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  • Emricasan
  • SAN DIEGO and EDMONTON, Alberta, July 19, 2012 /PRNewswire/ -- Conatus Pharmaceuticals Inc. and the University of Alberta announced today the treatment of the first patient in an investigator-initiated islet cell transplant Phase I/II trial of emricasan (IDN-6556), a pan-caspase inhibitor. (bio-medicine.org)
  • Here, we tested the hypothesis that emricasan, a pan-caspase inhibitor, ameliorates PHT and reduction in release of MPs. (springer.com)
  • recombinant
  • Results: Under conditions in which proliferation of CD3-activated human T lymphocytes is increased by recombinant FasL, there was activation of the transcription factors NF-κB and AP-1 and recruitment of the caspase-8 inhibitor and FADD-interacting protein FLIP (FLICE-like inhibitory protein). (mendeley.com)
  • enzymes
  • Specific inhibitors of these enzymes are newly available tools which can be used to test for their participation in particular physiological and experimental cell death systems (Henkart, 1996). (springer.com)
  • PARP
  • Cell attachment, DNA ladder, Western blotting of poly(ADP-ribose) polymerase (PARP), and caspase activities were measured to confirm the cytotoxic effect of OxyHb and the protective effect of the caspase inhibitors. (ahajournals.org)
  • induces
  • Background: Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain protein (FADD). (mendeley.com)
  • Conclusions
  • Conclusions: To the best of our knowledge this is the first report showing that caspase inhibitors can modulate the process of trans-differentiation in Zinnia xylogenic cell cultures. (ebscohost.com)
  • DMSO
  • The final DMSO concentrations of caspase inhibitor treatment groups (10 μmol/L, 100 μmol/L, and combined 100 μmol/L) were 0.05%, 0.5%, and 1.0% (vol/vol), respectively. (ahajournals.org)
  • Control cells received 1.0% DMSO in the cell density study and DNA ladder and 0.5% DMSO in the caspase activity study and Western blot study. (ahajournals.org)
  • investigate
  • Healthy male Sprague‑Dawley rats were used in the present study to examine the radioprotective effect of a type of pan-caspase inhibitor, z-VAD-fmk, following radiation, to investigate the effects of caspase blockade in a model of the nucleus of the abducens nerve. (sigmaaldrich.com)