Cardiomyocyte dysfunction. Medical search. Frequent questions

AAV gene delivery elevated the intracellular expression of the AR185 protein in a rat model of ischemic HF, and this treatment normalized the systolic and diastolic dysfunction of the failing myocardium in vivo by reversing myocardial Ca2+ handling. (bvsalud.org)
Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology. (otago.ac.nz)
Importantly, cardiomyocyte-specific inducible overexpression of Xbp1s partially ameliorated diastolic dysfunction, exercise intolerance and pulmonary congestion in HFpEF mice. (unina.it)
Specifically, does primary CMD lead to ventricular remodelling/diastolic dysfunction and HFpEF or do alterations in myocardial remodelling/diastolic dysfunction observed in HFpEF lead to secondary CMD, i.e. the chicken or the egg? (medscape.com)
This is consistent with a growing body of work from our group showing that women with CMD often have left ventricular (LV) diastolic dysfunction, [ 5 , 11 , 12 ] and are at increased risk of developing HFpEF. (medscape.com)
The exact mechanism(s) contributing to CMD-related diastolic dysfunction, however, remains incompletely understood. (medscape.com)

Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
Oxidative stress and mitochondrial dysfunction have been implicated in cocaine-related cardiomyopathy . (medscape.com)
We previously reported the MT-RNR2 variant associated with HCM that results in mitochondrial dysfunction. (jci.org)

Chronic overexpression of MT or acute in vitro treatment with the flavoprotein inhibitor diphenyleneiodonium or the angiotensin II type I receptor antagonist losartan eliminated excess ROS production in diabetic cardiomyocytes. (diabetesjournals.org)

Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
Isoproterenol infusion in control mice promoted overt cardiac hypertrophy and dysfunction (reduced ejection fraction, increased end systolic volume, increased cardiac weight index, increased cardiomyocyte area, increased fibrosis, and up-regulation of myocyte fetal genes and hypertrophy-associated microRNAs). (whiterose.ac.uk)
In vitro mechanistic studies determined that cardiac fibroblasts responded to damaged myocardium by secreting several paracrine factors known to induce cardiomyocyte hypertrophy, including IL-6, whose secretion was dependent upon p38α activity. (whiterose.ac.uk)
In conclusion, cardiac fibroblast p38α contributes to cardiomyocyte hypertrophy and cardiac dysfunction, potentially via a mechanism involving paracrine fibroblast-to-myocyte IL-6 signaling. (whiterose.ac.uk)

Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
A variety of observations suggest that coronary microvascular dysfunction (CMD) is related to the pathogenesis of cardiovascular disease, including myocardial ischaemia and heart failure. (medscape.com)

Coronary Microvascular Dysfunction and Heart Failure With Preserved Ejection Fraction as Female-pattern Cardiovascular Disease: The Chicken or the Egg? (medscape.com)

Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats. (nih.gov)
Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. (swansea.ac.uk)

Heart failure (HF) is a syndrome of ventricular dysfunction. (msdmanuals.com)

These findings suggest that antibodies to cTnI induce heart dysfunction and dilatation by chronic stimulation of Ca2+ influx in cardiomyocytes. (nih.gov)
What are the mechanisms by which excessive lipids induce contractile dysfunction of cardiomyocytes? (uit.no)

A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
Altogether, the altered immune and inflammatory responses, and endotoxemia contribute to the dysfunction and stress in cardiovascular cells (e.g . endothelial cells, vascular smooth muscle cells and cardiomyocytes), increasing cardiovascular risks. (degruyter.com)

In vivo electrocardiography showed PMCA1 CKO displayed signs of cardiac repolarisation dysfunction related to prolonged QT and JT intervals. (bmj.com)

2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
We explore the cellular mechanisms of glucose metabolism dysfunction in an in vitro model of cultured cardiomyocytes, with the aim of transposing our in vitro results to an animal model of diabetic cardiomyopathy. (unige.ch)

MI with significant cardiomyocyte necrosis but without microvascular injury. (medscape.com)
Cardiomyocyte and microvascular necrosis leading to reperfusion hemorrhage. (medscape.com)

2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
2017). Whether central inhibition of IKK2 could reverse the dysfunction of glucose and lipid metabolism remains unknown. (deepdyve.com)

To address these hypotheses, we examined contractility, Ca 2+ handling, and ROS levels in individual cardiomyocytes isolated from control hearts, diabetic OVE26 hearts, and diabetic hearts overexpressing antioxidant protein metallothionein (MT). Our data showed that diabetic myocytes exhibited significantly reduced peak shortening, prolonged duration of shortening/relengthening, and decreased maximal velocities of shortening/relengthening as well as slowed intracellular Ca 2+ decay compared with control myocytes. (diabetesjournals.org)
In addition, high glucose and angiotensin II promoted significantly increased generation of ROS in diabetic cardiomyocytes. (diabetesjournals.org)

Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. (biorxiv.org)

Dysbiosis of both oral and gut microbiomes result in systemic inflammation and endotoxemia to cause liver dysfunction and even liver diseases (e.g . cirrhosis, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis) [ 4 ]. (degruyter.com)

The cardiac remodeling and dysfunction in HFpEF is driven by comorbidities such as obesity, diabetes, arterial hypertension and endothelial dysfunction which lead to systemic inflammation. (unina.it)
Specifically, the spliced form of X-box binding protein 1 (Xbp1s), a downstream effector of the unfolded protein response (UPR), exhibited a significant reduction in the HFpEF model hearts and cardiomyocytes. (unina.it)
We have developed a novel preclinical model of HFpEF, unveiling iNOS-driven dysregulation of Xbp1s as a crucial mechanism of cardiomyocyte dysfunction. (unina.it)
These results demonstrate the essential role of protein homeostasis dysregulation in HFpEF cardiomyocytes and suggest that inhibiting iNOS activity may be a viable therapeutic strategy in this condition. (unina.it)

To investigate the role of PMCA1 in cardiac rhythm, cardiomyocyte-specific knockout mice (PMCA1 CKOÃ,Â- ) were generated. (bmj.com)

During an ischemic event, as occurs with coronary occlusion, the first line of defense for the myocardium is the stimulation of glucose transport and glycolysis in the cardiomyocytes. (unige.ch)

Embryonic stem cell-derived cardiomyocytes as a model for arrhythmia. (heartandcoeur.com)

Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)
SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)

Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats. (bvsalud.org)

Liver diseases are considered the risk factors for CVDs, where liver disease patients are more susceptible to endothelial dysfunction and arterial calcification, although the detailed mechanisms underlying the causality between liver diseases and CVDs require further study [ 5 ]. (degruyter.com)

This cardiomyopathy may be due to either organ-based damage, such as fibrosis, or to direct damage to cardiomyocytes. (diabetesjournals.org)

Administration of monoclonal antibodies to cTnI induced dilatation and dysfunction of hearts in wild-type mice. (nih.gov)

We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)

Chronic PKA phosphorylation of ryanodine receptor 2 ( RyR2 ) has been shown to increase diastolic sarcoplasmic reticulum (SR) Ca2+ leakage and lead to cardiac dysfunction. (bvsalud.org)

The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
The heart failure phenotype was only observed under combined treatment with HFD and L-NAME and was associated with molecular changes within the cardiomyocytes. (unina.it)

Furthermore, AR185 gene transfer to failing cardiomyocytes reduced the frequency of SR calcium leaks, thereby restoring the attenuated intracellular calcium transients and SR calcium load. (bvsalud.org)
Moreover, AR185 gene transfer inhibited the PKA-mediated phosphorylation of RyR2 in failing cardiomyocytes . (bvsalud.org)
The authors' findings, published online this week by the peer-reviewed journal Nature Medicine , suggest that mutations of either of two gene products -- proteins called KCNE2 and KCNQ1 -- already known to be involved in human cardiac arrhythmias, could also cause thyroid dysfunction. (sciencedaily.com)
Gene and Cell Therapy for Sinus and AV Nodal Dysfunction. (heartandcoeur.com)

Absence of coronary artery disease: Cardiac ischaemia with angina pectoris can exist in the absence of significant coronary artery disease, possibly due to microcoronary dysfunction (up to 10% of patients of which a majority of women). (escardio.org)

This study assessed the deleterious effects of diesel-derived PM 2.5 exposure in HL-1 mouse cardiomyocyte cell lines. (nih.gov)
Prenatal exposure to cholinolytics to pregnant females leads to sex-dependent disorders of the brain dopaminergic and serotonergic systems in 20-day-old rat fetuses, which determines the nature of future behavioral dysfunctions in puberty rat offspring. (sgma.info)
Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. (biorxiv.org)

The early postoperative period in CABG patients is associated with systemic inflammatory response syndrome (SIRS), which is complicated with multiple organ dysfunction and high mortality in 5%-16% of cases (EACTA 2007 data) [ 1 , 2 ]. (hindawi.com)

Human autopsy specimens from COVID-19 patients displayed similar sarcomeric disruption, as well as cardiomyocytes without DNA staining. (biorxiv.org)

Transcriptomic disruption of structural proteins corroborated adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and numerous iPSC-cardiomyocytes lacking nuclear DNA. (biorxiv.org)

We are now further exploring these observations, testing the basic hypotheses that ERK1/2 and ERK5 regulate TLR-dependent and TLR-independent activation of endothelial inflammatory pathways and contribute to endothelial dysfunction in septic shock and organ failure. (ucsf.edu)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)

We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)

SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)

Here, we screened a mitochondria-associated compound library by quantifying the mitochondrial membrane potential of HCM cybrids and the survival rate of HCM-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) in galactose media. (jci.org)
Furthermore, at reperfusion, should it happen, ATP obtained from anaerobic metabolism of glucose is preferentially used to restore the ionic gradients that are necessary for the survival and proper function of the cardiomyocytes. (unige.ch)

The dysfunction underlying this disorder may contribute in minor ways to other forms of heart disease. (imperial.ac.uk)

Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)

Cardiomyocytes were randomly assigned to the control group, ISO group (100 nM ISO for 48 h), Res + ISO group (50 μM Res and 100 nM ISO for 48 h) and Res group (50 μM Res for 48h only). (karger.com)

Anatomy8

Organisms6

Diseases13

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Psychiatry and Psychology2

Phenomena and Processes9

Diastolic dysfunction6

Mitochondrial dysfunction3

Overexpression1

Hypertrophy4

Myocardial2

Microvascular dysfunction1

Apoptosis2

Ventricular1

Induce2

Endothelial cells2

Repolarisation dysfunction1

Glucose metabolism dysfunction2

Necrosis2

Inhibition2

Diabetic2

Pathogenesis1

Liver dysfunction1

HFpEF4

Cardiac rhythm1

Myocardium1

Embryonic1

Injury2

Rats1

Mechanisms1

Fibrosis1

Mice1

Inflammation2

Chronic1

Molecular2

Gene4

Coronary1

Exposure3

Syndrome1

Human1

Adverse1

Inflammatory2

Cellular1

Protective1

Survival2

Contribute1

Lead1

Control1