• AA005 may trigger the cell death via mediated by AIF through caspase-3 independent pathway. (biomedcentral.com)
  • These results demonstrate that TrkA kinase initiates differentiation, and p75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway. (umassmed.edu)
  • The other pathway is controlled by the release of cytochrome c from mitochondria and the subsequent ATP-dependent activation of the death regulator apoptotic protease-activating factor 1 (Apaf-1). (diva-portal.org)
  • These results suggest that chemotherapeutic drug-induced caspase activation is entirely controlled by a receptor-independent mitochondrial pathway, whereas CD95-induced apoptosis can be regulated by a separate pathway not requiring Apaf-1 function. (diva-portal.org)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
  • Unexpectedly, however, at later times (6 and 24 hours) NETs apparently triggered a cell death process in these APCs by a caspase- and Apoptosis induced factor (AIF)-dependent pathway, suggesting mitochondrial damage. (springeropen.com)
  • Taken together, our findings suggest that denbinobin induces apoptosis of human colorectal cancer HCT-116 cells via DNA damage and an AIF-mediated pathway. (tmu.edu.tw)
  • ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
  • Metallic nickel particles induce cell apoptosis through a caspase-8/AIF-mediated cytochrome c-independent pathway. (cdc.gov)
  • Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase-8/AIF-mediated cytochrome c-independent pathway. (cdc.gov)
  • The characteristics of cell death induced by Ni-CE infection resemble those of apoptosis (rounded and shrunken cells, DNA fragmentation), but the intracellular signalling pathway for this process has not been fully investigated. (microbiologyresearch.org)
  • These findings demonstrate that in addition to their functions at mitochondria, Bax and Bak also localize to the ER and function to initiate a parallel pathway of caspase activation and apoptosis. (rupress.org)
  • Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
  • The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells. (biomedcentral.com)
  • Western Blot was used to determine the protein expression of the apoptosis inhibitors livin and caspase-3, the apoptosis-related proteins Bax and Bcl-2, as well as the key protein kinases in the Jak-stat3 signaling pathway, stat3 and p-stat3. (biomedcentral.com)
  • Activation of caspase-3, up-regulation of Bax, down-regulation of livin and Bcl-2, as well as inhibition of Jak-stat3 signaling pathway might be the important mechanisms for the bufalin-induced apoptosis. (biomedcentral.com)
  • Despite a large number of promising inhibitors for Ras/Raf/MEK/ERK pathway, recent works show that cancer cells often develop an autophagy-dependent resistance to inhibitors of Ras pathway [ 16 ]. (aging-us.com)
  • Oncogenic Ras induces the constitutive activation of Ras/Raf/MEK/ERK signaling pathway, which, in turn, activates other effector pathways, in particular, PI3K-mTOR signaling [ 17 ]. (aging-us.com)
  • Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
  • RD cells transfected with pcWNV-Cp-DJY or pcDNA3.1 sis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • We identified a significant induction of epithelial alarmin (thymic stromal lymphopoietin-TSLP)-dependent interleukin-13 pathway after co-exposure, associated with increased mucin and interferon gene expression. (cdc.gov)
  • AA005 induces a unique type of cell death in colorectal adenocarcinoma cells, characterized by lack of caspase-3 activation or apoptotic body formation, sensitivity to poly (ADP-ribose) polymerase inhibitor Olaparib (AZD2281) but not pan-caspase inhibitor Z-VAD.fmk, and dependence on apoptosis-inducing factor (AIF). (biomedcentral.com)
  • Moreover, blocking activation of RIP-1 by necroptosis inhibitor necrotatin-1 inhibits AIF translocation and partially suppresses AA005-induced cell death in SW620 cells demonstrating that RIP-1 protein may be essential for cell death. (biomedcentral.com)
  • Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
  • Both NGF and a caspase inhibitor reduced apoptosis and, thereby, enhanced differentiation. (umassmed.edu)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • The addition of a pan-caspase inhibitor (zVAD-fmk) did not suppress the denbinobin-induced apoptotic effect, and denbinobin-induced apoptosis was not accompanied by processing of procaspase-3, -6, -7, -9, and -8. (tmu.edu.tw)
  • However, we found that Ni-CE induced cell death despite the presence of a caspase inhibitor, Z-VAD-FMK. (microbiologyresearch.org)
  • The apoptosis rate was 34.63 ± 2.57% (vs 19.69 ± 1.63%, P = 0.002) in JAK kinase inhibitor AG490 plus bufalin treatment group. (biomedcentral.com)
  • We studied whether cellular senescence induced by HDAC inhibitor sodium butyrate in E1a+cHa-Ras -transformed rat embryo fibroblasts (ERas) and A549 human Ki-Ras mutated lung adenocarcinoma cells would enhance the tumor suppressor effect of MEK/ERK inhibition. (aging-us.com)
  • However, the activation of AMPK-dependent autophagy overcomes pro-apoptotic effects of MEK/ERK inhibitor and results in restoration of the mitochondria and rescue of viability. (aging-us.com)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • In contrast, inhibition of ATP production did not affect caspase activation after triggering of CD95. (diva-portal.org)
  • Because of its ability to induce cell growth inhibition and apoptosis in normal and pre-malignant cells, TGFβ has been described as a potent tumor suppressor [ 8 ] [ 9 ] . (encyclopedia.pub)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • The mechanism here is quite different, involving FOXO4's influence on p53 , but I wouldn't be surprised to see it turn out to be a part of the same system of inhibition of apoptosis. (fightaging.org)
  • [ 8 ] Caspase inhibition in clonal striatal cells showed no correlation between the reduction of aggregates in the cells and increased survival. (medscape.com)
  • Apoptosis involves the mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF), which activate caspase-dependent and -independent execution pathways, respectively. (wikipedia.org)
  • C5a blockade in the sepsis model almost completely inhibited caspase-3, -6, and -9 activation, significantly preserved cytochrome c in the mitochondrial fraction, and restored Bcl-XL expression. (jci.org)
  • In response to apoptotic stimulus, permeabilized mitochondria release cytochrome c into the cytoplasm, where cytochrome c forms an apoptosome with Apaf-1 and caspase-9 and triggers the caspase cascade. (biomedcentral.com)
  • Protein levels of caspases 8, 9, and 3 and cytochrome c in the ectopic and eutopic endometrium were measured by western blotting. (hindawi.com)
  • TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner. (hindawi.com)
  • Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF- α and its downstream signaling, including caspases and cytochrome c. (hindawi.com)
  • The investigational new drug SHetA2 targets these vulnerabilities in ovarian and endometrial cancer cells by disrupting complexes of the mortalin HSP with its client proteins (mitochondrial support proteins, metabolic enzymes, p53) leading to mitochondrial leakage of cytochrome c and apoptosis-inducing factor (AIF), and caspase-dependent apoptosis. (figshare.com)
  • Acute solvent exposure induced activation of cytochrome P4502E1 causes proximal tubular cell necrosis by oxidative stress. (cdc.gov)
  • These data suggest that systemic activation of complement induces C5a-dependent apoptosis of thymocytes and that the blockade of C5a during sepsis rescues thymocytes from apoptosis. (jci.org)
  • Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
  • Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
  • Purvalanol induced mitochondrial membrane potential loss, caspase-7 and caspase-3 activation and PARP cleavage following a 48 h treatment. (spandidos-publications.com)
  • However, the therapeutic efficacy is attenuated by the antitumor agent-induced activation of nuclear factor-κB (NF-κB). (oncotarget.com)
  • In pomalidomide and gemcitabine/nab-paclitaxel group, gemcitabine/nab-paclitaxel-induced NF-κB activation was inhibited and apoptosis was enhanced in comparison with those in the other groups both in vitro and in vivo . (oncotarget.com)
  • In all cases, apoptosis is mediated by caspases, although it is unclear how these diverse apoptotic stimuli cause protease activation. (diva-portal.org)
  • Prevention of ATP production completely inhibited caspase activation and apoptosis in response to chemotherapeutic drugs and staurosporine. (diva-portal.org)
  • As validation, excessive mitophagy and lack of caspase activation were observed in SHetA2-inhibited xenograft tumors. (figshare.com)
  • Metallic nickel particles showed only a very slight activation of caspase-3, -6 and -9. (cdc.gov)
  • In addition, activation of anti-apoptotic factors, including phospho-Akt and Bcl-2, was detected. (cdc.gov)
  • It is assumed that destructive changes in cultured nerve cells subjected to ischemia and reoxygenation are associated with the activation of caspase-3 (the data were obtained in collaboration with the laboratory of experimental neurocytology of the Research Institute of the Brain of the Russian Academy of Medical Sciences). (ihna.ru)
  • We demonstrated that the Ni-CE strain induced DNA fragmentation, cell membrane disruption, exposure of phosphatidylserine (PS), activation of caspase-3/7 and anti-poly (ADP-ribose) polymerase 1 (PARP-1) cleavage, an early apoptosis indicator, whereas the Nishigahara strain did not induce DNA fragmentation, caspase-3/7 activation, cell membrane disruption, or PARP-1 cleavage, but did induce PS exposure. (microbiologyresearch.org)
  • Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)
  • 0.01), further up-regulated Bax protein expression, down-regulated livin and Bcl-2 protein expression and enhanced caspase-3 activation. (biomedcentral.com)
  • Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)
  • Organic solvent-induced proximal tubular cell toxicity via caspase-3 activation. (cdc.gov)
  • Induction of growth factors [interleukin 6 (IL-6), insulin-like growth factor-1, and vascular endothelial growth factor/platelet-derived growth factor) may indirectly activate the AR and/or its downstream signaling pathways (5, 6, 7) . (aacrjournals.org)
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
  • The present study investigates metallic nickel particle-induced apoptosis and the signal pathways involved in this process in JB6 cells. (cdc.gov)
  • In conclusion, our data suggest that M95 mutation-related cell death is caused by both the caspase-dependent and -independent pathways. (microbiologyresearch.org)
  • On the other hand, non-genomic actions may indirectly affect gene transcription via the regulation of intracellular signaling pathways that target transcription factors ( 3 ). (jcancer.org)
  • However, denbinobin triggered the translocation of the apoptosis-inducing factor (AIF) from the mitochondria into the nucleus. (tmu.edu.tw)
  • Moreover, we found that apoptosis-inducing factor (AIF) was upregulated and released from mitochondria into cytoplasm in nickel- treated cells. (cdc.gov)
  • Agents that initiate ER stress responses can induce conformational changes and oligomerization of Bax on the ER as well as on mitochondria. (rupress.org)
  • In bax − / − bak − / − cells, introduction of Bak mutants selectively targeted to either mitochondria or the ER can induce apoptosis. (rupress.org)
  • However, ER-targeted, but not mitochondria-targeted, Bak leads to progressive depletion of ER Ca 2+ and induces caspase 12 cleavage. (rupress.org)
  • In contrast, mitochondria-targeted Bak leads to enhanced caspase 7 and PARP cleavage in comparison with the ER-targeted Bak. (rupress.org)
  • Autophagy represents a caspase-independent process characterized by accumulation of autophagosomes in the cytoplasm and their subsequent fusion with lysosomes for degradation of unused or misfolded proteins or damaged structures such as ribosomes (ribophagy) and mitochondria (mitophagy). (aging-us.com)
  • Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
  • Studies with bortezomib (VELCADE, formerly known as PS-341) and other proteasome inhibitors indicate that cancer cells are especially dependent on the proteasome for survival, and several mechanisms used by prostate cancer cells require proteasome function. (aacrjournals.org)
  • Use of specific inhibitors documented that AIF and mitophagy, but not caspases, contributed to the mechanism of SHetA2-induced cell death in cervical cancer cells. (figshare.com)
  • Co-Treatment of Prostate Cancer Cells with Mscs Expressing Trail and Iap Inhibitors Reduce Trail Resistance and Production of Trail-Induced Cytokines. (essex.ac.uk)
  • First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
  • ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
  • Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. (encyclopedia.pub)
  • Recent studies have shown that in addition to necrosis and apoptosis, there are also other new programmed death modes, such as autophagy, necrosis and necrotic apoptosis, which have unique biological processes and pathophysiological characteristics. (nature.com)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • Our previous study has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in METH-induced neuronal autophagy and apoptosis. (cancerindex.org)
  • We hypothesized that C/EBPβ is involved in METH-induced DDIT4-mediated neuronal autophagy and Trib3-mediated neuronal apoptosis. (cancerindex.org)
  • We tested our hypothesis by examining the effects of silencing C/EBPβ, DDIT4, Trib3 or α-syn with small interfering ribonucleic acid (siRNA) on METH-induced autophagy and apoptosis in the human neuroblastoma SH-SY5Y cells. (cancerindex.org)
  • In addition, loss of tumor suppressor activity or proapoptotic factors can contribute to androgen-independent growth (8) and has been reviewed (9) . (aacrjournals.org)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • tumor necrosis factor receptor superfamily. (wikigenes.org)
  • In UV models of ALCs and human lens epithelial cell lines, the expression levels of histone H3, cell apoptosis factors (Bax/Bcl-2, cleaved caspase-3), and inflammation factors (interleukin-6, tumor necrosis factor-α) were all up-regulated. (techscience.com)
  • We show that ApoBDs generated from IAV-infected monocytes contained IAV mRNA, protein and virions and consequently, could facilitate viral propagation in vitro and in vivo, and induce a robust antiviral immune response. (nature.com)
  • IAV was able to induce monocyte apoptosis and apoptotic cell disassembly in both in vitro and in vivo settings. (nature.com)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • In vitro , we assessed NF-κB activity and apoptosis in response to pomalidomide alone, gemcitabine/nab-paclitaxel, or combination of pomalidomide and gemcitabine/nab-paclitaxel in human pancreatic cancer cell lines (PANC-1 and MIA PaCa-2). (oncotarget.com)
  • Thymic atrophy was the result of direct action of THC and not based on maternal factors inasmuch as THC was able to induce T cell apoptosis in vitro in fetal thymic organ cultures. (aspetjournals.org)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
  • In this study, we aimed to elucidate the mechanism by which M95 affects cell death induced by human neuroblastoma cell infection with the Nishigahara, Ni-CE and M95-mutated strains. (microbiologyresearch.org)
  • Near all are destroyed, either through the programmed cell death mechanism of apoptosis , or by immune cells attracted by the signal molecules generated by senescent cells . (fightaging.org)
  • ActinomycinD- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89fragment that traverses into the cytoplasm. (2011globalhealth.org)
  • In wild-type cells, this is associated with caspase 12 cleavage that is abolished in bax − / − bak − / − cells. (rupress.org)
  • WNV has been reported in infected caspase-9 (DN caspase-9) construct, and cleavage of pro- mothers' breast milk, and WNV transmission by organ trans- caspase-9 protein was determined by Western blot analysis plantation and transfusion has been documented. (cdc.gov)
  • In the past decade, induction of apoptosis has become the major strategy to combat cancer. (hindawi.com)
  • Therefore, a search for innovative strategies other than induction of apoptosis is urgently needed. (hindawi.com)
  • mouse brain resulted in an induction of apoptosis similar to Ultrathin sections were stained with uranyl acetate and lead what is observed in natural infection. (cdc.gov)
  • Apoptosis mechanisms may have a more prominent role in developing an ischemic brain injury in neonatal humans than in adult brain ischemia, as a majority of cells die in the environment where edema developed after a neonatal stroke. (wikipedia.org)
  • However, the mechanisms underlying its cell-death-inducing activity are unclear. (biomedcentral.com)
  • Our work provided new mechanisms for AA005-induced cancer cell death and novel clues for cancer treatment via AIF dependent cell death. (biomedcentral.com)
  • However, the mechanisms of bufalin-induced apoptosis remain elusive. (biomedcentral.com)
  • It involves sabotaging one of the mechanisms that lingering senescent cells use in order to resist the fall into apoptosis, but which in normal cells has no important role to play. (fightaging.org)
  • Inhalation of agents in the workplace can induce asthma in a mechanisms involved in asthma. (cdc.gov)
  • Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)
  • We showed that denbinobin induces apoptosis in human colorectal cancer cells (HCT-116) in a concentration-dependent manner. (tmu.edu.tw)
  • Cytotoxicity, antiproliferative and apoptosis-inducing capacity of ACNVs against hepatoma carcinoma cell were assessed. (dovepress.com)
  • Using MTT the assay, we found that metallic nickel nanoparticle s (80 nm) exhibited higher cytotoxicity than fine particles (3 mu M). Both metallic nickel nano- and fine particles induced JB6 cell apoptosis in a dose-dependent manner. (cdc.gov)
  • NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
  • Results showed exposure of NHBEs to ABS emissions did not significantly affect epithelium integrity, ciliation, mucus production, nor induce cytotoxicity. (cdc.gov)
  • Rabbit polyclonal to Parp.Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-bindingzinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure,and apoptosis. (2011globalhealth.org)
  • Apoptosis-inducing factor (AIF) translocation from themitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent celldeath. (2011globalhealth.org)
  • Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)
  • Likewise, in the early stages of prostate cancer, the growth of cancerous prostatic epithelial cells is often androgen dependent (3) . (aacrjournals.org)
  • Blocking ROS formation significantly suppresses AA005-induced cell death in SW620 cells. (biomedcentral.com)
  • Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
  • On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
  • NGF, which can bind to endogenous p75, did not induce differentiation but enhanced the EGF-induced response, leading to differentiation of almost all cells. (umassmed.edu)
  • EGF may induce a limited number of neuronal cells because it also enhanced apoptosis. (umassmed.edu)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • Drug-targetable vulnerabilities of cancer cells include their dependence on heat shock proteins (HSPs) to support elevated mitochondrial metabolism and counteract cell death factors. (figshare.com)
  • Our results would suggest that early in inflammation, NETs can activate the two main APCs (Mfs and cDCs), but as the process continues, NETs can then initiate apoptosis of these cells through mitochondrial harm. (springeropen.com)
  • Small interfering RNA targeting of AIF effectively protected HCT-116 cells against denbinobin-induced apoptosis. (tmu.edu.tw)
  • Transforming growth factor-beta (TGFβ) was discovered more than thirty years ago as a secreted polypeptide from sarcoma virus-infected cells that promoted the soft agar independent growth of normal rat kidney (NRK) cells [ 1 ] [ 2 ] . (encyclopedia.pub)
  • The effects of ischemia (oxygen-glucose deprivation) and reoxygenation on the morphology of cultured rat cerebellar seed cells and the activity of caspase-3 in these cells were studied. (ihna.ru)
  • We previously reported that the avirulent fixed rabies virus strain Ni-CE induces a clear cytopathic effect in mouse neuroblastoma cells, whereas its virulent progenitor, the Nishigahara strain, does not. (microbiologyresearch.org)
  • We present a computational model for calculating the yield of radiation-induced chromosomal aberrations in human cells based on a stochastic Monte Carlo approach and calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. (bioone.org)
  • Bufalin not only inhibited the growth of colon cancer SW620 cells, but also induced apoptosis of SW620 cells. (biomedcentral.com)
  • Imidazo[1,2-b]pyrazole-7-carboxamides induce apoptosis in human leukemia cells at nanomolar concentrations. (celljournal.org)
  • Riedl S, Leber R, Rinner B, Schaider H, Lohner K, Zweytick D. Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. (celljournal.org)
  • Furthermore, transfection of CRYAA in FHL-124 cells induced overexpression of histone H3. (techscience.com)
  • By interfering with the FOXO4-p53 crosstalk, the peptide causes senescent cells to go through apoptosis, or cell suicide. (fightaging.org)
  • Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • There is an increased inflammatory response after hypoxia-ischemia, which corresponds to extensive neuronal apoptosis. (wikipedia.org)
  • GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
  • Fibroblast growth factor 23 (FGF-23) and Klotho are secretory proteins that regulate mineral-ion metabolism. (harvard.edu)
  • Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)
  • There was also evidence of down-regulation of serum interleukin 6, a downstream nuclear factor κB effector. (aacrjournals.org)
  • It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK . (sdbonline.org)
  • Recent research demonstrated that the potential to induce apoptosis through endoplasmic reticular (ER) stresses can be a target for cancer therapy. (hindawi.com)
  • Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
  • When C5a was generated in vivo by infusion of purified cobra venom factor (CVF), thymocyte apoptosis was significantly increased. (jci.org)
  • Co-exposure induced a significantly greater respiratory function decline compared to individual exposure. (cdc.gov)
  • One is mediated by recruitment of the proximal regulator caspase-8 to the death receptor complex. (diva-portal.org)
  • Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
  • Apoptosis is induced by different stimuli, among them triggering of the death receptor CD95, staurosporine, and chemotherapeutic drugs. (diva-portal.org)
  • Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. (biomedcentral.com)
  • Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)
  • According to the etiology, cataract is classified as age-related cataract (ARC), childhood cataract, traumatic cataract, cataract associated with systemic disease, complicated cataract, and drug-induced cataract, among which ARC was the most common type ( Richard, 2019 ). (techscience.com)
  • It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
  • caused by systemic administration of kainic acid, it has been shown that convulsive activity correlates with indicators of oxidative stress, apoptosis and expression of the AP-1 transcription factor in the rat hippocampus. (ihna.ru)
  • C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. (jci.org)
  • Thymic atrophy induced in the fetus correlated with caspase-dependent apoptosis in thymocytes. (aspetjournals.org)
  • Western-blot analysis showed an upregulation of proapoptotic factors, including Fas, FADD, caspase-8, DR3 and BID, following exposure to metallic nickel particles. (cdc.gov)
  • IP western blot analysis demonstrated the formation of the Fas-related death-inducing signaling complex (DISC) during the apoptotic process. (cdc.gov)
  • EGF activated the ET-R kinase and induced partial differentiation. (umassmed.edu)
  • inositol-requiring enzyme 1 (IRE1α), PRKR-like ER kinase (PERK) and activating transcription factor-6 (ATF-6). (spandidos-publications.com)
  • Active TGFβ induces the heteromeric complex formation of two single transmembrane serine/threonine kinase family receptors, i.e. (encyclopedia.pub)
  • Previous studies have demonstrated that DNA damage-inducible transcript 4 (DDIT4), Trib3 (tribbles pseudo kinase 3), alpha-synuclein (α-syn) are involved in METH-induced dopaminergic neurotoxicity. (cancerindex.org)
  • This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
  • Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. (jci.org)
  • Enhancement of EGF-induced differentiation required at least nanomolar concentrations of NGF, consistent with the low-affinity p75 binding site. (umassmed.edu)
  • The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
  • This study was designed to examine the constrictive potential of C-Phycocyanin (C-PC) in regulating changes imposed on gene expression in the selenite-induced cataract model. (molvis.org)
  • The combination of the exposure chamber and the ALI-based model is promising for assessing 3-D printer emission-induced toxicity. (cdc.gov)
  • Cp) in viral-induced pathogenesis. (cdc.gov)