• [ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
  • In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
  • Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
  • Interestingly, similar changes were seen in other microvascular complications as well. (e-dmj.org)
  • CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
  • Since miR-192 was shown to regulate extracellular matrix proteins Collagen, type I, α1 and α2 (Col1α1 and 2) that accumulate during diabetic nephropathy, miR-192 may play a role in kidney diseases as well. (wikipedia.org)
  • A correlation between elevated Notch signaling pathway gene expression, which is important for cell to cell communication, and diabetic nephropathy has also been shown. (wikipedia.org)
  • Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
  • We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
  • CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
  • Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
  • In recent years, variants of COL4A1 have been observed in a spectrum of brain malformations, such as autosomal dominant porencephaly, schizencephaly, intracranial calcifications, small vessel disease causing strokes and cerebral hemorrhages, and hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC syndrome). (cusabio.com)
  • Epigenetics may play a role in a wide array of vascular complications and in diabetes. (wikipedia.org)
  • Advanced glycation end-products (AGEs) contribute to vascular complications and organ damage in diabetes. (bvsalud.org)
  • Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • Since Type 2 diabetes is characterized by chronic hyperglycaemia as a result of impaired pancreatic beta cell function and insulin resistance in peripheral tissues, it was thought that the gene might be downregulated in type 2 diabetes patients through DNA methylation. (wikipedia.org)
  • This means that expression from the PPARGC1A genes were turned down in the diabetic patients. (wikipedia.org)
  • Further testing revealed that the more PPARGC1A was expressed, the more insulin was released from the islets, and as expected, in diabetic patients there was less PPARGC1A expressed and also less insulin secreted. (wikipedia.org)
  • Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
  • Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) Concentrations in Patients with Obesity and the Risk of Obstructive Sleep Apnea (OSA). (cdc.gov)
  • Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. (cdc.gov)
  • The wound swabs from ten patients diagnosed with diabetic foot ulcers were collected and 32 clinical strains comprising 22 bacterial species were obtained. (bvsalud.org)
  • We aimed at developing ELISA for AGE10 quantification, determining whether AGE10 is present in diabetic patients (n = 82), and evaluating its association with diabetic complications. (bvsalud.org)
  • The most pronounced deterioration of diurnal arterial stiffness indicators in the group of comorbid patients with EAH and SН, as well as the excess of vascular age over chronological and reliable correlation with the comorbidity index, revealed during the study, suggests an assessment of these indicators in patients with cardioendocrine pathology to assess the true risk cardiovascular complications and the selection of adequate therapy. (orscience.ru)
  • We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
  • METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
  • Cardiovascular complications, along with the levels of cTnI, creatine kinase (CK), and creatine kinase MB (CK-MB) in hospitalized PCR-confirmed COVID-19 patients were extracted. (nutrition-evidence.com)
  • BACKGROUND AND AIM Occasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients. (nutrition-evidence.com)
  • The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code for type 1 diabetes without complications is E10.9. (medscape.com)
  • Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
  • In a different study where transcriptional changes due to a risk factors for diabetes, were examined, changes in the methylation patterns of the PPARGC1A gene were also found. (wikipedia.org)
  • Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
  • Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease. (cdc.gov)
  • Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins. (cdc.gov)
  • MATERIAL AND METHODS: The AGE-1, expressed as median AGE-1 level and AGE-1 positivity, was determined in 246 individuals (198 with prediabetes/diabetes) using a new slot-dot-blot method (allowing for detection of barely traceable analytes) and related to the presence of diabetes-associated metabolic abnormalities and complications, and treatment. (bvsalud.org)
  • Here we briefly reviewed the characteristic and etiology of these complications emphasizing on cerebrospinal fluid. (scialert.net)
  • Genetic association study between T-786C NOS3 polymorphism and essential hypertension in an Algerian population of the Oran city. (cdc.gov)
  • Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. (cdc.gov)
  • The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population. (cdc.gov)
  • Genetic polymorphisms, increasing age and environmental cues are recognized to be primary risk factors. (maxwellmagneticmeds.co.za)
  • DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism. (cdc.gov)
  • Hypertension is associated with a variant in the RARRES2 gene in populations of Ouro Preto, Minas Gerais, Brazil: a cross-sectional study. (cdc.gov)
  • Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent. (cdc.gov)
  • Dysfunctional vascular traits represent key pathophysiological processes in the development of hypertension and cardiovascular disease, with both inherited and reversible elements. (biomedcentral.com)
  • Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
  • It has been found that many epigenetic mechanisms are involved in the regulation and expression of genes such as DNA methylation and chromatin remodeling. (wikipedia.org)
  • Using bisulfite testing, it was also found that there was an approximately twofold increase in DNA methylation of the PPARGC1A promoter of human islet cells from diabetics as compared to non-diabetic human islet cells. (wikipedia.org)
  • It was suggested that DNA methylation was the mechanism through which the PPARGC1A gene was turned down. (wikipedia.org)
  • In addition, it was shown that after the bed rest, there was a marked increase in DNA methylation of the PPARGC1A gene along with a decrease in mRNA expression. (wikipedia.org)
  • High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil. (cdc.gov)
  • Recent studies have shown that miRNAs have pivotal roles in many different gene regulatory pathways. (wikipedia.org)
  • In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of biology. (wikipedia.org)
  • single nucleotide polymorphism-DNA sequence variations with a single nucleotide (adenine, thymine, cytosine, or guanine) in the genome sequence altered. (biomedcentral.com)
  • In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
  • Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
  • We evaluate the efficacy of antimicrobial Photodynamic Therapy (APDT) for inactivating a variety of antibiotic-resistant clinical strains from diabetic foot ulcers. (bvsalud.org)
  • They offer utility in the assessment of hypertensive phenotypes, in cardiovascular risk prediction, and as surrogate endpoints in clinical trials. (biomedcentral.com)
  • Its elevation was associated with metabolic syndrome (MetS), obesity, hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD) but not with diabetic control or microand macroangiopathy, except for atherosclerotic plaques formation in carotid arteries. (bvsalud.org)
  • We furthermore examine genes and polymorphisms relevant to each technique. (biomedcentral.com)
  • method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease. (biomedcentral.com)
  • We finally make recommendations regarding planning and reporting of data relating to vascular assessment techniques, particularly when genomic data are also available, to facilitate integration of these tools into cardiovascular disease research. (biomedcentral.com)
  • alternatively, research trials may employ surrogate markers such as vascular stiffness and endothelial dysfunction-early functional traits known to be predictors of more advanced structural changes and development of cardiovascular disease. (biomedcentral.com)
  • It is becoming increasingly clear that, particularly for chronic neurodegenerative disorders occurring late in life, a complex combination of risk factors can initiate disease development and modify proteins that have a physiological function into ones with pathological roles via a number of defined mechanisms (Moreno-Gonzalez and Soto, 2011). (maxwellmagneticmeds.co.za)
  • complete set of exons present in an organism which accounts for all the coding regions of genes present. (biomedcentral.com)
  • In 2008, it was found that the mRNA expression of PPARGC1A was markedly reduced in pancreatic islets from type 2 diabetic donors compared with that of non-diabetic donors. (wikipedia.org)
  • In human type 2 diabetic islets, reduced PPARGC1A mRNA levels were associated with impaired glucose-mediated insulin secretion. (wikipedia.org)
  • Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
  • Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
  • Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice, suggesting that it is involved as well. (wikipedia.org)
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
  • The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men. (cdc.gov)
  • PGC-1α, the protein encoded by the gene PPARGC1A, can modulate glucose-mediated insulin secretion in human islets, most likely through an effect on ATP production. (wikipedia.org)
  • In the study done on physical inactivity, where subjects were required to have a sustained bed-rest of 10 days and were then examined, it was also found that there was significant downregulation of the PPARGC1A gene. (wikipedia.org)
  • We explore the relative influence of participant genetics, with reference to large-scale genomic studies, population-based cohorts, and candidate gene studies. (biomedcentral.com)
  • We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
  • Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)
  • The calculation of vascular age was carried out according to the Framingham SCORE risk scale modified according to D'Agostino. (orscience.ru)