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  • haptens
  • However, its signficantly better solubility provides greater flexibility in immunogen preparation protocols by allowing a broader range of buffer and pH conditions for coupling peptides, proteins and other haptens using classical crosslinkers such as glutaraldehyde, Sulfo-SMCC and EDC. (thermofisher.com)
  • Because of their large size and molecular complexity, KLH and CCH hemocyanins are carrier proteins of choice for use as immunogens to produce antibodies against haptens and peptides. (thermofisher.com)
  • Typically, unmodified carrier proteins are conjugated to peptides or other haptens via carboxyl-to-amine crosslinking with EDC (Part No. 22980 ). (thermofisher.com)
  • fatty acid syn
  • have devised a procedure to reconstitute E.Coli Fatty Acid Synthase using purified protein components ( including FabD) and reported a detailed kinetic analysis of this in-vitro reconstituted system. (wikipedia.org)
  • characterization
  • Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. (wikipedia.org)
  • mammalian
  • A homologous protein, which can be rendered ineffective by the antibody to pure chicken riboflavin carrier protein, has been shown to occur in several mammalian species, including two species of monkeys, and also in humans. (wikipedia.org)
  • adjuvants
  • In regards to future plans for the HGP-30 AIDS vaccine, Sarin said: "We plan to optimize conditions for linking HGP-30 to carrier proteins and to evaluate various adjuvants, so as to be able to obtain T-cell proliferative and CTL responses in all the immunized volunteers. (thefreedictionary.com)
  • polyketide
  • The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety. (wikipedia.org)
  • Gene
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • Imject
  • Imject Maleimide-Activated Carrier Proteins are prepared using a rigorous, carefully optimized manufacturing procedure, and each lot is tested to confirm that a high level of activation was achieved. (thermofisher.com)
  • ACPs
  • The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. (wikipedia.org)
  • The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. (wikipedia.org)
  • Nucleotide
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • immunogens
  • Immunogens Consisting of Oligosaccharides from the Capsule of Haemophilus influenzae Type b Coupled to Diphtheria Toxoid or the Toxin Protein CRM197",J. Clin. (patentgenius.com)
  • Purified and activated forms of ovalbumin (OVA) from egg whites for use as a carrier protein to prepare immunogens for antibody production or secondary target for screening. (thermofisher.com)
  • subunits
  • Proteins 9, 10, 12, 22 and 54 are subunits of the TIM system that mediates import of multispanning carrier proteins into the inner membrane (IM). (gsf.de)
  • The CCH protein is composed of two very large polypeptide subunits (404/351 kDa) that form an extremely stable heterodidecameric structure even in the absence of divalent cations. (thermofisher.com)
  • acyl-carrier
  • UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (EC 2.3.1.191, UDP-3-O-acyl-glucosamine N-acyltransferase, UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase, acyltransferase LpxD, acyl-ACP:UDP-3-O-(3-hydroxyacyl)-GlcN N-acyltransferase, firA (gene), lpxD (gene)) is an enzyme with systematic name (3R)-3-hydroxymyristoyl-(acyl-carrier protein):UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine N-acetyltransferase. (wikipedia.org)
  • kinase
  • Purpose Review aberrations of insulin signaling to atypical proteins kinase C (aPKC) in muscles and liver that generate cardiovascular risk elements, including, weight problems, hypertriglyceridemia, hypercholesterolemia, insulin level of resistance and blood sugar intolerance in type 2 diabetes mellitus (T2DM), and obesity-associated metabolic symptoms (MetSyn). (biomasswars.com)
  • as well as the downstream molecule extracellular indication regulated proteins kinase (ERK) 1/2, which induced the upregulation of p53 and Bcl-2-linked X proteins, mediating the next mobile apoptosis and proliferation in IECs. (biomasswars.com)
  • carbohydrate
  • In addition, dolichols can be adducted to proteins as a posttranslational modification, a process in which branched carbohydrate trees are formed on a dolichol moiety and then transferred to an assembly of proteins to form a large glycoprotein in the rough endoplasmic reticulum. (wikipedia.org)
  • receptors
  • Central nervous system Peripheral nervous system Heart Lungs Gastrointestinal tract Endothelial cells Like all histamine receptors, the H3 receptor is a G-protein coupled receptor. (wikipedia.org)
  • lipid
  • The increase in the sugar carrier dolichyl phosphate may reflect an increased rate of glycosylation in the diseased brain, and the increase in the endogenous anti-oxidant ubiquinone an attempt to protect the brain from oxidative stress, for instance, induced by lipid peroxidation. (wikipedia.org)
  • females
  • Recently[update] activated factor VII has become available as a treatment for haemorrhage in individuals with haemophilia and factor inhibitors Haemophilia A is inherited as an X-linked recessive trait, and occurs in males and in homozygous females (only possible in the offspring of a carrier female and a hemophilic male). (wikipedia.org)
  • However, mild haemophilia A is known to occur in heterozygous females due to X-inactivation, so it is recommended that levels of factor VIII and IX be measured in all known/potential carriers prior to surgery and in the event of clinically significant bleeding. (wikipedia.org)
  • domain
  • Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately 80% of the protein. (wikipedia.org)
  • The C-terminal domain of Beta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell. (wikipedia.org)
  • cell
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • components
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • shows
  • The drug has also been assessed at steroid hormone-associated carrier proteins, and shows very low binding to sex hormone-binding globulin (SHBG) but high affinity for corticosteroid-binding globulin (CBG) approximately equal to that of progesterone. (wikipedia.org)
  • important
  • These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport. (wikipedia.org)
  • small
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (wikipedia.org)
  • surface
  • We investigated the interaction of PEGylated and un-PEGylated PLGA NPs with Recombinant Human Mannose-Binding Protein (HMBP) in an effort to understand the effect of surface modification on their binding to the protein. (scirp.org)
  • normal
  • Susceptible persons are offspring of phenotypically normal parents who are carriers of the trait. (pharmacologicalsciences.us)
  • In matings between two phenotypically normal heterozygotes, the probability of having a susceptible child (the segregation frequency) averages 1 /4 (Figure 5.3) and that of having a carrier among phenotypically normal children is 2/3. (pharmacologicalsciences.us)
  • contains
  • These effects may be mediated by the defective functioning of estrogen via the estrogen receptor, which contains a zinc finger protein. (wikipedia.org)
  • make
  • About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, while the remainder are affected because they produced factor VIII in insufficient amounts (quantitative deficiency). (wikipedia.org)
  • food
  • The law requires 50% of Title II grains to be bagged in the U.S. and 75% of U.S. food aid must ship on U.S. flag carrier vessels. (wikipedia.org)