In insect cells, P35 inhibits an enzyme called Sf caspase-1, which was identified as a structural and functional ortholog of human CASP3 (CPP32) and CASP7 (MCH3). (wikipedia.org)
Studies using purified human caspases in vitro found that the protein is able to also inhibit several of these, including CASP1, CASP3, CASP6, CASP7, CASP8, and CASP10. (wikipedia.org)
Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. (nih.gov)
Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. (nih.gov)
With its E3 ubiquitin-protein ligase activity via interaction with several proteins such as RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, BCL10 etc., c-IAP2 can regulate NFkB signaling - positive regulation of canonical and negative regulation of non-canonical pathway. (novusbio.com)
Caspase7
Radiation induces caspase activation fundamentally via the mitochondrial pathway. (spandidos-publications.com)
Radiation and other agents induce caspase activation fundamentally via the mitochondrial pathway, which includes mitochondrial integration of apoptotic signals and the subsequent release of cytochrome c into the cytosol ( 5 , 9 , 10 ). (spandidos-publications.com)
As a result, the present study aimed to investigate changes in the expression of X-linked IAP (XIAP) induced by radiation injury, the activity and expression of caspase members following radiation and the effect of caspase blockade. (spandidos-publications.com)
The aim of this study was to evaluate the effect of the A1 receptor function on cell programmed death or proliferation, as well as the relationship between this receptor stimulation/inhibition and caspase 3 (casp3) expression in T47D cell line that has a mutant and non-functional P53 gene. (uitm.edu.my)
Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. (deathbase.org)
Here we report the identification and characterization of the caspase-8 (casp8) gene in the zebrafish Danio rerio. (deathbase.org)
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs, and our study suggests that the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution. (deathbase.org)
CASP91
Study the Effect of Eugenol on CASP8 and CASP9 Gene\'s Expression in Colon Cancer Cell Lines HT-29 by: Milad Banitalebi Dehkordi, et al. (uitm.edu.my)
Apoptosis-Inducing Ligand1
The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)
RIPK12
For death-receptor-induced necroptosis, the protein kinase receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL) are the key components of the necroptosis machinery [ 1 , 2 , 3 ]. (biomedcentral.com)
For viral infection-induced necroptosis, RIPK3 and MLKL, but not RIPK1, are required and another protein, Z-DNA-binding protein 1 (ZBP1), also known as DNA-dependent activator of IFN regulatory factors (DAI), functions upstream of RIPK3-MLKL to initiate the formation of the necrosome [ 16 ]. (biomedcentral.com)
Ligand1
Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. (deathbase.org)
CASP61
B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G(1) than wild-type B cells, and mitogen-induced G(1) entry of Casp6 KO B cells is much faster than that of wild-type B cells. (deathbase.org)
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1a induced cell death. (lu.se)
Epithelial cells1
Here we show that antimicrobial ROS are induced from lung epithelial cells by interactions of CpG oligodeoxynucleotides (ODN) with mitochondrial voltage-dependent anion channel 1 (VDAC1). (bvsalud.org)
CASP101
In contrast, the zebrafish casp10-like gene and the cflar gene separately localize on LG9 and LG11, respectively, and these genes form a cluster with CASP8 on the human chromosome. (deathbase.org)
Stimulation1
Finally, we demonstrated that the controlled PBM induced by the LED light exposure generates a preconditioning stimulation of the mitochondrial potential, which protects the cell from oxidative stress damage. (bvsalud.org)
Radiation-induced2
Studies on the molecular mechanism of neuronal cell apoptosis following radiation have enriched the number of protective therapeutic strategies against radiation-induced neuronal cell death ( 2 ). (spandidos-publications.com)
This study shows, using the alkaline comet assay, that lower levels of DNA damage are induced following FLASH irradiation, an effect that is modulated by the oxygen tension, and increases with the total dose and dose rate of irradiation, indicating that an oxygen related mechanism, e.g. transient radiation-induced oxygen depletion, may contribute to the tissue sparing effect of FLASH irradiation. (knoblauchpublishing.com)
Substrate1
Both DAPG and DPPG significantly increased the CASP3 protein expression that was detected by staining the cells with the super-view 488-CASP3 substrate. (harvard.edu)
Expression5
Conclusion: In general, DPCPX could up-regulate casp3 gene expression and subsequently increase the apoptosis rate in T47D cells with casp3 expression without the P53 gene interference. (uitm.edu.my)
The Effect of Citrullus colocynthis on the Induction of Casp3 and Casp8 Gene Expression on Human Glioblastoma U87 Cell Line by: N Abdi, et al. (uitm.edu.my)
Ectopic expression of Casp8 in zebrafish embryos induces apoptosis [16888647] . (deathbase.org)
Ectopic expression of these ligands during embryogenesis induced apoptosis in erythroblasts and notochord cells. (deathbase.org)
Expression analysis showed that casp8 is maternally expressed, and transcripts continue to be present throughout embryogenesis and into larval stages. (deathbase.org)
Gene2
An intense band of CASP8 gene product was observed agarose gel for DPPG treated HCT116 cells than DAPG. (harvard.edu)
The zebrafish casp8 gene has a genomic organization similar to mammalian casp8 genes, consisting of 10 exons. (deathbase.org)
Protein2
Importantly, we have shown that senescence of these cells induced by hydrogen peroxide treatment leads to the disappearance of potassium channel protein levels and channel activity measured by the single channel patch-clamp technique. (bvsalud.org)
Furthermore, we examined the function of zebrafish Casp8 protein in mammalian cells, and showed that it has pro-apoptotic activity when overexpressed. (deathbase.org)
Proteins1
Molecular docking simulation showed the high binding affinities (≥ 6.5 kcal/mol) of DPPG and DAPG with target proteins WNT1, MAPK1, CASP8, and CASP3 in HCT116 cells. (harvard.edu)
Mitochondrial1
The ODN-induced mitochondrial ROS yield protective antibacterial effects. (bvsalud.org)
Pathways2
Focusing on 35 pathways and processes, the autoimmune profiling panel allows for the evaluation of immune system dysfunction, helping to understand therapeutic mechanism of action, immuno-therapy induced adverse reactions, and discovery of disease and therapeutic specific biomarkers. (canopybiosciences.com)
The 35 pathways and processes in this panel provide a comprehensive view into immune system dysfunction in autoimmune disease and treatment-induced adverse immune events. (canopybiosciences.com)
Enzyme1
Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. (cancerindex.org)
Significantly1
Result: Our results indicated that DPCPX significantly induces apoptosis in T47D cells and the rate of survival cell after the reduction of this treatment, especially 72 hours after treatment. (uitm.edu.my)
Overexpression1
In addition, overexpression of recombinant Mch2 alpha, but not Mch2 beta, induces apoptosis in Sf9 insect cells. (deathbase.org)
Cell death1
Genetic and biochemical experiments have found that increased modification inhibits apoptosis in tissues and cell culture and that lowering O -GlcNAcylation induces cell death. (mcw.edu)
Therapeutic1
For use in therapeutic mechanism of action (MOA) studies and immuno-therapy induced adverse event investigations. (canopybiosciences.com)
Cells4
DPPG and DAPG induced apoptosis in the HCT116 and A549 cells that was confirmed by Hoechst 33342 and FITC-annexin V staining. (harvard.edu)
This manuscript demonstrated that DAPG and DPPG inhibited lung and colorectal cancer cells by inducing apoptosis. (harvard.edu)
DAPG and DPPG inhibited A549 and HCT116 cells growth by inducing apoptosis. (harvard.edu)
In addition, this molecule was capable of transmitting apoptotic signals mediated through not only Fas but also the TNF receptor in mouse Casp8-deficient cells. (deathbase.org)
Activation1
The resulting aggregate called death-inducing signaling complex (disc) performs CASP8 proteolytic activation. (lu.se)
Activity1
Generation of the subunits requires association with the death-inducing signaling complex (disc), whereas additional processing is likely due to the autocatalytic activity of the activated protease. (lu.se)
Maps1
By chromosome mapping, we found that casp8 maps on linkage group 6 (LG6), a zebrafish chromosome segment orthologous to the long arm of human Chr. (deathbase.org)