In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP 2 ) binding domains, or the entire C terminus, was without effect on the forskolin response, but the latter conferred responsiveness to arginine-vasopressin (an inhibitory PKC-dependent response). (aspetjournals.org)
Asthma is an immune-mediated inflammatory condition characterized by increased responsiveness to bronchoconstrictor stimuli. (bvsalud.org)
Doses2
Albuterol has been shown in most clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. (drugcentral.org)
Hyperreactivity in this context means a bronchoconstrictor response at "doses" that normally have no bronchoconstrictor effect. (isanagpur.org)
Disorders2
Use with caution in patients with underlying cardiovascular disorders. (nih.gov)
Use with caution in patients sensitive to sympathomimetic drugs and patients with cardiovascular or convulsive disorders. (nih.gov)
Effect2
Monoamine oxidase inhibitors (MAOs) or tricyclic antidepressants: May potentiate effect of albuterol on the cardiovascular system. (nih.gov)
Controlled clinical studies and other clinical experience have shown that inhaled albuterol, like other beta-adrenergic agonist drugs, can produce a significant cardiovascular effect in some patients, as measured by pulse rate, blood pressure, symptoms, and/or electrocardiographic changes. (guidelinecentral.com)
Patients1
The exaggerated responses of patients with airway disease have been ascribed to numerous factors like reduced resting airway caliber, presence of mucosal edema and inflammation and the volume of airway secretions. (isanagpur.org)
See WARNINGS, Cardiovascular Effects section. (drugcentral.org)
These compounds were stated to have anti-inflammatory, anti-serotonergic, anti-histamine and cardiovascular effects, while certain intermediates in their preparation were also pharmacologically active. (justia.com)
Bronchial asthma1
It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (lookformedical.com)
Tissue1
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
Airway3
The explanation is that relaxation of airway smooth muscle as a response to inhaled ß 2 -agonists is easier to demonstrate in a situation of contractile agonist-induced bronchomotor tone. (medscape.com)
Levalbuterol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved, thus protecting against all bronchoconstrictor challenges. (nih.gov)
For example, when an individual with asthma inhales a substance such as animal dander, the usual response is a narrowing of the airway, caused by the constriction of the smooth muscles surrounding the airway. (co.ke)
Physical1
The office visit rate in exaggerated broncho-constrictor the Northeast was almost 2.5 times that in the South, although the prevalence of response to many physical changes and chemical and pharmacologic agents. (cdc.gov)
Sensitive1
Unlike to other studies, however, we have measured the ß 2 -response after methacholine-induced bronchoconstriction, which is a more sensitive method to measure functional impairment of ß 2 -receptors. (medscape.com)