• Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
  • We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
  • The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
  • So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
  • However, clinical trials of these agents for cardiovascular diseases were hardly approved to carry out, even less to evaluate their clinical effectiveness and safety. (frontiersin.org)
  • Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
  • Research shows that cancer survivors are more likely to face heart and other cardiovascular diseases. (worldclasshealthcare.ca)
  • 2. One of the reasons for increased cardiovascular diseases (CVDs) worldwide is the increase in aged populations. (who.int)
  • The most important cardiovascular diseases (CVDs) in the African Region are those related to atherosclerosis, cardiomyopathies and rheumatic heart disease. (who.int)
  • 5. The WHO STEPwise approach to surveillance of noncommunicable diseases in general and cardiovascular disease in particular (otherwise known as STEPS) is based on community evaluation of eight risk factors (see Figure 1). (who.int)
  • Their concentration increases specifically and differently during various pathological states, including cardiovascular diseases ( table 1 ) [ 8 ]. (ersjournals.com)
  • Prolonged stress can increase the risk of cardiovascular diseases like heart disease and stroke. (fitelo.co)
  • ABSTRACT Associations of oral diseases with noncommunicable diseases such as diabetes, cardiovascular diseases, chronic respiratory diseases, osteoporosis and chronic renal failure are widely reported in the literature from developed countries. (who.int)
  • In fact, the last decade has been rich in illustrating the possible roles played by apelin in human physiology, namely as a regulating peptide of cardiovascular, hypothalamus-hypophysis, gastrointestinal, and immune systems. (nih.gov)
  • Ablation of the gly96/IEX-1 gene results in hypertension and cardiac hypertrophy, suggesting a novel role for this gene in cardiovascular physiology. (elsevierpure.com)
  • Our results clearly show that age and sex-dependent changes were both apparent in key proteins linked to cardiovascular physiology. (elsevierpure.com)
  • Despite the extensive use of genetically altered mice to study cardiovascular physiology and pathology, it remains difficult to quantify arterial function noninvasively in vivo. (houstonmethodist.org)
  • The first is improved management of cardiovascular risks, such as hypertension, high cholesterol, and smoking. (harvardmagazine.com)
  • A strong possibility, however, is that hypertension and other cardiovascular complications might damage small blood vessels leading to the brain, which he calls "a very strong predictor of dementia" because the resulting chronic decreased blood flow within the brain can lead to the death of neurons. (harvardmagazine.com)
  • OSA is a risk factor for cardiovascular disorders including hypertension, congestive heart failure (CHF), myocardial ischemia, arrhythmias and infarction, and cerebrovascular conditions including stroke [ 3 ]. (hindawi.com)
  • This may clinically manifest by an increased risk of cardiovascular incidents, hypertension, and reduced exercise tolerance. (ox.ac.uk)
  • The focus of my research has been on hypertension and cardiovascular disease, where there have been documented associations between occupational stress and cardiovascular disease. (cdc.gov)
  • Au total, 2 462 sujets ont fait l'objet d'une mesure ambulatoire de la pression artérielle, en raison d'une hypertension légère (groupe 1), aux fins de l'évaluation d'un traitement antihypertenseur (groupe 2), ou en raison d'une hypotension (groupe 3). (who.int)
  • Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control. (ox.ac.uk)
  • The role of the PAG in cardiovascular control in humans, with reference to electrical stimulation experiments, is also described. (ox.ac.uk)
  • Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts. (wakehealth.edu)
  • Exercise also affects other physiological and cardiovascular functions, such as blood pressure, blood loss and other metabolic processes. (ibexfilms.co.uk)
  • Dr. Sean Virani, a VGH cardiologist has a vision of creating a new Cardiovascular-Oncology Clinic which would be the first of its kind in Western Canada and only the second in Canada to focus on the unique challenges of cancer patients facing cardiac problems. (worldclasshealthcare.ca)
  • However, right cardiac sympathetic nerve stimulation elevated all cardiovascular parameters in the presence of raised [K+]a and offset the negative cardiac effects of hyperkalaemia. (ox.ac.uk)
  • Electrical pacing of the right atrium to heart rates (HRs) equivalent to those observed during right cardiac sympathetic nerve stimulation did not offset the depressive effects of hyperkalaemia and, indeed, hastened the decline in cardiovascular performance. (ox.ac.uk)
  • All the possible reasons, including the unobvious erectile dysfunction triggers, can be divided into two groups: psychological and physiological. (best-price-viagra-online.com)
  • Sometimes, a combination of psychological and physiological issues leads to weak erection, too. (best-price-viagra-online.com)
  • Psychosocial factors, such as stress and threat, can cause both psychological and physiological outcomes. (cdc.gov)
  • Cardiovascular disease is the number one killer of women in Canada. (worldclasshealthcare.ca)
  • It is well-documented that abnormally high levels of IGF-1, seen in acromegaly, are associated with higher mortality and a higher prevalence of cancer and cardiovascular disease. (brinkzone.com)
  • If low IGF-1 levels are associated with an increased risk of developing cardiovascular disease and high IGF-1 levels are associated with an increased risk of developing cancer, there might be an optimal set point for the GH/IGF-1 axis associated with increased longevity. (brinkzone.com)
  • A notable study investigated the relationship between IGF-1 levels and all-cause/cause-specific mortality, cardiovascular disease and cancer, in a national representative sample of community-dwelling older persons over 65 years of age. (brinkzone.com)
  • This study found no significant associations were found between IGF-1 levels and nonfatal cardiovascular disease and fatal and nonfatal cancer. (brinkzone.com)
  • 1. The burden of cardiovascular disease is increasing rapidly in Africa, and it is now a public health problem throughout the African Region. (who.int)
  • Cardiovascular disease has a major socioeconomic impact on individuals, families and societies in terms of health-care costs, absenteeism and national productivity. (who.int)
  • The Cardiovascular Health Study (CHS), a population-based prospective cohort study, has been used to identify major risk factors associated with cardiovascular disease and stroke in the elderly. (johnshopkins.edu)
  • Preventing disease in the 21st century: early breast milk exposure and later cardiovascular health in premature infants. (ox.ac.uk)
  • In this review article, we discuss the role of breast milk in preventing early adulthood cardiovascular disease in infants born premature. (ox.ac.uk)
  • Furthermore, we aim to demonstrate the vital role of early breast milk exposure in preventing cardiovascular disease in preterm infants. (ox.ac.uk)
  • Stress may also contribute to various physical illnesses such as cardiovascular disease.Stress builds up in an individual over time. (knowledgehut.com)
  • To assess their roles, we investigated the distribution of their receptors, CysLT(1) and CysLT(2), in the cardiovascular system. (nih.gov)
  • This is the first report on the physiological role of CysLT(2), and the findings suggest that CysLT(2) has biological significance in the cardiovascular system. (nih.gov)
  • The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. (frontiersin.org)
  • Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
  • In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)
  • Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
  • It has also been used to evaluate the impact of manipulative therapeutics and body position on autonomic regulation of the cardiovascular system. (biomedcentral.com)
  • Biological actions and events that support the functions of the CARDIOVASCULAR SYSTEM. (bvsalud.org)
  • The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM. (ouhsc.edu)
  • When the heart rate does not stay elevated, the work done by the cardiovascular system is not as efficiently done, muscle building drugs legal. (ibexfilms.co.uk)
  • The literature has already demonstrated that auditory stimulation with music influences the cardiovascular system. (bvsalud.org)
  • Cardiovascular Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • B. Examination by physician A physician performed and recorded the results of a medical examination giving special attention to specified findings related to nutrition, to hearing, to the thyroid gland,and to the cardiovascular, respiratory, neurological and musculoskeletal systems. (cdc.gov)
  • This proactive response, termed "anomalous preemptive activity," defies conventional biological understanding, facilitating the prediction of ensuing physiological shifts. (anomalien.com)
  • Exploring the nuances of estrogen's role is crucial in comprehending the physiological shifts during menopause. (rollingout.com)
  • Another reason is exposure to behavioural and physiological risk factors (Figure 1) which are responsible for 75% of CVDs.1 These risk factors have been prioritized according to their impact on mortality and morbidity, possibility of modification through primary prevention, and quantification by available easy standardized methods. (who.int)
  • In this context it is important to understand some basics about stress and stress management.Stress is the "psychological, physiological and behavioural response by an individual when they perceive a lack of equilibrium between the demands placed upon them and their ability to meet those demands, which, over a period of time, leads to ill-health" (Palmer, 1989).Stress is a process, not a diagnosis. (knowledgehut.com)
  • it also allowed the development of complex physiological responses. (nobelprize.org)
  • Anxiety is often observed in dental procedures and may cause promote alteration in the physiological responses during implant surgeries. (bvsalud.org)
  • To the best of our knowledge, there are no studies assessing the influence of the clinical environment on cardiovascular responses to dental procedures. (bvsalud.org)
  • In high performance athletes who exercise more than an hour a day, distinct cardiovascular physiological change can occur. (worldclasshealthcare.ca)
  • In normal physiologic sleep, distinct sleep stage-related changes occur in cardiovascular regulation. (hindawi.com)
  • Our studies have shown that changes occur in this region during anticipation of exercise, indicating a possible role in the central command of cardiovascular variables before and during exercise. (ox.ac.uk)
  • In your early 40's, many physiological events occur that can be detrimental to your health: decreased metabolism, changing hormones, a decrease in bone density, and a loss of lean muscle tissue. (todddurkin.com)
  • Beyond reproductive changes, menopause significantly influences cardiovascular health. (rollingout.com)
  • Birru MS, Matthews KA, Thurston RC, Brooks MM, Ibrahim S, Barinas-Mitchell E, Janssen I, Sutton-Tyrrell K. African-American ethnicity and cardiovascular risk factors are related to aortic pulse-wave velocity progression. (rush.edu)
  • Instead, he offers two main hypotheses to explain the phenomenon, both focusing on environmental factors. (harvardmagazine.com)
  • The physiological mechanism relating cardiovascular risk factors to dementia, he says, "is not altogether clear. (harvardmagazine.com)
  • Vascularity is a physiological phenomenon where veins become more visible due to factors like reduced body fat and increased blood circulation, often resulting in a more defined and vascular appearance. (outlookindia.com)
  • His major areas of research are the cardiovascular effects of occupational stress and the social and organizational factors that play a role in indoor air quality problems. (cdc.gov)
  • These are physiological effects from psychosocial factors. (cdc.gov)
  • We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
  • Further studies are necessary to add new elements in the literature to improve new therapies to treat cardiovascular disorders. (bvsalud.org)
  • Nucleus tractus solitarius (NTS) is the central integration hub for afferents from upper airway (somatosensory/gustatory), respiratory, gastrointestinal, cardiovascular (baroreceptor and chemoreceptor) and other systems. (hindawi.com)
  • A more than 2-fold increased risk of cardiovascular mortality was found for both low-normal (239% increased risk) and high-normal (203 % increased risk) IGF-1 levels. (brinkzone.com)
  • It is interesting that having low-normal IGF-1 levels impose a greater risk of all-cause mortality and cardiovascular mortality than having high-normal IGF-1 levels. (brinkzone.com)
  • DATA EXTRACTION: Outcomes were measures of physical activity (self-reported and objectively measured) and cardiovascular fitness. (ox.ac.uk)
  • Today, I am going to be talking about stress as a phenomenon that includes both physical and psychological outcomes. (cdc.gov)
  • 10 (2008) analyzed dental anxiety (Corah's Dental Anxiety) in 180 patients who underwent tooth extraction under local anesthesia in the mandible and reported anxiety with cardiovascular alterations. (bvsalud.org)
  • They reported that the cardiovascular alterations were similar among the different anesthetic drugs, but the cardiovascular parameters were influenced by the phase of the dental treatment. (bvsalud.org)
  • Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
  • We explore the emerging evidence and examine the possible mechanistic pathways mediating this phenomenon. (ox.ac.uk)
  • 3. An important phenomenon of CVD in developing countries is the trend of complications occurring at younger ages. (who.int)
  • Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. (elsevierpure.com)
  • Infusion of noradrenaline (1 microgram kg min-1 i.v.) during hyperkalaemia caused an increase in all cardiovascular parameters similar to that seen during sympathetic nerve stimulation. (ox.ac.uk)
  • The anxiety scale was applied before anesthesia, and cardiovascular parameters (i.e. (bvsalud.org)
  • The cardiovascular parameters were higher before the beginning of treatment and before local anesthesia, during the test of pulp vitality after anesthesia, during the procedure itself and at the end of treatment. (bvsalud.org)
  • It may be assumed that anxiety had an effect on these cardiovascular parameters during the root filling treatment. (bvsalud.org)
  • Vascularity supplements, also known as vein supplements, are like your secret weapon for boosting blood flow, promoting nitric oxide production, and improving cardiovascular health. (outlookindia.com)
  • Cardiovascular health of premature infants reaching early adulthood is an area of ongoing research. (ox.ac.uk)
  • Recent evidence suggests that early exposure to breast milk slows down or even arrests those pathophysiological changes, thereby mitigating the long-term adverse effects of premature birth on cardiovascular health. (ox.ac.uk)
  • These differences should be considered when autonomic regulation of cardiovascular function is studied in different postures. (biomedcentral.com)
  • There are many aspects to consider regarding the etiology and diagnosis of SD, and the literature on osteopathic issues provides details on physiological signs that characterize it, including tissue texture changes. (mdpi.com)
  • Stress in today's world has become an omnipresent phenomenon in every one's lives. (knowledgehut.com)
  • Prioritizing various aspects of one's life such as family, friends, finance, work and personal things, with clarity and conviction goes a long way in reducing stress.The organizations and employers also need to recognize this phenomenon and do their bit to help their employees manage stress effectively. (knowledgehut.com)
  • Considering the importance of cardiovascular function in surgical trauma 11 , the objective of the present study was to evaluate BP and HR in two different dental settings in patients who underwent dental implant surgery or a related procedure. (bvsalud.org)