The surgeon plans on using a clear pump prime with a hyperpolarized cardioplegic arrest. (ccasociety.org)
Warm blood cardioplegia1
Cold crystalloid cardioplegia ("St. Thomas solution") or warm-blood cardioplegia was used according to the surgeon's preference to induce and maintain cardioplegic arrest. (biomedcentral.com)
Crystalloid cardioplegia3
BestBets: Is blood cardioplegia superior to crystalloid cardioplegia? (bestbets.org)
You have always used blood cardioplegia but you start to work for a consultant who uses crystalloid cardioplegia. (bestbets.org)
2582 received blood cardioplegia and 2462 patients received crystalloid cardioplegia Most trials assessed at least 1 co-intervention including temperature (warm vs. cold), timing (intermittent vs. continuous), and/or route of delivery (antegrade, antegrade/retrograde) Elective CABG surgery trials (n=18). (bestbets.org)
Myocardial9
Cardioplegia is a solution given to the heart during cardiac surgery, to minimize the damage caused by myocardial ischemia while the heart is paused. (wikipedia.org)
The main goals of hypothermic cardioplegia are: Immediate and sustained electromechanical quiescence Rapid and sustained homogeneous myocardial cooling Maintenance of therapeutic additives in effective concentrations Periodic washout of metabolic inhibitors The most common procedure for accomplishing asystole is infusing cold cardioplegic solution into the coronary circulation. (wikipedia.org)
Cardioplegic solutions cause diastolic arrest, decrease cardiac metabolic demand, and improve myocardial tolerance to ischemia. (ccasociety.org)
Extracellular cardioplegic solutions often contain high concentrations of sodium (Na + ), calcium (Ca 2+ ), potassium (K + ), magnesium (Mg 2+ ), and bicarbonate and cause cardiac arrest by depolarizing the myocardial membrane. (ccasociety.org)
Numerous studies have demonstrated that multiple cardioplegia options safely achieve myocardial protection. (ccasociety.org)
In the first group (control), myocardial anoxia was induced in normothermia and no cardioplegic solution was administered. (rbccv.org.br)
In the second group, the body temperature was reduced to 28ºC before the onset of myocardial anoxia, and no cardioplegic solution was used. (rbccv.org.br)
We may conclude that both cardioplegic solutions used, associated to hipothermia, protect efficiently the myocardial cells against anoxia. (rbccv.org.br)
Coronary2
Cardioplegia is administered after cross clamp of the aorta either in an antegrade fashion via the coronary arteries or retrograde via the coronary sinus. (ccasociety.org)
In the third and fourth groups, in addition to 28ºC systemic hypothermia, coronary infusion of 4ºC cardioplegic solutions were performed immediately and after 30 minutes of clamping of the aorta. (rbccv.org.br)
Custodiol HTK2
Histidine-tryptophan-ketoglutarate (HTK) solution (Custodiol HTK®/Bretschneider solution) is an intracellular cardioplegic solution that was introduced in the 1970s. (ccasociety.org)
The purpose of the study is to demonstrate that Custodiol-HTK is not inferior to cold cardioplegic solution in patients undergoing cardiovascular surgery requiring cardioplegic arrest. (custodiol.com)
Lidocaine2
To mitigate this effect, contemporary depolarizing cardioplegia solutions contain lidocaine and magnesium. (ccasociety.org)
Del Nido cardioplegia includes lidocaine and magnesium and is categorized as a modified extracellular depolarizing solution. (ccasociety.org)
Induce2
The ability to induce cardiac arrest and facilitate open-heart surgery by infusing a high potassium-containing solution into the coronaries was first demonstrated by Melrose et al. (ccasociety.org)
These solutions induce a hyperpolarizing arrest of the myocardium which decreases energy consumption and intracellular accumulation of Ca 2+ . (ccasociety.org)
Arrest2
Which cardioplegia solution produces a hyperpolarized cardiac arrest? (ccasociety.org)
HTK solution is particularly useful for long complex repairs as it reliably produces cardiac arrest for up to 120 minutes without redosing. (ccasociety.org)
Cardioplegia lowers the metabolic rate of the heart muscle, thereby preventing cell death during the ischemic period of time. (wikipedia.org)
Cardiac surgery1
The del Nido cardioplegia solution was developed for pediatric cardiac surgery due to the specific needs of an immature and developing myocardium. (ccasociety.org)
Cold1
A compounding factor in critically ill or cardiac surgical patients with compromised circulation is that the glycocalyx is easily disrupted by hypoxia, 6 by use of cold cardioplegia solutions, 7 and with ischemia-reperfusion. (silverchair.com)
Myocardium3
As the cardioplegia solution distributes to the entire myocardium, the ECG will change and eventually asystole will ensue. (wikipedia.org)
Cardioplegic solution is the means by which the ischemic myocardium is protected from cell death. (wikipedia.org)
Electron microscopy also showed less edema of the myocardium and better myofibrillar architecture with del Nido solution. (ccasociety.org)
Membrane1
When extracellular cardioplegia displaces blood surrounding myocytes, the membrane voltage becomes less negative and the cell depolarizes more readily. (wikipedia.org)
Blood3
The Buckberg and St. Thomas' Hospital cardioplegia solutions both contain high K + content and are delivered with blood. (ccasociety.org)
However, a recent 2018 study by Panigrahi et al suggests that the del Nido solution may offer some additional benefits including quicker resumption of normal cardiac rhythm and decreased inotropic support compared to conventional blood cardioplegia. (ccasociety.org)
It was not possible, however, to demonstrate any superiority of the blood solution over an acellular solution. (rbccv.org.br)
Extracellular1
However, the high potassium concentration of the cardioplegia extracellular prevents repolarization. (wikipedia.org)
Thomas1
demonstrated a six-fold decrease in the rate of defibrillation post cross-clamp with del Nido cardioplegia compared to the St. Thomas Hospital solution. (ccasociety.org)
Patients1
bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)
Initial1
If you are aware preoperatively that your patient is hperkalemic, during CPB you can scavenge the initial flush of cardioplegia to the cell saver. (perfusion.com)
Concentration1
Intracellular cardioplegia solutions have low levels of Na + and Ca 2+ mimicking the intracellular electrolyte concentration. (ccasociety.org)
Single1
You then realise that you have never actually read a single paper on the comparison between these two solutions even though you use it every day and resolve to look up the evidence. (bestbets.org)
Hypothermic1
The warm ischemic phase includes the time from the interruption of circulation to the donor organ to the time the organ is flushed with hypothermic preservation solution. (medscape.com)
Hypothermia1
Different causes have been associated with this situation, like hypothermia and duration of CPB, total cardioplegic volume infused, reduced left ventricular function, preoperative treatment with angiotensin-converting enzyme inhibitors, and systemic inflammatory response syndrome (SIRS), or inappropriate low arginine-vasopressin secretion. (biomedcentral.com)
Means2
Cardioplegic solution is the means by which the ischemic myocardium is protected from cell death. (wikipedia.org)
The ascending aorta may be occluded and cardioplegic fluid delivered by means of an occlusion balloon attached to the distal end of an elongated catheter positioned transluminally in the aorta from a femoral, subclavian, or other appropriate peripheral artery. (justia.com)
Left1
bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)
Heart2
Cardioplegia lowers the metabolic rate of the heart muscle, thereby preventing cell death during the ischemic period of time. (wikipedia.org)
This article discusses the pathophysiology and techniques of organ preservation and describes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantation . (medscape.com)