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  • mouse carotid
  • With the simultaneous development of a novel ECM-specific MR contrast agent (BMS753951) non-invasive assessment of changes in remodeling of the injured mouse carotid wall has become feasible. (biomedcentral.com)
  • vivo
  • Furthermore, balloon injury or treatment in vivo with PDGF also induces PDGF receptor tyrosyl phosphorylation in vascular smooth muscle, 6,9 a finding consistent with experiments in vitro. (ahajournals.org)
  • Caspase-3 cleavage assay and fluorescence-activated cell-sorting (FACS) analysis showed no evidence of apoptosis in 2-ME-treated SMCs, and TUNEL staining in carotid segments showed no evidence of 2-ME-induced apoptosis in vivo. (ahajournals.org)
  • Trivedi RA, Mallawarachi C, King-Im JM et al (2006) Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. (springer.com)
  • A catheter balloon-denuded rat carotid artery was transfected in vivo with the replication-deficient adenovirus Ad5/RSVeNOS or with Ad5/RSVLacZ as the control. (ahajournals.org)
  • balloon
  • Methods and Results -We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. (ahajournals.org)
  • Abstract The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase chain reaction and substrate zymography, after balloon catheter angioplasty of the rat carotid artery. (ahajournals.org)
  • These results demonstrate that the process of extracellular matrix breakdown by MMPs after balloon catheter-induced injury is controlled by a tightly regulated temporal response by the genes responsible for the production of these enzymes and their inhibitor and by post-translational activation of the proenzymes. (ahajournals.org)
  • Smooth muscle cells have been shown to express mRNA for urokinase plasminogen activator and tissue-type plasminogen activator after balloon injury in the rat model of angioplasty. (ahajournals.org)
  • gelatinase B) was induced after balloon catheter injury during the period of migration of smooth muscle cells from the media to the intima. (ahajournals.org)
  • Methods and Results- Treatment of cultured cells with adenovirus expressing PTP1B decreased PDGF-BB- or FGF2-induced cell motility and blocked PDGF-BB- or FGF2-induced proliferation, whereas expression of dominant negative PTP1B (C215S-PTP1B) uncovered the motogenic effect of subthreshold levels of PDGF-BB or FGF2, increased neointimal and medial cell proliferation, and induced neointimal enlargement after balloon injury. (ahajournals.org)
  • This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
  • Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. (springer.com)
  • angiography
  • Accordingly, unlike the situation in zone II of the neck, where the proximal and distal control of blood vessels can be easily achieved, angiography should be performed in cases of penetrating injury occurring in zones I and III. (biomedsearch.com)
  • Grade I and II injuries are of particular concern and require follow-up angiography owing to the risk of pseudo-aneurysm formation despite heparin therapy. (scielo.org.za)
  • vessel walls
  • Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on vessel walls with injury. (naver.com)
  • proliferation
  • Medial smooth muscle cell proliferation begins immediately after injury and peaks early, reaching a maximum at 2 days. (ahajournals.org)
  • The current study was designed to test the hypothesis that PTP1B attenuates PDGF- or FGF-induced motility and proliferation of cultured cells, as well as neointima formation in injured rat carotid arteries. (ahajournals.org)
  • 2 Several reports indicate that injury-induced movement of smooth muscle cells from media to intima and the proliferation of smooth muscle cells in intima are significantly reduced by pharmacological antagonists of the function or availability of PDGF or FGF2. (ahajournals.org)
  • Abstract -Injury-caused dedifferentiation accompanied by proliferation and migration of smooth muscle cells (SMCs) is an important process in the development of the neointima. (ahajournals.org)
  • left
  • It extends at the middle stage of the base of the skull with fracture of the right temporal condylar fossa, the greater wing of the right sphenoid bone, the walls of the sphenoid canal and the left carotid canal and finally with an extralabyrinthic fracture of the left petrous bone with no damage to the ossicular chain. (imaios.com)
  • sensitivity
  • Despite having a sensitivity of 50 - 68%, it is a popular diagnostic screening modality because of fast scanning times, and has the added benefit of excluding multiple injuries in the polytrauma patient. (scielo.org.za)
  • None of the multi-contrast weighted sequences detected edema in the carotid artery with reasonable sensitivity or specificity. (springer.com)
  • inhibits
  • Here we studied the intracellular mechanisms by which 2-ME inhibits SMC growth and whether 2-ME prevents injury-induced neointima formation. (ahajournals.org)
  • Furthermore
  • Furthermore, seemingly innocuous wounds may not manifest clear signs or symptoms, and potentially lethal injuries could be easily overlooked or discounted. (medscape.com)
  • detection
  • In this study we investigated whether the use of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury and whether it would facilitate the detection of impaired ECM formation in CRP2-/- mice. (biomedcentral.com)
  • T2-STIR CMR allowed carotid artery wall edema detection and may therefore be a useful non-invasive diagnostic tool for determination of inflammatory activity in the carotid artery wall. (springer.com)
  • significantly
  • The data showed that the expression of paxillin was significantly downregulated after injury. (ahajournals.org)
  • eNOS gene transfer showed no effect on paxillin downregulation 2 days after injury but significantly enhanced the recovery of paxillin protein 5 days and 2 weeks after injury. (ahajournals.org)
  • atherosclerotic lesions
  • Because homocysteine is known to exert a direct inhibitory effect on endothelial cell growth in vitro, we hypothesized that this effect contributes to the progression of atherosclerotic lesions initiated by endothelial damage caused by mechanical injury. (ahajournals.org)