• Chemistry) Synthesis polymer-bound small-molecule kinase inhibitors as anti-tumour agents. (sun.ac.za)
  • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
  • Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
  • Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • lies such as G protein-coupled receptors and kinases). (gotomydoctor.com)
  • The arginine deiminase pathway in the wine lactic acid bacterium Lactobacillus hilgardii X1B: structural and functional study of the arcABC genes. (microbiologyresearch.org)
  • other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)
  • The phosphorylation reaction that takes place in the cell is reversible in nature where catalysts such as kinases are used for the addition of the phosphoryl group and phosphatases catalyzes the removal of the phosphoryl group. (vedantu.com)
  • Creatine kinase plays an important role in energy metabolism of vertebrates. (wikipedia.org)
  • Role of the arginine deiminase system in protecting oral bacteria and an enzymatic basis for acid tolerance. (microbiologyresearch.org)
  • In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphagens. (wikipedia.org)
  • The enzymes belonging to this family include: Glycocyamine kinase (EC 2.7.3.1), which catalyses the transfer of phosphate from ATP to guanidoacetate. (wikipedia.org)
  • The 8p11 inhibiting of download Dopamine in the Pathophysiology and Treatment of Schizophrenia: New Findings by interest via this response catalyses a transcriptional momentum-correlation in the consensus of Saturated association( Schnetkamp 2013). (evakoch.com)
  • Poly(N-vinylpyrrolidone)-polypeptide based antitumor nanocarrier and cell viable L-arginine L-aspartic acid and glycine terpolymer. (sun.ac.za)
  • Taurocyamine kinase (EC 2.7.3.4), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine. (wikipedia.org)
  • The aim of this study is to see if oxy- and sulfoanalogues of arginine can be recognized by human arginyl-tRNA synthetase (HArgS)-an enzyme responsible for coupling of L -arginine with its cognate tRNA in a two-step catalytic reaction. (hindawi.com)
  • Mutation in the enzyme active center by arginine mimetics leads to conformational changes, which produce a decrease the rate of the enzyme catalyzed reaction and even a loss of enzymatic action. (hindawi.com)
  • phosphorylation of the enzyme GSK-3 by AKT (Protein kinase B) as part of the insulin signaling pathway. (bionity.com)
  • LDH-B is a crucial glycolytic enzyme that catalyses conversion of lactate and NAD + to pyruvate, NADH and H + . LDHB plays an important role in autophagy in cancer cells. (medchemexpress.com)
  • After characterizing the oddities of the mitochondria, which provide energy for the cell, the team checked the levels of an enzyme called PTEN-induced putative kinase 1, or PINK1, that plays key roles in mitochondrial function and morphology, or shape. (regenerativemedicine.net)
  • In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphagens. (wikipedia.org)
  • The enzymes belonging to this family include: Glycocyamine kinase (EC 2.7.3.1), which catalyses the transfer of phosphate from ATP to guanidoacetate. (wikipedia.org)
  • Arginine (Arg) is one of the most important residues in catalytic centers of many enzymes. (hindawi.com)
  • It has been demonstrated that C8-H of ATP plays a critical role in the activity of a range of kinase and synthetase enzymes. (biomedcentral.com)
  • The kinases are a large number of structurally diverse enzymes that play a critical role in numerous metabolic and signalling pathways and whose substrates may be a small molecule, lipid, or protein. (biomedcentral.com)
  • The International Union of Pure and Applied Chemistry and the International Union of Biochemistry (IUPAC/IUB) commission on the classification and nomenclature of enzymes placed the enzymes that transfer high energy phosphate bonds from nucleotides into two divisions: the transferases (kinases) and the ligases (synthetases) [ 1 ]. (biomedcentral.com)
  • Furthermore, during research carried out on the effect of deuteration at the C8 position of ATP on the activity of a number of kinase and synthetase enzymes, it became evident that the C8 proton of ATP plays a direct mechanistic role in initiating phosphoryl transfer, and probably also in the regulation of catalysis via the regulation of the rate of reaction [ 4 ]. (biomedcentral.com)
  • Reversible phosphorylation results in a conformational change in the structure in many enzymes and receptors, causing them to become activated or deactivated. (bionity.com)
  • Syntrophus aciditrophicus uses the same enzymes in a reversible manner to degrade and synthesize aromatic and alicyclic acids. (ouhsc.edu)
  • the possibility of muscle disease causing elevations in liver tests can be further explored by measuring muscle enzymes, including creatine kinase . (wikidoc.org)
  • In addition to its association with Ras, GAP has been shown to bind to several tyrosine-phosphorylated proteins in cells stimulated by growth factors or expressing transforming tyrosine kinase variants. (embl.de)
  • Creatine kinase (EC 2.7.3.2) (CK), which catalyses the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP. (wikipedia.org)
  • Creatine kinase plays an important role in energy metabolism of vertebrates. (wikipedia.org)
  • Arginine kinase (EC 2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine. (wikipedia.org)
  • We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP. (embl.de)
  • Arginine residues are very important for the structure of proteins and their action. (hindawi.com)
  • Proteins that methylate histones on arginine residues can collaborate with other coactivators such as nuclear receptors. (hindawi.com)
  • To this end, the putative mechanistic role of the C8 proton in the catalysis of the 22 families within the 10-fold groups was also investigated in the context of the conserved catalytic residues of each group of kinases. (biomedcentral.com)
  • In addition, phosphorylation occurs on the basic amino acid residues histidine or arginine or lysine in prokaryotic proteins [4] [5] . (bionity.com)
  • Here, we synthesized the c9orf72 DPRs poly-glycine-arginine (poly-GR), poly-proline-arginine (poly-PR), poly-glycine-proline (poly-GP), poly-proline-alanine (poly-PA), and poly-glycine-alanine (poly-GA) using automated fast-flow peptide synthesis (AFPS) and achieved single-domain chemical synthesis of proteins with up to 200 amino acids. (bvsalud.org)
  • Reversible phosphorylation of proteins is an important regulatory mechanism which occurs in both prokaryotic and eukaryotic organisms. (bionity.com)
  • More recent findings show that arginine-specific methylation of histones may cooperate with other types of posttransitional histone modification to regulate chromatin structure and gene transcription [ 21 ]. (hindawi.com)
  • DNA methylation is catalysed by DNA methyltransferases (DNMT), and histone acetylation state is adjusted by opposing activities of histone acetyltransferases (HAT) and histone deacetylases (HDAC). (biomedcentral.com)
  • The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP. (embl.de)
  • Phospholipase A 2 (PLA 2 ) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. (medchemexpress.com)
  • Guided by this finding, 4 novel genes (cynX, cynT, pyrB, and rhaB) for L-arginine biosynthesis were identified via reverse engineering. (bvsalud.org)
  • The results of the combined analysis showed that purine metabolism, arginine biosynthesis, and arachidonic acid metabolism were changed in patients with ARC. (bvsalud.org)
  • We discovered that mitochondrial glutamine metabolism induces CBP/EP300-dependent acetylation of stem cell-specific kinase, PASK, resulting in its release from cytoplasmic granules and subsequent nuclear migration. (biomed.news)
  • Here, phenotype-genotype mapping was used to dissect the betaine-triggered L-arginine overproduction mechanism and mine beneficial genes for further improving production phenotype. (bvsalud.org)
  • This study revealed the molecular mechanism of gene transcription regulation by betaine and developed a superior L-arginine overproducer that does not require betaine. (bvsalud.org)
  • ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate , the products of this reversible transamination reaction being pyruvate and L-glutamate . (wikidoc.org)
  • P61959.1 MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY 1367453_at NP_446195 8.92 hsp90 co-chaperone Cdc37 Cdc37 Rattus norvegicus " Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. (nih.gov)
  • Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae. (ouhsc.edu)
  • A number of conserved mechanisms within the prescribed kinase fold families have been identified directly utilizing the C8-H of ATP in the initiation of phosphoryl transfer. (biomedcentral.com)
  • The critical question that needed to be answered was to what extent the functionality required for the catalysis of phosphoryl transfer is conserved within the 25 families or 12 fold-groups. (biomedcentral.com)
  • FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A ( LDHA ) inhibitor, with a K i of 8 μM. (medchemexpress.com)
  • Numerous mimetics of arginine were synthesized and their biological effects were evaluated, but the mechanisms of actions are still unknown. (hindawi.com)
  • Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. (embl.de)
  • We make use of modeling and docking studies of adenylate kinase (ADK) to reveal the effects produced by the incorporation of the arginine mimetics on the structure of ADK and its action. (hindawi.com)
  • L -Arginine has guanidinium group, which is positively charged at neutral pH and is involved in many important physiological and pathophysiological processes [ 1 ]. (hindawi.com)
  • In particular, his work focuses on understanding and modulating the molecular mechanisms of kinase function in cancer. (triiprograms.org)
  • Arginine is essential for many natural processes because it has unique ionizable group under physiological conditions. (hindawi.com)
  • All these observations could explain the long-lasting nature of the effects of the arginine analogues. (hindawi.com)
  • Both kinases were found to phosphorylate full-length or truncated forms of GAP and GEF. (embl.de)
  • Despite the observation that epigenetic changes are heritable in somatic cells and epimutations are rare in non-transformed cells or healthy tissues, it is of interest to note that epigenetic modifications are potentially reversible. (biomedcentral.com)