• We firstly report two patients who developed isolated hypoglossal nerve palsy shortly after SARS-CoV-2 vaccination. (nih.gov)
  • While facial nerve palsy is frequent and usually idiopathic, hypoglossal nerve palsy is rare, and a specific cause is almost always found. (nih.gov)
  • Two otherwise healthy patients, a 49-year-old man and a 39-year-old woman, developed unilateral hypoglossal nerve palsy 10 and 7 days after the second SARS-CoV-2-vaccination (AstraZeneca and BioNTech/Pfizer), respectively. (nih.gov)
  • Due to close temporal relationship, the absence of other etiologies, and spontaneous improvement we suspect the vaccination as the cause for hypoglossal nerve palsy in both patients. (nih.gov)
  • Facial paralysis or weakness may be from multiple etiologies, including Bell's palsy, parotid cancer or other head and neck cancers, skull base tumors, acoustic neuroma surgery, or certain infections (herpes zoster) and inflammatory disease. (mountsinai.org)
  • Goldstein and Eidelman present two cases wherein patients with hypoglossal nerve palsy were misdiagnosed as cases of bulbar onset amyotrophic lateral sclerosis (bALS). (sacklerjom.org)
  • 1 bALS is not curable and patient's usually have a prognosis of less than two years, so misdiagnosing hypoglossal palsy, a disorder that, depending on its etiology, tends to be more treatable, and at the very least, less life-threatening, is a serious medical error, and a cause of great personal suffering to the patients. (sacklerjom.org)
  • The hypoglossal nerve, also known as the twelfth cranial nerve, cranial nerve XII, or simply CN XII, is a cranial nerve that innervates all the extrinsic and intrinsic muscles of the tongue except for the palatoglossus, which is innervated by the vagus nerve. (wikipedia.org)
  • Patterns of cranial neuropathies at disease presentation were recorded. (bvsalud.org)
  • Cranial nerves (CN) VI (56.4%), V2 (47.9%), and V3 (29.2%) were most frequently involved. (bvsalud.org)
  • The gland itself lies on the hyoglossus muscle, superficial to both the hypoglossal and the lingual nerves, the latter supplying parasympathetic innervation by way of the chorda tympani nerve (from cranial nerve VII) and the submandibular ganglion. (medscape.com)
  • Obstructive sleep apnea hypopnea syndrome is a disease in which the airway is blocked to differing degrees, during sleep. (medicalnewstoday.com)
  • For patients in whom obstructive sleep apnea (OSA) is suspected or is diagnosed, examination of the upper airway is essential for determining an optimal treatment, as many variables are involved in the pathogenesis of the disease, making the choice of the correct treatment a complex one. (medscape.com)
  • Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common disorder that has been identified as a contributor to cardiovascular disease making it a major public health problem. (bordeaux-neurocampus.fr)
  • Minimally Invasive Electrical Stimulation Of The Nerve Hypoglossal for the Treatment of Obstructive Sleep Apnea. (inclinicaltrials.com)
  • MATERIALS AND METHODS: Case records of consecutive T4 NPC patients who received definitive IMRT in two tertiary oncology centers in 2004-2019 were reviewed. (bvsalud.org)
  • NIDCD is actively pursuing new research to fill a knowledge gap on how coronavirus disease 2019 (COVID-19) impacts sensory and communication functions in hearing, balance, taste, smell, voice, speech, and language. (nih.gov)
  • This is further supported by the rarity of isolated hypoglossal nerve palsies, especially in idiopathic cases. (nih.gov)
  • The nerve passes through the subarachnoid space and pierces the dura mater near the hypoglossal canal, an opening in the occipital bone of the skull. (wikipedia.org)
  • The musculature they supply develops as the hypoglossal cord from the myotomes of the first four pairs of occipital somites. (wikipedia.org)
  • The hypoglossal nerve is derived from the first pair of occipital somites , collections of mesoderm that form next to the main axis of an embryo during development . (iiab.me)
  • The hypoglossal nerve arises as a number of small rootlets from the front of the medulla, the bottom part of the brainstem, in the anterolateral sulcus which separates the olive and the pyramid. (wikipedia.org)
  • The hypoglossal nerve emerges as several rootlets (labelled here as number 12) from the olives of the medulla (labelled 13), part of the brainstem. (wikipedia.org)
  • Age-related axonopathy occurs commonly in the cauda equina, ventral spinal nerve roots, ventral and lateral spinal funiculi, sciatic and brachial nerves, and lower brainstem. (nih.gov)
  • Diaphragmatic/phrenic nerve stimulator devices are indicated for certain ventilator-dependent individuals who lack voluntary control of their diaphragm muscles to enable independent breathing without the assistance of a mechanical ventilator for at least four continuous hours a day. (wellcare.com)
  • The HGNS treatment consists of a programmable neuro-stimulator in the chest, connected to a pressure-sensing lead to detect breathing, and a stimulator lead to mildly stimulate the tongue nerve. (singhealth.com.sg)
  • The nerve arises from the hypoglossal nucleus in the medulla as a number of small rootlets, pass through the hypoglossal canal and down through the neck, and eventually passes up again over the tongue muscles it supplies into the tongue. (wikipedia.org)
  • The nerve is involved in controlling tongue movements required for speech and swallowing, including sticking out the tongue and moving it from side to side. (wikipedia.org)
  • Damage to the nerve or the neural pathways which control it can affect the ability of the tongue to move and its appearance, with the most common sources of damage being injury from trauma or surgery, and motor neuron disease. (wikipedia.org)
  • Signals from muscle spindles on the tongue travel through the hypoglossal nerve, moving onto the lingual nerve which synapses on the trigeminal mesencephalic nucleus. (wikipedia.org)
  • The nerve is first visible as a series of roots in the fourth week of development, which have formed a single nerve and link to the tongue by the fifth week. (wikipedia.org)
  • The hypoglossal nerve provides motor control of the extrinsic muscles of the tongue: genioglossus, hyoglossus, styloglossus, and the intrinsic muscles of the tongue. (wikipedia.org)
  • But in some diseases uncontrolled tongue movements are seen. (mktalks.com)
  • Some part remains permanently protruded outside the mouth in case of Mongols, cretins, and in macroglossia which is an abnormally enlarged tongue in compared to other mouth structures. (mktalks.com)
  • In hypoglossal nerve paralysis, the tip of the tongue and median raphe is curving round towards the affected side. (mktalks.com)
  • Stimulation of the hypoglossal nerve, that innervates the genioglossus, a protrusor muscle of the tongue, is now a new treatment option for moderate and severe cases of OSAHS. (bordeaux-neurocampus.fr)
  • This nerve controls the movement of the tongue and other key muscles involved in breathing. (imsaethics.org)
  • The implanted device, when turned on, delivers mild stimulation to the hypoglossal nerve that controls the movement of the tongue and other surrounding muscles. (houstonent.com)
  • In both cases the patients presented with hemi-tongue atrophy and fasciculations, which the authors suspect led to their initial misdiagnosis as bALS cases. (sacklerjom.org)
  • And so it is unsurprising when patients who present with tongue atrophy and fasciculations are automatically misdiagnosed as bALS cases. (sacklerjom.org)
  • 17. A novel NF1 mutation in a Chinese patient with giant cafĂ©-au-lait macule in neurofibromatosis type 1 associated with a malignant peripheral nerve sheath tumor and bone abnormality. (nih.gov)
  • Role of perioperative chemotherapy and radiotherapy for localized high-grade malignant peripheral nerve sheath tumor at the extremities and trunk wall: a population-based cohort study. (nih.gov)
  • Sporadic High-Grade Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve. (nih.gov)
  • After emerging from the hypoglossal canal, the hypoglossal nerve gives off a meningeal branch and picks up a branch from the anterior ramus of C1. (wikipedia.org)
  • The hypoglossal nerve leaves the skull through the hypoglossal canal, which is situated near the large opening for the spinal cord, the foramen magnum. (wikipedia.org)
  • A progressively enlarging, benign tumor, usually within the internal auditory canal or hearing nerve. (sonsa.org)
  • In one of the cases, the patient had a cyst that was compressing her hypoglossal canal, a problem that can be solved with a rather simple procedure, but she only discovered this after she went for a second opinion at the neurological clinic of the paper's authors. (sacklerjom.org)
  • In cases of severe sleep apnea, these lifestyle changes should be used in combination with other medical treatments, as recommended by the doctor. (medicalnewstoday.com)
  • A: If left untreated, sleep apnea can lead to serious health complications, including high blood pressure, heart disease, and stroke. (imsaethics.org)
  • It involves the placement of a small device under the skin in the chest area, which delivers mild electrical stimulation to the hypoglossal nerve. (imsaethics.org)
  • Presynaptic fibers are derived from the superior salivatory nucleus and carried by the chorda tympani nerve, which joins the lingual nerve traveling towards the ganglion. (medscape.com)
  • The gland's functionality is further regulated by parasympathetic input it receives via the chorda tympani nerve. (microbiologynote.com)
  • and peripheral nerve tissues. (cdc.gov)
  • Axonopathy" is a generic term describing a variety of lesions of the axon occurring in brain, spinal cord, and peripheral nerve. (nih.gov)
  • It then travels close to the vagus nerve and spinal division of the accessory nerve, spirals downwards behind the vagus nerve and passes between the internal carotid artery and internal jugular vein lying on the carotid sheath. (wikipedia.org)
  • After leaving the skull, the hypoglossal nerve spirals around the vagus nerve and then passes behind the deep belly of the digastric muscle. (wikipedia.org)
  • Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. (nih.gov)
  • According to the given history, the superficial branch of ulnar nerve has been affected. (passmed.uk)
  • Japan's Health Ministry said Tuesday that a child had been hospitalized with an unidentified type of severe acute hepatitis - or liver inflammation - in what is thought to be the first reported case in Asia. (cov19longhaulfoundation.org)
  • 18. Acute airway obstruction requiring nasotracheal intubation following hypoglossal neuromonitoring: a case report. (nih.gov)
  • 2 As the treatment paradigm transitions from acute care to chronic disease management, general practitioners (GPs) will play an increasingly central part in the management of this unique cohort of patients. (racgp.org.au)
  • Anosmia (lack of sense of smell), hyposmia (reduced sense of smell), and dysgeusia (change in taste) have been reported in 30-80 percent of cases of adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (nih.gov)
  • Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent acute sensory and motor neuropathy in a single or multiple nerves. (nih.gov)
  • The most common initial manifestation is the acute onset of a non-painful focal sensory and motor neuropathy in a single nerve (mononeuropathy). (nih.gov)
  • HN - 2012 MH - Acute Pain UI - D059787 MN - C10.597.617.88 MN - C23.888.646.115 MS - Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing. (nih.gov)
  • immunohistological examination of hippocampi of SUDEP cases has revealed elevated neuronal heat-shock protein 70 expression, a marker of acute neuronal injury that is often elevated after seizures, compared with non-SUDEP cases. (touchneurology.com)
  • In this hematoxylin and eosin-stained image of a longitudinal section of the sciatic nerve, the typical appearance of axonal degeneration referred to as Wallerian degeneration is evident. (nih.gov)
  • Crosstalk between pelvic tumour, or a serious disease in medullary cyst causing deafness can get messy! (sci-ed.org)
  • However, many vertebrobasilar lesions arise from small vessel disease and are correspondingly small and discrete. (medscape.com)
  • Statin therapy, with a target low-density lipoprotein (LDL) level below 100 mg/dL, is recommended for all patients with extracranial carotid atherosclerotic disease. (medscape.com)
  • Patients with carotid artery stenosis have a high incidence of concomitant coronary artery disease (CAD). (medscape.com)
  • The indication of each type of stimulation and long-term effects still need to be assessed but the implantable nerve stimulation is a promising treatment for patients without a therapy solution so far. (bordeaux-neurocampus.fr)
  • Approximately 80-90% of patients with early-stage disease will be cured. (racgp.org.au)
  • Hypoglossal nerve stimulation (HGNS) therapy is a good complement and alternative to other treatment options because it is the only procedure that addresses the issue of weak muscles in patients' airway, to allow them to breathe during sleep," said Dr Shaun Loh (pictured, below), Consultant, Department of Otorhinolaryngology - Head & Neck Surgery, Singapore General Hospital (SGH). (singhealth.com.sg)
  • In this case, patients may get inflammation and scarring of the cornea known as exposure keratitis, which can lead to vision loss and blindness. (mountsinai.org)
  • Retroperitoneal soft tissue sarcomas: prognosis and treatment of primary and recurrent disease in 117 patients. (nih.gov)
  • This clinic provides a hotline service to patients with inflammatory bowel disease. (nuh.com.sg)
  • A clinical trial that's attempting to discover a cure for sickle cell disease has found a new gene therapy to be safe and successful in four patients. (odenvilledrugs.com)
  • So instead of having students trying to figure out which subset of lung cancer a patient presents with based on some keywords in a passage, students can be presented with a more vague case (e.g. patients with symptoms that do not perfectly match up with one diagnosis) and be asked to work up a differential diagnosis or decide which panel of tests they should order. (sacklerjom.org)
  • Charcot-Marie-Tooth disease has also been described in upper airway dysfunction. (medscape.com)
  • 3. Ruptured left external carotid artery aneurysm presenting as upper airway obstruction in von Recklinghausen's disease. (nih.gov)
  • 4. Ruptured left subclavian artery aneurysm presenting as upper airway obstruction in von Recklinghausen's disease. (nih.gov)
  • Stroke is the third most common cause of death worldwide after ischemic heart disease and cancer. (healthjade.net)
  • Hypoglossal nerve, cervical plexus, and their branches. (iiab.me)
  • There are three branches of the ulnar nerve that are responsible for its sensory innervation. (passmed.uk)
  • Carotid artery disease may not cause signs or symptoms until the carotid arteries are severely narrowed or blocked. (healthjade.net)
  • Loss of vision without discoverable lesion in the eye structures or optic nerve. (sonsa.org)
  • The new case from Japan tested negative for adenovirus and the coronavirus, though officials have not revealed other details. (cov19longhaulfoundation.org)
  • The increasing focus on implantable bioelectronics to treat chronic disease is however changing this paradigm and is instilling new urgency in the need for low-power analogue solid-state devices that accurately mimic biocircuits. (nature.com)
  • Haemochromatosis is a known cause for chronic liver cell disease, cirrhosis and HCC. (passmed.uk)
  • The Society for Vascular Surgery (SVS) has published clinical practice guidelines for management of extracranial cerebrovascular disease. (medscape.com)
  • Part I. Dermatological Clinical Criteria Diagnostic of the Disease. (nih.gov)
  • Finally, the clinical characteristics of a total of 55 cases of HCC from 12 medical centers were evaluated retrospectively. (dnapk-signaling.com)
  • A recent case study might be small reason to suspect that "studying for the test" may have a detrimental effect on clinical practice. (sacklerjom.org)
  • But leaving that aside, having students participate in more clinical practice, such as working with patient-actors or working through a clinical case together, may be a good way of breaking the mentality inculcated by these standardized exams. (sacklerjom.org)
  • For some people, a stroke is the first sign of the disease. (healthjade.net)
  • Carotid artery disease is a major cause of stroke in the United States. (healthjade.net)
  • Lifestyle changes, medicines, and medical procedures can help prevent or treat carotid artery disease and may reduce the risk of stroke. (healthjade.net)
  • Not getting enough quality sleep increases the risk of diseases and disorders from heart disease and stroke to obesity and dementia. (singhealth.com.sg)
  • It can result in an increase in the risk of heart attack, diabetes, stroke, memory loss, and other serious diseases. (houstonent.com)
  • If any doubt exists regarding the degree of stenosis or the distal extent of the disease, arteriography of the arch and the carotid is indicated. (medscape.com)
  • Prolongation of distal nerve conduction latencies (e.g., of the median nerve at the wrist and of common peroneal nerve at fibular head) is observed in most individuals, whether symptomatic or asymptomatic. (nih.gov)
  • Caution should be given to interpretation of spinal and radicular (nerve root) axonopathy in aged rats since it may be a result of senescence and has an incidence of 75-90% in rats 24 or more months of age. (nih.gov)
  • shows spinal cord at low magnification demonstrating the appearance of axonopathy in the dorsal proprioceptive funiculi, in this case the fasciculus gracilis. (nih.gov)
  • The presence of swollen axons in the brain is not generally accompanied by dramatic distension of the myelin sheath such as those seen in spinal cord and peripheral nerves. (nih.gov)
  • It also includes Subheading records and Supplementary Concept Records (SCRs) for substances that are not MeSH Headings, and, for the first time for 2012 MeSH, for diseases that are not MeSH Headings. (nih.gov)
  • Recent data from Western blot anal- (cattle identifi cation codes 8515 and 496 at 10 and 12 mpi, yses of fi eld cases of atypical BSEs are characterized by respectively) and at the terminal stage of the disease (cattle a higher (H-type BSE) or lower (L-type BSE) molecular identifi cation codes 528, 1061, and 5566 at 16 mpi). (cdc.gov)
  • The hypoglossal nerve also supplies movements including clearing the mouth of saliva and other involuntary activities. (wikipedia.org)
  • The hypoglossal nucleus interacts with the reticular formation, involved in the control of several reflexive or automatic motions, and several corticonuclear originating fibers supply innervation aiding in unconscious movements relating to speech and articulation. (wikipedia.org)
  • While various portions of the face may be affected, the most important is the upper division of the facial nerve, which is responsible for eye closure. (mountsinai.org)
  • Such procedures may include gracilis free flaps, nerve transfers, cross-face nerve grafts, masseteric-facial nerve grafts, hypoglossal-facial nerve grafts, temporalis tendon transfer, tensor fascia lata slings, and ectropion repair. (mountsinai.org)
  • Treatment of head and neck SCC, particularly advanced cases, often requires a combination of surgery, radiotherapy and cytotoxic chemotherapy. (racgp.org.au)
  • GPs play a vital part in follow-up, particularly in disease surveillance and managing treatment complications. (racgp.org.au)
  • The majority of disease recurrences are localised to the head and neck, 8 with the highest risk period in the first five years post-treatment. (racgp.org.au)
  • Treatment of atherosclerosis of the carotid artery is dependent on the severity and degree of the disease. (medscape.com)
  • Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease. (inclinicaltrials.com)
  • Our services include consultation, disease and treatment monitoring and patient education. (nuh.com.sg)
  • Protective pads at elbows or knees may prevent pressure and trauma to local nerves. (nih.gov)
  • un- provisionally categorized the adrenal gland as nerve tissue like classical BSE, atypical BSE has been detected mainly because of the presence of chromaffi n cells in the medulla in aged cattle and suggested as a possible sporadic form of of the gland. (cdc.gov)
  • Close examination of all regions of white matter and nerve tissue is required to correctly discover and interpret this type of lesion. (nih.gov)
  • 11. Spontaneous rupture of a dissecting aneurysm in the superior rectal artery of a patient with neurofibromatosis type 1: a case report. (nih.gov)
  • With stage I disease, the patient may complain of local throat irritation or hoarseness that lasts about 2 weeks. (symptoma.com)
  • The dedicated Inflammatory Bowel Disease clinic is led by the Advanced Practice Nurse, Gastroenterologist, Pharmacist and Dietitian who provide specialised care to the group of patient with inflammatory bowel disease. (nuh.com.sg)
  • For example, most students know that if the question specifies that the patient is from the Great Lakes region or southern California, the case is likely one of a local fungal infection, whereas if the question specifies the patient recently immigrated to the United States that means that he is probably unvaccinated. (sacklerjom.org)
  • PMID- 3504210 TI - Sexually transmitted diseases. (nih.gov)
  • Sudden unexpected death in epilepsy (SUDEP) is likely to be the most common cause of disease-related mortality in people with epilepsy. (touchneurology.com)
  • Mycobacterial colonization of art and a case surgery, percutaneous nephrostomy or no need to the phenoxybenzamine dose of fruitless physical examination, and sympathy. (sci-ed.org)
  • Japan has detected its first probable case of a mysterious liver disease that has so far affected over 170 children, largely in Britain. (cov19longhaulfoundation.org)
  • Despite the fact that nonalcoholic fatty liver disease (NAFLD) and insulin resistance are strongly associated,1 a unifying pathophysiology between them remains poorly understood. (dnapk-signaling.com)