AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Cardiovascular SystemCardiovascular DiseasesShock, SepticBlood PressureVasodilationHeartEndothelium, VascularDiabetes Mellitus, ExperimentalHeart RateHemodynamicsNitric OxideRats, WistarMyocardiumErectile DysfunctionVentricular Dysfunction, LeftVentricular DysfunctionSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalVentricular Dysfunction, RightDisease Models, AnimalOxidative StressPrimary Graft DysfunctionPenile ErectionDiastoleAutonomic Nervous System DiseasesMitochondriaTime FactorsHeart FailureMyocardial ContractionEchocardiographyMultiple Organ FailureCardiomyopathiesVasodilator AgentsImpotence, VasculogenicMitochondrial DiseasesMice, Inbred C57BLCognition DisordersSystoleBiological MarkersVentricular Function, LeftPenisStroke VolumeReactive Oxygen SpeciesRats, Sprague-DawleyHeart Failure, DiastolicNitric Oxide Synthase Type IIIKidney DiseasesTreatment OutcomeSeverity of Illness IndexRisk FactorsProspective StudiesVascular DiseasesMice, KnockoutVentricular RemodelingAcetylcholineEchocardiography, DopplerCase-Control StudiesAgingMice, TransgenicAnalysis of VarianceBrainMyocytes, CardiacCells, CulturedSulfonesSphincter of Oddi DysfunctionNeuropsychological TestsHeart DiseasesEndothelial CellsMicrocirculationFollow-Up StudiesHypertensionChronic DiseaseKidneyDose-Response Relationship, DrugSignal TransductionBrachial ArteryNatriuretic Peptide, BrainMagnetic Resonance ImagingSepsisSuperoxidesPhosphodiesterase 5 InhibitorsNitroprussideApoptosisCoronary CirculationInflammationRetrospective StudiesHeart VentriclesRenal InsufficiencyPredictive Value of TestsMembrane Potential, MitochondrialNitric Oxide SynthaseFibrosisAntioxidantsDiabetes Mellitus, Type 2CreatinineThyroid DiseasesCardiomyopathy, DilatedMyocardial IschemiaPurinesPosterior Tibial Tendon Dysfunction
Modeling cardiomyMicrovascular dysfunctionVascularHypertensionSexual dysfunctionIndicating severeAtherosclerosisErectile Dysfunction and Cardiovascular DiseaseAssociated with endothelial dysfunctionAutonomicDiastolic dysfunctionMyocardial dysfunctionHistory of cardiovascular diseasePredictor of cardiovascularContribute to endothelial dysfunctionDisease and erectile dysfunctionMetabolicLeft ventricular dysfunctionSymptomsDiabetesSystemicMicrocirculatorySedentary lifestyleCardiac dysfunctionOxidativeTreatment of erectile dysfunctionObservationalTreat Erectile DysfunctionNitricMortalityEndothelial cellUrologyCoronary arteryInflammationSevere erectile dysfunctionRelated to coronaryAtrialKidney dysfunctionErectionRisk factorsSepsisPathophysiologyPrevalencePatients with severeMultiorganOrgan dysfunctionExtracellular matrixMajor cardiovascularEvidencePsychologicalRenalAssessmentVivo
Modeling cardiomy1
Microvascular dysfunction5
  • Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation. (insidescientific.com)
  • In this webinar, Dr. Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underly ischemic events and the need for appropriate animal models for optimal translation. (insidescientific.com)
  • Aims: Coronary microvascular dysfunction (CMD) has been proposed as an important pathophysiological mechanism in Takotsubo syndrome (TTS). (lu.se)
  • Conclusions: Coronary microvascular dysfunction is common in patients with TTS and more frequent than in patients with INOCA. (lu.se)
  • Invasive coronary angiography may identify up to 60% of patients with nonobstructive coronary artery disease (CAD), of whom nearly two-thirds may, in fact, have coronary microvascular dysfunction (CMD) that may account for their symptoms. (mssm.edu)
Vascular14
  • The combined findings highlight that αCGRP protects against cardiovascular dysfunction, signaling via the canonical CGRP receptor and acting when nitric oxide production is lost, such as in endothelial dysfunction associated with vascular disease. (kcl.ac.uk)
  • Diabetics seeking diabetes refinement therapy were screened for vascular or neurogenic erectile dysfunction which was confirmed in 43 patients. (biomedcentral.com)
  • Only patients with vascular or neurogenic erectile dysfunction were included. (biomedcentral.com)
  • Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidence that mitochondrial dysfunction may be a relevant intermediate mechanism by which cardiovascular risk factors lead to the formation of vascular lesions. (biomedcentral.com)
  • The mitochondrial dysfunction theory postulates that excess release of ROS and RNS from mitochondria can contribute to the inflammatory vascular reaction leading to the development of atherosclerotic lesions [ 17 , 18 ]. (biomedcentral.com)
  • In fact, increased mitochondrial ROS production causes endothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation and apoptosis of VSMCs and macrophages, with ensuing ATS lesion progression and possible plaque rupture [ 18 ]. (biomedcentral.com)
  • This review will discuss the molecular mechanisms by which atherosclerotic risk factors could lead to mitochondrial dysfunction and subsequent vascular impairment. (biomedcentral.com)
  • Recent studies suggest that erectile dysfunction could be considered a potential marker for underlying silent cardiac or vascular disease processes. (mssm.edu)
  • With the initiation in 1998 of vasoactive drugs such as the phosphodiesterases inhibitors for the treatment of erectile dysfunction, the underlying vascular components of erectile dysfunction have become a more prominent focus of attention in the clinical and research setting. (mssm.edu)
  • In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. (wikipedia.org)
  • Endothelial dysfunction may be involved in the development of atherosclerosis and may predate vascular pathology. (wikipedia.org)
  • The lack of NO production can lead to high blood pressure, sexual dysfunction, and chronic inflammatory vascular disease leading to heart attack, stroke, or heart failure," explains a report from The Epoch Times that cites Bryan's work. (newstarget.com)
  • Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction. (cdc.gov)
  • The peptide fraction was then found bioactive, producing endothelial cell inflammation and vascular dysfunction ex vivo akin to that induced with whole serum. (cdc.gov)
Hypertension8
Sexual dysfunction6
  • Erectile dysfunction (ED) is a common type of male sexual dysfunction. (medlineplus.gov)
  • Erectile dysfunction is often an indicator for a number of medical issues, so it's vital that anyone experiencing sexual dysfunction talk to a doctor, especially if a family history of heart disease or any other serious illness exists. (urologyhealthstore.com)
  • Endothelial dysfunction seems to play a major role in both sexual dysfunction and heart disease. (mssm.edu)
  • Erectile dysfunction (ED) is the most common male sexual dysfunction, and shares many risk factors with systemic conditions including cardiovascular disease (CVD) and the metabolic syndrome (MetS). (medscape.com)
  • Erectile dysfunction (ED) is the most frequently treated sexual dysfunction in men worldwide, and is defined as the recurrent or consistent inability to obtain and/or maintain an erection sufficient for satisfactory sexual performance. (medscape.com)
  • How Is Antidepressant-Associated Sexual Dysfunction Managed? (medscape.com)
Indicating severe1
Atherosclerosis2
  • In the TTS patients, left ventricular function was assessed with echocardiography and cardiovascular magnetic resonance (CMR) imaging, and coronary atherosclerosis was visualized with intravascular ultrasound with near-infrared spectroscopy (IVUS-NIRS). (lu.se)
  • Although subclinical hypothyroidism (SCH) is associated with cardiovascular risk, there is scarce data about subclinical atherosclerosis in subjects with SCH. (nih.gov)
Erectile Dysfunction and Cardiovascular Disease1
Associated with endothelial dysfunction1
  • Here we show the ability of endogenous and exogenous CGRP to restore blood pressure, when nitric oxide synthesis is blocked, in a model of cardiovascular disease associated with endothelial dysfunction and impaired nitric oxide production. (kcl.ac.uk)
Autonomic7
  • Autonomic dysfunction can occur even in the early stages of PD, often preceding the onset of the classic motor symptoms of PD. (bmj.com)
  • Detection of autonomic dysfunction may therefore be helpful in diagnosing PD in the early or pre-motor stages, and/or in differentiating it from other parkinsonian disorders, such as multiple system atrophy and progressive supuranuclear palsy. (bmj.com)
  • The aim of this review is to describe aspects of autonomic dysfunction, including symptoms, assessment and pathophysiology, resulting from autonomic impairment in PD and other parkinsonian syndromes. (bmj.com)
  • Non-motor features of Parkinson's disease (PD) are increasingly being defined and include dysfunction of the autonomic nervous system. (bmj.com)
  • Autonomic dysfunction was previously reported in the advanced stage of PD but recent evidence suggests it may occur even in the early stage of PD, independent of medication. (bmj.com)
  • 2 These lesions may result in autonomic dysfunction. (bmj.com)
  • The non-dipping phenomenon is closely related to a high incidence of CV diseases, a poor long-term survival and profound autonomic dysfunction. (fujita-hu.ac.jp)
Diastolic dysfunction3
  • In response to injury, myocardial fibroblasts show abnormal activation and secrete excessive extracellular matrix, resulting in chamber wall stiffness and diastolic dysfunction [ 5 ]. (hindawi.com)
  • Doppler echocardiographic (Echo) measurements of the mitral and pulmonary venous flow have been used to assess diastolic dysfunction (DD). (biomedcentral.com)
  • Ve-CMR maybe useful for the assessment of diastolic dysfunction. (biomedcentral.com)
Myocardial dysfunction3
  • Myocardial dysfunction in hypertrophic cardiomyopathy. (ox.ac.uk)
  • Strain rate imaging after dynamic stress provides objective evidence of persistent regional myocardial dysfunction in ischaemic myocardium: regional stunning identified? (bmj.com)
  • Myocardial dysfunction is a common complication in patients with severe sepsis, and early recognition and aggressive supportive therapy are mandatory as mortality in patients with septic shock is still high. (hindawi.com)
History of cardiovascular disease2
  • METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. (ox.ac.uk)
  • We excluded individuals using medications that affect thyroid function and those with a history of cardiovascular disease. (nih.gov)
Predictor of cardiovascular2
  • however, it is less commonly discussed or advertised that ED may be a predictor of cardiovascular disease (e.g. heart attacks and strokes). (doctorblick.com)
  • 26 remained an independent predictor of cardiovascular event risk at 180 days when adjusted for the Seattle Heart Failure Model Score and the Charlson comorbidity index (hazard ratio 1.7, 95% confidence interval 1.1 to 2.6, p = 0.03). (edu.au)
Contribute to endothelial dysfunction1
  • Going back to the endothelium, if the content of nitro oxide is too low, it will contribute to endothelial dysfunction. (urologyhealthstore.com)
Disease and erectile dysfunction2
Metabolic2
Left ventricular dysfunction6
  • 4. Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial / T. A. Holly, R. O. Bonow, J. M. Arnold [et al. (org.ua)
  • 5. Myocardial viability and survival in ischemic left ventricular dysfunction / R. O. Bonow, G. Maurer, K. L. Lee [et al. (org.ua)
  • 6. Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction / J. A. Panza, T. A. Holly, F. M. Asch [et al. (org.ua)
  • 7. Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass graft surgery or medical therapy: an analysis from the STICH trial (Surgical Treatment for Ischemic Heart Failure) / R. A. Stewart, D. Szalewska, L. She [et al. (org.ua)
  • 10. Revascularization in severe left ventricular dysfunction: outcome comparison of drug-eluting stent implantation versus coronary artery by-pass grafting / G. Gioia, W. Matthai, K. Gillin [et al. (org.ua)
  • 11. Kunadian V. Revascularization among patients with severe left ventricular dysfunction: a meta-analysis of observational studies / V. Kunadian, A. Zaman, W. Qiu // Eur. (org.ua)
Symptoms7
  • Many patients with sinus node dysfunction are asymptomatic, but depending on the heart rate, all the symptoms of bradycardias and tachycardias can occur. (msdmanuals.com)
  • That is why specialists recommend not to ignore symptoms of erectile dysfunction and go to a doctor in any case. (cialis-online-secure.com)
  • If you notice any symptoms of erectile dysfunction, don't hesitate to consult a specialist. (best-price-viagra-online.com)
  • What are the symptoms of erectile dysfunction? (clevelandclinic.org)
  • Describe cardiovascular symptoms and complications associated with post-COVID conditions. (cdc.gov)
  • Determine which clinical assessments and tests are needed for a patient with cardiovascular symptoms. (cdc.gov)
  • Today I'll present an overview of post-COVID conditions as an introduction of the main presentation on evaluating and supporting patients with cardiovascular symptoms and complications following COVID-19. (cdc.gov)
Diabetes6
  • Epidemiological research studies have revealed that the threat of establishing ED is related to numerous elements, consisting of age, weight problems, smoking cigarettes, and specific medical conditions such as diabetes and cardiovascular disease. (transatcasa.com)
  • Physical aspects that can add to ED include cardiovascular disease, diabetes, and neurological disorders. (transatcasa.com)
  • It is likewise important to keep in mind that ED can be a symptom of a hidden health condition, such as cardiovascular disease or diabetes. (transatcasa.com)
  • Patients who had diabetes less than 1 year, psychogenic erectile dysfunction, history of a myocardial infarction or significant coronary artery lesions, impaired systolic left ventricular function, right or left bundle block, or atrial fibrillation were not considered for the study. (biomedcentral.com)
  • CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function. (ox.ac.uk)
  • Diabetes also can be a risk factor for erectile dysfunction. (todaysdietitian.com)
Systemic1
  • Recent work has established the existence of an indirect process by which factors released from the lung into the circulation promote systemic inflammation and cellular dysfunction, particularly on the vasculature. (cdc.gov)
Microcirculatory3
  • Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study. (bvsalud.org)
  • We sought to identify patients with acutely reversible microcirculatory dysfunction using a low- dose topical nitroglycerin solution and handheld videomicroscopy during circulatory shock after cardiac surgery . (bvsalud.org)
  • To test whether microcirculatory dysfunction is acutely reversible during shock , the sublingual microcirculation was imaged with incident dark field microscopy before and after the application of 0.1 mL of a 1% nitroglycerin solution (1 mg/mL). (bvsalud.org)
Sedentary lifestyle1
Cardiac dysfunction2
  • This narrative paper attempts to review the literature on the importance of early recognition of cardiac dysfunction using echocardiography and biomarkers such as troponin and brain type natriuretic peptide. (bmj.com)
  • These tools may allow accurate assessment of cardiac dysfunction and guide therapy to improve outcome. (bmj.com)
Oxidative1
  • Age-related increases in protein acetylation were predominantly in mitochondrial pathways such as mitochondrial dysfunction, oxidative phosphorylation, and TCA cycle signaling. (springer.com)
Treatment of erectile dysfunction2
  • As of today, the most common treatment of erectile dysfunction involves lifestyle changes that are beneficial to the patient's overall health and sexual function. (frontiersin.org)
  • Although effective oral and injectable drugs have been introduced for the treatment of erectile dysfunction, these medications have not been demonstrated to restore natural erectile physiology, and in some cases these drugs are contraindicated, intolerable, expensive, or ineffective. (frontiersin.org)
Observational1
  • Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. (ox.ac.uk)
Treat Erectile Dysfunction2
Nitric3
  • Dysfunction in the endothelium is made worse by diminishing supplies of nitric oxide. (urologyhealthstore.com)
  • Are you deficient in nitric oxide, the most critical molecule for cardiovascular health? (newstarget.com)
  • One of the key components of cardiovascular health that many people overlook is a molecule called nitric oxide, or NO, which according to Nathan S. Bryan, PhD, is involved in virtually every organ system of the body. (newstarget.com)
Mortality5
  • Our goal was to evaluate the association between erectile dysfunction (ED) and risk of cardiovascular disease (CVD) and all-cause mortality by conducting a meta-analysis of prospective cohort studies. (qxmd.com)
  • This meta-analysis of prospective cohort studies suggests that ED significantly increases the risk of CVD, coronary heart disease, stroke, and all-cause mortality, and the increase is probably independent of conventional cardiovascular risk factors. (qxmd.com)
  • Lack of nocturnal blood pressure (BP) fall (non-dipping) is common among haemodialysis (HD) patients, but much less is known regarding its association with cardiovascular (CV) disease morbidity and mortality. (fujita-hu.ac.jp)
  • Higher consumption of fruit and vegetables is associated with a lower risk of all cause mortality, particularly cardiovascular mortality. (greenmedinfo.com)
  • Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. (medscape.com)
Endothelial cell1
  • The serum peptide fraction, having cell-surface receptor ligand properties, conveys peripheral bioactivity in promoting endothelial cell inflammation, vasodilatory dysfunction and inhibiting angiogenesis. (cdc.gov)
Urology1
Coronary artery1
Inflammation1
Severe erectile dysfunction1
Related to coronary1
  • It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. (ox.ac.uk)
Atrial2
  • David Barefield discusses his work investigating the role of the Myosin binding protein H-like (MyBP-HL) protein in atrial dysfunction. (insidescientific.com)
  • Sinus node dysfunction refers to a number of conditions causing physiologically inappropriate atrial rates. (msdmanuals.com)
Kidney dysfunction4
  • OBJECTIVE: Kidney dysfunction is a major complication in the postoperative cardiac surgery setting. (unesp.br)
  • The objective of this study was to identify the risk factors for developing kidney dysfunction in patients undergoing cardiac surgery. (unesp.br)
  • RESULTS: It was observed that intraoperative transfusion of fresh frozen plasma in the control group was 2.05 ± 0.78 units and 3.80 ± 2.16 units in the kidney dysfunction group with P= 0.032. (unesp.br)
  • CONCLUSION: It was possible to associate that fresh frozen plasma transfusion is a risk factor for postoperative kidney dysfunction after cardiovascular surgery. (unesp.br)
Erection4
  • Erectile Dysfunction (ED) is defined by the National Institutes of Health as the inability of a man to achieve and maintain a penile erection sufficient for sexual activity. (doctorblick.com)
  • Erectile dysfunction (ED) is the inability to get or maintain an erection long enough to have sexual intercourse. (clevelandclinic.org)
  • One in 10 men experiences erectile dysfunction, negatively affecting quality of life and potentially causing low self-esteem, stress, and anxiety.1-3 The Cleveland Clinic defines erectile dysfunction as "the inability to achieve and sustain an erection suitable for sexual intercourse. (todaysdietitian.com)
  • Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient to permit satisfactory sexual intercourse [1]. (who.int)
Risk factors7
  • Several cardiovascular risk factors are demonstrated causes of mitochondrial damage. (biomedcentral.com)
  • Common cardiovascular risk factors could be involved in this process by adversely affecting the function of endothelial mitochondria, and growing evidence supports the hypothesis that mitochondrial dysfunction may be the most important unifying mechanism explaining the atherogenic action of major cardiovascular risk factors [ 17 - 19 ]. (biomedcentral.com)
  • Conversely, if a patient presents with known heart disease or risk factors for cardiovascular disease, he should be questioned regarding his sexual health and ED. Many of these patients can benefit by receiving therapy for ED. (doctorblick.com)
  • Sensitivity analysis restricted to studies with control for conventional cardiovascular risk factors yielded similar results. (qxmd.com)
  • We performed logistic and linear regression models to evaluate the association with IMT (mean values and categorized at the 75th percentile) as a dependent variable and SCH as an independent variable, adjusted for other cardiovascular risk factors. (nih.gov)
  • This continuing education course explores specific lifestyle risk factors associated with erectile dysfunction and whether the condition can be improved by modifying them. (todaysdietitian.com)
  • This study aimed to determine the relationship between selected clinical risk factors and erectile dysfunction in men residing in upper Egypt. (who.int)
Sepsis4
  • MODS is defined as a clinical syndrome characterized by the development of progressive and potentially reversible physiologic dysfunction in 2 or more organs or organ systems that is induced by a variety of acute insults, including sepsis. (medscape.com)
  • The clinical process usually begins with infection, which potentially leads to sepsis and organ dysfunction. (medscape.com)
  • [ 4 ] The task force concluded that sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. (medscape.com)
  • A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. (medscape.com)
Pathophysiology1
  • This review critically examines the background, pathophysiology, and mechanisms behind erectile dysfunction and its close correlation to cardiovascular disease. (mssm.edu)
Prevalence4
Patients with severe1
Multiorgan1
  • Multiorgan dysfunction commonly occurs as part of the asphyxial episode, with cardiovascular dysfunction occurring in up to a third of infants. (bmj.com)
Organ dysfunction2
  • Alteration in organ function can vary widely from a mild degree of organ dysfunction to completely irreversible organ failure. (medscape.com)
  • The degree of organ dysfunction has a major clinical impact. (medscape.com)
Extracellular matrix1
  • A database search curated for known matrix protease substrates and predicted signaling motifs enabled identification of 73 MWCNT-responsive peptides, which were significantly associated with an abnormal cardiovascular phenotype, extracellular matrix organization, immune-inflammatory processes, cell receptor signaling, and a MWCNT-altered serum exosome population. (cdc.gov)
Major cardiovascular1
  • Life style modifications such as smoking cessation have also been shown to improve endothelial function and lower the risk of major cardiovascular events. (wikipedia.org)
Evidence1
  • Besides, the results of coronarography in patients with ICD with marked systolic dysfunction of LV gives evidence for LCA stem lesions with multivessels involvement of coronary arteries with predominant type C proximal level of lesion. (org.ua)
Psychological4
Renal4
  • OBJETIVO: A disfunção renal é uma complicação importante no cenário de pós-operatório de cirurgia cardiovascular. (unesp.br)
  • O objetivo deste estudo é identificar os fatores de risco na transfusão de sangue e derivados para o desenvolvimento de disfunção renal em pacientes submetidos à cirurgia cardiovascular. (unesp.br)
  • CONCLUSÃO: Foi possível associar, nesta série de pacientes, que a transfusão de plasma fresco congelado foi um fator de risco para disfunção renal pós-operatório de cirurgia cardiovascular. (unesp.br)
  • BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. (ox.ac.uk)
Assessment1
  • We sought to determine the influence of cognitive dysfunction, identified using the Montreal Cognitive Assessment (MoCA), on 180-day cardiovascular events. (edu.au)
Vivo2
  • These in vivo results support the proposal that CGRP provides a novel treatment for cardiovascular disease. (kcl.ac.uk)
  • Early endothelial dysfunction in cholesterol-fed rabbits: a non-invasive in vivo ultrasound study. (biomedcentral.com)