DiseasesPsychiatry and Psychology
Akinetic MutismMutism
State of akinetic mutismAnterior cerebrEncephalitisApatheticStuporAtypicalDiagnosisDementiaRigidityApathyAkinesiaNegativismBilateralFinal stagesSevereSymptomsPathologyLesionsMovementsOccurOccursClinicalVariantVoluntaryPatientMedicalFrontalIntravenousLackCatatoniaYearsInpatientWomanTreatmentImmunotherapyAdolescenceHandsFormREPORTBrain injurySimilarSewing needlePresentTreatmentsSurgeryStudiesManagementControl
State of akinetic mutism2
  • This state of akinetic mutism varies in intensity, but it is distinguished by drowsiness, lack of motivation, hyper-somnolence, and reduction in spontaneous verbal and motor actions. (wikipedia.org)
  • The clinical picture slowly worsened to a state of akinetic mutism in about 2 years, and the patient died six years after the onset of symptoms. (longdom.org)
Anterior cerebr1
Encephalitis5
  • Other causes of akinetic mutism are as follows: Respiratory arrest and cerebral hypoxia Acute cases of encephalitis lethargica Meningitis Hydrocephalus Trauma Tumors Aneurysms Olfactory groove meningioma Cyst in third ventricle Toxical lesions and infections of central nervous system Delayed post-hypoxic leukoencephalopathy (DPHL) Creutzfeldt-Jakob disease (mesencephalic form) Akinetic mutism can be misdiagnosed as depression, delirium, or locked-in syndrome, all of which are common following a stroke. (wikipedia.org)
  • This case illustrates that anti-NMDAR encephalitis is a poorly identified entity in our settings. (revmexneurociencia.com)
  • Herein, we present two cases of anti-NMDAR encephalitis preceded by meningitis. (bvsalud.org)
  • We also considered other possible etiologies, including post-COVID-19 encephalitis, akinetic mutism, mood disorder with psychotic features, and delirium. (psychiatrist.com)
  • Functional status of children with encephalitis in an inpatient rehabilitation setting: a case series. (ctsicn.org)
Apathetic1
Stupor1
Atypical1
  • In some cases, an atypical form of absence seizure occurs in children who have Lennox-Gastaut syndrome and Dravet syndrome, two forms of epilepsy. (differencebetween.net)
Diagnosis2
  • A definitive diagnosis can only be made by histopathological examination of brain tissue, and only in rare cases is a diagnosis confirmed ante-mortem. (health.gov.au)
  • Information about diagnosis and treatment of such cases either in the acute or chronic phases is lacking and ambiguous in the literature. (blogspot.com)
Dementia5
  • It usually begins with memory loss, followed by rapidly progressing dementia, loss of coordination, slurred speech and myoclonus, and - in the final stages - akinetic mutism, coma and death. (health.gov.au)
  • Hallmark features of CJD are neuronal vacuolation, neuronal death, and pronounced glial reactions with rapidly progressive dementia, seizures, myoclonus, ataxia and eventually the absence of voluntary movements and speech/akinetic mutism [ 3 ]. (biomedgrid.com)
  • Although no precise definition for rapidly progressive dementia (RPD) exists, this term is generally used to refer to cases with significant and progressive cognitive impairment that occurs over weeks or months. (touchneurology.com)
  • The term rapidly progressive dementia (RPD) is used to describe cases with a progression course which usually ranges between weeks and months. (touchneurology.com)
  • However, it is important to point out that even neurodegenerative disorders such as Alzheimer's disease (AD), dementia with Lewy bodies and frontotemporal dementia present in rare cases as a subacute dementia instead of a slowly progressive deterioration of higher functions. (touchneurology.com)
Rigidity1
  • Intravenous lorazepam 1 mg was administered with subsequent improvement in mutism and rigidity. (psychiatrist.com)
Apathy2
  • Lack of motor function (but not paralysis) Lack of speech Apathy Slowness Disinhibition Akinetic mutism can be caused by a variety of things. (wikipedia.org)
  • Patients with depression can experience apathy, slurring of speech, and body movements similar to akinetic mutism. (wikipedia.org)
Akinesia2
  • Akinetic mutism is a medical condition where patients tend neither to move (akinesia) nor speak (mutism). (wikipedia.org)
  • citation needed] Another cause of both akinesia and mutism is ablation of the cingulate gyrus. (wikipedia.org)
Negativism1
  • Motor immobility is described along with excessive motor activity, negativism along with automatic obedience and echopraxia, and mutism along with verbigeration and echolalia. (biomedcentral.com)
Bilateral1
  • Akinetic mutism can occur in the frontal region of the brain and occurs because of bilateral frontal lobe damage. (wikipedia.org)
Final stages1
  • citation needed] Akinetic mutism is a symptom during the final stages of Creutzfeldt-Jakob disease (a rare degenerative brain disease) and can help diagnose patients with this disease. (wikipedia.org)
Severe2
  • Akinetic mutism is often the result of severe frontal lobe injury in which the pattern of inhibitory control is one of increasing passivity and gradually decreasing speech and motion. (wikipedia.org)
  • We hypothesize that, despite a dramatic neurological picture (i.e. akinetic mutism) and a severe sleep micro-structural alteration, the persistence of an autonomic modulation and the persistence of a rudimental circadian and ultradian oscillation, are related to the relatively conserved anatomo-functional integrity of foundamental neuronal systems in the brainstem. (longdom.org)
Symptoms6
  • citation needed] Treatments using intravenous magnesium sulfate have shown to reduce the symptoms of akinetic mutism. (wikipedia.org)
  • As seen in the case of Elsie Nicks, the puncture or removal of a cyst causing akinetic mutism can relieve symptoms almost immediately. (wikipedia.org)
  • Symptoms of akinetic mutism suggest a possible presynaptic deficit in the nigrostriatal pathway, which transmits dopamine. (wikipedia.org)
  • The annual incidence of CJD is approximately one case per million population, and is invariably fatal, usually within a year of onset of symptoms. (health.gov.au)
  • In contrast to cCJD, the vCJD PrP has been found in the lymphoreticular tissue of all cases of vCJD studied, and in the appendix of an asymptomatic person who developed symptoms of vCJD 8 months later. (health.gov.au)
  • In many cases, the physical manifestations of a brain injury remain in a patient's skull, and symptoms are hard to identify. (damoreinjurylaw.com)
Pathology1
  • However, in this case, tau and TDP-43 pathology was exceedingly more abundant than α-synuclein pathology. (mmp-signal.com)
Lesions1
  • Now, a research analyzing the places of mind lesions in these patients-and those who have akinetic mutism, by which people can scratch an itch and chew food positioned into their mouths with out being aware they've initiated these actions-are shedding gentle on how our brains know what is going on on with our bodies. (quidsit.com)
Movements1
  • They also identify fifty cases where brain injury disrupted agency and caused patients to feel their movements were not their own, a syndrome known as alien limb syndrome. (health-innovations.org)
Occur3
  • Akinetic mutism can also occur as a result of damage to the mesencephalic region of the brain. (wikipedia.org)
  • citation needed] Many cases of akinetic mutism occur after a thalamic stroke. (wikipedia.org)
  • Almost 10 per cent of cases of CJD occur in persons with a family history of the disorder, and the pattern of disease transmission is consistent with an autosomal dominant gene mutation. (health.gov.au)
Occurs3
  • Onset occurs mainly during infancy or adolescence (range: age 1-31 years) and in rare cases as late as age 60 years. (nih.gov)
  • Genetic CJD (gCJD) occurs in families in an autosomal dominate fashion and accounts for 10% of all CJD cases [ 8 ]. (biomedgrid.com)
  • We will zealously represent your interests in connection with a brain injury case that occurs because of the medical negligence of a doctor or hospital. (damoreinjurylaw.com)
Clinical2
  • The few published case series of RPD have shown that the relative frequency of underlying diseases depends mainly on the clinical setting. (touchneurology.com)
  • In clinical practice, for the cases presenting with RPD, the diagnostic procedure must be exhaustive, starting with a detailed clinical evaluation and proceeding to a complete laboratory work-up and sophisticated neuroimaging studies. (touchneurology.com)
Variant2
  • Variant CJD (vCJD) was first reported from the UK in 1996, and to date (28 September 2000) 73 confirmed cases have been reported to the UK National CJD Surveillance Unit. (health.gov.au)
  • 1 There has been a growing number of reports of the akinetic variant of catatonia in patients with SARS-CoV-2 infection, 2 exceeding all other viral infections. (psychiatrist.com)
Voluntary1
  • CJD is not notifiable, and accurate case ascertainment is largely dependent on voluntary reporting by medical practitioners. (health.gov.au)
Patient4
  • CASE PRESENTATION: We report a case of 76-year-old female patient with GFAP-A complicated with breast cancer. (bvsalud.org)
  • Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report 3. (luga.co.kr)
  • A new study reported that zolpidem, a drug normally used to treat insomnia, temporarily improved brain function in a patient suffering from akinetic mutism, a condition in which the person is alert but cannot speak or move. (sciencedaily.com)
  • They conclude that single patient trials can be a logical approach to identifying potentially beneficial drugs, especially in the case of rare or orphan diseases. (sciencedaily.com)
Medical3
  • The current study identifies 28 cases in the medical literature where brain injury disrupted volition, leaving patients with akinetic mutism, a lack of motivation to move or speak. (health-innovations.org)
  • Iatrogenic CJD (iCJD) are cases that arise due to medical procedures [ 7 ]. (biomedgrid.com)
  • After the first consultation, the attorney must commence a thorough investigation of your case, which includes a review of all the relevant medical records, factual evidence, and expert medical opinion information. (damoreinjurylaw.com)
Frontal2
Intravenous2
  • In one case, a 59-year-old woman was administered intravenous magnesium sulfate in an attempt to resolve her akinetic mutism. (wikipedia.org)
  • Effects of intravenous methylprednisolone on intraoperative neurophysiological monitoring during spinal cord tumor surgery: A Case Report 4. (luga.co.kr)
Lack3
  • Akinetic mutism was first described in 1941 as a mental state where patients lack the ability to move or speak. (wikipedia.org)
  • Patients with akinetic mutism are not paralyzed, but lack the will to move. (wikipedia.org)
  • This case is important given the lack of research on preferred treatments of catatonia in the setting of COVID-19 infection. (psychiatrist.com)
Catatonia2
  • Many catatonia cases respond to benzodiazepines-especially lorazepam-but up to 30% do not. (mhaus.org)
  • The objective of this case report is to discuss the successful use of amantadine that resulted in the remission of benzodiazepine-resistant catatonia associated with COVID-19 infection. (psychiatrist.com)
Years1
Inpatient2
  • Cases of CJD were identified using the principal diagnoses by ICD-9 code among 55 million inpatient hospital discharge records reported to the Florida Center for Health Information and Transparency from 1988 to 2012. (biomedgrid.com)
  • We demonstrate that cases identified through inpatient hospital discharge records provide similar epidemiologic profiles as those cases identified at autopsy or through disease specific registries. (biomedgrid.com)
Woman1
  • Led by Christine Brefel-Courbon, M.D., of the University Hospital in Toulouse, France, researchers conducted a study of a 48 year-old woman who developed akinetic mutism due to oxygen deprivation to her brain following an attempted suicide by hanging. (sciencedaily.com)
Treatment2
  • 1-6 Case control studies have also reported a weak association between surgical treatment and the occurrence of CJD, 7,8 although there have been no confirmed reports of surgical transmission of CJD other than through neurosurgical procedures. (health.gov.au)
  • Montemurro N, Indaimo A, Di Carlo DT, Benedetto N, Perrini P. Surgical Treatment of Long-Standing Overt Ventriculomegaly in Adults (LOVA): A Comparative Case Series between Ventriculoperitoneal Shunt (VPS) and Endoscopic Third Ventriculostomy (ETV). (neurotips.org)
Immunotherapy1
  • Some cases of neuropil antibody-positive ISA responded to immunotherapy. (bvsalud.org)
Adolescence1
  • Rare cases of sCJD during adolescence have also been reported [ 9 ]. (biomedgrid.com)
Hands1
Form2
  • About 85 per cent of cases of CJD are regarded as sporadic, and are initiated by a rare stochastic change in the secondary structure of one or a few molecules of protein to form the abnormal structure. (health.gov.au)
  • Sporadic CJD (sCJD) is by far the most common form of the disease accounting for 85- 90% of all cases [ 8 , 9 ]. (biomedgrid.com)
REPORT1
  • Amirjamshidi A, Ghasvini AR, Alimohammadi M, Abbassioun K. Attempting homicide by inserting sewing needle into the brain Report of 6 cases and review of literature. (blogspot.com)
Brain injury4
  • Experienced brain injury attorneys, like the attorneys at D'Amore Personal Injury Law, know what to look for in a brain injury case. (damoreinjurylaw.com)
  • The added value that D'Amore brain injury attorneys bring to your case is a nurturing of the client relationship. (damoreinjurylaw.com)
  • Once your attorney has gathered all the relevant evidence and can show that the negligent party caused your brain injury, the case can then be brought to court. (damoreinjurylaw.com)
  • We will marshal our substantial resources to comprehensively investigate your case, and make sure that we can prove that the negligent party was responsible for your brain injury. (damoreinjurylaw.com)
Similar1
  • CJD cases identified through hospital records in Florida have similar characteristics to previously reported data. (biomedgrid.com)
Sewing needle1
  • Tuncer N, Yayci N, Ekinci G, Inanici MA, Elmaci I. Intracranial sewing needle in a man with seizure: a case of child abuse? (blogspot.com)
Present1
  • The present case was diagnosed with adult-onset NBIA-1 with typical histological findings in the basal ganglia and brainstem. (mmp-signal.com)
Treatments1
Surgery1
  • Among the 4 patients who underwent surgery, 1 died after a short period of 'akinetic mutism. (blogspot.com)
Studies1
  • Case-control studies are needed to elucidate environmental triggers of this rare condition. (biomedgrid.com)
Management2
  • This may deliver some evidences to the literature regarding management of further cases encountered by neurosurgeons. (blogspot.com)
  • as a result, a plethora of antibodies against the CNS can now be detected in cases of autoimmune dementias, which has dramatically changed the diagnostic approach and early management of cases of RPD. (touchneurology.com)
Control1
  • In other cases, mutated genes that control calcium channels of the nerve cells have been implicated in petit mal seizures. (differencebetween.net)