Linoleic acid also promotes the optimal molecular composition of the phospholipid, cardiolipin (CL), an important mitochondrial phospholipid crucial (in its optimal form) for the function of a large number of enzymes involved in oxidative phosphorylation. (nih.gov)
Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure. (bvsalud.org)
Cardiolipin (CL) is an essential phospholipid for mitochondrial structure and function. (bvsalud.org)
Based on emerging and qualified peer-reviewed research, independent study demonstrates that DHA is the only omega-3 used to make mitochondrial cardiolipin, but only when sufficient DHA intake levels are maintained over time. (source-omega.com)
Most people persist at about 4% total omega-3 membrane levels and have very little, if any, DHA in their mitochondrial cardiolipin. (source-omega.com)
But now we observe studies with similar intake levels that support DHA accretion in mitochondrial cardiolipin within the same time periods. (source-omega.com)
Cardiolipin also participates in a structural scaffold essential for the distinctive shape of mitochondrial cristae. (source-omega.com)
Cardiolipin peroxidation products are required for the mitochondrial membrane permeabilization, release of pro-apoptotic factors and completion of the cell death program. (cdc.gov)
Peroxidation of cardiolipin leads to mitochondrial dysfunction and loss of ATP production. (uvm.edu)
Researchers speculate that the abnormal cardiolipin affects mitochondrial function, reducing cellular energy production and leading to the neurological and hearing problems characteristic of MEGDEL syndrome. (medlineplus.gov)
6. Interaction of NDPK-D with cardiolipin-containing membranes: Structural basis and implications for mitochondrial physiology. (nih.gov)
8. The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration. (nih.gov)
9. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. (nih.gov)
11. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. (nih.gov)
2015). C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization. (tcdb.org)
Mitochondria6
Cardiolipin is a novel phospholipid made only in the mitochondria, which are the sole power factories for our body and cells. (source-omega.com)
One of the most contemporary examples includes selective peroxidation of cardiolipin in mitochondria of cells undergoing apoptosis. (cdc.gov)
Thus, cardiolipin contains four linoleic acids, which is essential to its function as this imparts its characteristic cone shape that is important in forming the cristae of the mitochondria. (uvm.edu)
Cardiolipin mediates the interaction between proteins in the membranes of mitochondria - the powerhouses of cells. (imperial.ac.uk)
2. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. (nih.gov)
12. LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease. (nih.gov)
Antibodies12
What is Anti-cardiolipin antibodies? (thyrocare.com)
Anti-cardiolipin antibodies are acquired auto-antibodies produced against cardiolipins and are found in the immunoglobulin classes- IgG, IgM and/or IgA. (thyrocare.com)
The presence of anti-cardiolipin antibodies in systemic lupus erythematosus can be related to the development of thrombosis. (thyrocare.com)
Anti-cardiolipin antibodies have been found in some cerebrovascular insufficiency, cerebral ischemia and in myocardial infarction. (thyrocare.com)
The test is an immunoassay (e.g., enzyme immunoassay (EIA), Treponema pallidum particle agglutination assay (TPPA), enzyme-linked immunosorbent assay (ELISA), lateral flow device, dipstick or flow-through device) that uses modified cardiolipin, a lipoidal entity thought to be released from host cells and/or Treponema pallidum (bacterial) cells that are damaged over the course of infection, as an antigen to detect anti-cardiolipin antibodies in blood samples. (nih.gov)
Cardiolipin antibodies are useful in identifying patients with an increased risk of thrombosis, recurrent spontaneous abortions and phospholipid antibody syndrome (APS). (apollodiagnostics.in)
The Rabbit Anti- cardiolipin antibody IgG(ACA-IgG) ELISA Kit is a ready to use kit manufactured by using high quality antibodies sets, plates, solutions and detection molecules. (antibodies-shop.com)
We herewith report a rare case of an11 year old girl, who presented with left-sided hemiparesis, dysarthria, left UMN facial palsy, feeble pulses on right side, high Blood Pressure recordings and positive anti- cardiolipin antibodies. (who.int)
I generally avoid estrogens, both in the form of hormone replacement and in the form of birth control, in lupus women who have antiphospholipid antibodies (such as cardiolipin antibodies) because of their association with clotting events. (medicinenet.com)
Seizures in lupus patients were reported to be associated with increased signs of disease activity and high levels of cardiolipin antibodies. (medicinenet.com)
The 2006 revised Sapporo laboratory criteria for APS as previously mentioned includes the lupus anticoagulant tests as well as immunoassays for the detection of IgG and IgM antibodies to cardiolipin (CL) and β2GPI. (aacc.org)
The RPR test measures IgM and IgG antibodies to lipoidal material released from damaged host cells, as well as to lipoprotein-like material and possibly cardiolipin released from the treponemes. (cdc.gov)
Phospholipid2
Negativ geladene Phospholipide wie Cardiolipin interagieren mit der positiv geladenen fünften Domäne von b2 GP-I, eine Interaktion, die zu Konformationsänderungen des Proteins und zur Bildung neuer Epitope führt, die von autoimmunen Phospholipid-Autoantikörpern erkannt werden. (medipan.de)
Another phospholipid called cardiolipin is made from phosphatidylglycerol. (medlineplus.gov)
Lipid4
Cardiolipin is a lipid complex that can only be made from certain fatty acids. (source-omega.com)
Cardiolipin is an essential lipid that is important in energy metabolism. (nih.gov)
Dr Sarah Rouse , from the Department of Life Sciences at Imperial, is particularly interested in how proteins interact via a lipid molecule called cardiolipin. (imperial.ac.uk)
Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. (nih.gov)
ANTIBODY5
This test measures the levels of Anti Cardiolipin Antibody (IgM) in the blood. (hod.care)
Small volumes from the liquid components of the Anti- cardiolipin antibody IgG(ACA-IgG) EIA kit may get caught on the walls and lid of the vials. (antibodies-shop.com)
This EIA test for Rabbit Rabbit Anti- cardiolipin antibody IgG(ACA-IgG) will yield accurate and reproducible results. (antibodies-shop.com)
Store all components and reagents of the Anti- cardiolipin antibody IgG(ACA-IgG) ELISA Kit refrigerated and +4 degrees Celcius. (antibodies-shop.com)
One GPL/MPL unit is defined as the cardiolipin-binding activity of 1 g/ml of affinity-purified IgG or IgM aCL antibody. (aacc.org)
Peroxidation2
Therefore, search for effective inhibitors of cardiolipin peroxidation is critical to discovery and development of anti-apoptotic antioxidants. (cdc.gov)
This suggests that protective effects of vitamin E homologues against tetralinoleoyl cardiolipin peroxidation catalyzed by cytochrome c/ hydrogen peroxide are realized largely due to their effects on the peroxidase activity of cytochrome c towards tetralinoleoyl cardiolipin rather than via their scavenging activity. (cdc.gov)
Binds1
It binds cardiolipin, possibly regulating its own turnover. (tcdb.org)
Cytochrome1
Our data indicate that vitamin E homologues inhibit not only accumulation of tetralinoleoyl cardiolipin hydroperoxides but also hydroxy-derivatives of tetralinoleoyl cardiolipin formed in the enzymatic peroxidase half-reaction catalyzed by cytochrome c. (cdc.gov)
Synthase2
Cardiolipin functions as a proton trap giving ATP synthase the juice needed to enhance electron transfer and reduce electron leakage. (source-omega.com)
Exposure to targocil causes damage to the cellular barrier and activates EdsRS to induce expression of a previously uncharacterized cardiolipin synthase, which we have named ClsT. (nih.gov)
Affects1
But only by knowing the detailed mechanisms of how cardiolipin affects proteins and their related actions in ageing can researchers hope to design potential new drug molecules to slow any degenerative processes. (imperial.ac.uk)
Composition1
As a result, phosphatidylglycerol remodeling is impaired, which likely alters the composition of cardiolipin. (medlineplus.gov)
Activation1
Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis. (nih.gov)
Levels2
Induction of clsT by EdsRS during targocil treatment results in an increase in cardiolipin levels, which protects B. anthracis from envelope damage. (nih.gov)
Josiah Hardesty, Ph.D. , at the University of Louisville, who leads a project titled "Restoration and Preservation of Hepatic Cardiolipin Levels Promotes Liver Regeneration in Alcohol-associated Hepatitis. (nih.gov)
Diagnosis1
The method allows the measurement of the ratio between monolysocardiolipin and cardiolipin for the rapid diagnosis of Barth syndrome. (jove.com)
Important1
Cardiolipin is known to be important in ageing, as well as in age-related disorders including neurodegenerative disease, cardiomyopathies (heart-related diseases) and cancer. (imperial.ac.uk)
Anti2
Der Anti-Cardiolipin Screen ist ein semi-quantitativer Immunoassay zur Bestimmung von IgG, IgM und IgA Antikörpern gegen Cardiolipin in humanem Serum. (medipan.de)
Der Anti-Cardiolipin Screen dient zur Unterstützung bei der Diagnose des Antiphospholipid Antikörper Syndroms (APAS) in Verbindung mit anderen klinischen und laboratoriums-medizinischen Untersuchungen. (medipan.de)
Leads1
It is caused by a mutation in the tafazzin gene (TAZ, also known as G4.5) which leads to decreased production of an enzyme required to produce cardiolipin. (nih.gov)
Small1
We tested this hypothesis by intraperitoneally injecting APP/PS1 transgenic mice with small unilamellar vesicles containing either phosphatidic acid or cardiolipin over 3weeks. (nih.gov)
Phosphatidylglycerol1
As a result, phosphatidylglycerol remodeling is impaired, which likely alters the composition of cardiolipin. (medlineplus.gov)
Researchers2
The researchers identified a molecular pump, called Atp8b1, in lung cells that normally helps to keep cardiolipin levels in check by removing the molecule from lung fluid. (nih.gov)
The researchers are now working to develop techniques for treating lungs with compounds that can bind tightly to cardiolipin and reduce lung injury. (nih.gov)
Tissue3
Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. (cdc.gov)
When the scientists administered cardiolipin to mice, the animals' lung function declined and the resulting tissue damage appeared similar to human pneumonia. (nih.gov)
Additional experiments confirmed that elevated cardiolipin appears to harm lung tissue. (nih.gov)
Results1
Our results indicate that selective cardiolipin (CL) oxidation is a result of a non-random free radical process. (cdc.gov)
Damage2
Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis. (nih.gov)
Cardiolipin is then used to repair envelope damage and promote B. anthracis viability.IMPORTANCE Compromising the integrity of the bacterial cell barrier is a common action of antimicrobials. (nih.gov)