AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
Muscular Atrophy, SpinalReperfusion InjurySMN Complex ProteinsSurvival of Motor Neuron 1 ProteinCardiovascular DiseasesMyocardial Reperfusion InjuryIschemiaReperfusionSpinal CordRibonucleoproteins, Small NuclearMyocardial IschemiaMyocardial ReperfusionBrain IschemiaMotor NeuronsSpinal Cord InjuriesIschemic PreconditioningMyocardiumRats, Sprague-DawleyIschemic Preconditioning, MyocardialDisease Models, AnimalRats, WistarMyocardial InfarctionTime FactorsRisk FactorsCardiotonic AgentsIschemic PostconditioningWarm IschemiaSpinal Cord IschemiaPeroxidaseOxidative StressHeartMyocytes, CardiacMice, Inbred C57BLMalondialdehydeCold IschemiaProtective AgentsIschemic Attack, TransientBlood PressureApoptosisInjections, SpinalNeuroprotective AgentsAntioxidantsInfarction, Middle Cerebral ArteryKidneyBiological MarkersPerfusionSpinal NervesMitochondria, HeartCoronary CirculationNecrosisSpinal Cord DiseasesHemodynamicsRandom AllocationAnesthesia, SpinalL-Lactate DehydrogenaseReactive Oxygen SpeciesCreatine KinaseNitric OxideMice, KnockoutConstrictionMyocardial ContractionSuperoxide DismutaseInflammationSpinal Nerve RootsCoronary DiseaseSpinal Cord NeoplasmsCytoprotectionSpinal CanalHindlimbLiverProspective StudiesModels, AnimalSpinal DiseasesSpinal Cord CompressionDogsNeutrophil InfiltrationSignal TransductionHypertensionSpinal NeoplasmsEndothelium, VascularTioproninVentricular Function, LeftFollow-Up StudiesMyocardial StunningGerbillinaeStrokeFree Radical ScavengersMicrocirculationCohort StudiesImmunohistochemistryOrgan PreservationRabbitsRisk AssessmentBrainAspartate AminotransferasesRecovery of FunctionAtherosclerosisEnzyme InhibitorsCerebral InfarctionCells, Cultured
InjuryParkinson'sHypoxiaInflammationIschemicAlzheimer'sCancerCardiacNeurodegenerativeHeartPreventionDiabetes mellitusMechanismsDegenerative diseasesInvasiveSystemicArterialExperimentalEffectsTherapeuticConsumptionDisordersCentral nervouAorticNeuromuscularTherapiesProgressionFunctionalTherapyMechanismOrganResearchRolesBrainInfluencesFunctionGeneticSystemBloodMeSH
Injury10
  • Therefore, it is speculated that astaxanthin can reduce the oxidation of apolipoprotein and can be used to prevent atherosclerosis, coronary heart disease and ischemic brain injury.D. Enhancing immunity astaxanthin can significantly affect the immune function of animals. (rainwoodbio.com)
  • Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury. (duke.edu)
  • Traumatic Spinal Cord Injury is a prevalent problem that affects millions of people world-wide. (anova-irm.com)
  • The combination of Stem Cell Therapy with neuromuscular feedback training with HAL may advance success rates in patients with Spinal Cord Injury. (anova-irm.com)
  • Spinal Cord Injury (SCI) is affecting 40 to 80 million people every year 1 . (anova-irm.com)
  • CBD protects against pathological T-cell invasion after spinal cord injury in the laboratory. (healthneu.com)
  • 5) Previous reports have described the utility of "visceral branch-first techniques" in reducing visceral ischemic time with minimal reperfusion injury. (authorea.com)
  • This may minimize the risk or degree of ischemia-reperfusion injury even if no selective organ perfusion was applied. (authorea.com)
  • The preclinical work focuses on animal models of myocardial ischemia-reperfusion injury, which is an experimental model for STEMI, as well as ex-vivo models of myocardial ischemia. (gu.se)
  • N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
Parkinson's3
  • Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. (molecularhydrogenstudies.com)
  • Improving memory- "Researchers at China's Tangdu Hospital think that jiaogulan gypenosides may offer some protection from oxidative stress in the brain that leads to Parkinson's disease. (thischickisraw.com)
  • In the May-June 2010 issue of the Journal of International Medical Research, the scientists reported that the introduction of gypenosides to mouse brains chemically induced to mimic the symptoms of the disease resulted in an increase in glutathione output and superoxide dismutase activity in the substantia nigra, the area of the brain most impacted by Parkinson's disease. (thischickisraw.com)
Hypoxia4
  • Intrauterine hypoxia can cause cellular damage that occurs within the central nervous system (the brain and spinal cord). (wikipedia.org)
  • Utero-placental hypoxia is associated with abnormal placental implantation, impaired vascular remodeling and vascular diseases. (wikipedia.org)
  • Background: Ischemic stroke (IS) is one of the most common serious secondary diseases of atrial fibrillation (AF) within 1 year after its occurrence, both of which have manifestations of ischemia and hypoxia of the small vessels in the early phase of the condition. (bvsalud.org)
  • Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)
Inflammation2
  • Whilst it is often thought that the mechanical forces to the spinal cord at the time of the accident are responsible for most of the functional deficits, much of the damage actually occurs after the initial trauma by different pathophysiological processes such as neuronal death by apoptosis and necrosis, inflammation, dysfunction of the blood-brain barrier, ionic dysregulation, lipid peroxidation and the generation of free radicals. (anova-irm.com)
  • H 2 S has been described to participate in several physiological processes, such as neurotransmission, inflammation and immune reactions, gastrointestinal function, cancer development, and cardiovascular responses [ 20 , 28 , 29 ]. (hindawi.com)
Ischemic1
  • Leonurus heterophyllus sweet has demonstrated pharmacological effects on ischemic diseases in experimental and clinical studies, with improved coronary blood flow, platelet aggregation, and improved heart function [ 8 ]. (biomedcentral.com)
Alzheimer's1
  • Astaxanthin protects the skin and eyes against radiation, cardiovascular aging, Alzheimer's disease and cancer.Astaxanthin has 550 times the antioxidant capacity of vitamin E and 10 times the antioxidant capacity of beta carotene. (rainwoodbio.com)
Cancer4
  • In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. (nature.com)
  • All this in conjunction can contribute to the generation or aggravation of many diseases, such as cancer, diabetes, Parkinson and so on. (psychosocialsomatic.com)
  • It's quickly becoming about what's happening on the inside as more and more scientific literature comes out linking those extra pounds to diabetes, heart disease, cancer, and more. (pursueahealthyyou.com)
  • Additional anti-inflammatory and antioxidant properties offer promise in fighting atherosclerosis, diabetes, cancer, neurodegenerative diseases, and even arthritis. (olives101.com)
Cardiac2
  • Despite recent findings regarding the functional implications of TRPM4 in cardiac diseases, the molecular and cellular mechanisms leading to altered conduction are poorly understood. (frontiersin.org)
  • reveals a relative underutilization of heart donors with cardiovascular mechanism of brain death which provide similar long-term survival as donors with other mechanisms of brain death, highlighting the potential role of these donors to provide life saving cardiac allografts and mitigate the persistent shortage of hearts for transplantation. (authorea.com)
Neurodegenerative1
  • Ohno K, Ito M, Ichihara M, Ito M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. (molecularhydrogenstudies.com)
Heart4
  • It can also be caused by maternal respiratory conditions (such as asthma), cardiovascular conditions (such as heart failure, pulmonary hypertension, and cyanotic heart disease), and hematological conditions (such as anemia). (wikipedia.org)
  • In recent years various techniques have been inspired and refined to reduce the duration and risk of visceral ischemia such as mild, moderate, or deep hypothermic repair with left heart bypass, or complete or partial cardiopulmonary bypass combined with selective perfusions to vital viscera, the lower extremities and the spinal cord. (authorea.com)
  • Our research has pioneered significant pre and early symptomatic defects in the cardiovascular system, where the heart, blood vessels and circulating cells are all defective in SMA. (abdn.ac.uk)
  • According to the literature there are protective effects against coronary heart disease. (healthjade.com)
Prevention2
  • The MedDiet is suggested as the prevalent dietary regimen and is strongly correlated with prevention of degenerative diseases and longevity. (researchgate.net)
  • prevalent dietary regimen and is strongly correlated with prevention of degener ative diseases and longevity. (researchgate.net)
Diabetes mellitus2
Mechanisms4
  • The greater promise is that with this understanding, the ECS will yield insights into the mechanisms of health and disease and provide important new therapeutic options. (medscape.com)
  • Whilst immensely complex, the mechanisms involved in spinal cord repair are now increasingly better understood. (anova-irm.com)
  • Further investigation into this exciting field promises to shed insights into the mechanisms of health and disease and provide new therapeutic options. (medscape.com)
  • Multiple mechanisms have been proposed to explain how lead intoxication impairs the cardiovascular system and leads to hypertension. (hindawi.com)
Degenerative diseases1
  • This, in turn, may lead the body to the occurrence of many chronic degenerative diseases. (psychosocialsomatic.com)
Invasive2
  • 4) These results can be attributed to the nature of open surgical repair of TAAA, which represents the pinnacle of invasive cardiovascular surgery and comes with the burden of a relatively high association of comorbidities.Estrera and colleagues reported the "distal first approach" assumes the advantage of providing a distal fenestration and ensuring adequate antegrade blood flow at an early stage for patients with chronic aortic dissection. (authorea.com)
  • The clinical unit of the Research lab is closely integrated with the Cardiology department's research infrastructure, which includes facilities for invasive and non-invasive evaluation of cardiovascular function. (gu.se)
Systemic1
  • There is an increasing appreciation that this is not a classical motor neurone disease, but rather a systemic disease in which motor neurones are either most vulnerable or that defects in them are most clinically relevant. (abdn.ac.uk)
Arterial1
  • Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (rush.edu)
Experimental1
Effects5
  • Although taurine is considered a conditionally essential nutrient for humans and is thought to play a key role in several human diseases, clinical studies evaluating the effects of taurine are limited. (researchgate.net)
  • At the cardiovascular level, they concluded that 'if there are any interactions between caffeine and taurine, taurine might reduce the cardiovascular effects of caffeine. (researchgate.net)
  • Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. (molecularhydrogenstudies.com)
  • Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease. (molecularhydrogenstudies.com)
  • Due to its potent vasodilatory action and its inotropic and chronotropic effects, CGRP is likely to play a role in cardiovascular homeostasis. (bachem.com)
Therapeutic3
  • Nucleic acid-based therapies hold promise for treating previously intractable diseases but require effective delivery vectors to protect the therapeutic agents and ensure efficient transfection. (bvsalud.org)
  • Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges. (nature.com)
  • We explore the therapeutic value of O3 in pathologies of the cardiovascular system, gastrointestinal tract, genitourinary system, central nervous system, head and neck, musculoskeletal, subcutaneous tissue, and peripheral vascular disease. (diegovitello.it)
Consumption1
  • Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine-taurine containing beverages. (researchgate.net)
Disorders1
  • 3 Greek Association of Alzheimer's Disease and Related Disorders - GAADRD. (researchgate.net)
Central nervou1
  • Most of the safety concerns have centered on the effect of energy drinks on cardiovascular and central nervous system function. (researchgate.net)
Aortic1
  • 743 wordsMinimization of end organ ischemia is a key tenet in successful thoracoabdominal aortic aneurysm (TAAA) surgery. (authorea.com)
Neuromuscular1
  • In the periphery, CGRP is mainly detected in sensory afferents projecting to the spinal cord, in motor neurons at the neuromuscular junctions and in nerve fibers associated with the vasculature. (bachem.com)
Therapies1
Progression1
  • We are now particularly interested to determine how this impacts on SMA disease development and progression. (abdn.ac.uk)
Functional1
  • In the chronic phase, disturbed neuro-architecture, glial scarring, disruption of axons and obstruction of axonal re-growth along the fiber tracts of the spinal cord impede functional neuro-regeneration. (anova-irm.com)
Therapy1
  • Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
Mechanism1
  • Recent evidence indicates that altered degradation rate of mutant proteins represents a pathogenic mechanism underlying genetic diseases. (frontiersin.org)
Organ1
  • Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. (duke.edu)
Research1
  • Recent research has shown that MSCs also support the re-establishment of blood supply to the damaged spinal cord by inducing angiogenesis. (anova-irm.com)
Roles1
  • Figure 2: Roles of extracellular vesicles in normal physiology and disease pathogenesis. (nature.com)
Brain1
  • Understanding the Potential Value of Cardiovascular Brain Death Donors to Increase th. (authorea.com)
Influences1
  • For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. (greenmedinfo.com)
Function1
  • There is growing evidence that mesenchymal stem cells (MSCs) could change the fate of SCI victims by re-establishing spinal cord function. (anova-irm.com)
Genetic1
  • If you have this disease or genetic conditions like idiopathic copper toxicosis or childhood cirrhosis, you shouldn't take copper supplements. (supplemented.net)
System1
  • T-cells are part of the immune system, and abnormal T-cell activity may be involved in diseases like lupus. (healthneu.com)
Blood1
  • During these reattachments, antegrade pulsatile blood flow to the spinal cord was guaranteed not only via the Adamkiewicz artery but also the collateral network, which ultimately minimizes spinal cord ischemia. (authorea.com)
MeSH1
  • 339 disease terms (MeSH) has been reported with MBL2 gene. (cdc.gov)