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  • functional
  • Laid out in a new article published today in Advanced Functional Materials , a team of researchers at Michigan Technological University in collaboration with Harvard Medical School, shows how cardiomyocytes grown in a heart-like environment mature more quickly, have improved functionality and are less likely to be rejected by patients' bodies. (eurekalert.org)
  • This results in more robust, mature and functional cardiomyocyte-like cells. (medgadget.com)
  • H9c2
  • The present study was designed to elucidate the key parameters associated with X-ray radiation induced oxidative stress and the effects of STS on X-ray-induced toxicity in H9c2 cardiomyocytes. (hindawi.com)
  • receptors
  • Integrins serve as the signaling receptors of cardiomyocytes responsible for mechanotransduction toward intracellular signaling. (hindawi.com)
  • RT-PCR showed the presence of P2X2 and P2X4 receptor transcripts on E14 cardiomyocytes with a lower expression of P2X3 and P2X7 receptors. (springer.com)
  • Responses mediated by agonists specific for P2Y receptors subtypes showed that P2Y receptors (P2Y 1 , P2Y 2 , P2Y 4 and P2Y 6 ) were also present in both E14 and E18 cardiomyocytes. (springer.com)
  • adult human heart
  • Although there are indications that human adult heart has certain level of endogenous regeneration capacity, with different estimations of the rate of cardiomyocyte turnover between studies, adult human heart cannot effectively regenerate after injury [ 3 - 6 ]. (hindawi.com)
  • The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies. (sciencemag.org)
  • substantial
  • However, studies over several decades in rodents with labeled nucleotide analogs have led to conflicting results, ranging from no to substantial generation of cardiomyocytes postnatally ( 6 ). (sciencemag.org)
  • taken
  • We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. (sciencemag.org)
  • scientists
  • This volume has been assembled for scientists interested in basic and applied biomedical research directed toward understanding the development, genetics, and function of cardiomyocytes. (springer.com)