OxidativeEnzymesReactionDiamine oxidaseEnzymeReactionsGlutamateUracil-DNA glycosySynthesisGuanineAdenineAmino acidsAmmoniaRemovalOxidative deaminationCytosineHydrolytic deaminationOxidationMonoamineInhibitionAdenosine2022SubstrateAmino acidSpontaneousProteinMetabolismMechanismRolesFormationResultsTransferGroupFoundBasisArticle
Oxidative8
- The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization. (genome.jp)
- Diamine oxidase catalyses the oxidative deamination of diamines to their corresponding aminoaldehydes. (gla.ac.uk)
- EC 1.4.1.2-4) catalyse the oxidative deamination of L-glutamate to α-ketoglutarate, using NAD(+) and/or NADP(+) as a cofactor. (anl.gov)
- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. (expasy.org)
- Second, some of the lysine residues are hydroxylated or glycosylated, and some lysine as well as hydroxylysine residues undergo oxidative deamination catalysed by lysyl oxidase. (gotoh.com.br)
- c) It catalyzes the oxidative deamination of the unnatural (D-) forms of amino acids. (biologydiscussion.com)
- c) It catalyzes the oxidative deamination of naturally occurring L-amino acids. (biologydiscussion.com)
- Basic principle involved in Biogenic amines biosensor is the action of diamine oxidase (DAO) that catalyzes the oxidative deamination of primary amines to the corresponding aldehydes, hydrogen peroxide and ammonia. (ijpsr.com)
Enzymes4
- Enzymes that catalyse this reaction are called deaminases. (wikipedia.org)
- Ammonia is toxic to the human system, and enzymes convert it to urea or uric acid by addition of carbon dioxide molecules (which is not considered a deamination process) in the urea cycle, which also takes place in the liver. (wikipedia.org)
- a) Enzymes that catalyse the removal of hy-drogen from a substrate but use only oxy-gen as a hydrogen acceptor to form water as a reaction product (with the exception of uricase and monoamine oxidase which form H 2 O 2 ). (biologydiscussion.com)
- New family of deamination repair enzymes in uracil-DNA glycosylase superfamily. (musc.edu)
Reaction3
- Spontaneous deamination is the hydrolysis reaction of cytosine into uracil, releasing ammonia in the process. (wikipedia.org)
- Most of the compounds did inhibit the diamine oxidase catalysed reaction. (gla.ac.uk)
- Hypoxanthine can also produce xanthine by catalysis of xanthine oxidoreductase and xanthosine can be generated in a reaction catalyzed by purine nucleoside phosphorylase. (notesbard.com)
Diamine oxidase1
- degradation of histamine is mediated by the enzyme diamine oxidase (DAO) and histamine N-methyltransferase (HNMT), which catalyses histamine deamination [ 2 , 3 ]. (hindawi.com)
Enzyme3
- We report on the preparation of a new type of immunotoxin via in vitro ligation of the αHer2 antigen binding fragment (Fab) of the clinically-validated antibody trastuzumab to the plant toxin gelonin, employing catalysis by the bacterial enzyme sortase A (SrtA). (cipsm.de)
- In a joint effort between our group, the Heterogeneous Catalysis group and the Analytical Chemistry group at the HIMS-UvA, we have developed a novel biosensor based on the use of an engineered oxidoreductase enzyme. (hims-biocat.eu)
- Chen, T., Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. (cas.cn)
Reactions2
- The Base Excision Repair (BER) pathway is a highly conserved DNA repair system targeting chemical base modifications that arise from oxidation, deamination and alkylation reactions. (ucdavis.edu)
- Alkyl nitrite-metal halide deamination reactions. (google.cl)
Glutamate2
- Glutamate participates in the combined deamination centered on glutamate dehydrogenase. (mgm-biochem.com)
- And then under the catalysis of alanine transaminase, glutamate with pyruvate can form α-ketoglutarate and alanine. (mgm-biochem.com)
Uracil-DNA glycosy2
- In DNA, this spontaneous deamination is corrected for by the removal of uracil (product of cytosine deamination and not part of DNA) by uracil-DNA glycosylase, generating an abasic (AP) site. (wikipedia.org)
- Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily. (musc.edu)
Synthesis2
- Very Important Publication' in Advanced Synthesis & Catalysis We present a review in Advanced Synthesis & Catalysis by Elena Tomarelli et al. (hims-biocat.eu)
- Our recent publication in ACS Catalysis entitled "Enzymatic synthesis of primary, secondary and tertiary amines containing two stereocenters" (News Item of November 2022) was highlighted in the journal Organic Process Research and Development (OPRD) and disseminated through the Dutch press. (hims-biocat.eu)
Guanine2
- Deamination of guanine results in the formation of xanthine. (wikipedia.org)
- Deamination of adenine can lead to the formation of hypoxanthine and xanthine is formed due to the deamination of guanine. (notesbard.com)
Adenine1
- Deamination of adenine results in the formation of hypoxanthine. (wikipedia.org)
Amino acids1
- In situations of excess protein intake, deamination is used to break down amino acids for energy. (wikipedia.org)
Ammonia1
- Spontaneous deamination of 5-methylcytosine results in thymine and ammonia. (wikipedia.org)
Removal2
- Deamination is the removal of an amino group from a molecule. (wikipedia.org)
- a) They catalyse the removal of hydrogen from a substrate and use either oxygen or artificial substances such a methylene blue as hydrogen acceptor. (biologydiscussion.com)
Oxidative deamination6
- [ 24 ] The main metabolic pathway of serotonin is the metabolism by monoamine oxidase (MAO) that catalyses the oxidative deamination of the amine substrate, with production of its aldehyde intermediate and hydrogen peroxide as a by-product. (medscape.com)
- The scientists have also experimentally proved that the MAO enzyme, a group of flavoenzymes that catalyse the oxidative deamination of dietary amines and biological amines, may be used as a novel therapeutic target to develop a new class of anti-inflammatory agents, the release says. (thehindubusinessline.com)
- Mechanistic analysis of the 3-methyllumiflavin-promoted oxidative deamination of benzylamine. (kist.re.kr)
- Monoamine oxidases (MAO-A and MAO-B), that catalyse oxidative deamination of primary amines, produce H 2 O 2 . (turkupetcentre.net)
- This gene is one of two neighbouring family members that encode mitochondrial enzymes that catalyse the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. (unitedwecare.com)
- Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). (nih.gov)
Cytosine13
- Spontaneous deamination is the hydrolysis reaction of cytosine into uracil, releasing ammonia in the process. (wikipedia.org)
- In DNA, this spontaneous deamination is corrected for by the removal of uracil (product of cytosine deamination and not part of DNA) by uracil-DNA glycosylase, generating an abasic (AP) site. (wikipedia.org)
- A known result of cytosine methylation is the increase of C-to-T transition mutations through the process of deamination. (wikipedia.org)
- 1. Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions. (nih.gov)
- 2. Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo. (nih.gov)
- 3. Unusual kinetics of uracil formation in single and double-stranded DNA by deamination of cytosine in cyclobutane pyrimidine dimers. (nih.gov)
- 2. Kinetics of cytosine deamination. (nih.gov)
- 5. On the possible role of cytosine deamination in delayed photoreversal mutagenesis targeted at thymine-cytosine dimers in E. coli. (nih.gov)
- 6. Deamination of single-stranded DNA cytosine residues in aerobic nitric oxide solution at micromolar total NO exposures. (nih.gov)
- 8. Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA. (nih.gov)
- 10. Relative contribution of cytosine deamination and error-prone replication to the induction of propanodeoxyguanosine-->deoxyadenosine mutations in Escherichia coli. (nih.gov)
- 12. Cytosine deamination in mismatched base pairs. (nih.gov)
- 16. In vivo deamination of cytosine-containing cyclobutane pyrimidine dimers in E. coli: a feasible part of UV-mutagenesis. (nih.gov)
Hydrolytic deamination4
- DNA adducts of propylene oxide and acrylonitrile epoxide: hydrolytic deamination of 3-alkyl-dCyd to 3-alkyl-dUrd. (nih.gov)
- 3-HP-dUrd was formed after initial alkylation at N-3 of dCyd followed by conversion of the adjacent exocyclic imino group at C-4 to an oxygen (hydrolytic deamination) with the formation of a dUrd adduct. (nih.gov)
- As with 3-HP-dUrd, 3-HOCE-dUrd resulted from hydrolytic deamination of an initially formed dCyd adduct. (nih.gov)
- The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. (enzyme-database.org)
Oxidation2
- A new study has found that inhibitors of monoamine oxidases (MAOs), a family of enzymes that catalyse the oxidation of amines, may be repurposed for treating acute inflammation and used as a novel therapeutic target to develop a new class of anti-inflammatory agents. (thehindubusinessline.com)
- The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. (nih.gov)
Monoamine2
- A potential model for monoamine oxidase catalysis. (kist.re.kr)
- Photochemical models for monoamine oxidase catalysis and inhibition. (kist.re.kr)
Inhibition2
- 14. Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis. (nih.gov)
- Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). (nih.gov)
Adenosine1
- Non-specific adenosine deamination has a role in defence against viruses that have dsRNA stages in their life-cycle [ 1 ], as hypermutation of the viral genome by adenosine-to-inosine conversion disrupts viral open reading frames. (biomedcentral.com)
Substrate1
Amino acid1
- Aminotransferase - catalyses the transfer of an a-amino group from the a-amino acid to the a-keto acid. (elizabethfilips.com)
Spontaneous1
- Spontaneous deamination of 5-methylcytosine results in thymine and ammonia. (wikipedia.org)
Protein2
- In situations of excess protein intake, deamination is used to break down amino acids for energy. (wikipedia.org)
- Fig. 1: DarT is a PARP-like protein that catalyses ADP-ribosylation of DNA at the thymidine base nitrogen. (nature.com)
Metabolism1
- PAL catalyzes the formation of transcinnamicacid by nonoxidative deamination of L-phenylalanine, which could be the rate-limiting step in the phenylalanine metabolism pathway. (scirp.org)
Mechanism1
Roles1
- The roles of divalent metal ions in catalysis. (rhea-db.org)
Formation2
- Deamination of guanine results in the formation of xanthine. (wikipedia.org)
- Deamination of adenine results in the formation of hypoxanthine. (wikipedia.org)
Results1
- LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). (nih.gov)
Transfer1
- This new pathway for catalyst transfer in dual gold catalysis opens up the possibility of highly regioselective transformations directed by the gold in the organogold intermediates. (lookchem.com)
Group1
- Deamination is the removal of an amino group from a molecule. (wikipedia.org)
Found1
- The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. (enzyme-database.org)
Basis1
- Boissièere-Junot Nathalie, Tellier Charles, Rabiller Claude: On the Regioselective Acylation of 1,6-Anhydro-β-d- andl-Hexopyranoses Catalysed by Lipases: Structural Basis and Synthetic Applications. (cas.cz)