• Perform hapten-carrier conjugation with cysteine-containing peptides and other thiolated antigens with this sulfhydryl-reactive mariculture KLH. (fishersci.com)
  • Thermo Scientific™ Imject Maleimide-Activated mcKLH is sulfhydryl-reactive immunogenic mariculture keyhole limpet hemocyanin (KLH) for hapten-carrier conjugation with cysteine-containing peptides and other thiolated antigens. (fishersci.com)
  • ActiveHOOK™ carrier proteins have been pre-activated with the heterobifunctional protein cross linker sulfoSMCC and therefore are ready for the addition of cysteine containing peptides or proteins for a simple one step reaction. (gbiosciences.com)
  • Landsteiner first coined the term "haptenic immune response" to assist generate the idea of detecting anti-hapten antibodies in immunodiagnostics and therapies [11]. (biomedres.us)
  • Thorpe, (1985) "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review," in Monoclonal Antibodies '84: Biological And Clinical Applications, A. Pinchera et al (ed.s), pp. 475-506). (justia.com)
  • Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
  • The carrier proteins, once coupled to the peptides, provide these additional motifs and generate a strong antibody response. (gbiosciences.com)
  • There are many varieties of antibody conjugation technologies available and each has its benefits, though no single one is optimal for every payload and antibody. (stratech.co.uk)
  • Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
  • The high-quality mariculture KLH is rendered sulfhydryl-reactive by chemical modification with Sulfo-SMCC crosslinker, and the resulting maleimide-activated protein is then stabilized and lyophilized in phosphate buffer. (fishersci.com)
  • However, from the cellular perspective, after binding of hapten to a carrier protein and formation of the complexes that are processed inside Antigen Presenting Cells (APCs) and presented as a stable hapten-peptide complex to the major histocompatibility complex class II (MHC II) settled in the tissues, an immune response will begin [13]. (biomedres.us)
  • Screen Quest™ assay kits, a set of HTS-ready tools for high throughput screening of biochemical and cellular targets such as protein kinases, proteases, HDAC, cell apoptosis and cytoxicity, GPCR, ion channels, ADME/metabolism and transporters. (stratech.co.uk)
  • From the chemical standpoint, the hapten is a low molecular weight chemical agent, that must bind to a large carrier protein to create a conjugate (Figure 1), before being detected by the immune system and eliciting an immunological response. (biomedres.us)
  • The purpose of this article is to share information with researchers and clinicians about creating a vaccine by incorporating a specific substance of abuse in a hapten conjugate that triggers an immune response against the effect of the drug. (biomedres.us)
  • Using hapten-based vaccination to treat drug addiction is a novel approach worth investigating. (biomedres.us)
  • Heterobifunctional Reactive groups maleimide and NHS ester Primary amine and sulhydryl reactive Hapten-carrier protein conjugation 1,2 Soluble in DMSO and chloroform Storage: Shipped at ambient temperature, upon receipt store at 4°C. (thomassci.com)
  • M-PEG-2-methylacrylate can be used as a carrier for poorly soluble drugs, which can enhance their absorption and effectiveness in the body. (axispharm.com)