• Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, vasoproliferative, idiopathic condition that manifests in adults as isolated or grouped papules, plaques, or nodules in the skin of the head and neck. (medscape.com)
  • Although angiolymphoid hyperplasia with eosinophilia (ALHE) may be a benign tumor, numerous factors suggest that it is an unusual reactive process. (medscape.com)
  • Histologically, most cases of ALHE show damaged and/or tortuous arteries and veins at the base of the lesion, suggesting that arteriovenous shunting may play a role in the pathogenesis. (medscape.com)
  • Additionally, three reported cases describe follicular mucinosis and ALHE occurring in the same biopsy specimen. (medscape.com)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is idiopathic. (medscape.com)
  • The EHs were subclassified as typical (n=25), cellular (n=21), and angiolymphoid hyperplasia with eosinophilia (ALHE) (n=12) variants. (tmu.edu.tw)
  • All 12 ALHE cases lacked FOS gene abnormalities, suggesting different pathogenesis. (tmu.edu.tw)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign disease of unknown etiology, characterized by abnormal vascular proliferation. (afsu.edu.tr)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. (shengsci.com)
  • The palm is a very unusual site for ALHE, and there have been very few case. (shengsci.com)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign condition featuring nodular or papular lesions of the dermis, subcutaneous tissue, and adjacent lymph nodes, commonly affecting the head and neck. (clinmedjournals.org)
  • We describe here a case of ALHE occurring as an adverse effect of anti-tumor necrosis factor-alpha (TNF-α) inhibitor use, which has not previously been reported. (clinmedjournals.org)
  • Background: The angiolymphoid hyperplasia with eosinophilia (ALHE) is a sporadic vasoproliferative lesion of uncertain etiology involving the skin and the subcutaneous tissue. (univaq.it)
  • Conclusion: Up to now, literature has described 8 cases of ALHE involving the arteries, and only one case originating from the ulnar nerve. (univaq.it)
  • The authors report a case of a female with ALHE involving the ulnar artery that compressed the ulnar nerve. (univaq.it)
  • The differential diagnosis consists of angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura disease. (najms.com)
  • The etiology is unknown, but case reports have thus far demonstrated an idiopathic origin. (clinmedjournals.org)
  • It should be stressed that the vast majority of cases are entirely benign. (medscape.com)
  • García Carretero R, Romero Brugera M, Rebollo-Aparicio N, Vazquez-Gomez O. Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. (medscape.com)
  • Aouidad et al reported the case of a 51-year-old woman presenting with orbital "pseudotumors" (I do not understand why these are not just "tumors" - large swellings of any cause that may be benign or malignant) that histologically demonstrated eosinophilic angiocentric sclerosis related to IgG4. (aad.org)
  • Eleni G, Panagiotis S, Andreas K, Georgia A. Traumatic ulcerative granuloma with stromal eosinophilia: a lesion with alarming histopathologic presentation and benign clinical course. (medscape.com)
  • The histopathologic features include intimal hyperplasia, endothelial hyperplasia, disruption of the internal elastic lamina and a lymphoeosinophilic panarteritis that lacks germinal centers and granulomatous inflammation. (najms.com)
  • Specific treatments are dictated by the causative condition, though in idiopathic eosinophilia, the disease may be controlled with corticosteroids. (wikipedia.org)
  • Eosinophilia is not a disorder (rather, only a sign) unless it is idiopathic. (wikipedia.org)
  • The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic syndrome. (wikipedia.org)
  • When overproduced and over-activated, which occurs in certain cases of hypereosinophilia and to a lesser extent eosinophilia, eosinophils may misdirect their reactive oxygen species and armamentarium of preformed molecules toward normal tissues. (wikipedia.org)
  • In the latter classification, secondary hypereosinophilia/eosinophilia is not viewed as a true disorder of eosinophils. (wikipedia.org)
  • Increase of serum IgE with frequent localization of IgE in the germinal centres, mast cell hyperplasia in lymph nodes and changes of specific granules in the infiltrated eosinophils, such as roughness of the matrix and appearance of tubular structures together with fusing and disappearance of the core, were demonstrated in eosinophilic granuloma of the soft tissue, so-called Kimura's disease, in association with increase of anti-Candida IgE antibody. (indexindex.com)
  • Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5×108/L (500/μL). (wikipedia.org)
  • Nearly all patients with Kimura disease demonstrate peripheral eosinophilia and elevated levels of serum IgE. (medscape.com)
  • Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process. (najms.com)
  • According to Takayama et al: "Dermatologists may be consulted to evaluate several seemingly disparate skin problems associated with IgG4-RD, which may include prurigo-like nodules, nonspecific, rosacea-like papules and pustules, scleroderma-like skin changes, xanthogranulomas, papules and nodules mimicking angiolymphoid hyperplasia with eosinophilia, and lymphoma-like presentations with striking swelling of secretory glands and lymph nodes, especially in the head and neck region. (aad.org)
  • Although a small subset of EHs with atypical features harbor ZFP36-FOSB fusions, no additional genetic abnormalities have been found to date in the remaining cases. (tmu.edu.tw)
  • Thus 57 additional EH cases lacking FOSB rearrangements were studied for FOS gene abnormalities by fluorescence in situ hybridization, and results were correlated with morphologic appearance and clinical presentation. (tmu.edu.tw)
  • Mediastinal epithelioid hemangioendothelioma metastatic to lymph nodes and pleural fluid: report of a case. (uchicago.edu)
  • Follicular hyperplasia, marked eosinophilic infiltrate and eosinophilic abscesses, and the proliferation of postcapillary venules are characteristic histological findings. (medscape.com)
  • Pilolli GP, Lucchese A, Scivetti M, Maiorano E, Favia G. Traumatic ulcerative granuloma with stromal eosinophilia of the oral mucosa: histological and immunohistochemical analysis of three cases. (medscape.com)
  • The clinical spectrum of cutaneous adverse drug reactions (ADRs) of out-patients, in-patients admitted in the department of dermatology and also cases referred from other departments was recorded over a period of one year (January 2000 to January 2001) by the department of Pharmacology in collaboration with the department of Dermatology. (e-ijd.org)
  • Most FOS-rearranged EHs occurred in the bone (10) and soft tissue (6), whereas only 1 case was cutaneous. (tmu.edu.tw)
  • We present a case of epithelioid hemangioma of the penis in a 50-year-old Caucasian man. (biomedcentral.com)
  • Some diseases have a particular predilection for the skin of the ear, including gout, keloids (often secondary to ear piercing), relapsing polychondritis, angiolymphoid hyperplasia with eosinophilia (epithelioid or histiocytoid hemangioma), and chondrodermatitis nodularis (the latter is discussed below). (basicmedicalkey.com)
  • Here these two classifications are merged and expanded to include the many forms of secondary, i.e. reactive hypereosinophilia/eosinophilia, disorders and also includes another subtype, organ-restricted hypereosinophilias, a disorder in which eosinophil-mediated tissue damage is restricted to one organ and is often but not always associated with increased blood eosinophil counts. (wikipedia.org)
  • A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. (wikipedia.org)
  • We report a case of an 18-year-old man with a clinical presentation of temporal artery psuedoaneurysm, but with histopathologic features of JTA. (najms.com)
  • This genetic abnormality can be useful in challenging cases, to distinguish cellular EHs from malignant epithelioid vascular tumors. (tmu.edu.tw)
  • There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant. (lookformedical.com)
  • IgG4-related ophthalmic disease (IgG4-ROD), the preferred nomenclature for IgG4-RD affecting the ocular adnexa or orbit, is a common manifestation of IgG4-RD. A large IgG4-RD disease registry in North America found ophthalmic involvement in 23 % of all IgG4-RD cases. (aad.org)
  • type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)
  • Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede's disease and traumatic eosinophilic granuloma). (medscape.com)
  • Damevska K, Gocev G, Nikolovska S. Eosinophilic ulcer of the oral mucosa: report of a case with multiple synchronous lesions. (medscape.com)
  • Eosinophilic ulcer mimicking malignancy of the lower lip: A case report. (medscape.com)
  • Oral eosinophilic or traumatic ulcer: A case report and brief review. (medscape.com)
  • Eosinophilic ulcer of the tongue--Case report. (medscape.com)
  • Twelve of the FOS-rearranged cases were cellular EH (P=0.001) associated with moderate mitotic activity (2 to 5/10 HPF) and milder inflammatory background. (tmu.edu.tw)
  • We present four cases of wounds on the scalp that did not heal and in all of them there was abundant granulation tissue and lack of epidermal migration. (bvsalud.org)
  • Endometrial hyperplasia is classified by its cytology and glandular tissue. (lookformedical.com)
  • In those rare cases in which the patient has a history of lymphoma or lymphoma is suspected clinically, fresh tissue should be processed according to the standard lymphoma work-up protocol. (basicmedicalkey.com)
  • Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. (uchicago.edu)
  • There were 17 (29%) cases bearing FOS gene rearrangements among 58 cases tested, including 12 male and 5 female patients, with a mean age of 42 years. (tmu.edu.tw)
  • Up to about half of all patients are considered atopic, displaying a mild eosinophilia and/or elevated IgE. (aad.org)
  • Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (lookformedical.com)
  • In the leprosy clinic, 2100 new cases attended, of which 567 were PB and 1533 MB as per WHO classification. (e-ijd.org)
  • [ 39 ] One of the largest case series to date notes the characteristic findings to be multiple ill-defined, enhancing lesions around the parotid gland, with associated lymphadenopathy. (medscape.com)
  • Diagnosis of eosinophilia is via a complete blood count (CBC), but diagnostic procedures directed at the underlying cause vary depending on the suspected condition(s). (wikipedia.org)
  • However, cases of eosinophilia, which exhibit eosinophil counts between 500 and 1,500/μL, may fit the clinical criteria for, and thus be regarded as falling into, one of these hypereosinophilia categories: the cutoff of 1,500/μL between hypereosinophilia and eosinophilia is somewhat arbitrary. (wikipedia.org)
  • Nugent S, Karaisz F, Elbadawi M, Touati A, Nikbakht N, Lee JB, Arif H. An unexpected case of non-uremic calciphylaxis in a patient with multiple risk factors. (jefferson.edu)
  • A case report and short literature review. (medscape.com)
  • Cornejo KM, Deng A. Pilomatrix carcinoma: a case report and review of the literature. (umassmed.edu)
  • Benzodiazepine-induced photosensitivity reactions: A compilation of cases from literature review with Naranjo causality assessment. (harvard.edu)
  • Tariq N, Sadiq S, Si K. Angiolymphoid Hyperplasia with Eosinophillia - A Rare Entity. (medscape.com)
  • Although frequency is unknown, cases have been reported worldwide. (medscape.com)
  • Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. (lookformedical.com)
  • [5] Treatment is recommended in all symptomatic cases and also in asymptomatic cases involving certain anatomical sites. (mdwiki.org)
  • Successful treatment of polymorphic light eruption with UVA rush hardening: A report of 5 cases. (harvard.edu)
  • A study of 36,58 8 new cases who attended the Dermatology OPD of the school of Tropical Medicine was carried out for the year 2002. (e-ijd.org)
  • Biopsy study of four cases. (najms.com)
  • Characterization and Analysis of the Skin Microbiota in Rosacea: A Case-Control Study. (uams.edu)
  • Some case reports and series presumed a link between malignancy and relapsing polychondritis. (clinmedjournals.org)
  • Skin smear was positive in181 cases, all of them were MB. (e-ijd.org)