Catalytic acetyltransferases. Medical search. Frequent questions

Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). (nih.gov)
30054468 ). These enzymes consist of three main oligomeric complexes NatA, NatB, and NatC, which are composed of at least a unique catalytic subunit and one unique ribosomal anchor. (hmdb.ca)
MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. (novusbio.com)
ELP3, the catalytic subunit of Elongator complex, is an acetyltransferase and associated with tumor progression. (bvsalud.org)
The human essential gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex, also including the accessory protein, NAA15. (nebraska.edu)

Other names in common use include acetyl-CoA-carnitine O-acetyltransferase, acetylcarnitine transferase, carnitine acetyl coenzyme A transferase, carnitine acetylase, carnitine acetyltransferase, carnitine-acetyl-CoA transferase, and CATC. (wikipedia.org)

This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively). (biologists.com)
Rtt109, also known as KAT11, is a recently characterized fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promotegenome stability. (embl.de)
Although originally termed histone acetyltransferases (HATs) for their lysine acetylation activity on histone N-terminal tails, CBP and its paralogue, p300, have been shown to acetylate a variety of non-histone proteins including p53, DNA polymerase β and nuclear import factors. (enzolifesciences.com)

Other enzymes can use this space to reach the growing protein chain and, in turn, chemically alter the amino acids before the protein reaches the catalytic center of the acetyltransferase. (uni-muenchen.de)
The histone acetyltransferase (Head wear) p300/CBP is a transcriptional coactivator implicated in lots of gene regulatory pathways and protein acetylation events. (woofahs.com)
CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. (ox.ac.uk)
Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors. (ox.ac.uk)

Arylamine N-acetyltransferases (NATs), a class of xenobiotic-metabolizing enzymes, catalyze the acetylation of aromatic amine compounds through a strictly conserved Cys-His-Asp catalytic triad. (pasteur.fr)
Certain enzymes, called N-acetyltransferases (NATs), receive the chain at the tunnel exit to chemically modify it, while at the other end it is further extended by the ribosome. (uni-muenchen.de)

Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)
N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. (hmdb.ca)
1996). Within the ensuing years, p300/CBP provides been shown to be always a rather promiscuous acetyltransferase, with an increase of than 75 proteins substrates referred buy 1062159-35-6 to including p53, MyoD, and NFB (Gu et al. (woofahs.com)
Proteins in the CDY-related family contain a chromodomain, involved in chromatin binding, and a histone acetyltransferase catalytic domain. (antibodiesinc.com)

2007). While research on histone deacetylases buy 1062159-35-6 possess resulted in the breakthrough of highly powerful compounds with scientific impact in tumor, the id of histone acetyltransferase inhibitors provides proved more difficult (Cole, 2008). (woofahs.com)

C10 peptide binding blocks access to OASS catalytic residues, explaining how complex formation downregulates OASS activity. (rcsb.org)

However, a putative atypical NAT harboring a catalytic triad Glu residue was recently identified in Bacillus cereus ((BACCR)NAT3) but has not yet been characterized. (pasteur.fr)
The Rtt109 structure reveals noteworthyhomology to the metazoan p300/CBP HAT domain but exhibits functional divergence, including atypical catalytic properties and mode of cofactor regulation. (embl.de)

The overall fold of (BACCR)NAT3 and the geometry of its Cys-His-Glu catalytic triad are similar to those present in functional NATs. (pasteur.fr)

His343 is the catalytic residue in CRAT. (wikipedia.org)

This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11 (PMID:18568037). (embl.de)
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog ofmetazoan p300/CBP. (embl.de)
2009). A recently available high res X-ray framework from the p300 Head wear in complex using the bisubstrate analog Lys-CoA provides revealed key areas of substrate reputation and catalytic system (Liu et al. (woofahs.com)

Glutaryl-CoA degradation ( link ) involves glutaryl-CoA dehydrogenase (decarboxylating) to crotonyl-CoA (trans-but-2-enoyl-CoA), hydration to (S)-hydroxybutanoyl-CoA, oxidization to acetoacetyl-CoA, and cleavage by a C-acetyltransferase to two acetyl-CoA. (lbl.gov)

Catalytic domain (aa 1319-1710) of human CBP. (enzolifesciences.com)

Carnitine O-acetyltransferase also called carnitine acetyltransferase (CRAT, or CAT) (EC 2.3.1.7) is an enzyme that encoded by the CRAT gene that catalyzes the chemical reaction acetyl-CoA + carnitine ⇌ {\displaystyle \rightleftharpoons } CoA + acetylcarnitine where the acetyl group displaces the hydrogen atom in the central hydroxyl group of carnitine. (wikipedia.org)
The systematic name of this enzyme class is acetyl-CoA:carnitine O-acetyltransferase. (wikipedia.org)

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. (novusbio.com)

Image of a cryo-electron microscopic 3D reconstruction of the complex of ribosome and N-acetyltransferase. (uni-muenchen.de)
In plants, association of O-acetylserine sulfhydrylase (OASS) and Ser acetyltransferase (SAT) into the Cys synthase complex plays a regulatory role in sulfur assimilation and Cys biosynthesis. (rcsb.org)

Because the "expansion segments" protrude a little from the surface of the ribosome, there is a gap between the tunnel exit and the catalytic center of the acetyltransferase, which the fresh amino acid chain has to protrude by at least 20 building blocks from the tunnel end. (uni-muenchen.de)

These findings overturn the conventional view, demonstrating that the catalytic triad of this family of acetyltransferases is plastic. (pasteur.fr)

Until now, it was unknown how these acetyltransferases interact with the ribosome," says co-author Dr. Birgitta Beatrix. (uni-muenchen.de)

This study has found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. (sdbonline.org)

2008). Predicated on this framework and steady-state kinetic research, a Theorell-Chance catalytic system has been suggested (Liu et al. (woofahs.com)

Here, the pantothenic arm's terminal thiol group and the ε2 nitrogen on the catalytic His343 side chain form a hydrogen bond. (wikipedia.org)

Moynihan, P.J. & Clarke, A.J. The Mechanism of Action of Peptidoglycan O-Acetyltransferase B Involves a Ser-His-Asp Catalytic Triad . (bioinfor.com)
Site-directed mutagenesis determined that TviD possesses an atypical catalytic triad compared to members of the SGNH hydrolase family. (uoguelph.ca)

Acetyltransferase enzymes transfer an acetyl moiety, usually from acetyl coenzyme A (AcCoA), onto a target substrate, thereby modulating activity or stability. (nih.gov)

Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase. (nih.gov)
The regulation of the first step of urea synthesis could thus depend mainly on the intramitochondrial substrate and perhaps product concentrations of amino acid acetyltransferase. (rhea-db.org)

Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens. (nih.gov)
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. (ox.ac.uk)
Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the cholesterol sterol-ring degradation and is essential for intracellular survival. (ox.ac.uk)

To return to the original lysine acetyltransferase database click here . (nih.gov)

Carnitine O-acetyltransferase also called carnitine acetyltransferase (CRAT, or CAT) (EC 2.3.1.7) is an enzyme that encoded by the CRAT gene that catalyzes the chemical reaction acetyl-CoA + carnitine ⇌ {\displaystyle \rightleftharpoons } CoA + acetylcarnitine where the acetyl group displaces the hydrogen atom in the central hydroxyl group of carnitine. (wikipedia.org)
Other names in common use include acetyl-CoA-carnitine O-acetyltransferase, acetylcarnitine transferase, carnitine acetyl coenzyme A transferase, carnitine acetylase, carnitine acetyltransferase, carnitine-acetyl-CoA transferase, and CATC. (wikipedia.org)
To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine carnitine acetyltransferase (CrAT) in a ternary complex with its substrates acetyl-CoA and carnitine, and the structure of the S554A/M564G double mutant in a ternary complex with the substrates CoA and hexanoylcarnitine. (proteopedia.org)
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. (proteopedia.org)

pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). (gla.ac.uk)

We find that TcNaa30 catalyzes the acetylation of N-termini similar to those acetylated by NatC in yeast (yNaa30) and hNaa30 in vitro and our analyses indicate that the protein may function both as a N α - and as a N ε -acetyltransferase. (hindawi.com)
Here, we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors, bromodomain inhibitor, and gene knockout to reveal a comprehensive map of regulated acetylation sites and their dynamic turnover rates. (broadinstitute.org)
Histone acetylation is highly dynamic with its level regulated by the opposing action of histone acetyltransferases (HATs) and histone deacetylases (HDACs). (le.ac.uk)
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. (nih.gov)
Chemoproteomic profiling of lysine acetyltransferases highlights an expanded landscape of catalytic acetylation. (nih.gov)

We also investigate the interactions between Gcn5 and other histone deacetylases and acetyltransferases and show overlapping functionality between Gcn5 and another histone acetyltransferase, Mst2, in stress response, regulation of subtelomeric genes and DNA damage repair. (diva-portal.org)

We demonstrate that the catalytic subunits (TcNaa10 and TcNaa30), and the predicted auxiliary subunits are expressed and cosediment with the ribosome. (hindawi.com)
The two substrates are found in an extended conformation at the two opposite entrances of the 30 A long channel which runs at the interface between two 3-fold-related subunits and forms the catalytic center. (rcsb.org)
E2 has a multi-domain structure where the C-terminal catalytic domains (CD) of several E2 subunits interact to form the core of the complex. (gla.ac.uk)

11. The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. (nih.gov)
The structural information provides significant new insights into the catalytic mechanism of CrAT and possibly carnitine acyltransferases in general. (proteopedia.org)
The resulting 'entropy-reduced' ChAT (MR = 68.1 kDa) crystallizes readily and reproducibly and the crystals diffract X-rays to approximately 2.2 A. The availability of these crystals will allow us to study the structure of human ChAT on its own as well as in complex with its substrates and inhibitor molecules, leading to a greater understanding of its catalytic mechanism and regulation. (inra.fr)

3. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. (nih.gov)

Therefore, we revealed a catalytic system for H3K9ac mark and how this system is specifically brought to the AREB TF for gene activation to develop drought tolerance in Populus . (plantae.org)
Notable examples include nerve damage among individuals homozygous for some variants of the N-acetyltransferase 2 gene ("slow acetylators") given isoniazid as an antituberculosis therapy, hemolytic anemia among glucose 6-phosphate dehydrogenase-deficient patients given aminoquinoline antimalarial drugs, and varied rates of biotransformation of debrisoquine, an antihypertensive drug, due to genetic variation at the CYP2D6 locus. (cdc.gov)

The systematic name of this enzyme class is acetyl-CoA:carnitine O-acetyltransferase. (wikipedia.org)
BRD4 HAT activity maps to two consensus acetyl CoA binding sites and a 40 aa catalytic site. (nih.gov)
In particular, N-Acetylleucine can be biosynthesized from L-leucine and acetyl-CoA by the enzyme leucine N-acetyltransferase (EC 2.3.1.66). (hmdb.ca)
Specifically, the enzyme known as aspartate N-acetyltransferase (EC 2.3.1.17) catalyzes the transfer of the acetyl group of acetyl CoA to the amino group of aspartate. (hmdb.ca)
Purification and properties of acetyl-CoA:L-glutamate N-acetyltransferase from human liver. (rhea-db.org)
Acetyl-CoA:L-glutamate N-acetyltransferase (amino acid acetyltransferase, EC 2.3.1.1) was isolated from human liver mitochondria by precipitation with (NH4)2SO4 and chromatography on hydroxyapatite, DEAE-cellulose and Sephacryl 300. (rhea-db.org)
Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine from choline and acetyl-CoA, and its presence is a defining feature of cholinergic neurons. (inra.fr)
Human choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA. (inra.fr)
Choline acetyltransferase (ChAT) catalyzes the transfer of an acetyl group from acetyl-CoA to choline to produce the neurotransmitter acetylcholine (ACh). (inra.fr)
Ignore hits to P07256 when looking for 'other' hits (acetyl-CoA C-acetyltransferase (EC 2.3.1.9). (lbl.gov)

15. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (nih.gov)

If in vivo the constants are of the same order of magnitude as in vitro, the synthesis of N-acetylglutamate, an obligate activator of the first step of urea synthesis, can be expected to occur in the mitochondrion under conditions where the amino acid acetyltransferase is not saturated by its substrates. (rhea-db.org)

Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the penultimate enzyme in melatonin biosynthesis. (nih.gov)

5. Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. (nih.gov)

19. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. (nih.gov)

His343 is the catalytic residue in CRAT. (wikipedia.org)

Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. (rhea-db.org)

Recombinant expression of rNat3 1 and rNat3 2 in COS-1 cells yielded equivalent protein levels but undetectable catalytic activities. (nih.gov)
Furthermore, we show that purified recombinant human ChAT is highly prone to oxidation, leading to the formation of covalent dimers and/or a loss of catalytic activity. (inra.fr)

Computational modeling showed the direct interaction of the carboxylic acid moiety of statins with the catalytic site of HDAC2. (aacrjournals.org)

12. The histone acetyltransferase activity of PCAF cooperates with the brahma/SWI2-related protein BRG-1 in the activation of the enhancer A of the MHC class I promoter. (nih.gov)
The rNat3*2 single nucleotide polymorphism reduced Nat3 protein levels and N- and O-acetyltransferase activity when recombinantly expressed in bacteria. (nih.gov)
The weak catalytic activity of nanocatalysts and the insufficient endogenous hydrogen peroxide (H2O2) in tumor microenvironment (TME) seriously restricted the efficacy of catalytic therapy, and the non-degradability of inorganic nanocarriers was also unfavorable for their clinical applications. (bvsalud.org)
Herein, by depositing gold nanoparticles (AuNPs) and platinum nanoparticles (PtNPs) with ultrasmall size and modifying photosensitizer (IR808), a biocompatible bovine serum albumin (BSA) nanoplatform (BSA@Au/Pt-IR808) with triple-amplification of enzyme activity was constructed to enhance photodynamic therapy (PDT) and catalytic therapy. (bvsalud.org)
Displays alpha (N-terminal) acetyltransferase activity. (nih.gov)

The catalytic domain of dihydrolipoyl transacetylase (E2pCD) forms the core of the pyruvate dehydrogenase multienzyme complex and catalyzes the acetyltransferase reaction using acetylCoA as acetyl donor and dihydrolipoamide (Lip(SH)2) as acceptor. (rcsb.org)

1. Expression, purification, and analysis of MOZ and MORF histone acetyltransferases. (nih.gov)

Thus, the hemoglobin adduct is sensitive to dose, cytochrome P-450-mediated activation, and N-acetyltransferase-mediated detoxification. (nih.gov)

In general, carnitine acetyltransferases have molecular weights of about 70 kDa, and contain approximately 600 residues1. (wikipedia.org)

Here, the pantothenic arm's terminal thiol group and the ε2 nitrogen on the catalytic His343 side chain form a hydrogen bond. (wikipedia.org)

Violin plots show distribution of expression levels for N-acetyltransferase domain-containing protein (SMED30009746) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)

Subunidad catalítica del complejo histona acetil transferasa NuA4 que participa en la activación transcripcional de los genes por acetilación de las HISTONAS H4 y H2A del nucleosoma, alterando las interacciones nucleosoma-ADN y la interacción de las histonas modificadas con otros factores de transcripción activadores. (bvsalud.org)
Puede ejercer un control sobre cambios en la expresión de genes asociados a la inducción del crecimiento mediada por oncogenes y protooncogenes, la detención del crecimiento mediada por supresores tumorales, el ENVEJECIMIENTO CELULAR, la APOPTOSIS y la REPARACIÓN DEL ADN. (bvsalud.org)

Background: Histone acetyltransferase enzymes (HATs) are implicated in egulation of transcription. (diva-portal.org)

7. The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase. (nih.gov)

It appears that the anion is bound in the middle of the catalytic center and is therefore capable of hosting and stabilizing a negative charge, which is of special interest since the reaction catalyzed by E2pCD is thought to proceed via a negatively charged tetrahedral intermediate. (rcsb.org)

There are 18 HDAC enzymes in mammalian cells that can be sub-divided according to the presence of Zn2+-dependent (Class I, II and IV) or NAD+-dependent (Class III/Sirtuins) catalytic domains. (le.ac.uk)

TviD contains an N-terminal O-acetyltransferase, verified by the structure of the product made by a tviD-mutant polysaccharide. (uoguelph.ca)

9. Histone H3 specific acetyltransferases are essential for cell cycle progression. (nih.gov)

Anatomy8

Organisms2

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes39

Information Science3

Subunit5

Transferase1

Lysine3

Protein4

Enzymes2

Proteins4

Inhibitors1

Peptide1

Atypical2

NATs1

Residue1

P3003

Cleavage1

Domain1

Enzyme2

Transcriptional1

Complex2

Tunnel1

Family1

Unknown1

Core1

Research1

Chain1

Triad2

Transfer an acetyl1

Substrate2

Arylamine3

Lysine acetyltransferase1

Carnitine acetyltransferase4

DIHYDROLIPOAMIDE ACETYLTRANSFERASE1

Acetylation5

Histone deacetylases1

Subunits3

Mechanism3

Superfamily1

Gene2

Acetyl-CoA10

Complexes1

Substrates1

Biosynthesis1

Selectivity1

GCN51

CRAT1

Synthase1

Recombinant2

Moiety1

Activity5

Catalyzes1

Purification1

Cytochrome1

Molecular1

Thiol1

Expression1

Genes2

HATs1

Leukemia1

Bound1

Domains1

Structure1

Specific1