InflammationApoptosisPhosphorylationMyocardial ischemia-reperfusion injuryIncrease in oxidativeReperfusionInflammatoryCardiacCardiovascularNeuronalMitochondrialRatsCellularInsulinMolecularEndothelialNitric oxideTissuesLipidContributesInsultMitochondriaViabilityAntioxidantMechanisms involvedBeneficialHeartResultsCellKidneyProtectionStudyCells
Inflammation5
- Silent information regulator transcript-1 (Sirt1) is a histone deacetylase that is nicotinamide adenine dinucleotide (NAD+) reliant and closely associated with several cellular processes, including cell metabolism, aging, apoptosis, inflammation, and oxidative stress [ 10 ]. (biomedcentral.com)
- In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
- To this aim, we assessed the involvement of these MVs in vessel damage related processes, i.e., oxidative stress, inflammation, and leukocyte-endothelial adhesion. (bvsalud.org)
- These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
- After 48 hours of exposure, these mice showed persistent cardiac inflammation and oxidative tissue damage that caused sarcomeric disruption, cardiomyocyte death, left ventricular dysfunction, and cardiomyopathy, while control hearts showed minimal damage. (jci.org)
Apoptosis9
- STA significantly suppressed oxidative stress, reduced MDA content, and increased SOD activity in H9c2 cells exposed to H/R. STA reduced apoptosis in H9c2 cells exposed to H/R, as evidenced by the reduced TUNEL positive cells and caspase-3 activity. (biomedcentral.com)
- Our data speculated that STA protects H/R injury and inhibits oxidative stress and apoptosis in cardiomyocytes by activation of the SIRT1-Nrf2 pathway. (biomedcentral.com)
- In human cells, BCCs' activity is involved in the regulation of specific enzymes, the binding of particular receptors, mRNA splicing, and inducing apoptosis. (borates.today)
- Thus, inhibition of oxidative stress and myocardial apoptosis is beneficial in the treatment of myocardial I/R injury. (spandidos-publications.com)
- The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
- Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)
- Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
- Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
- Inhibition of Fas expression prevents I/R induced apoptosis. (ac.ir)
Phosphorylation3
- Gilkerson, R. W., Selker, J. M. L. & Capaldi, R. A. The cristal membrane of mitochondria is the principal site of oxidative phosphorylation. (nature.com)
- Light microscopy confirmed some degree of morphological change associated with differentiation, and a significant increase in oxidative phosphorylation following RA treatment was observed. (sun.ac.za)
- Accordingly, substrate availability, oxidative phosphorylation, and high-energy phosphate transfer are critical to cardiac performance. (biomedcentral.com)
Myocardial ischemia-reperfusion injury2
- While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. (hindawi.com)
- Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
Increase in oxidative1
- MVs released by HS-activated cells triggered a threefold increase in oxidative burst in a concentration-dependent manner. (bvsalud.org)
Reperfusion2
- Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
- One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Inflammatory3
- In this respect, progranulin (PGRN) serves as one of the main components of the regulation of inflammatory processes, which significantly contributes to the immunopathogenesis of such disorders. (biomedcentral.com)
- these socalled pleiotropic properties include anti-inflammatory effects, plaque stabilization, improved endothelial function and inhibition of vascular smooth muscle cell proliferation. (ac.ir)
- Hydrogen sulfide (H 2 S) has been shown to be a neuromodulator that is thought to have anti-apoptotic, anti-inflammatory, and anti-oxidative benefits. (biomedcentral.com)
Cardiac2
- This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
- Inhibition of RBC NO synthase with L-NAME or soluble guanylyl cyclase (sGC) with ODQ, and inhibition of cardiac protein kinase G (PKG) abolished the cardioprotective effect. (bvsalud.org)
Cardiovascular3
- The term "cardioprotection" refers to all methods of preserving cardiovascular health. (borates.today)
- Red blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. (bvsalud.org)
- Hmox1 ) enzyme system is among the most important inducible mechanisms for cell protection against oxidative damage in the cardiovascular system. (jci.org)
Neuronal2
- Tokmak et al ( 10 ) reported that SA pretreatment in spinal cord I/R reduced oxidative stress and neuronal degeneration. (spandidos-publications.com)
- Liang HW, Qiu SF, Shen J et al (2008) Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. (springer.com)
Mitochondrial6
- Oxidative stress induces cyclosporine A-sensitive mitochondrial efflux of calcium and proapoptotic factors through MPTP (mi- tochondrial permeability transition pore) opening in heart mito- chondria which may contribute to tissue damage and mitochon- drial dysfunction in aging rats. (kiev.ua)
- Mitochondrial Stress: A Novel Thermogenic Pathway to Fight Obesity and Diabetes. (utah.edu)
- Mitochondrial Stress: A Novel Pathway to Activate Thermogenesis in Fat. (utah.edu)
- Stress Turns on the Heat: Regulation of Mitochondrial Biogenesis and UCP1 by ROS in Adipocytes. (utah.edu)
- Fig. 1: Regulation of mitochondrial respiratory capacity. (nature.com)
- HO-1) pathway was tested for defense of mitochondrial quality control in cardiomyocyte-specific Hmox1 KO mice (HO-1[CM] -/- ) exposed to oxidative stress (100% O 2 ). (jci.org)
Rats1
- We tested the levels of NO and superoxide generation in mitochondria simultaneously with cyclosporine A-sensitive MPTP opening by Ca 2+ and phenylarsine oxide (PAO) to determine whether down- regulation of both NO and .O 2 - generation in heart mitochon- dria by potent steroid antioxidant and free radical scavenger ecdysterone may protect heart mitochondria of aging rats again tissue damage. (kiev.ua)
Cellular3
- 3, 5-diiodothyropropionic acid (DITPA) have evidences of improving effects on I/R in heart through modulation of cellular signaling in response to ischemic stress. (biomedcentral.com)
- These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. (biomedcentral.com)
- MicroRNAs offer an alternative mechanism for cellular regulation by altering gene expression. (edu.au)
Insulin1
- Westermeier F, Bustamante M, Pavez M, García L, Chiong M, Ocaranza MP, Lavandero S. Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9). (uchile.cl)
Molecular4
- The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side-effects attributed to nonselective inhibitors such as theophylline. (wikipedia.org)
- It is important to understand how these mechanisms are dynamically regulated by pivotal molecular targets and potentially reversed in the context of cardioprotection [ 6 ]. (hindawi.com)
- The Boudina Laboratory we are interested in understanding the molecular mechanisms involved in weight gain regulation and adipose tissue expansion in diet-induced obesity (DIO). (utah.edu)
- Heusch G: Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning. (spandidos-publications.com)
Endothelial1
- Fenofibrate pretreatment ameliorated TNF-alpha-induced endothelial dysfunction by reversing the loss of NO, improving oxidative stress, restoring cell viability and preventing caspase-3 activation. (sun.ac.za)
Nitric oxide1
- The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. (wikipedia.org)
Tissues1
- Adiponectin connects energy balance regulation in the central nervous system and peripheral tissues [ 10 ] . (encyclopedia.pub)
Lipid1
- Oxidative stress was assessed by lipid oxidation product MDA and a ROS-scavenging enzyme SOD in culture media. (biomedcentral.com)
Contributes1
- Oxidative radicals contributes to inhibition and depletion of antioxidants (CAT, SOD and GSH). (springeropen.com)
Insult1
- Regulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects. (springeropen.com)
Mitochondria1
- 25- dihydroxyvitamin D3) and exert its cardio protection in aging heart mitochondria by inhibition of MPTP opening with effectivity of action of hormone melatonine (150mkg/100g, 2 weeks [ V.F.Sagach et al. (kiev.ua)
Viability1
- Conclusions: Fenofibrate protects TNF-alpha-induced dysfunctional ECs via up-regulated eNOS-NO, reduced oxidative stress and improved cell viability. (sun.ac.za)
Antioxidant1
- The boosted antioxidant capacity responded in sequestration of increasing oxidative radicals within the system to restore stability. (springeropen.com)
Mechanisms involved1
- 1 Thus, it is imperative to understand the mechanisms involved in inhibition of myocardial fibrosis. (dovepress.com)
Beneficial1
- Increased expression of PDE5 has also been measured in hypertrophic disease and has been linked to oxidative stress, and PDE5 inhibition has shown beneficial effects in the failing heart. (wikipedia.org)
Heart1
- While the heart is capable of utilizing a variety of available substrates to generate adenosine triphosphate, this metabolic flexibility is compromised under circumstances in which the heart is stressed, particularly by myocardial ischemia. (biomedcentral.com)
Results1
- The kinetics of inhibitor binding and inhibition of catalysis imply the existence of two PDE5 conformers, and results of native gel electrophoresis reveal that PDE5 exists in two apparently distinct conformations, i.e., an extended conformer and a more compact conformer. (wikipedia.org)
Cell1
- El factor epithelial cell adhesion molecule (EpCAM), implicado en la cohesión de las células epiteliales, está poco estudiado en el contexto de la OMV. (bvsalud.org)
Kidney1
- Both kidney were excised, the right one homogenized for oxidative stress parameters (MDA and GSH) measurements and the left kidney fixed in formalin for histological examination. (biomedcentral.com)
Protection1
- The researchers attributed the protection to H2S opening K-ATP channels, scavenging radical oxidative species (ROS), and possibly lowering metabolism. (gotomydoctor.com)
Study1
- A recent study demonstrated that SA prevented oxidative stress in l-arginine-induced acute pancreatitis ( 9 ). (spandidos-publications.com)
Cells1
- CFB-treated cells were exposed to exogenous hydrogen peroxide to recreate environmentally induced oxidative stress. (borates.today)