• pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
  • Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. (wikipedia.org)
  • The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types, and belongs to the Src family of tyrosine kinases. (wikipedia.org)
  • Identification of novel SH3 domain ligands for the Src family kinase Hck. (wikipedia.org)
  • Src (src proto-oncogene, non-receptor tyrosine kinase) is a protein coding gene. (anthonyvandarakis.org)
  • Src is a proto-oncogene encoding a non-receptor tyrosine kinase, similar to the v-src gene of the rous sarcoma virus (14), which was initially. (anthonyvandarakis.org)
  • src kinase (src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. (anthonyvandarakis.org)
  • Catalytic domain of Src kinase-like Protein Tyrosine Kinases. (umbc.edu)
  • The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
  • and protein tyrosine kinase activity. (nih.gov)
  • and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)
  • Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. (wikipedia.org)
  • HCK has been shown to interact with: ADAM15 BCR gene, Cbl gene, ELMO1, Granulocyte colony-stimulating factor receptor, RAPGEF1, RAS p21 protein activator 1, and RASA3. (wikipedia.org)
  • This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. (idrblab.net)
  • ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. (iiab.me)
  • HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)
  • c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
  • These data demonstrate that the src family tyrosine kinases are direct effectors of g proteins. (anthonyvandarakis.org)
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
  • After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
  • The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. (wikipedia.org)
  • Src (or c-Src) proteins are cytoplasmic (or non-receptor) tyr kinases which are anchored to the plasma membrane. (umbc.edu)
  • However, the complement C5a receptor 2 may act as a decoy receptor for C5a, as it has no reported G protein signalling capacity. (guidetomalariapharmacology.org)
  • Src was originally identified as a transforming protein of the rous sarcoma virus (rsv) that had enzymatic. (anthonyvandarakis.org)
  • Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. (umbc.edu)
  • HCK and the Src family kinases have also been implicated in driving cell survival in drug-tolerant cancer cells. (wikipedia.org)
  • ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (iiab.me)
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • c-Src is made up of 6 functional regions: Src homology 4 domain (SH4 domain), unique region, SH3 domain, SH2 domain, catalytic domain and short regulatory tail. (wikipedia.org)
  • This work lead to a detailed study of the effect of a mutation (w260a) in the linker between the catalytic domain and sh2 domain in src. (anthonyvandarakis.org)
  • catalytic (c) domain. (umbc.edu)
  • This domain occurred 423 times on human genes ( 970 proteins). (umbc.edu)
  • ERBB2 , a known proto-oncogene , is located at the long arm of human chromosome 17 (17q12). (iiab.me)
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer . (iiab.me)
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
  • targeted mutations of some of these genes (hck and fgr) have been made in the mouse germ line to determine their physiological roles in hematopoiesis. (nih.gov)
  • Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia. (umassmed.edu)
  • HCK and the Src family kinases have also been implicated in driving cell survival in drug-tolerant cancer cells. (wikipedia.org)
  • ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (iiab.me)
  • In efforts to understand the actions of sre protein, the protein has been localized to endosomes in fibroblasts, and extracatalytic regions that mediate interactions with other proteins have been defined with genetic and bio- chemical means. (nih.gov)
  • After viral DNA is synthesized by reverse transcriptase, it is efficiently inserted into chromosomes by a small viral protein, integrase, that performs a recombination reac- tion required for transposition of many types of elements. (nih.gov)
  • Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer . (iiab.me)
  • adaptor related protein complex 1 s. (gsea-msigdb.org)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (iiab.me)