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  • common caroti
  • The human carotid body is a small structure located at the upper end of the common carotid artery. (springer.com)
  • In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). (readbyqxmd.com)
  • autonomic
  • The proposed studies assessing the role of transmitter(s) in CIH- induced sensory LTF of the carotid body and assessing the physiological significance of sensory LTF is of importance in developing novel therapeutic strategies for alleviating and/or retarding autonomic abnormalities associated with CIH. (grantome.com)
  • In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. (conicyt.cl)
  • Aortic
  • The aortic bodies also play a role, but appear to be in humans at least considerably less important. (springer.com)
  • Intravenous (IV) injections of LPS in anesthetized cats induce tachypnea, tachycardia and hypotension, but ventilatory changes are suppressed after sectioning carotid and aortic nerves. (udd.cl)
  • respiratory
  • It focuses on modulation of the carotid body - a key chemosensor located at the fork of the carotid artery that helps regulate respiratory activity. (medgadget.com)
  • 2 Since activation of PLC may be part of the general mechanism by which the carotid body stimuli induce physiologic effects, we now extended that study by characterization of the effects on phosphoinositide metabolism of two further natural carotid body stimuli, respiratory and metabolic acidosis. (springer.com)
  • An integrated approach with a repertoire of techniques including measurements of carotid body sensory activity, cardio-respiratory variables, neurotransmitters and second messenger pathways will be employed. (grantome.com)
  • responses
  • In this study, we investigated the possible molecular mechanisms of carotid body pH-sensing by recording the responses of glomus cells isolated from rat carotid body to rapid changes in extracellular pH using whole-cell patch-clamping technique. (ahajournals.org)
  • Thus, the carotid and vagus nerves provide routes between the immune system and CNS structures involved in systemic inflammatory responses. (udd.cl)
  • hypertension
  • Cibiem's proprietary, minimally invasive, catheter-based approach is focused on Carotid Body Modulation (CBM) for the treatment of sympathetic nervous system-mediated diseases such as hypertension, heart failure, diabetes and renal failure. (medgadget.com)
  • Of the different medical conditions such as congestive heart failure, hypertension, renal failure, or diabetes - where do you feel carotid body modulation will have the greatest impact and why? (medgadget.com)
  • However, the idea of inventing a minimally-invasive, catheter-based medical device to modulate the carotid body is truly novel and could fundamentally change the way we treat diseases like heart failure, hypertension, diabetes and renal failure - all conditions that are not optimally addressed or managed by the current drug therapies or standard of care. (medgadget.com)
  • This is a pilot study to assess the effectiveness, safety and feasibility of carotid body removal in patients with high blood pressure (hypertension) resistant to medical treatment. (clinicaltrials.gov)
  • chronic
  • Dr. Levin and Mr. Gelfand recently participated in an interview with Medgadget , answering questions about Cibiem and the potential role of Carotid Body Modulation for well known chronic diseases. (medgadget.com)
  • Experimental
  • The current proposal proposes to investigate the role of neurotransmitters in altered carotid body function by CIH in experimental models that may lead to novel therapeutic strategies that help preventing or retarding the deleterious consequences of CIH associated with sleep-disordered breathing. (grantome.com)
  • However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. (conicyt.cl)
  • stimulation
  • The aim of this work was to determine contents and turnover rates for dopamine (DA) and norepinephrine (NE) and to identify the catecholamine (CA) released during stimulation of the rat carotid body (CB). (nih.gov)
  • sympathetic
  • The idea of modulating the carotid body to have an effect on sympathetic nervous system-mediated diseases is not a new one - it had been surgically done in the 1940s and lasted through the 1990s in some places. (medgadget.com)
  • Notwithstanding, a growing body of evidence involved the CB in several sympathetic-mediated human diseases [8- (conicyt.cl)