Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. (wikipedia.org)
ADP/ATP translocase 1 is the major AAC in human cells and the archetypal protein of this family. (wikipedia.org)
Adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. (bomiprot.org)
2.Zamora M, Granell M, Mampel T, Viñas O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (bomiprot.org)
Protein10
ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family. (wikipedia.org)
Mot en sadan hantering ar de nuvarande ansvarsbestammelserna inte tillrackligt effektiva, protein per ägg. (anabelcastroplaza.com)
CHCHD2 (mutations of which cause an autosomal dominant form of PD) encodes a mitochondrial intermembrane protein 1 . (nature.com)
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. (thermofisher.com)
Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. (springeropen.com)
In this tutorial article, we review the current concepts related to the pathophysiology of neuroinflammation and neurodegenerative diseases and give a glance on the status of PET imaging of 18-kDa translocator protein (TSPO) tracers in neuroinflammation of the living brain, with the aim of providing a basis for future discussions on the development of TSPO tracers for the diagnosis and therapy of neurodegenerative diseases. (springeropen.com)
To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with selective inhibition of mitochondrial Complex III and identified OCIA domain-containing protein 1 (OCIAD1) as a Complex III assembly factor. (biorxiv.org)
Zn(2+) addition to the cell culture medium induces an increase in the proliferative activity of the BDNF(1-12) peptide and of the whole protein on the SHSY5Y neuroblastoma cell line. (cnr.it)
Mitochondria4
Transport is fully reversible, and its directionality is governed by the concentrations of its substrates (ADP and ATP inside and outside mitochondria), the chelators of the adenine nucleotides, and the mitochondrial membrane potential. (wikipedia.org)
The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. (justia.com)
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. (nih.gov)
[1] pl. mitochondria ) is an organelle found in the cells of most eukaryotes , such as animals , plants and fungi . (wikipedia.org)
Subfamily1
Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified. (guidetopharmacology.org)
Fragment2
the shortened Eco RI fragment in FSHD is 1-10 units. (medscape.com)
Zn(2+) complexes with the peptide fragment BDNF(1-12) encompassing the sequence 1-12 of the N-terminal domain of BDNF were studied by means of potentiometry, electrospray mass spectrometry, NMR, and density functional theory (DFT) approaches. (cnr.it)
Mitochondrial carrier2
These proteins are classified under the mitochondrial carrier superfamily. (wikipedia.org)
The atomic structure of the bovine ANT confirmed this notion, and provided the first structural fold of a mitochondrial carrier. (wikipedia.org)
SLC25A41
Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP . (guidetopharmacology.org)
Proteins1
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. (justia.com)
Subunit5
Our data indicate that OCIAD1 is required for maintenance of normal steady state levels of Complex III and the proteolytic processing of the catalytic subunit cytochrome c 1 (CYC1). (biorxiv.org)
Description: A sandwich ELISA for quantitative measurement of Rat Calpain small subunit 1(CAPNS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Calpain, Small Subunit 1 (CAPNS1) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (resourcerecovery.be)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Calpain, Small Subunit 1 (CAPNS1) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)
Description: A sandwich ELISA kit for detection of Calpain, Small Subunit 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (resourcerecovery.be)
Then biochemical assays such as oxidative phosphorylation activity by respiratory chain enzymes were used to characterize enzyme disorders (eg, complex 1 or complex 3 deficiencies). (medlink.com)
X-ray based imaging modalities [traditional X-ray and computed tomography (CT)] primarily deal with anatomy and patterns, whereas radionuclide imaging, including positron emission tomography (PET) and single photon emission computed tomography (SPECT), assess function and physiology [ 1 ] (Fig. 1 ). (springeropen.com)
Associations of DPP9 with human liver cancer, exonic single nucleotide polymorphisms (SNPs) in DPP9 and loss of function (LoF) variants have not been explored. (preprints.org)
Cytochrome1
The electron transport chain consists of 4 multimeric complexes (I to IV) plus 2 small electron carriers, coenzyme Q10 (or ubiquinone) and cytochrome c . (medlink.com)
Genes1
Using culture medium supplemented with CFS (pH 3.6) or lactic acid (pH 3.6) at a 1:1 ratio, 677 differentially transcribed genes and 374 metabolites were detected in G. anatis . (springeropen.com)
Gene1
Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. (medscape.com)
Species1
The TVC values for beef mince, produced by respirometry and calculated using the available calibration equation, correlated well with the conventional plate counting method, ISO 4833-1:2013, 2013, while for the other species the correlation was less good. (bvsalud.org)
FSHD2
Those without FSHD have approximately 11-100 D4Z4 units, whereas patients with FSHD have 1-10 D4Z4 units. (medscape.com)
At least 1 copy of D4Z4 is required to develop FSHD. (medscape.com)
Transport1
The relationship of these parameters can be expressed by an equation solving for the 'reversal potential of the ANT" (Erev_ANT), a value of the mitochondrial membrane potential at which no net transport of adenine nucleotides takes place by the ANT. (wikipedia.org)
Ratio1
ANT transports the free, i.e. deprotonated, non-Magnesium, non-Calcium bound forms of ADP and ATP, in a 1:1 ratio. (wikipedia.org)
Single1
The coordination features of the acetylated form [AcBDNF(1-12)] and of a single mutated peptide [BDNF(1-12)D3N] were also characterized, highlighting the role of the imidazole side chain as the first anchoring site and ruling out the direct involvement of the aspartate residue in the metal binding. (cnr.it)
Cells1
Mosaic males are mostly affected, where as mosaic females with an equal complement of affected cells are more often asymptomatic carriers. (medscape.com)
Figure2
Bcl-2 is antiapoptotic), and other inhibitors (Figure 1). (cdc.gov)
Prevention of lymphocyte apoptosis, same process by which these cell populations are regulat- through either genetic modification of the host or treatment ed during normal health ( 1 , 2 ). (cdc.gov)
Un estudio en animales demostro que Cardarine puede ayudar a mantener el flujo normal de sangre al cerebro, anabola steroider biverkningar man. (anabelcastroplaza.com)