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  • inhibits
  • Title: Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway. (nih.gov)
  • CX-4945 is selective for CK2, as it only inhibits 7 of the 238 kinases by more than 90% at concentration of 0.5 μM, which is 500-fold greater than the IC50 of CK2. (selleckchem.com)
  • acidic
  • Casein kinase, a ubiquitous well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Ser or Thr in acidic stretches of amino acids. (ebi.ac.uk)
  • Phosphoproteomics
  • Jens Boesger, Volker Wagner, Wolfram Weisheit, and Maria Mittag, "Application of Phosphoproteomics to Find Targets of Casein Kinase 1 in the Flagellum of Chlamydomonas ," International Journal of Plant Genomics , vol. 2012, Article ID 581460, 9 pages, 2012. (hindawi.com)
  • Cellular
  • By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. (acris-antibodies.com)
  • assessment
  • Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection," Antimicrobial Agents and Chemotherapy , vol. 58, no. 3, pp. 1501-1515, 2014. (hindawi.com)
  • CELL CYCLE
  • Because casein kinase 1 is associated with sites of polar growth, it may regulate Mih1 as part of a signaling mechanism that links successful completion of growth-related events to cell cycle progression. (rupress.org)