Cases of dili. Medical search. Frequent questions

Elevated liver enzymes and drug-induced liver injury: ALT, AST, and bilirubin elevations have occurred with pirfenidone including cases of drug-induced liver injury. (nih.gov)
In the post-marketing setting, non-serious and serious cases of drug-induced liver injury, including severe liver injury with fatal outcomes, have been reported. (nih.gov)
2021) Incidence, characteristics and risk factors for drug‐induced liver injury in hospitalized patients: A matched case‐control study. (news-medical.net)
These seemingly innocuous symptoms can be early indications of drug-induced liver injury (DILI). (pharmexec.com)
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable type of liver injury following exposure to medication within the recommended dose which is distinctive from liver injury caused by drug overdosage, commonly caused by paracetamol overdose (POD). (bsg.org.uk)
The FRAME Alternatives Laboratory is one of 51 partners from 16 countries working with COST (European Cooperation in Science and Technology) to research the causes of drug-induced liver injury in a project known as the Pro Euro DILI Network. (drugdiscoverytoday.com)
Idiosyncratic drug-induced liver injury, or DILI, is an acute adverse hepatic reaction that occurs in a small proportion of patients exposed to a drug. (drugdiscoverytoday.com)
Idiosyncratic drug-induced liver injury (DILI) is an acute adverse hepatic reaction that occurs in only a small proportion of individuals exposed to a drug, it is unexpected from the known pharmacological action of the agent, leading to illness, disability, hospitalization, including life threatening liver failure and death or need for liver transplantation. (proeurodilinet.eu)
Deeper understanding of drug-induced liver injury (DILI) mechanisms is the goal of an international team of experts from the Prospective European Drug-induced Liver Injury Network (PRO-EURO DILI Network), who met on March 9 and 10 at the Institute of Physics of the Academy of Sciences of the Czech Republic. (fzu.cz)
Within the PRO-EURO DILI Network there are five working groups dealing, for example, with the standardization of approaches to the diagnosis of drug-induced liver damage, the assessment of the hepatotoxicity potential of individual drugs and their interaction or trying to contribute to better decision-making by regulatory bodies related to DILI. (fzu.cz)
The term drug-induced liver injury (DILI) may be used to mean clinically significant liver injury or all (including asymptomatic) liver injury. (msdmanuals.com)
Drug-induced liver injury (DILI) is an injury of the liver that may occur when you take certain medicines. (medlineplus.gov)

Following a large national audit in the UK of 881 consecutive patients admitted with jaundice, where a biliary obstruction was ruled out by imaging, idiosyncratic DILI was the second most common cause of liver injury (15% of cases) after alcoholic liver disease (2). (bsg.org.uk)
One of the aims of the next phase of this joint research is the prevention of the so-called idiosyncratic DILI, i.e., a rare condition occurring independently of a drug dose, or route or duration, of administration. (fzu.cz)

Dili (Portuguese/Tetum: Díli) is the capital and largest city of East Timor. (wikipedia.org)
Dili became the capital of an independent East Timor in 2002. (wikipedia.org)
Dili has played a central role in the history of East Timor. (wikipedia.org)
Dili is a city of 222,000 people (2015) on the northern coast of East Timor, squeezed along the narrow plains between the central mountains which run the length of the Timor and the Ombai Strait. (wikivoyage.org)
Some of the displaced told UNHCR that residents fled elsewhere in East Timor when violence first erupted in Liquisa, thinking that larger towns like Dare and Dili would be safer. (unhcr.org)
There are now 2500 Australian soldiers and police in East Timor, mostly in the capital, Dili. (theage.com.au)

The United States Embassy in Dili, Timor-Leste is pleased to announce the opening of the Fulbright Foreign Student Scholarship Competition for the 2018-2019 Academic Year. (usembassy.gov)

Aim To characterise phenotype presentation, outcome and severity of AAS DILI. (medscape.com)
As we have observed an increase in the reporting rate of AAS DILI cases to the Spanish DILI Registry, we aimed to analyse the reported frequency of AAS hepatotoxicity over the years in this database and the recently set up Spanish-Latin-American DILI Network as well as to characterise the clinical signature and severity of this form of hepatotoxicity. (medscape.com)

Mortality/ liver transplant rates exceed 10% in DILI patients with hepatocellular injury and jaundice (5, 6). (bsg.org.uk)
Young men (mean age 32 years), requiring hospitalisation, hepatocellular injury and jaundice were predominating features among the AAS cases. (medscape.com)

Their goal is also to establish standards for clinical trial designs and precise criteria for evaluating the effectiveness of new interventions or for investigating new biomarkers in DILI. (fzu.cz)

DILI can progress to acute liver failure (ALF) accounting to 7-15% of total ALF cases (3). (bsg.org.uk)
The outcome is worse when acute liver failure develops in DILI than that in paracetamol overdose. (bsg.org.uk)
Although hepatocellular injury predominates, acute kidney injury develops in cholestatic cases with pronounced jaundice. (medscape.com)

In January of 2020, the development of inarigavir was halted after the tragic death of patient who presented with clear signs of DILI. (pharmexec.com)
DILI, 25 May 2020 (TATOLI) - Timor-Leste will spend another month under the state of emergency decree - subject to presidential approval - following a decision by the Council of Ministers. (tatoli.tl)

4-5 From 1788 to 1790, a civil war broke out between the Governor in Dili and an official based in Manatuto, which was resolved upon the arrival of a new governor. (wikipedia.org)
In a sign of an improving security climate in Interfet-controlled areas, humanitarian convoys will from tomorrow, Thursday, be able to travel the road linking Dili with Manatuto, Baucau and Los Palos without military escort by peacekeeping troops. (unhcr.org)

There is no high-quality evidence that supports empirical use of steroids to treat DILI unless in scenarios when auto-immune hepatitis cannot be excluded. (bsg.org.uk)

Until a few weeks ago, there had been no reported COVID-19 cases in Timor-Leste for months. (thediplomat.com)

Prolonged investigations, delays in bringing cases to trial, and critical editorials from watchdog NGOs also contributed to this perception. (state.gov)
In Dili, UNHCR and NGOs have completed preparations for the first return of East Timorese from West Timor. (unhcr.org)

Furthermore, the cholestatic AAS cases presented significantly higher mean peak bilirubin ( P = 0.029) and serum creatinine values ( P = 0.0002), compared to the hepatocellular cases. (medscape.com)

DFAT is seeking a suitably qualified Medical Practitioner to lead its small medical team in Dili, Timor Leste. (rdaa.com.au)
They serve the airport, too, but a meter fare to central Dili (around Lecidere) will be US$10 anyway, although only $5 to Timor Plaza. (wikivoyage.org)
Staff in West Timor will select only Dili residents for the first repatriation flights until conditions and transportation allow for the return of inhabitants of other areas. (unhcr.org)
A view of Ataúro Island from the hills above Dili, the capital of Timor-Leste. (thediplomat.com)
Over the Easter weekend, as the first shipment of COVID-19 vaccines was expected to arrive in Timor-Leste's capital of Dili, Tropical Cyclone Seroja arrived instead. (thediplomat.com)
The government cites the "worrying" increase in cases in Indonesia as a reason to extend the state of emergency in Timor-Leste once more. (tatoli.tl)
The Council said the decrees have "greatly contributed" to the fact that there are currently no active cases of COVID-19 in Timor-Leste. (tatoli.tl)
Timor-Leste has no active cases of the virus , after the last patients in isolation recovered 10 days ago. (tatoli.tl)

Anti-infective agents, cancer medications, and nonsteroidal anti-inflammatory drugs were the major categories of drugs causing DILI, and the highest incidence was due to voriconazole (an antifungal medication). (news-medical.net)
Its estimated crude incidence ranges between 14-19 per 100,000 inhabitants, the annual incidence of DILI in a prospective population-based study in Europe was 19.1 (95%CI, 15.4 - 23.3) (1). (bsg.org.uk)
The organisation said: "DILI, due to commonly used drugs, continues to be an important clinical problem with a crude annual incidence of 19 per 100,000 individuals and 22 per cent of the cases requiring hospitalisation. (drugdiscoverytoday.com)

Conclusions Illicit recreational AAS use is a growing cause of reported DILI that can lead to severe hepatic and renal injury. (medscape.com)

An insidious condition, DILI develops when a therapeutic turns toxic in a patient's liver, leading to a decline in liver function and ultimately death. (pharmexec.com)
COST said the network of scientific organisations taking part will promote and coordinate a highly translational and innovative research programme in Europe and beyond, with the ultimate goal to pre-empt and prevent DILI, develop innovative therapeutic approaches that could improve clinical outcomes and enhance public awareness, while developing a forum for knowledge exchange and training of young European researchers. (drugdiscoverytoday.com)

AAS DILI is associated with a distinct phenotype, characterised by considerable bilirubin elevations independent of type of damage. (medscape.com)

As a partner in the project, FRAME gets access to a €100,000 funding pot per annum over four years to support training and research into the causes of DILI. (drugdiscoverytoday.com)

This year alone, both Pfizer and Aligos Therapeutics halted production of promising therapeutics as a result of unforeseen DILI in clinical trial patients. (pharmexec.com)

DILI usually occurs after a latency period ranges from few days to months post-exposure compared to a period from hours to days in liver injury due to overdose. (bsg.org.uk)
The complex reasons why DILI occurs in some patients and not others are not well understood, which is why DILI represents a major challenge for clinicians, the pharmaceutical industry and regulatory agencies worldwide. (drugdiscoverytoday.com)

AAS DILI caused significantly higher bilirubin values independent of type of damage when compared to other drug classes ( P = 0.001). (medscape.com)

Under Indonesian rule infrastructure in the city was developed, with landmarks such as the Immaculate Conception Cathedral and Cristo Rei of Dili being built during this time. (wikipedia.org)
Resistance to Indonesian rule faced violent repression, and a massacre in Dili led to international pressure culminating in an independence referendum. (wikipedia.org)
You can also walk out to the main road - which is the main road linking Dili with Batugade on the Indonesian border - to catch a mikrolet (25 centavos). (wikivoyage.org)

However, this heritage left Dili with a distinct Portuguese flavour and together with Macau , is probably the furthest east where you can savour genuine Portuguese food and architecture. (wikivoyage.org)

In reviewing the literature, it becomes clear that relying on animal models to predict toxicity generally, and DILI specifically, is unlikely to prevent many toxic compounds from entering clinical trials and causing harm to patients. (pharmexec.com)

To investigate the groundwater behavior in the three subsurface media, a 3-D hybrid model (equivalent porous media/discrete fracture network) involving various in situ investigation techniques (borehole drilling, outcrop investigation, borehole televiewer logging, sonic logging, and downhole hydraulic tests) was proposed to assess the hydraulic properties and groundwater storage of the Dili fault zone of Central Taiwan and its surrounding formations. (ntou.edu.tw)
Subsequently, the model was verified through a case study of a simple fracture network. (ntou.edu.tw)
The PRO-EURO DILI Network will expand the DILI issue towards not only standard drugs but also to herbs and herbal supplements. (fzu.cz)
It is important not only to investigate the causes of this disease and its appropriate prevention, but also to spread awareness about it, and the PRO-EURO DILI Network consortium succeeded in this," said Alexandr Dejneka, Head of the Division of Optics, whose scientists are involved in the network. (fzu.cz)
The goal of the PRO-EURO-DILI-NET Cost Action is to create a unique, cooperative, interdisciplinary European DILI network that would coordinate efforts of experts from different research fields in understanding mechanisms of DILI development. (fzu.cz)

The Judicial System Monitoring Programme, JSMP, an East Timorese NGO, can provide legal advice and support to take the issue to court but the judicial process is slow, due to the backlog of cases, and the potential outcome is uncertain, so this prospect is daunting. (fmreview.org)

It also serves as the capital of the Dili Municipality, which includes some rural subdivisions in addition to the urban ones which make up the city itself. (wikipedia.org)
The last camps and transitional shelters were due to close at the end of 2009 but a recent World Bank Study on Dili, East Timor's capital city, reported constant levels of violence, with up to 40% of returning IDPs in one city ward stating that they continue to experience conflict. (fmreview.org)
Dili is also capital of a district with the same name. (wikivoyage.org)
Nearly 34,000 homes were destroyed amid a strict COVID-19 lockdown in the capital, Dili, which has seen a surge in cases. (un.org)

For example, a 2009 paper in Toxicologic Pathology estimated that, over a ten year period, failure to detect drug candidates' potential to cause DILI meant one pharmaceutical company wasted some $3bn developing products that were subsequently discontinued or withdrawn. (outsourcing-pharma.com)

Patients with high cholesterol, cardiovascular disease, pre-existing liver disease, and prior surgeries faced a higher risk of DILI. (news-medical.net)
Without quick action, patients developing DILI may progress to multi-organ failure and potentially death. (pharmexec.com)
This means that potential toxicities can be missed as candidates move through the development cycle putting trial participants and, in some cases, patients at risk of injury. (outsourcing-pharma.com)

Organ-on-a-Chip technology has been proven to predict DILI with a higher rate of confidence than traditional in vitro methods and animals. (pharmexec.com)
The goal of the working group, which our team from FZU takes part in, was to review the current expertise on preclinical methods and technologies that assess the risk of DILI based on the action of a given drug, and thereby contribute to better regulatory decision-making regarding DILI. (fzu.cz)
Methods Data on 25 cases of AAS DILI reported to the Spanish (20) and Latin-American (5) DILI Registries were collated and compared with previously published cases. (medscape.com)

Effects of Accessibility and Environmental Health Risk on Housing Prices: A Case of Salt Lake County, Utah. (utah.edu)
This is a major concern for drugmakers, as is the impact that an undetected DILI risk can have on research efficiency. (outsourcing-pharma.com)
The next phase of the research will therefore be examining and scaling samples of damaged liver so that it were possible to determine in advance who who is at risk of suffering from DILI when administered a particular drug. (fzu.cz)

This separation of family members, combined with the closure of many schools in Dili for long periods of time in 2006 and 2007, resulted in a breakdown of domestic life and a rupture in the established routines and patterns of school and work. (fmreview.org)

Interrupt pirfenidone in case of signs or symptoms of SCAR. (nih.gov)

Centuries of Portuguese rule were interrupted in World War II, when Dili became the site of a battle between Allied and Japanese forces. (wikipedia.org)
210 In 1769, seeking to break the influence of powerful local families in Lifau, the Portuguese governor moved the administration and 1,200 people to the site of what would become Dili. (wikipedia.org)

The pattern of DILI is based on the earliest identified liver chemistry elevations above the upper limit of normality (ULN) that fit DILI criteria and defined using R-value where R = (ALT/ULN)/(ALP/ULN). (bsg.org.uk)

Growing information on the relationship of drugs and AIH is being available, being drugs like statins and biologic agents more frequently involved in cases of DIAILD. (wjgnet.com)
Bringing harm to a patient is the worst-case scenario that looms large as new drugs transition from preclinical to clinical studies. (pharmexec.com)
The research team used 780 liver-chips to analyze the model's ability to predict DILI caused by 27 known hepatotoxic and non-hepatotoxic small molecule drugs. (pharmexec.com)
Liver biopsy and HLA genotyping can help clinical management by differentiating DILI from AIH and excluding DILI secondary to certain drugs. (bsg.org.uk)
They also want individual data from clinical trials of drugs in development to be shared even after they are on the market in case DILI has been identified. (fzu.cz)

DILI as a polygenic disease. (proeurodilinet.eu)

They shared their experience and findings from the first stage of joint research on DILI and set plans for the future development of cooperation among different disciplines to mitigate the DILI problem. (fzu.cz)
Investigating DILI and understanding it begins with a drug's preclinical development, through clinical trials, to its launch on the market. (fzu.cz)

This week, the virus claimed a life of a 44-year-old woman in Dili, the first recorded death in the country since the pandemic began. (thediplomat.com)

The hurdles in the path of an independent government in Dili are many. (socialism.com)

Infrastructure in Dili continues to be developed. (wikipedia.org)
However, he stressed that the Nicolau Lobato International Airport in Dili continues to operate, but only to bring in essential goods. (tatoli.tl)

A case study in the Nebraska state of USA is demonstrated. (researchgate.net)
We have carried out DILI-related real-world study with the help of information technology to provide a more accurate reference for safe and rational drug use. (news-medical.net)
She refers to a study showing that in 2004 there were 250 female and 110 male sex workers in Dili. (theage.com.au)

The U.S. government's Millennium Challenge Corporation is developing plans to assist with renovating the Dili municipal water and waste management system once its planned five-year compact is signed and comes into effect. (state.gov)
The DCPO recorded 94 focus crimes in the city from January to April this year, which was down from 167 cases for the same period last year. (mindanaotimes.com.ph)
For rape, she said they recorded 31 from January to April last year, down from the 57 cases for the same period last year. (mindanaotimes.com.ph)

In addition, there are instances showing mixed features of DI-AIH and IM-DILI, as well as DILI cases with positive autoantibodies. (wjgnet.com)

During this time, there was a rise in the number of cases of domestic violence and sexual and gender-based violence (SGBV) for reasons intrinsically related to changing social relations, family breakdown, a destruction of trust and economic hardship. (fmreview.org)

Concerns that Dili's Presidente Nicolau Lobato Airport would be too inundated with water to receive the vaccine shipment spread across social media as the 9,000 people who lost their homes in Dili alone began to crowd into temporary shelters. (thediplomat.com)
On Ataúro Island, 25 kilometers from Dili on the mainland, power has been wrested from the hands of elite foreign interests and delivered back to local people through the establishment of the Asosiasaun Turizmu Koleku Mahanak Ataúro (ATKOMA), an organization bringing together local stakeholders to develop, manage, and market Ataúro as a tourist destination on their own terms. (thediplomat.com)
In terms of safety and security dili dapat mahadlok ang katawahan (people in Davao should not be afraid because the city is safe and secured). (mindanaotimes.com.ph)

Ang whole Davao city, we don't have direct threats what happened were isolated cases only, and nagkataon na sunod-sunod (it was just coincidental events that happened)," DCPO spokesperson Major Catherine Dela Rey said in an interview on Sunday. (mindanaotimes.com.ph)

We see too many cases where media reports and even some medical professionals get this issue wrong," said Pierre Guyomarch, the head of ICRC's forensics unit. (ifrc.org)
To date, only isolated case reports and smaller case series of AAS-induced liver injury (AAS DILI) have been reported. (medscape.com)

Aid workers travelled today, Wednesday, 45 kms west from Dili to Liquisa where they found thousands of displaced hiding in the surrounding hills, still afraid to return to their homes. (unhcr.org)

Dignified management of bodies is important for families and communities, and in the cases of conflict, is often an important component of bringing about a swifter end to the fighting," said Dr Kazunobu Kojima, Medical Officer for biosafety and biosecurity in WHO's Health Emergencies Programme. (ifrc.org)

Au cours de ces trois dernières années, mon pays, représenté dans les instances exécutives de l'OMS et du Fonds mondial de lutte contre le VIH/sida, le paludisme et la tuberculose, a fait de son mieux pour contribuer efficacement aux travaux de ces organes et aux efforts de plaidoyer qu'impliquait cette fonction notamment pour la mobilisation de ressources financières en faveur de la lutte contre les trois maladies. (who.int)

How European hepatologists can benefit from the Pro Euro DILI Net Cost? (proeurodilinet.eu)

Anatomy2

Diseases5

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes1

Information Science2

Health Care4

Geographicals1

Drug-induced liver12

Idiosyncratic2

East Timor6

20191

Severity2

Injury and jaundice2

Biomarkers1

Acute3

20202

Manatuto2

Hepatitis1

Reported COVID-191

NGOs2

Hepatocellular1

Timor8

Incidence3

Hepatic1

Therapeutic2

Phenotype1

100,0001

Clinical trial1

Occurs2

Bilirubin1

Indonesian3

Distinct1

Toxic1

Network5

Outcome1

Capital4

Pharmaceutical1

Patients3

Methods3

Risk3

Patterns1

Interrupt1

Portuguese2

Elevations1

Drugs5

Disease1

Development2

Death1

Independent1

Continues2

Study3

Year3

Features1

Time1

People3

Major1

Reports2

West1

Management1

Efforts1

COST1