• The conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics. (wikipedia.org)
  • The optimized formulation of second-generation nanocrystals with concentrations 0.75% w/v poloxamer 188 and 2% w/v PLGA, could produce particle size of 114.6 nm, entrapment efficiency of 63.48% and drug release 80.23% at 12 h. (nanobe.org)
  • 3. A solid PVP-iodide monionic detergent product as defined in claim 2 wherein the poloxamer is one in which the molecular weight of (C 3 H 6 O) y is in the range of about 1500 to 5000 and the groups (C 2 H 4 0) x+x' constitute 70 to 90% of the total weight of said poloxamer. (google.com.au)
  • Critical Reviews in Therapeutic Drug Carrier Systems, 33 (6). (sussex.ac.uk)
  • In conclusion, the study emphasizes that poloxamer 188 was a versatile excipient, which played a pivotal role in producing nanosize carrier with high drug release profile of MHc loaded PLGA nanosuspensions of second generation nanocrystals. (nanobe.org)
  • Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition. (google.co.uk)
  • In vivo studies showing the effects of biologic healing-promoting factors on tendon-to-bone healing after rotator cuff repair have focused only on biologic healing-promoting factors and have not taken into consideration the effect of the carrier vehicle. (biomedcentral.com)
  • Carrier vehicles may have differing effects at the early stages of rotator cuff healing. (biomedcentral.com)
  • For groups in which the poloxamer gel was used as a carrier for BMP or where BMP was used in combination with DBM, the amount of bone generated by 8 weeks was similar to that produced by autogenous bone. (jcda.ca)
  • The use of Poloxamer 407 as a carrier vehicle may be useful for promoting the early stages of healing and for maintaining the initial biomechanical properties of the repaired rotator cuff tendon. (biomedcentral.com)
  • However, most studies have focused only on the biologic healing-promoting factors and not taken into consideration the effect of the carrier vehicle. (biomedcentral.com)