• Carmustine (BCNU) is a parenterally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several forms of cancer including leukemias, lymphomas, and breast, testicular, ovarian, gastric and pancreatic cancer. (nih.gov)
  • Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. (wikipedia.org)
  • Carmustine is an orange-yellow solid medication used mainly for chemotherapy. (wikipedia.org)
  • Carmustine for injection was marketed under the name BiCNU by Bristol-Myers Squibb and now[when? (wikipedia.org)
  • Other medications may also interact with carmustine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Other medications may interact with carmustine. (rxwiki.com)
  • Other drugs that can interact with carmustine include nalidixic acid. (marsoclinic.com)
  • Carmustine wafers may increase your chance of brain infection, swelling or increased pressure in the brain, and seizures. (rxwiki.com)
  • No prior treatment with carmustine wafers. (nih.gov)
  • Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase6with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. (nih.gov)
  • Also, 8 of the 75 identified upregulated genes showed positive correlation with resistance to the drugs that are normally used for glioma treatment, including procarbazine, carmustine, vincristine, and temozolomide. (thejns.org)
  • At its latest meeting, the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) recommended approval of a generic version of carmustine (Carmustine Obvius, from Obvius Investment BV) for use in the treatment of brain tumors, non-Hodgkin's lymphoma, and Hodgkin's disease. (medscape.com)
  • Because the drug is administered intravenously and is 100% bioavailable, a bioequivalence study comparing Carmustine Obvius with the reference product Carmubris was not required, the committee noted. (medscape.com)
  • FarmaMondo has been appointed to exclusively manage the access of Carmustine Obvius to Italian healthcare providers looking to fulfill unmet medical needs of patients with brain tumors and Hodgkin's /non-Hodgkin's lymphomas, types of cancer that originate from white blood. (farmamondo.com.ar)
  • Carmustine Obvius was approved by EMA on June, 2018. (farmamondo.com.ar)
  • Obvius investment BV is the global rights holder to commercialize the product Carmustine Obvius, licensed from the developer MERR Holding. (farmamondo.com.ar)
  • over 4 d) and 61 patients received rituximab and stem cell harvest, followed by BEAM (carmustine, etoposide, Ara-C, melphalan) and autologous stem cell rescue. (eur.nl)
  • The underlying disease and baseline pulmonary function, along with conditioning regimens consisting of carmustine, etoposide, aracytin and melphalan for lymphoma, melphalan alone for multiple myeloma or busulpan and cyclophosphamide for acute myeloid leukaemia, all concur to cause pulmonary complications [ 3 , 4 ]. (ersjournals.com)
  • citation needed] In the treatment of brain tumours, the U.S. Food and Drug Administration (FDA) approved biodegradable discs infused with carmustine (Gliadel). (wikipedia.org)
  • Biodegradable implants of carmustine are already used in the treatment of malignant brain tumors. (researchandmarkets.com)
  • Carmustine implant is used along with surgery and sometimes radiation therapy to treat malignant glioma (a certain type of cancerous brain tumor). (nih.gov)
  • 24. Pharmacokinetics of the carmustine implant. (nih.gov)
  • Carmustine injection is used to treat certain types of brain tumors. (medlineplus.gov)
  • Carmustine injection is also used along with prednisone to treat multiple myeloma (a type of cancer of the bone marrow). (medlineplus.gov)
  • Carmustine injection comes as a powder to be added to fluid and injected over at least 2 hours intravenously (into a vein) by a doctor or nurse in a medical office or hospital outpatient clinic. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to carmustine or any of the ingredients in carmustine injection. (medlineplus.gov)
  • You should not become pregnant while you are receiving carmustine injection. (medlineplus.gov)
  • Talk to your doctor about the risk(s) of receiving carmustine injection. (medlineplus.gov)
  • These highlights do not include all the information needed to use CARMUSTINE FOR INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for CARMUSTINE FOR INJECTION. (nih.gov)
  • Suppression of marrow function, notably thrombocytopenia and leukopenia, is the most common and severe of the toxic effects of carmustine for injection. (nih.gov)
  • Pulmonary toxicity from carmustine for injection appears to be dose related. (nih.gov)
  • Recommended Dosage: As a single agent, 150 mg/m 2 to 200 mg/m 2 carmustine for injection intravenously every 6 weeks as a single-dose or divided into daily injections such as 75 mg/m 2 to 100 mg/m 2 on 2 successive days. (nih.gov)
  • For injection: 100 mg of carmustine lyophilized powder in a single-dose vial for reconstitution and a vial containing 3mL sterile diluent (Dehydrated Alcohol Injection, USP). (nih.gov)
  • Phenytoin: Carmustine for injection may reduce the efficacy of phenytoin. (nih.gov)
  • Becenun (carmustine) is an antineoplastic alkylating agent, which cross-links DNA and disrupts the cell-cycle (NCI Drug Dictionary). (jax.org)
  • Carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma, multiple myeloma, and lymphoma (Hodgkin's and non-Hodgkin). (wikipedia.org)
  • Cite this: EU OK for Generic Carmustine for Brain Tumors and Lymphoma - Medscape - Apr 27, 2018. (medscape.com)
  • Carmustine is a prescription medication used to treat certain types of brain tumors, multiple myeloma (cancer of the bone marrow), and Hodgkin's and non-Hodgkin's lymphoma (cancers of the immune system). (rxwiki.com)
  • Carmustine is used to treat cancers (called multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, and brain tumors). (marsoclinic.com)
  • Carmustine is indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in Brain tumors - (glioblastoma, medulloblastoma, astrocytoma and metastatic brain tumors), Multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas. (farmamondo.com.ar)
  • 2023. https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51132/all/carmustine. (unboundmedicine.com)
  • Before receiving carmustine, tell your doctor if you are allergic to it. (rxwiki.com)
  • Carmustine is in a class of medications called alkylating agents. (medlineplus.gov)
  • It is possible that medications that suppress the immune system could increase the risk of low blood cell counts and infections associated with carmustine. (rxwiki.com)
  • Check for carmustine drug interactions, and if you are taking a drug that interacts with this drug, talk to your doctor about using your medications. (marsoclinic.com)
  • If you become pregnant while receiving carmustine, call your doctor. (medlineplus.gov)
  • The risk of lung damage, which has caused death in people who received this medication as children, is increased in people who receive carmustine treatments lasting for a long duration. (rxwiki.com)
  • The AGT-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of DNA repair, which will prevent formation of the interstrand crosslink between the N1 of guanine and the N3 of cytosine. (wikipedia.org)
  • Due to the shortage of carmustine, bendamustine and nimustine in China, we aimed to examine conditioning with idarubicin and to compare the efficacy and toxicity between BEAC and idarubicin-substituted BEAC (IEAC). (nature.com)
  • Carmustine also can cause lung damage, even years after treatment. (medlineplus.gov)
  • It is important for you to tell your doctor how you are feeling during your treatment with carmustine. (medlineplus.gov)
  • Carmustine can cause lung damage that may be revealed years after treatment. (rxwiki.com)
  • The dose of Carmustine and the course of treatment with this drug depends on the patient's weight and its effectiveness for the patient. (marsoclinic.com)
  • Carmustine may increase the risk that you will develop other cancers. (medlineplus.gov)
  • Carmustine may increase the risk of developing other cancers. (rxwiki.com)
  • The disc allows for controlled release of carmustine in the extracellular fluid of the brain, thus eliminating the need for the encapsulated drug to cross the blood-brain barrier. (wikipedia.org)
  • Carmustine can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • Carmustine can cause a severe decrease in the number of blood cells in your body, increasing your risk for anemia, infections, and bleeding. (rxwiki.com)
  • Carmustine treats certain types of cancer. (rxwiki.com)
  • carmustine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • Before receiving carmustine, tell your doctor if you have lung disease, or if you have ever had lung disease. (rxwiki.com)
  • Pay attention to the expiration date of Carmustine and do not take it if your medicine has expired. (marsoclinic.com)
  • Neither salicylsalicylic acid sequence nor prescription medicine sodium potentiated the effect of Carmustine. (sbolot.org)
  • Carmustine may cause side effects. (medlineplus.gov)
  • Common side effects of carmustine include nausea, vomiting, and headache. (rxwiki.com)
  • Consult your doctor if you have any other symptoms that you feel may be due to the use of Carmustine. (marsoclinic.com)