for intraoperative miosis. (zib.de)
• It is a topical ophthalmic drug to induce miosis, during certain intraocular surgical procedures, such as cataract surgery, ridectomy, penetrating keratoplasty, and other anterior-segment surgery. (pharmacy180.com)

0.014

• CARBASTAT ® (Carbachol Intraocular Solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. (nih.gov)
• Intraocular carbachol 0.01% should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease. (nih.gov)
• Following wound closure 0.5 ml of 0.01% carbachol or balanced salt solution was instilled into the anterior chamber. (zib.de)
• In addition, carbachol, 0.01%, is an effective hypotensive drug that lowers intraocular pressure (IOP) during the crucial 24-hour period after surgery. (aao.org)

Refractive Surgery2

• Dr Kaufman presented the results here at the American Society of Cataract and Refractive Surgery 2015 Symposium on behalf of Almamoun Abdelkader, MD, from Al-Azhar University in Cairo, who was not able to obtain a visa to attend the meeting. (medscape.com)
• These refractive disorders can be corrected with glasses or Lasik refractive surgery. (vinmec.com)

Cholinergic2

• Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. (nih.gov)
• Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). (wikipedia.org)

CARBASTAT1

• In addition, Carbastat ® (Carbachol Intraocular Solution USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery. (nih.gov)

Cause of blindness3

• Cataracts are the most frequent cause of blindness in dogs. (crstoday.com)
• Eye fatigue will disappear quickly Cataracts: this is the leading cause of blindness, accounting for more than 20 million people worldwide. (vinmec.com)
• It is the second leading cause of blindness globally, but the blindness it causes is a greater public health challenge than that caused by cataracts and unaddressed refractive errors, the top two causes of blindness. (medscape.com)

Lowers1

• The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. (nih.gov)

Small-incision1

• Because veterinary ophthalmologists consider postoperative astigmatism to be a relatively small obstacle to the goal of near emmetropia, they are not as strongly motivated toward small-incision surgery. (crstoday.com)

Retinal2

• Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction have been reported. (nih.gov)
• Vision Research Centers: The National Eye Institute Concept 223~ Retinal and Choroidal Diseases 227 Corneal Diseases 243 Cataract 25! (nih.gov)

Capsular bag1

• The Capsular Tension Ring manufactured by Devine Meditech is an Ophthalmic device to facilitate cataract surgery by improving capsular bag stability and centration. (devinemeditech.com)

Parasympathomimetic1

• Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. (wikipedia.org)

Extraction1

• Complications following cataract extraction. (medscape.com)

Injection1

• Carbachol is also available as an injection and is given into the eye during the eye procedure. (rxwiki.com)

Contact Lenses1

• Wearing eyeglasses, contact lenses, or surgery is called low vision. (vinmec.com)

Chloride2

• Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption. (wikipedia.org)
• A recent review indicates that carbachol is a strong promoter of ICC activity, which is mediated through the calcium-activated chloride channel, anoctamin 1. (wikipedia.org)

Implantation1

• Phacoemulsification with IOL implantation has been the standard of treatment for cataracts in dogs for the past 25 years. (crstoday.com)

Constrict2

• It is sometimes used to constrict the pupils during cataract surgery. (wikipedia.org)
• Carbachol is a prescription medication used to constrict the pupil and lower eye pressure during surgery as well as reduce the pressure elevation in the eye after cataract surgery. (rxwiki.com)

Systemic1

• Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol. (nih.gov)

Presbyopia1

• To evaluate safety and efficacy, Dr Abdelkader compared the combination of carbachol and brimonidine with placebo in two groups of patients with emmetropic presbyopia. (medscape.com)

Topical2

• Carbachol is not easily metabolized by cholinesterase, it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
• The dogs' eyes are medicated with topical antibiotics, corticosteroids, and NSAIDs for several days prior to surgery. (crstoday.com)

Induce1

• In the cat and rat, carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. (wikipedia.org)

Procedure1

• Canine cataract surgery is performed as an outpatient procedure under general anesthesia. (crstoday.com)

Lens2

• For older presbyopes who already have lenticular changes, I am more likely now to recommend early lens surgery than I would have been a decade ago. (optometrytimes.com)
• When the lens is cloudy, so light cannot pass through, it is called a cataract, which occurs as we age. (vinmec.com)

Complication2

• A particularly vexing complication of cataract surgery is thermal damage to the corneal incision. (millennialeye.com)
• 1 Thankfully, the development and adoption of advanced phaco power modulation programs and femtosecond laser technology to presoften and divide a cataract have made this complication rare. (millennialeye.com)

Medications1

• Carbachol belongs to a group of medications called cholinergics. (rxwiki.com)

Rapidly1

• Rapidly progressive cataracts commonly occur in dogs with diabetes mellitus (Figure 1). (crstoday.com)

Patients5

• In the first group, the nondominant eye of 30 patients was treated with a combination of 2.25% carbachol plus 0.2% brimonidine, and of 18 patients was treated with placebo. (medscape.com)
• In the second group, 10 patients received 3% carbachol, 0.2% brimonidine, a combination of the two, or placebo. (medscape.com)
• Patients who received carbachol monotherapy experienced a drop to a little above 5 in the first hour, which rose to just above 7 at 8 hours. (medscape.com)
• Use of carbachol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. (wikipedia.org)
• PC IOL technology has reached a level that makes me confident in encouraging patients with cataract and those who are closer to needing cataract surgery to make this choice. (optometrytimes.com)

Hours2

• At 6 hours the mean change of intraocular pressure from baseline was ±2.8 ± 5.3 mmHg in the carbachol group compared with +4.7 ± 8.0 mmHg in the BSS group (p 〈 0.0001). (zib.de)
• At 18 hours 4 (13%) eyes of the control group and 1 (3%) of the carbachol group still had an increase of intraocular pressure. (zib.de)

Include1

• These techniques include implanting artificial drainage valves (tube shunts) and surgically cutting additional passageways to drain the fluid by filtering surgery (trabeculectomy or Xen Gel stent). (medscape.com)

Group1

• A "mild burning sensation" was reported by some subjects in each of the groups, including the placebo group, but most frequently in the carbachol monotherapy group. (medscape.com)

Solution1

• Before removing the OVD, the surgeon injects carbachol intraocular solution (Miostat, Alcon) into the anterior chamber. (millennialeye.com)

Effects2

• Serious side effects have been reported with carbachol. (rxwiki.com)
• This is not a complete list of carbachol side effects. (rxwiki.com)

Direct1

• Many animals presenting for cataract surgery have bilaterally mature cataracts that prevent the direct visualization of the fundus. (crstoday.com)

Technology1

• Technology and technique follow the human cataract experience. (crstoday.com)

SECTION1

• See "Carbachol Precautions" section. (rxwiki.com)

Treat1

• Carbachol can also be used to stimulate bladder emptying to treat the condition of underactive bladder. (wikipedia.org)

Drug1

• Carbachol, also known as carbamylcholine and sold under the brand name Miostat among others, is a cholinomimetic drug that binds and activates acetylcholine receptors. (wikipedia.org)

Recommend1

• How likely would you be to recommend Carbachol to a friend? (rxwiki.com)

Experience1

• How was your experience with Carbachol? (rxwiki.com)

Years1

• Most cataracts are inherited and affect dogs older than 5 years of age. (crstoday.com)

Means1

• organic compounds called flavonoids have proved to be the most effective means yet found of slowing the development of diabetic cataracts in animal models. (nih.gov)

Vision1

• Keeping in mind the relative contribution of vision to a normal dog's lifestyle, there are many ways in which the typical canine patient differs from a human patient presenting for cataract surgery. (crstoday.com)