AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Diabetic AngiopathiesPolymorphism, GeneticCardiovascular DiseasesDiabetic RetinopathyDiabetic NephropathiesPolymorphism, Single NucleotideDiabetes Mellitus, ExperimentalGenetic Predisposition to DiseaseGenotypeGene FrequencyDiabetes Mellitus, Type 2Diabetic FootAllelesRisk FactorsCase-Control StudiesPregnancy in DiabeticsDiabetes Mellitus, Type 1Diabetes MellitusBlood GlucoseHaplotypesStreptozocinAsian Continental Ancestry GroupDiabetes ComplicationsGenetic Association StudiesPolymerase Chain ReactionDiabetic CardiomyopathiesInsulinPeptidyl-Dipeptidase ALinkage DisequilibriumCohort StudiesAlbuminuriaHypertensionHyperglycemiaHypoglycemic AgentsChinaHemoglobin A, GlycosylatedBlood PressureDiabetic DietProspective StudiesJapanBiological MarkersOdds RatioEuropean Continental Ancestry GroupMethylenetetrahydrofolate Reductase (NADPH2)HomozygoteObesityPolymorphism, Restriction Fragment LengthPhenotypeGenetic VariationFollow-Up StudiesReference ValuesCross-Sectional StudiesLipidsRisk AssessmentTime FactorsAtherosclerosisBody Mass IndexGenetic MarkersPrevalenceRiskDiabetic ComaReceptors, CalcitriolSmokingMice, Inbred NODOxidative StressPolymorphism, Single-Stranded ConformationalTriglyceridesCholesterolSex FactorsGlycosylation End Products, AdvancedKidney Failure, ChronicGlucoseBody WeightRats, WistarChi-Square DistributionBase SequenceLogistic ModelsMetabolic Syndrome XRetinal VesselsTreatment OutcomeInsulin ResistanceIncidenceAge FactorsCoronary Artery DiseasePromoter Regions, GeneticDisease ProgressionHeterozygoteKidneyCoronary DiseaseNitric Oxide Synthase Type IIIRats, Sprague-DawleyCholesterol, HDLDyslipidemiasDisease Models, AnimalSequence Analysis, DNAC-Reactive ProteinProportional Hazards ModelsAldehyde ReductaseEndothelium, VascularCholesterol, LDL
ComplicationsSingle nucleotide poNephropathyNOS3HypertensiveMedicine and Cellular LongevityHypertensionGenotypeChronic kidneyPatientsAlzheimer'sOxidativeCOL4A1Genetic2001OrgansVarious diseasesVariantsMutations2021AssessmentEndothelialDisordersPreventionNeuropathyVariationsFactorsAtheroscleroticClinicalExamineMarkersAssociationRoleAdultsTypePresentDiabetesResponsesLevelsInflammationImportantPopulation-based
Complications11
  • The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code for type 1 diabetes without complications is E10.9. (medscape.com)
  • [ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
  • Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
  • Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
  • We aimed at developing ELISA for AGE10 quantification, determining whether AGE10 is present in diabetic patients (n = 82), and evaluating its association with diabetic complications. (bvsalud.org)
  • The most pronounced deterioration of diurnal arterial stiffness indicators in the group of comorbid patients with EAH and SН, as well as the excess of vascular age over chronological and reliable correlation with the comorbidity index, revealed during the study, suggests an assessment of these indicators in patients with cardioendocrine pathology to assess the true risk cardiovascular complications and the selection of adequate therapy. (orscience.ru)
  • In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
  • Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
  • CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
  • Cardiovascular complications, along with the levels of cTnI, creatine kinase (CK), and creatine kinase MB (CK-MB) in hospitalized PCR-confirmed COVID-19 patients were extracted. (nutrition-evidence.com)
Single nucleotide po1
  • Six phenotypes were observed as a result of two single nucleotide polymorphisms (SNPs) at amino acid positions 112 and 158. (dovepress.com)
Nephropathy5
  • Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
  • We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
  • CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
  • Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
  • In recent years, variants of COL4A1 have been observed in a spectrum of brain malformations, such as autosomal dominant porencephaly, schizencephaly, intracranial calcifications, small vessel disease causing strokes and cerebral hemorrhages, and hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC syndrome). (cusabio.com)
NOS34
  • Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women. (ircabral.com)
  • Genetic association study between T-786C NOS3 polymorphism and essential hypertension in an Algerian population of the Oran city. (cdc.gov)
  • High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil. (cdc.gov)
  • Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent. (cdc.gov)
Hypertensive1
  • They offer utility in the assessment of hypertensive phenotypes, in cardiovascular risk prediction, and as surrogate endpoints in clinical trials. (biomedcentral.com)
Medicine and Cellular Longevity1
  • Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption, Oxidative Medicine and Cellular Longevity. (ircabral.com)
Hypertension8
  • Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. (ircabral.com)
  • Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. (cdc.gov)
  • DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism. (cdc.gov)
  • The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population. (cdc.gov)
  • Hypertension is associated with a variant in the RARRES2 gene in populations of Ouro Preto, Minas Gerais, Brazil: a cross-sectional study. (cdc.gov)
  • There are no validated tests that can identify early in the disease process which individuals will develop hypertension-mediated organ damage. (biomedcentral.com)
  • Dysfunctional vascular traits represent key pathophysiological processes in the development of hypertension and cardiovascular disease, with both inherited and reversible elements. (biomedcentral.com)
  • Hypertension was the most common in 161 (48.8%) patients, followed by diabetes (16.7%, n = 55) and coronary heart disease (13.3%, n = 44). (nutrition-evidence.com)
Genotype1
  • Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa, 2021. (ircabral.com)
Chronic kidney1
  • AGE10 elevation is associated with microangiopathy while its decrease accompanies stage ≥3 chronic kidney disease. (bvsalud.org)
Patients8
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
  • Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) Concentrations in Patients with Obesity and the Risk of Obstructive Sleep Apnea (OSA). (cdc.gov)
  • The wound swabs from ten patients diagnosed with diabetic foot ulcers were collected and 32 clinical strains comprising 22 bacterial species were obtained. (bvsalud.org)
  • We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
  • METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
  • BACKGROUND AND AIM Occasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients. (nutrition-evidence.com)
Alzheimer's4
  • This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19. (nutrition-evidence.com)
  • Transcranial electromagnetic brain stimulation is a non-invasive novel technique used recently to treat different neurodegenerative disorders, in particular Alzheimer's disease. (maxwellmagneticmeds.co.za)
Oxidative1
COL4A11
  • There are six human genes associated with it: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 Type IV collagen is a type of collagen that is responsible for providing a scaffold for stability and assembly. (wikipedia.org)
Genetic3
  • citation needed] Parallel direction of fibers in Type I Depending on genetic and nongenetic factors including alterations in gene expression, splice variations, post-translational modifications, and the chain-specific assembly of particular α-chains, different organs can be affected during their development and in the adult life span. (wikipedia.org)
  • New discoveries keep unraveling information about genetic mutations, biosynthesis, molecular assembly, and network formation of type IV collagen, and this increases the understanding of the critical role of this collagen in health and disease. (wikipedia.org)
  • Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. (cdc.gov)
20011
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
Organs1
  • BACKGROUND The newly emerged coronavirus disease 2019 (COVID-19) seems to involve different organs, including the cardiovascular system. (nutrition-evidence.com)
Various diseases1
  • Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. (dovepress.com)
Variants1
  • specify fewer variants of interest a priori, and aim to establish if a disease association can be confirmed. (biomedcentral.com)
Mutations1
  • Mutations to the genes[COL4A5] coding for collagen IV lead to Alport syndrome. (wikipedia.org)
20211
  • The Importance of the Extracellular Matrix in HPV-Associated Diseases, 2021. (ircabral.com)
Assessment2
  • Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
  • We finally make recommendations regarding planning and reporting of data relating to vascular assessment techniques, particularly when genomic data are also available, to facilitate integration of these tools into cardiovascular disease research. (biomedcentral.com)
Endothelial2
  • Endothelial dysfunction in asthma: eNOS, iNOS and ACE polymorphisms. (ircabral.com)
  • alternatively, research trials may employ surrogate markers such as vascular stiffness and endothelial dysfunction-early functional traits known to be predictors of more advanced structural changes and development of cardiovascular disease. (biomedcentral.com)
Disorders1
  • BMC Cardiovascular Disorders. (nyu.edu)
Prevention2
  • The breaking research is revealing a number of roles for vitamin K reaching well beyond coagulation to not only long term cardiovascular and skeletal health, but that of the brain and nervous system, and also for insulin production and sensitivity, and genomic stability / cancer prevention. (vitamindwiki.com)
  • Until recently, the majority of the research investigating vitamin K's potential for the prevention and treatment of age-associated diseases has been conducted using pharmacological doses of supplemental K1 or MK-4. (vitamindwiki.com)
Neuropathy2
  • In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
  • Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Variations1
  • single nucleotide polymorphism-DNA sequence variations with a single nucleotide (adenine, thymine, cytosine, or guanine) in the genome sequence altered. (biomedcentral.com)
Factors2
Atherosclerotic1
  • Its elevation was associated with metabolic syndrome (MetS), obesity, hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD) but not with diabetic control or microand macroangiopathy, except for atherosclerotic plaques formation in carotid arteries. (bvsalud.org)
Clinical3
  • We evaluate the efficacy of antimicrobial Photodynamic Therapy (APDT) for inactivating a variety of antibiotic-resistant clinical strains from diabetic foot ulcers. (bvsalud.org)
  • Clinical, pathological and immunological aspects of periodontal disease. (edu.pl)
  • BACKGROUND Inflammation can facilitate development of coronavirus disease 2019 (COVID-19) and cardiac injury is associated with worse clinical outcomes. (nutrition-evidence.com)
Examine2
  • We furthermore examine genes and polymorphisms relevant to each technique. (biomedcentral.com)
  • method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease. (biomedcentral.com)
Markers2
  • They are stable compounds and are considered as potential diseases markers. (bvsalud.org)
  • 1] Pussinen PJ, Paju S, Mäntylä P, Sorsa T. Serum microbial- and host-derived markers of periodontal diseases: a review. (edu.pl)
Association1
  • The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men. (cdc.gov)
Role1
  • 6] Mahanonda R, Pichyangkul S. Toll-like receptors and their role in periodontal health and disease. (edu.pl)
Adults2
  • Although onset frequently occurs in childhood, the disease can also develop in adults. (medscape.com)
  • Onset most often occurs in childhood, but the disease can also develop in adults in their late 30s and early 40s. (medscape.com)
Type3
  • This is the only collagen type that is encoded by six different genes. (wikipedia.org)
  • Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
  • Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
Present1
  • complete set of exons present in an organism which accounts for all the coding regions of genes present. (biomedcentral.com)
Diabetes1
Responses1
  • The protective nature of host responses in periodontal diseases. (edu.pl)
Levels2
  • Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
  • Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children. (ircabral.com)
Inflammation1
  • 5] Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. (edu.pl)
Important2
  • and a review of the expanding list of age-associated diseases for which K2 insufficiency is being revealed to be an important contributing factor. (vitamindwiki.com)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
Population-based1
  • We explore the relative influence of participant genetics, with reference to large-scale genomic studies, population-based cohorts, and candidate gene studies. (biomedcentral.com)