Cartilage diseases. Medical search. Frequent questions (2)

Osteoarthritis (OA) is a progressive, degenerative joint disease. (nature.com)
To retrospectively correlate radiographic findings of osteoarthritis of the tibiofemoral joint with arthroscopic findings of articular cartilage degeneration within the tibiofemoral joint in patients with chronic knee pain. (nih.gov)
The sensitivity and specificity of the radiographic features of osteoarthritis for the detection of articular cartilage degeneration within the medial and lateral compartments of the tibiofemoral joint were determined. (nih.gov)
Osteoarthritis is a bone disease caused by the breakdown of cartilage, the connective tissue found between bones. (supergene.com)
However, these methods are not able to reverse the damage to cartilage, hence will not 'cure' the underlying cause of osteoarthritis. (supergene.com)
Is osteoarthritis a disease involving only cartilage or other articular tissues? (jointdrs.org)
Osteoarthritis (OA) is a progressive and disabling disease resulting from a combination of risk factors, including advancing age, genetics, trauma, knee malalignment, increased biomechanical loading of joints through obesity, augmented bone density and an imbalance in physiological processes resulting in catabolic cascades on a molecular level. (jointdrs.org)
Osteoarthritis (OA) is a degenerative joint disease affecting an estimated 27 million Americans. (healthline.com)
Since osteoarthritis of the spine has symptoms that are similar to other conditions, your doctor may also take your blood to rule out other diseases. (healthline.com)
There are also opportunities related to evaluation of native cartilage, particularly as related to in vivo animal models of osteoarthritis. (uhhospitals.org)
Osteoarthritis: An Important Disease? (vin.com)
Osteoarthritis (OA) is a disorder of diarthrodial joints characterized by deterioration of the articular cartilage, osteophyte formation and bone remodeling, changes in the periarticular tissues (synovium, joint capsule) and a low-grade inflammation of the synovial fluid. (vin.com)
Osteoarthritis has many forms: the most common one observed in veterinary medicine is degenerative joint disease. (vin.com)
If a patient has osteoarthritis involving the MCP joints and wrists, consider CPPD associated with an underlying metabolic disease. (medscape.com)
Also called osteoarthritis, this is a degenerative disease that occurs in the joints and starts to worsen over time. (centralillinoisproud.com)
With osteoarthritis, multiple causes may damage the cartilage that covers the ends of the bones in a joint. (everydayhealth.com)
The most common type of arthritis, osteoarthritis is considered more of a mechanical (wear and tear) disease. (everydayhealth.com)
Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis - making Tai Chi a viable treatment alternative for people suffering with the degenerative disease, according to new research. (sciencedaily.com)
Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis -- making Tai Chi a viable treatment alternative for people suffering with the degenerative disease, according to research presented this week at the American College of Rheumatology Annual Meeting in San Francisco. (sciencedaily.com)
Osteoarthritis, sometimes called degenerative joint disease, is a slowly progressive disease in which joint cartilage breaks down. (sciencedaily.com)
Osteoarthritis (OA) is the most common type of joint disease associated with cartilage breakdown. (iasp-pain.org)
Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. (cabi.org)
Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. (cabi.org)
Mainstream medicine has yet to find true disease-modifying drugs for osteoarthritis, 5,6 leaving us mainly with drugs in the class called non-steroidal anti-inflammatory drugs (NSAIDs, like ibuprofen), or with painkillers in the opioid narcotic category. (lifeextension.com)
The finding of reduced bone and cartilage destruction in arthritis joints, by direct examination of the affected joints, represents a disease-modifying effect that has never been shown with any pain-relieving drug (NSAIDs or opiates) commonly used to treat osteoarthritis. (lifeextension.com)
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage loss, subchondral bone remodeling, and synovial inflammation. (frontiersin.org)
Osteoarthritis - the most common type of arthritis, osteoarthritis involves wear-and-tear damage to your joint's cartilage - the hard, slick coating on the ends of bones where they form a joint. (mayoclinichealthsystem.org)
Like many aging animals, Shanthi had osteoarthritis, a degenerative disease affecting joint cartilage and the underlying bone with associated pain and stiffness. (si.edu)
Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular cartilage (AC) degradation. (bepress.com)
According to Clegg, osteoarthritis is a very common disease in which a person's cartilage is abnormal and not as resilient. (dailyutahchronicle.com)
The chances of getting osteoarthritis dramatically increase with age, and while about 20 million Americans currently have the disease, the number will most likely double by 2020. (dailyutahchronicle.com)
In Paper III, we developed and validated a robust and specific ELISA assay measuring a MMP-1 and MMP-13 cleaved type II collagen fragment (T2CM) that we identified in the study for Paper I. It was elevated in response to pro-inflammatory cytokine treatment of bovine articular cartilage, and in osteoarthritis patients referred for a total knee joint replacement surgery compared to patients with moderate or severe disease. (lu.se)
Either alone or in a biomarker panel T2CM could be useful for assessing cartilage degradation in osteoarthritis. (lu.se)
Osteoarthritis was previously known as degenerative joint disease. (lu.se)
However, a direct injury to the knee, for example, often leads to osteoarthritis, which means that the disease also affects younger people. (lu.se)
He and his colleagues are now trying to look into the 'black hole', the period between the knee injury and the osteoarthritis diagnosis in which the disease has started but is not yet noticed by the patient. (lu.se)
Skeletal remains from the Stone Age show changes indicative of osteoarthritis, so the disease seems to have been around for a long time. (lu.se)
But he thinks that research into osteoarthritis gets too little support in comparison to other common diseases. (lu.se)
Osteoarthritis isn't a direct cause of death, it's true, but the disease does cause both great suffering and major costs to healthcare and through sick leave", he points out. (lu.se)

Degenerative joint disease leads to structural and functional changes. (vin.com)
Relapsing polychondritis is a rare immune-mediated degenerative disease that causes cartilage inflammation in a person's body, including the ears and nose. (medicalnewstoday.com)
A degenerative joint disease like HD (Hip Dysplasia, see below), ED causes arthritic changes to occur in the elbow joint. (bmdca.org)
I had torn my knee cartilage, had a detached ACL, and degenerative bone disease. (allears.net)
Coloured X-ray of a knee affected by arthrosis (yellow/red, also called degenerative joint disease or osteoarthrosis), viewed from the side. (lu.se)

The pathologic changes in OA joints include degradation of the articular cartilage, especially at the superficial zones, thickening of the subchondral bone, osteophyte formation, and variable degrees of synovial inflammation 11 . (nature.com)
Here is one of the most recent reaching consensus: "OA diseases are a result of both mechanical and biological events that destabilize the normal coupling of degradation and synthesis of articular chondrocytes and extracellular matrix, and subchondral bone. (vin.com)
In this study, scientists first examined the impact of the formulation on degradation of proteoglycans , essential components of the cartilage matrix. (lifeextension.com)
Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. (lu.se)
In mice, we know how to slow down cartilage degradation. (lu.se)

A typical distinction of KBD from OA or other bone and joint diseases is the damage of epiphyseal cartilage and hyaline cartilage in the deep zones of cartilage 11 , 14 . (nature.com)
The nasal cartilages are made up of a flexible material called hyaline cartilage (packed collagen) in the distal portion of the nose. (wikipedia.org)
The septal nasal cartilage is a flat, quadrilateral piece of hyaline cartilage that separates both nasal cavities from one another. (wikipedia.org)
Like the septal nasal cartilage, the lateral nasal cartilage is composed of hyaline cartilage. (wikipedia.org)
Hyaline cartilage provides form and flexibility within a specific structure. (wikipedia.org)
Composed of hyaline cartilage, these structures are very thin and folded to form the lateral and medial crus. (wikipedia.org)
The classic radiologic findings include chondrocalcinosis of the hyaline cartilage and fibrocartilage of the knees, the fibrocartilage of the triangular ligament of the wrist, the fibrocartilage of the symphysis pubis, and the acetabulum labrum of the hips. (medscape.com)
As the self-healing capacity of hyaline cartilage is limited, timely mechanical support during neo-cartilage formation is crucial to achieving optimal repair efficacy. (bvsalud.org)
Upon implantation, the scaffold facilitated the simultaneous regeneration of bone and cartilage tissue in a porcine model, resulting in (i) a smoother cartilage surface, (ii) more hyaline-like cartilage, and (iii) a superior integration into the adjacent host tissue. (bvsalud.org)
The cartilage of the rings is hyaline. (medscape.com)

Research to be published in the April 18 issue of the Journal of the American College of Cardiology provides the first explanation of an active rather than passive process that leads to heart valve degeneration, furthering a Northwestern researcher's effort to lead a paradigm shift in the medical community's beliefs about the cause of valve disease. (sciencedaily.com)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Untreated cartilage defects often lead to joint pain and degeneration over time, often requiring joint replacement. (ca.gov)
The proposed candidate is a universal cell therapy designed to generate new articular cartilage in these defects and interrupt the cycle of degeneration. (ca.gov)
The proposed treatment may be of major public benefit, as it would represent the first curative strategy for cartilage injury and subsequent degeneration, likely decreasing economic burden on the state and its people. (ca.gov)
This review will highlight the involvement early in the disease process of not only the cartilage but also the synovial membrane and subchondral bone and the pathophysiological mechanisms of each of these tissues that lead to joint degeneration. (jointdrs.org)
Back on the "spare parts" front, both Novartis and Genentech are developing drugs to treat a form of eye disease known as dry macular degeneration. (bostonglobe.com)
1 These herbs work to slow the progression of cartilage degeneration . (lifeextension.com)
Several techniques, such as histological scoring, magnetic resonance imaging, and tissue section staining, are available for detecting cartilage degeneration and lesions and evaluating cartilage repairs. (bvsalud.org)
However, the main sign of the disease is cartilage degeneration which impairs joint function. (lu.se)
The most common changes in an OA-affected joint are cartilage degeneration, bone spurs, and an inflamed joint capsule. (lu.se)
Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. (lu.se)

The recently demonstrated ability to grow relatively large (centimeter sized) pieces of cartilage in the Skeletal Research Center has opened up several opportunities related to evaluation of tissue mechanics. (uhhospitals.org)
Fractures and bony healing may produce many loose pieces of cartilage or bone that can slough into the joint, causing a coarse, grating, often audible crepitus usually more unpleasant for the observer than for the patient. (msdmanuals.com)

Cartilage-hair hypoplasia (CHH), which is Online Mendelian Inheritance in Man (OMIM) disease number 250250, is an autosomal recessive inherited disorder that results in short-limb dwarfism associated with T-cell and B-cell immunodeficiency. (medscape.com)
[ 1 ] Cartilage-hair hypoplasia and other short-limb dwarfism phenotypes are associated with metaphyseal or spondyloepiphyseal dysplasia. (medscape.com)
Cartilage-hair hypoplasia is a variant of short-limb dwarfism in which fine sparse hair is also present. (medscape.com)
The immunodeficiency in cartilage-hair hypoplasia may be an isolated T-cell immunodeficiency, isolated B-cell immunodeficiency, or combined T-cell and B-cell immunodeficiency. (medscape.com)
Although originally described by McKusik et al in 1964 in Amish children and known as metaphyseal chondrodysplasia McKusick type, cartilage-hair hypoplasia has been described in non-Amish persons throughout the United States, Europe, and Mexico. (medscape.com)
[ 2 ] The genetic defect in cartilage-hair hypoplasia has been confirmed to be mutations in the RMRP gene. (medscape.com)
The genetic defect in cartilage-hair hypoplasia has been identified as a mutation in the gene for RNAase RMRP, mapped to 9p12. (medscape.com)
[ 15 ] The second consists of single nucleotide substitutions and other changes that involve at most 2 nucleotides in highly conserved regions of the gene.These are considered leaky mutations and result in variable expression of the gene, which may explain the variable phenotype seen in cartilage-hair hypoplasia. (medscape.com)
These latter mutations result in variable expression of the gene, which may explain the variable phenotype seen in cartilage-hair hypoplasia. (medscape.com)
G, which occurs in 30-50% of patients with cartilage-hair hypoplasia and causes an alteration in ribosomal processing. (medscape.com)
This suggests a common cell proliferation defect in cartilage-hair hypoplasia. (medscape.com)
Cartilage-hair hypoplasia is a rare defect. (medscape.com)
Cartilage hair hypoplasia is a hereditary condition. (hopkinsmedicine.org)
Cartilage hair hypoplasia is commonly found in the Amish community. (hopkinsmedicine.org)
A full medical exam and X-rays will be done to diagnose cartilage hair hypoplasia. (hopkinsmedicine.org)
Individuals with cartilage hair hypoplasia may experience additional orthopaedic conditions of the hip, spine and limbs. (hopkinsmedicine.org)
Treatment options for cartilage hair hypoplasia vary depending on each patient's symptoms and may include surgery. (hopkinsmedicine.org)
Cartilage hair hypoplasia is a genetic disorder that affects the metaphyseal area of the long bone - the wider part at the end - causing lower-extremity abnormalities. (hopkinsmedicine.org)
What are the symptoms of cartilage hair hypoplasia? (hopkinsmedicine.org)
X-rays of the neck, spine, pelvis (hips) and legs will be ordered to diagnose cartilage hair hypoplasia and/or related conditions, like scoliosis and kyphosis. (hopkinsmedicine.org)
There are multiple treatment options for the symptoms of cartilage hair hypoplasia based on the area and severity of the condition. (hopkinsmedicine.org)
People with cartilage-hair hypoplasia have unusually short limbs and short stature from birth. (medlineplus.gov)
Most people with cartilage-hair hypoplasia are unusually flexible in some joints, but they may have difficulty extending their elbows fully. (medlineplus.gov)
The extent of the immune deficiency in cartilage-hair hypoplasia varies from mild to severe. (medlineplus.gov)
Autoimmune disorders, which occur when the immune system malfunctions and attacks the body's tissues and organs, occur in some people with cartilage-hair hypoplasia. (medlineplus.gov)
Some people with cartilage-hair hypoplasia experience gastrointestinal problems. (medlineplus.gov)
Cartilage-hair hypoplasia occurs most often in the Old Order Amish population, where it affects about 1 in 1,300 newborns. (medlineplus.gov)
Cartilage-hair hypoplasia is caused by mutations in the RMRP gene. (medlineplus.gov)

We found already that fibromodulin and cartilage oligomeric matrix protein (COMP) are potent activators of complement. (lu.se)

OA diseases are characterized by joint pain, tenderness, limitation of movement, crepitus, occasional effusion and variable degrees of inflammation without systemic effects. (vin.com)
Both drugs aim to block the inflammation that can lead to the disease. (bostonglobe.com)
Three herbal extracts have been shown to reduce arthritis pain and inflammation, while limiting destruction of cartilage in afflicted joints. (lifeextension.com)
These herbs have been shown to reduce destruction of cartilage and bone in arthritis-afflicted joints, and to significantly reduce pain and inflammation. (lifeextension.com)
They noted that, after a few episodes of inflammation, the cartilage was replaced by fibrous connective tissue. (medscape.com)
Joint inflammation in rheumatoid arthritis (RA), a common chronic inflammatory disease that causes long-term suffering and disability in 1% of our population, is a complex process also involving complement activation. (lu.se)
The clinical rationale for this project is based on the observation that cartilage contains molecules that initiate/enhance joint damage and inflammation in arthritis. (lu.se)
Indeed, when the cartilage is removed surgically, a dramatic decrease in inflammation and disease symptoms is observed. (lu.se)

Final considerations: Current treatments for articular cartilage repair have major limitations. (bvsalud.org)

The nasal cartilages associate with other cartilage structures of the nose or with bones of the facial skeleton. (wikipedia.org)
The septal nasal cartilage fits in a place between the perpendicular plate of the ethmoid and vomer bones while also being covered by an internal mucous membrane. (wikipedia.org)
The superior portion of the septal nasal cartilage attaches to the nasal bones, while the inferior portion attaches to the alar cartilages via fibrous tissues. (wikipedia.org)
The lateral nasal cartilage lies inferiorly to the nasal bones while sitting superiorly to the major alar cartilage, separated by a narrow fissure. (wikipedia.org)
They typically have malformations in the cartilage near the ends of the long bones in the arms and legs (metaphyseal chondrodysplasia), which then affects development of the bone itself. (medlineplus.gov)
OA of the spine specifically affects the facet joints, the cartilage between the bones that make up the spine, and the ligaments in the spine. (healthline.com)
Normally, cartilage on the ends of bones allows smooth, pain-free joint movements. (sciencedaily.com)
Cartilage cushions the ends of the bones and allows nearly frictionless joint motion, but enough damage can result in bone grinding directly on bone, which causes pain and restricted movement. (mayoclinichealthsystem.org)
A healthy joint consists of a relatively thin layer of articular cartilage coating the surfaces of the two or more bones that meet inside the joint. (lu.se)
Joint cartilage is important as it acts as a "shock absorber" between the bones. (lu.se)
Therefore, when the cartilage gradually starts to degenerate, the bones in the joint are less protected. (lu.se)
The long-term effects of these infections include multiple cutaneous lesions and destruction of bones or cartilage. (medscape.com)
Arthrosis is a progressive condition causing damage to the cartilage and bones of a joint. (lu.se)

The knee cartilage samples were collected from gender- and age-matched KBD (n = 9) and OA (n = 9) patients. (nature.com)
Recent studies have already shown Tai Chi to be effective in treating the physical and mental symptoms associated with the disease, and researchers recently took this a step further to determine if Tai Chi would hold up against physical therapy -- a highly-regarded treatment for knee OA. (sciencedaily.com)

In cases of immune-mediated diseases, such as relapsing polychondritis, they can help prevent relapses of the disease or further damage to the joints or cartilage. (medicalnewstoday.com)

Pathological processes involving the chondral tissue (CARTILAGE). (uchicago.edu)
They then supplemented the stem cells with a gel containing hyaluronic acid, a type of molecule normally found in cartilage and connective tissue. (supergene.com)
One cause is connective tissue disease, like RP. (tripod.com)
Dr. Mansour's research concerns the mechanical behavior of soft tissues, focusing primarily on tissue engineered and native cartilage. (uhhospitals.org)
Literature review: The articular cartilage is a highly specialized tissue that reduces joint friction and distributes forces related to high mechanical loads between bone ends. (bvsalud.org)
Accordingly, tissue engineering could overcome these limitations by producing in vitro cartilage substitutes. (bvsalud.org)
In this study, we devised a biodegradable bilayered scaffold, comprising chondroitin sulfate (CS) hydrogel to regenerate chondral tissue and a porous pure zinc (Zn) scaffold for regeneration of the underlying bone as mechanical support for the cartilage layer. (bvsalud.org)

Background Joint destruction in rheumatoid arthritis is comprised of cartilage and bone damage, which can be evaluated radiographically separately by the joint space narrowing (JSN) and erosion (ERO) scores. (bmj.com)
These data suggest that particular attention should be given to therapeutic interference with cartilage destruction. (bmj.com)
Rheumatoid arthritis (RA) is a systemic inflammatory disease that results in cartilage and bone destruction. (medscape.com)
4,7 Suppressing these pro-inflammatory enzymes is an essential mechanism when seeking to protect against joint cartilage destruction. (lifeextension.com)
Ligamentous laxity, muscular hypotonia, and rapid destruction of joint cartilage are common, predisposing to joint dislocations, which also accelerate disease progression. (msdmanuals.com)
During later stages, pain may be more severe if the disease has caused rapid joint destruction (eg, periarticular fractures or tense hematomas). (msdmanuals.com)

Keshan Disease is a cardiomyopathy characterized by cardiac enlargement, abnormal ECG patterns, cardiogenic shock, and congestive heart failure, with multifocal necrosis of the myocardium. (cdc.gov)

Collagen turnover is an essential part of growth and can vary as a function of age and disease. (lu.se)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)

Relapsing polychondritis is an autoimmune disease that affects the cartilage in the body. (tripod.com)
This disease most often affects the joints of the hands, wrists, and knees symmetrically. (everydayhealth.com)

Here, they demonstrated that the formulation reduced cartilage breakdown by 31.5% to 54.8% , depending on the dose used. (lifeextension.com)
The aim of this thesis is to investigate how the turnover (synthesis/breakdown) of cartilage extracellular matrix proteins responds to selected pro-inflammatory cytokines, thereby, gaining knowledge about cartilage biology, function and pathology. (lu.se)

Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. (ca.gov)

Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
During cartilage injury, large quantities of complement factors are exposed to components of extracellular matrix, which are liberated from cartilage by proteases. (lu.se)

Our group of scientists and clinicians has been continuously funded by the California Institute of Regenerative Medicine (CIRM) to develop a first-in class pluripotent stem cell-based therapy for focal articular cartilage lesions. (ca.gov)
The work described in this proposal is designed to produce a universal treatment for articular cartilage lesions. (ca.gov)
Articular cartilage lesions remain a major challenge for clinicians and researchers. (bvsalud.org)
Untreated treponematosis may cause disfiguring cutaneous lesions and deformities of bone, cartilage (particularly the nose), and skin, potentially leading to significant disfigurement, pain, and disability. (medscape.com)

Over time, the inflamed synovium can damage the cartilage and bone within the joint, as well as weaken supportive muscles, ligaments, and tendons. (everydayhealth.com)

Radiography is cheap, is easily reproducible, and allows easy serial comparison for assessment of disease progression. (medscape.com)
Treatment often involves addressing a person's symptoms and helping prevent disease progression. (medicalnewstoday.com)
Treatment consists of external or sometimes surgical joint stabilization to slow disease progression and reduce pain. (msdmanuals.com)
Hemorrhagic joint effusions and multiple small fractures can occur, accelerating disease progression. (msdmanuals.com)

This disease is caused by the deterioration of cartilage. (healthline.com)
OA is caused by slow deterioration of cartilage around joints in the lower back. (healthline.com)
The exact cause of this deterioration is unknown, but some people have a higher risk for the disease. (healthline.com)

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints. (everydayhealth.com)
Rheumatoid arthritis is a complex disease that is not well understood by medical practitioners or researchers. (everydayhealth.com)

Abnormalities or defects in the nasal cartilages affect airflow through the nasal cavity, resulting in respiratory issues. (wikipedia.org)

Unlike OA, Kashin-Beck disease (KBD) is a chronic and serious endemic osteoarticular disease, which has been in high prevalence and morbidity in Eastern Siberia of Russia, Northeast China to Sichuan-Tibet Plateau, and North Korea 4 , 5 . (nature.com)
Idea: Development of a Sarcopenia Center to diagnose and treat skeletal muscle loss due to chronic obstructive pulmonary disease. (clevelandclinic.org)
Idea: Chronic Disease Self-Management Program (CDSMP) is an evidence-based, peer-led program for people living with chronic disease that empowers them to take charge of their own health. (clevelandclinic.org)
The Center for Community Health Workers plans to pilot CDSMP shared medical appointments to give our patients the tools to medically and emotionally manage their chronic diseases to improve quality of life and self-efficacy. (clevelandclinic.org)
She was first diagnosed with the chronic condition in her carpi (wrists) when she was in her teens, and elephant keepers and veterinarians have spent decades successfully managing her disease with multi-modal therapies. (si.edu)
www.cdc.gov/pcd/issues/2022/21_0277.htm Preventing Chronic Disease. (cdc.gov)

In Paper II we developed a novel biomarker ELISA assay for MMP-cleaved prolargin (PROM), that was elevated in psoriatic arthritis patients compared to healthy controls, indicating that this is a marker that is associated with disease. (lu.se)

Aortic valve disease can lead to heart failure, arrhythmia, infections in the heart, and sudden death may occur in 15 to 20 percent of people who have symptoms. (sciencedaily.com)

When they looked at these pigs twelve weeks after the treatment, they observed greater and more complete regeneration of cartilage compared to the pigs with injured knees that did not receive the stem cell transplant. (supergene.com)
In recent years, the cartilage regeneration potential of mesenchymal stem cells has been investigated in rats and rabbits. (supergene.com)
The long-term goal of our research is to understand the fundamental mechanisms that govern and reprogram cellular fate during development, regeneration and disease. (stanford.edu)
Our research is geared towards applying reprogramming approaches towards musculoskeletal regeneration especially cartilage regeneration that remains an unmet medical need. (stanford.edu)
We are exploring the role of these novel DNA demethylation regulators in cartilage development, regeneration and disease. (stanford.edu)

Mechanical behavior of cartilage including effects of disease and repair. (uhhospitals.org)
In addition, to address the main challenges for the production of functional cartilage: mechanical and lubricant properties. (bvsalud.org)
Moreover, one should consider the application of mechanical stimuli and surface properties to produce an articular cartilage with satisfactory characteristics for in vivo application. (bvsalud.org)

For knees, for example, Novartis has discovered an agent that in animal studies may help torn and worn cartilage rebuild to original form. (bostonglobe.com)

The lateral nasal cartilage and major alar cartilage curl up upon interaction with one another, forming a tight connection through fibrous tissues. (wikipedia.org)
Superiorly, the major alar cartilages are connected to the lateral nasal cartilage via fibrous tissues. (wikipedia.org)

Micro/nano-engineered strategies and engineered biological systems developed at CASE BML enable broad applications in musculoskeletal research, regenerative medicine, clinical diagnostics, pharmaceutical research, in vitro models of human diseases, and national security. (uhhospitals.org)
The possibility that biomarker technology could be used to detect occupational musculoskeletal disease at an early, preclinical stage and allow intervention methods to be taken prior to irreversible damage occurring was discussed. (cdc.gov)
While most musculoskeletal biomarkers are not specific for a particular disorder, they can be compatible with and aid in supporting the presence and extent of disease when used as part of a profile of appropriate tests and accurate work histories. (cdc.gov)

if untreated, the inflammatory disease may damage cartilage and bone. (everydayhealth.com)

Dr. Rajamannan has focused her research for the past seven years on advancing the knowledge of mechanisms of aortic and mitral valve disease using animal models and human studies. (sciencedaily.com)
In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. (lu.se)

There is no cure, but RA can be managed with good treatment, according to the Centers for Disease Control and Prevention (CDC). (everydayhealth.com)
The Centers for Disease Control and Prevention (CDC) recommends BMI categorization for children and teens between age 2 and 20. (calculator.net)
The Centers for Disease Control and Prevention (CDC) BMI-for-age percentiles growth charts. (calculator.net)
Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
I'm Dr. Loretta Jackson-Brown and I'm representing the Clinician Outreach and Communication Activity, COCA in the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
Dr. Tauben and Dr. Robinson would like to disclose that their employer, the University of Washington, received a contract payment from the Centers for Disease Control and Prevention. (cdc.gov)
Dr. Dowell is Senior Medical Advisor for the Division of Unintentional Injury Prevention and Control at the Centers for Disease Control and Prevention. (cdc.gov)
It may be found in children immigrating from areas of endemicity, and the US Centers for Disease Control and Prevention (CDC) has recommended screening of all refugee children from endemic regions with a nontreponemal test at initial health screening. (medscape.com)
Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
However, these tradition- ally measured factors fail to adequately explain patients' risk of The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

However, most signs of OA are not visible on X-rays until the disease is in its later stages, which is the reason why OA primarily is a clinical diagnosis, meaning that the diagnosis is based on medical history, presence of risk factors, and symptoms. (lu.se)

Clinically, these findings have uncovered the possibility of unprecedented sources for patient-autologous cells with far reaching implications in a variety of diseases. (stanford.edu)

The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)
The observation system enabled the detection of autofluorescence emitted by the cartilage matrix without species specificity, facilitating both qualitative and quantitative analyses of the cartilage matrix. (bvsalud.org)

Since this is a progressive disease, symptoms typically worsen over time. (healthline.com)
Early signs of disease, such as joint swelling, joint pain, and joint stiffness, typically begin in a gradual and subtle way, with symptoms slowly developing over a period of weeks to months and getting worse over time. (everydayhealth.com)
In OA, cartilage becomes thin and irregular, resulting in symptoms of joint pain and stiffness. (sciencedaily.com)
Now these patients are approaching the end of the period in which the disease remains hidden and does not cause any symptoms. (lu.se)

Objective: To review the literature regarding sources of cells, scaffolds, and morphogenic agents currently used to produce articular cartilage. (bvsalud.org)
The utilization of the 3D fluorescence model may serve as a dependable option for the fabrication of cartilage matrix biomimetic scaffolds in future studies. (bvsalud.org)

Autoantibodies to minor cartilage-specific collagens (ie, types IX and XI) have been described. (medscape.com)

Therefore, we are investigating the possible modulatory effects that cartilage proteins may have on complement. (lu.se)

Carpal bone ankylosis is a common and fairly specific sign, particularly in the Asian population, in whom it tends to occur early in the disease process. (medscape.com)
Although occasional flares of joint pain occur throughout the course of the disease, these can usually be controlled with the use of anti-inflammatory medication, especially early in their course. (medscape.com)
Rear end paralysis can occur for a number of reasons (spinal embolism, back injuries / pinched nerves, cervical disc disease, spondylosis, etc. (bmdca.org)
In later stages of the disease, misalignment of the joint may occur. (lu.se)

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease involving skin, joints and kidneys and is characterized by autoantibodies against self-antigens including DNA and histones. (lu.se)

Autoimmune diseases need more research money committed to finding a cure. (tripod.com)
Further we aim to study handling of apoptotic cells and DNA from various sources by complement, in relation to autoimmune diseases . (lu.se)

Treponema species typically associated with nonvenereal disease are transmitted among children living in tropical, subtropical, or warm arid climates, chiefly by direct contact. (medscape.com)

The pathological mechanism of Kashin-Beck disease (KBD), an endemic osteoarthritic disease, remains to be poorly understood. (nature.com)
Treponematosis, also known as treponemiasis, traditionally refers to the group of nonvenereal diseases (including endemic syphilis [nonvenereal syphilis]) caused by Treponema species that are morphologically and serologically identical to each other and to Treponema pallidum subspecies pallidum, the cause of venereal syphilis. (medscape.com)

The molecular pathways behind the disease pathology can overlap across different joint diseases. (lu.se)

Anatomy29

Organisms1

Diseases7

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes5

Technology, Industry, Agriculture1

Osteoarthritis39

Degenerative5

Degradation5

Hyaline10

Degeneration12

Pieces of cartilage2

Hypoplasia28

Oligomeric Matrix Protein1

Inflammation8

Articular cartilage repair1

Bones13

Knee2

Joints or cartilage1

Tissue7

Destruction6

Abnormal1

Collagen3

Affects2

Breakdown2

Chondrocytes1

Extracellular matrix2

Lesions4

Synovium1

Progression4

Deterioration3

Rheumatoid arthritis2

Defects1

Chronic6

Arthritis1

Aortic valve1

Regeneration5

Mechanical3

Torn1

Fibrous2

Musculoskeletal3

Inflammatory disease1

Mechanisms2

Centers for Diseas13

Diagnosis1

Clinically1

Specificity2

Symptoms4

Scaffolds2

Collagens1

Proteins1

Occur4

Autoantibodies1

Autoimmune Diseases2

Typically1

Endemic2

Joint diseases1