Lamin Type AAging, PrematureFarnesyltranstransferaseCell Nucleus ShapeNuclear LaminaWerner SyndromePrenylationProtein PrecursorsProtein PrenylationBone Demineralization, PathologicFibroblastsNuclear EnvelopeNuclear ProteinsSkin AbnormalitiesLaminsProtein Modification, TranslationalLamin Type BOrganelle ShapeContractureLipodystrophyMaxillofacial AbnormalitiesMetalloendopeptidasesCell AgingSomatotrophsCockayne SyndromeCell NucleusAgingBone Diseases, DevelopmentalPhenotypeMutationSyndromeAlkyl and Aryl TransferasesProgeriaHeterochromatinLongevityCells, CulturedMembrane ProteinsSkinDisease Models, AnimalEnzyme InhibitorsDNA RepairHeterozygoteMitosisDNA DamageBone and BonesMice, TransgenicCell LineMice, KnockoutProtein Binding