Cardiovascular therapeutic agents. Medical search. Frequent questions

Free radicals have been associated with pathogenesis of various disorders like cancer, diabetes, cardiovascular diseases, autoimmune diseases, neurodegenerative disorders and are implicated in aging. (nutrimedical.com)
Several antioxidants like SOD, CAT, epigallocatechin-3-O-gallate, lycopene, ellagic acid, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C and vitamin E have been found to be pharmacologically active as prophylactic and therapeutic agents for above mentioned diseases. (nutrimedical.com)
However, targeting oral microbiome might still provide preventive and therapeutic insights on cardiovascular diseases. (degruyter.com)
Oral dysbiosis, which potentially causes periodontitis to subsequently promote systemic inflammation and local vascular inflammation, increases the risks of cardiovascular diseases (CVDs). (degruyter.com)
Systems pharmacology: the biological basis of diseases states affecting different physiological systems, therapeutic approaches to treating these diseases, and the cellular/molecular mode of action of drugs used. (kent.ac.uk)
However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. (blogspot.com)
These conditions included occupational lung diseases, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, and occupational cardiovascular diseases. (cdc.gov)
Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. (frontiersin.org)
Currently available pharmacotherapeutical agents used for the treatment of depression have a low margin of safety and reduced therapeutic index with deleterious adverse effects including osteoporosis, obesity, hypertension, diabetes, cardiovascular diseases, infertility and even fatalities if abused. (novapublishers.com)
Hypertension is known as the main risk parameters in patients with cardiovascular diseases, such as myocardial infarction and stroke. (hindawi.com)
The research points to the potential of developing a new therapeutic agent for the treatment of cardiovascular diseases. (shen-nong.com)
Mao Dong Qing is a traditional herb commonly used in cardiovascular diseases. (shen-nong.com)
It has been found to play a role in cancer development and progression, inflammation-related disorders, cardiovascular diseases, and neurodegenerative diseases. (creativebiomart.net)
Conclusion: The study's findings indicate that dyslipidemia in T2DM patients is associated with reduced KLF14 functionality due to CC and CT genotypes, leading to insulin resistance and an increased risk of cardiovascular diseases. (bvsalud.org)

High levels of inflammatory markers, such as C-reactive protein, were associated with left ventricular dysfunction ( 2 ), higher cardiovascular event rates ( 3 ) and worse clinical prognosis ( 4 ) following an acute myocardial infarction, independent of traditional risk factors. (frontiersin.org)
Altogether, the altered immune and inflammatory responses, and endotoxemia contribute to the dysfunction and stress in cardiovascular cells (e.g . endothelial cells, vascular smooth muscle cells and cardiomyocytes), increasing cardiovascular risks. (degruyter.com)
For example, chronic exposure to cigarette tobacco smoke can cause and accelerate microvascular dysfunction in cardiovascular disease (CVD) and age-related macular degeneration (AMD). (frontiersin.org)
The primary intent is to mitigate cardiovascular dysfunction while optimizing cancer outcomes. (nih.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative applications that will contribute to the identification and characterization of patients at risk of developing cancer treatment-related cardiotoxicity with the primary intent to mitigate cardiovascular dysfunction while optimizing cancer outcomes. (nih.gov)
Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients With Renal Dysfunction. (janusinfo.se)

Use with caution in patients sensitive to sympathomimetic drugs and patients with cardiovascular or convulsive disorders. (nih.gov)
Use with caution in patients with underlying cardiovascular disorders. (nih.gov)

With agents like tirzepatide, we're seeing so much more weight loss, paving the way for looking at cardiovascular outcomes down the line. (medscape.com)
Chronic kidney disease (CKD) with type 2 diabetes (T2D) is a major public health problem, resulting in significant cardiovascular and kidney adverse outcomes worldwide. (bepress.com)
3 This expense is justified for studying investigational agents that have been demonstrated to be safe with a good effect on surrogate outcomes, but is prohibitive in the preapproval phase. (bmj.com)
Our goals are to identify cardiovascular risk early in patients with CKD, to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes. (ed.ac.uk)
In population-based studies utilising high-fidelity linked healthcare data unique to Scotland, we are investigating temporal trends in the incidence and outcomes of cardiovascular disease, including rates of secondary prevention prescribing, in patients with kidney failure. (ed.ac.uk)
Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)

Many patients on potent agents addressing modifiable cardiovascular risk factors, such as hypertension, hyperlipidemia or diabetes, still suffer from cardiovascular complications, including acute coronary syndromes (ACS). (frontiersin.org)
Thus, agmatine-like compound has the potential to develop as a new therapeutic agent for hypertension in the future. (hindawi.com)
Thus, development of the better agent to handle hypertension is urgent [ 1 ]. (hindawi.com)
Thus, development of new agent for management of hypertension is essential. (hindawi.com)
Then, this may help the development of new agent(s) for hypertension in the future. (hindawi.com)

We know that people living with type 2 diabetes have a much harder time losing weight, probably because of commonly used agents like insulin or sulfonylurea. (medscape.com)
A key part will be the upcoming cardiorenal and hepatic outcome data, which will allow us to bespoke use of these agents, I think, according to the presence of type 2 diabetes and obesity but also specific comorbidities, particularly things like NAFLD - which is another epidemic we're facing over the next few years. (medscape.com)
Cardiorenal Protection With the Newer Antidiabetic Agents in Patients With Diabetes and Chronic Kidney Disease: A Scientific Statement From the American Heart Association. (bepress.com)
The commentary on the trial by Marso et al 1 assessing the cardiovascular (CV) safety of a new agent for treating type 2 diabetes highlights a recognised dilemma in clinical research on CV risk in assessment of new therapeutic agents. (bmj.com)

It reviews potential mechanistic pathways that may drive these benefits and summarizes the literature on adverse effects in patients with CKD and T2D at risk for or with established cardiovascular disease. (bepress.com)

Imidazoline receptors are introduced to play a role in cardiovascular regulation [ 2 , 3 ]. (hindawi.com)
Dupuis (2000) Endothelin receptor antagonists and their developing role in cardiovascular therapeutics. (multispaninc.com)

Using large datasets, we are investigating the role of high-sensitivity troponin I (and other cardiovascular biomarkers) as a measure of outcome in patients with CKD and those undergoing kidney transplantation. (ed.ac.uk)

Experimental evidence identified quercetin, a natural senolytic drug, as a cardioprotective agent against inflammatory injuries. (frontiersin.org)

Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. (blogspot.com)
This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer. (blogspot.com)
Curcumin has extensive therapeutic potential because of its antioxidant, anti-inflammatory, and antiproliferative properties. (hindawi.com)

Coenzyme Q10 (CoQ10) may represent a safe therapeutic option for patients with HF. (nih.gov)
This is really a great therapeutic option for, particularly, our younger, higher-risk cardiometabolic patients. (medscape.com)
Importantly, although we have all these fantastic new therapeutic options, they really only work if our patients take them. (medscape.com)
The advent of the newer classes of antihyperglycemic agents, including SGLT2 (sodium glucose cotransporter 2) inhibitors and GLP-1 (glucagon-like peptide-1) receptor agonists, has changed the landscape of therapeutic options for patients with CKD with T2D, with demonstration of significant reductions in cardiovascular adverse events and progression to end-stage kidney disease. (bepress.com)
Last, it provides practical guidance on a proposed collaborative care model bridging cardiologists, nephrologists, endocrinologists, and primary care physicians to facilitate the prompt and appropriate integration of these therapeutic classes in the management of patients with T2D and CKD. (bepress.com)
For many years the principle therapeutic approach was to treat patients with drugs that altered the electrophysiology of the heart. (britannica.com)
Although current treatments have improved the short-term prognosis of AAV, these patients remain at a significantly increased risk of cardiovascular disease. (ed.ac.uk)
We are examining if short- and long-term ET receptor blockade will reduce cardiovascular risk in optimally managed patients with AAV. (ed.ac.uk)

The recent publication of the Q-SYMBIO randomized controlled trial demonstrated a reduction in major adverse cardiovascular events with CoQ10 supplementation in a contemporary HF population. (nih.gov)
Pethidine, piroxicam, Increased plasma concentrations of norpethidine, propoxyphene piroxicam and propoxyphene, thereby, increasing the risk of serious respiratory depression or haematologic abnormalities, or other serious adverse effects from these agents. (who.int)
Thereby, increasing the risk of arrhythmias or other serious adverse effects from these agents. (who.int)
Research applications should focus on mitigation/management of adverse effects associated with anti-cancer treatments including: cytotoxic chemotherapies, targeted agents, immunomodulatory therapies and radiation (that occur during cancer treatment and/or long-term survivorship) as defined by cardiac and/or vascular specific common terminology criteria for adverse events (CTCAE). (nih.gov)
Additionally, exploring the potential of plant-based bioactive compounds as therapeutic agents offers promising avenues for addressing the adverse effects of bisphenols. (bvsalud.org)

To date, the polyunsaturated fatty acids (PUFAs) have been linked to a range of cardiovascular benefits, from improving in blood lipid levels to reducing the tendency of thrombosis, and from improving blood pressure and heart rate to reducing the risk of coronary heart disease (CHD) and cardiac death. (nutraingredients.com)
Adult stem cells remain of particular interest as therapeutic agents for cardiac regeneration in ischemic heart disease [ 1 - 4 ]. (biomedcentral.com)

Monoamine oxidase inhibitors (MAOs) or tricyclic antidepressants: May potentiate effect of albuterol on the cardiovascular system. (nih.gov)

Endothelin is a hormone produced predominantly by endothelial cells that have been recognized to play a significant role in the development of several cardiovascular disease states. (multispaninc.com)
Wu-Wong (2002) Endothelin receptor antagonists as therapeutic agents for cancer. (multispaninc.com)

Oral dysbiosis refers to the imbalance between symbionts and pathobionts in the oral cavity, posing potential threats to host cardiovascular health. (degruyter.com)
This article delves into the extensive, up-to-date research on BHT's health benefits and its potential as a therapeutic agent. (earthclinic.com)
It is also being investigated as a potential therapeutic target in these conditions. (creativebiomart.net)

These headaches can often be controlled with amitriptyline, propranolol, or other commonly prescribed migraine prophylaxis agents. (medscape.com)

These observations opened the door to testing anti-inflammatory agents as a new therapeutic adjunct in the management of cardiovascular disease ( 5 ). (frontiersin.org)

A case in which a potentially exposed person is being evaluated by health-care workers or public health officials for poisoning by a particular chemical agent, but no specific credible threat exists. (cdc.gov)
The case can be confirmed if laboratory testing was not performed because either a predominant amount of clinical and nonspecific laboratory evidence of a particular chemical was present or the etiology of the agent is known with 100% certainty. (cdc.gov)
They are also not meant to be used for persons who are exposed to a chemical agent but remain asymptomatic. (cdc.gov)

Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s). (hindawi.com)

Despite the widespread use of standard-of-care therapies for CKD with T2D over the past few decades, rates of progression to end-stage kidney disease remain high with no beneficial impact on its accompanying burden of cardiovascular disease. (bepress.com)
My group's research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease (CKD) from early in the disease trajectory through to kidney failure requiring either dialysis or kidney transplantation. (ed.ac.uk)
Cardiovascular disease is the commonest complication of kidney disease and cardiovascular risk is greatest in those with kidney failure. (ed.ac.uk)

Significant to their activity as migraine prophylactic agents is the lack of partial agonistic activity. (medscape.com)
Antioxidants are emerging as prophylactic and therapeutic agents. (nutrimedical.com)

Importantly, oral dysbiosis promotes cardiovascular pathophysiology through different mechanisms. (degruyter.com)
Common mechanisms of oral dysbiosis-promoted cardiovascular pathophysiology. (degruyter.com)

A 38-year-old woman presented to the emer- disease remains a therapeutic dilemma [ 3 ]. (who.int)

Some common mechanisms by which oral dysbiosis increases cardiovascular risks have been illustrated in Figure 1 . (degruyter.com)

Further extensive efforts are needed to deepen our understanding on oral-cardiovascular connection in the context of diagnostic and therapeutic perspectives. (degruyter.com)

Thereby, increasing the risk of serious arrhythmias from these agents. (who.int)
An example of a highly effective therapeutic agent used for arrhythmias is amiodarone, a structural analog of thyroid hormone. (britannica.com)

Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)

Cardiovascular effects may occur. (nih.gov)
Thus, the indication that ventricular tachycardia or ventricular fibrillation might occur demands prompt therapeutic intervention. (britannica.com)

In Beijing, officials announced that a traditional formula called Jin Hua Qing Gan Fang ( ???M P ) has been designated as the world's first "optimized effective agent" for alleviating the symptoms of the H1N1 virus. (shen-nong.com)
2 chemicals can result in symptoms that are not typical for either agent alone. (cdc.gov)

4 As per the FDA guidance, in order for investigational agents to be approved they added the requirement that they demonstrate no excess increase in CV risk in large safety outcome studies. (bmj.com)

Sophora Japonica promotes healthy blood vessels and can support overall cardiovascular system health. (nutramedix.com)

Tests may be done to determine cause, assess organ damage, and identify other cardiovascular risk factors. (msdmanuals.com)

We now are seeing that there can be significant weight loss with agents like survodutide, another incretin therapy. (medscape.com)

Latency from initial treatment to therapeutic results may be as long as 2 months. (medscape.com)
To accomplish this, methods that evaluate cardiovascular risk prior to treatment and integrate evidence-based cancer treatment regimens with cardiovascular screening, diagnostic, and/or management strategies are sought. (nih.gov)

CD133 + stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. (biomedcentral.com)

Studies at UTSW two decades ago by Dr. Makoto Kuro-o , Professor of Pathology, demonstrated that mice lacking either a-Klotho or the hormone FGF23 suffered from premature and multiple organ failure as well as other conditions, including early onset cardiovascular disease, cancer, and cognitive decline. (newswise.com)

These agents are the drugs of choice. (medscape.com)

Although [omega-3s] likely possess heterogeneous properties beneficial to cardiovascular health, the effect of EPA and DHA on genome integrity in the context of atherosclerosis has been remained unknown. (nutraingredients.com)

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). (nih.gov)

Physical examination revealed massage, rebreathing with carbogen, oral a visual acuity of 2/400 in the right eye, acetazolamide and topical antiglaucomatous which was more preserved in the temporal agents. (who.int)

Toxicants are synthetic (i.e., manufactured) or naturally found chemicals that are not produced by organisms as a result of cellular metabolism (e.g., nerve agents or arsenic). (cdc.gov)

This agent has been developed for NAFLD management. (medscape.com)

Anatomy11

Organisms17

Diseases21

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Psychiatry and Psychology1

Phenomena and Processes44

Disciplines and Occupations6

Technology, Industry, Agriculture11

Information Science3

Health Care3

Diseases14

Dysfunction6

Disorders2

Outcomes6

Hypertension5

Diabetes4

Established cardiovascular disease1

Role in cardiovascular2

Biomarkers1

Quercetin1

Curcumin3

Patients8

Adverse5

Cardiac2

Tricyclic Antidepressants1

Endothelin2

Potential3

Commonly1

Inflammatory1

Chemical3

Derivatives1

Kidney disease3

Prophylactic2

Pathophysiology2

Dilemma1

Mechanisms1

Perspectives1

Arrhythmias2

Renal1

Occur2

Symptoms2

Outcome1

Blood vessels1

Risk factors1

Therapy1

Treatment2

Therapies1

Cancer1

Drugs1

Beneficial1

Prevention1

Temporal1

Cellular1

Management1