Cardiolipin in mitochondrial cardiolipin effects mitochondrial. Medical search. Frequent questions

Diet restriction (DR) ameliorates obesity by regulating mitochondrial function. (myjournals.org)

it was found that during apoptosis, cardiolipin in the outer membrane of the mitochondria increased from 10% to 30% saturation. (wikipedia.org)
Lee's study looked into the consequences of cardiolipin redistribution in the mitochondria and found that cardiolipin plays a critical role in proteins that are involved with oxidative respiration (such as ATP synthase), which in turn affects ATP production. (wikipedia.org)
Thus, when PLS3 flips cardiolipin across the inner to outer membrane of the mitochondria, the oxidative phosphorylation induced is greatly disturbed. (wikipedia.org)
Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. (frontiersin.org)
Recently, two additional essential functions of cyt c in apoptosis have been discovered that are carried out via its interactions with anionic phospholipids: a mitochondria specific phospholipid, cardiolipin (CL), and plasma membrane phosphatidylserine (PS). (cdc.gov)
Genetic mutations in the gene Optic Atrophy 1 ( OPA1 ) cause autosomal dominant optic atrophy (DOA), one of the most common forms of mitochondrial disease where mitochondria are fragmented in small vesicles. (pasteur.fr)
PGS1 depletion reduces mitochondrial fission and restores normal mitochondrial morphology to OPA1 -deficient fibroblasts, but does not recover all defects displayed by the mitochondria. (pasteur.fr)
Preclinical SBT-272 data have demonstrated mitochondria-protective and neuroprotective effects in models of ALS, FTD, alpha-synucleinopathy, a rare form of dementia that is similar to Parkinson's disease, Huntington's disease and ischemic stroke. (stealthbt.com)
Down-regulation of cardiolipins is due to a reduction of mitochondria, which is caused by an ATRA-dependent decrease in the expression of nuclear genes encoding mitochondrial proteins. (slub-dresden.de)
Using flies, mice and patient cells, the team focused on cardiolipin, a fat unique to cells' mitochondria, organelles that produce energy. (drugtargetreview.com)
They demonstrated that reducing the effects of the protein FASN influences the mitochondria, leading to increased cardiolipin levels and reduced Parkinson's symptoms. (drugtargetreview.com)
Using fly, mouse and human cell models, they saw that FASN has a direct effect on mitochondria, which have their own separate genomes and operate as energy producing entities within their cells. (drugtargetreview.com)
Prof Patrik Verstreken said, "The PINK1 gene encodes the PINK1 protein, and mutations in it lead to lower levels of cardiolipin in mitochondria. (drugtargetreview.com)
It was unexpected to see that blocking FASN - which is not localised to the mitochondria - actually sidesteps the mitochondrial effects of the PINK1 mutation. (drugtargetreview.com)
And while we successfully demonstrated that cardiolipin can improve the function of mitochondria in flies, mouse models and in human cells, we need to explore its effects in actual patients. (drugtargetreview.com)

Szeto-Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that have demonstrated efficacy in treating a wide array of mitochondrial disorders, and are believed to target mitochondrial membranes due to their enrichment in the anionic phospholipid cardiolipin (CL). (biorxiv.org)
The mitochondrial signature phospholipid cardiolipin shows a stabilizing function on Mic10 oligomers. (rug.nl)
This system constitutes a model to decipher the role of the above electrostatic interaction in the unfolding of cytochrome c at physiological pH upon interaction with the membrane component phospholipid cardiolipin in the early stages of the apoptosis cascade. (unimore.it)

Cardiolipin is a mitochondrion-specific phospholipid found in both the mitochondrial inner and outer membranes Many studies speculate that cardiolipin is a likely player in mitochondrial apoptosis. (wikipedia.org)
Finding that cardiolipin concentration in the outer mitochondrial membrane increased during apoptosis (as well as knowing the function that PLS3 plays in mitochondrial apoptotic effects) clued Lee in to the fact that PLS3 may have effects on this cardiolipin membrane redistribution. (wikipedia.org)
It was deduced experimentally that a lack of proper oxidative phosphorylation is directly linked with mitochondrial apoptosis. (wikipedia.org)
Thus, this PLS3-induced redistribution of cardiolipin during apoptosis has major effects on mitochondrial function. (wikipedia.org)
Since the (re)discovery of cytochrome c (cyt c) in the early 1920s and subsequent detailed characterization of its structure and function in mitochondrial electron transport, it took over 70 years to realize that cyt c plays a different, not less universal role in programmed cell death, apoptosis, by interacting with several proteins and forming apoptosomes. (cdc.gov)
Because antioxidant enhancements protect cells against apoptosis, ROS production was viewed not as a meaningless side effect of mitochondrial disintegration but rather playing some - as yet unidentified - role in apoptosis. (cdc.gov)
Crocin induced apoptosis and restored mitochondrial function in HCT-116 cells via repressing the JAK pathway. (bvsalud.org)
Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis. (nacalaiusa.com)
How does mitochondrial Grx2 protect from doxorubicin toxicity, cardiolipin peroxidation and apoptosis? (mpg.de)
Propolis protective effects against doxorubicin-induced multi-organ toxicity via suppression of oxidative stress, inflammation, apoptosis, and histopathological alterations in female albino rats. (mosuljournals.com)

This newly found member of the scramblase family is "responsible for phospholipid translocation between two lipid compartments," the inner mitochondrial membrane and the outer membrane. (wikipedia.org)
It was subsequently deduced that PLS3 is an effector for the redistribution of cardiolipin from the inner to outer mitochondrial membrane. (wikipedia.org)
Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
As a proof of concept, we show that SS-31 alters ion distribution at the membrane interface with implications for maintaining mitochondrial membranes subject to divalent cation (calcium) stress. (biorxiv.org)
The multi-subunit mitochondrial contact site and cristae organizing system (MICOS) is a conserved protein complex of the inner mitochondrial membrane that is essential for maintenance of cristae architecture. (rug.nl)
The reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) were examined by flow cytometer. (bvsalud.org)
SBT-272 is a novel small molecule that targets the cardiolipin-rich inner mitochondrial membrane which is crucial for normal mitochondrial structure and function. (stealthbt.com)
The latter mimics the electrostatic interaction with the inner mitochondrial membrane. (unimore.it)
Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity. (bioblast.at)
Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. (mpg.de)

Cs-Lpin1 -/- mice exhibited diminished cardiac cardiolipin content and impaired mitochondrial respiration rates when provided with pyruvate or succinate as metabolic substrates. (bioblast.at)
SARS-CoV-2 infection of cultured cells is accompanied by elevated glycolysis and decreased mitochondrial function, whereas 2DG represses glycolysis and stimulates respiration, and restricts viral replication. (nature.com)
On coupling control of mitochondrial respiration. (bioblast.at)

In this study, we have analyzed the interactions of the lead compound SS-31 (Elamipretide) with model and mitochondrial membranes using biophysical and computational approaches. (biorxiv.org)
Most notably, SS-31 modulates the surface electrostatic properties of model and mitochondrial membranes, which could play a significant role in the mitoprotective properties of this compound. (biorxiv.org)
ATRA perturbs the homeostasis of numerous lipids and the most relevant effects are observed on cardiolipins, which are located in the mitochondrial inner membranes and play a role in oxidative-phosphorylation. (slub-dresden.de)
Cardiolipin promotes pore-forming activity of alpha-synuclein oligomers in mitochondrial membranes. (mpg.de)

Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. (frontiersin.org)
Mitochondrial dysfunction includes heritable diseases, acquired pathologies, and age-related declines in health. (biorxiv.org)
Oxidative stress induces cyclosporine A-sensitive mitochondrial efflux of calcium and proapoptotic factors through MPTP (mi- tochondrial permeability transition pore) opening in heart mito- chondria which may contribute to tissue damage and mitochon- drial dysfunction in aging rats. (kiev.ua)
MITO ), a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel therapies for diseases involving mitochondrial dysfunction, announced today the presentation of new SBT-272 preclinical data demonstrating functional improvement in upper motor neurons with TDP-43 pathology, which plays a significant role in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (stealthbt.com)
We designed SBT-272 to target mitochondrial dysfunction in the brain, which is known to precede and contribute to several neurodegenerative diseases, including ALS. (stealthbt.com)
We aim to develop SBT-272 for ALS and other neurological diseases of mitochondrial dysfunction. (stealthbt.com)
We are a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel therapies for diseases involving mitochondrial dysfunction. (stealthbt.com)
We believe our lead product candidate, elamipretide, has the potential to treat ophthalmic diseases entailing mitochondrial dysfunction, such as dry AMD, rare neuromuscular disorders, such as primary mitochondrial myopathy and Duchenne muscular dystrophy, and rare cardiomyopathies, such as Barth syndrome. (stealthbt.com)
Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)

Quantification of mitochondrial fission and fusion rate through photoactivation in Glioblastoma Multiforme. (bioblast.at)
Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. (nih.gov)

This is of paramount interest as it is known that excess lipids will be shunted into pathways that ultimately disrupt normal cellular function leading to altered metabolic demands and damaging effects, in part due to a reprogramming of the bioenergetics. (bergdahllab.com)

They then identified genes involved in mitochondrial morphology maintenance and fragmentation, among which PGS1, a key enzyme in cardiolipin biosynthesis. (pasteur.fr)

Execution of apoptotic program in cells is accompanied by substantial and early mitochondrial production of reactive oxygen species (ROS). (cdc.gov)

In addition, systemic effects of cardiolipin deficiency like neutropenia, T cell defects or other immune-related pathologies are important comorbidity factors in Barth syndrome patients in particular in respect to their higher susceptibility to recurrent infections. (barthsyndrome.org)
Systemic implications of 'cardiolipin' , a phospholipid that gets released in large amounts from the heart following a myocardial infarction. (bergdahllab.com)

The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
Defects in the adaptive branch of immunity might also further deteriorate muscle function if inflammation is modulated by cardiolipin deficiency. (barthsyndrome.org)
Cardiolipin (CL), a mitochondrial phospholipid, is closely associated with mitochondrial function. (myjournals.org)
Source-Omega ( www.source-omega.com ) today asserts the newest DHA omega-3 structure-function claim filed with the FDA to demonstrate how their exclusive product, SOURCE OIL® - Water Extracted Chromista Oil - best supports mitochondrial health and maintenance. (source-omega.com)
These data suggest that loss of lipin 1 impairs cardiac functional reserve, likely due to effects on glycerolipid homeostasis, mitochondrial function, and protein kinase A signaling. (bioblast.at)
Thus, decreasing glycolysis and augmenting mitochondrial function could be beneficial to tackle the disease. (nature.com)
The heart is a highly oxidative muscle and any disruption in mitochondrial function can cause disturbed cardiac function and ultimately myocardial infarction. (bergdahllab.com)
Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure. (bioblast.at)
Metallothioneins are involved in mitochondrial function and disease. (bioblast.at)
Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. (plantbasedacademy.com)
induced cardiac toxicity such as oxidative stress and deteriorated mitochondrial function, a disturbance in iron regulatory protein [(IRP)-1], the release of nitric oxide, autophagy and dysregulation of Ca 2+ level. (mosuljournals.com)

Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
Additionally, molecular dynamics simulations were performed to estimate stability and flexibility of best complexes, while collagenase activity colorimetric assay was carried out to study the effects of (1), (2) and (3) on collagenase. (ijpsonline.com)
We have studied electrochemically the effects of urea-induced unfolding on the protein electrostatically immobilized on an electrode surface functionalized by means of a negatively charged molecular spacer. (unimore.it)
Mitochondrial molecular diagnostics in South Africa: Lessons from the past 20 years. (bioblast.at)
Our findings indicate that tumor associated macrophages including Kupffer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects. (stanford.edu)

Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: The protective role of melatonin. (bioblast.at)
Hozayen WG, Seif HSA, Amin S. Protective Effects of Ruitn and / or Hesperidin Against Doxorubicin-Induced Hepatotoxicity. (mosuljournals.com)

On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. (frontiersin.org)
Heart failure is thought to be the end result following the combination of mitochondrial derived oxidative stress and decreased energy production. (bergdahllab.com)
Najeem Eldeen A, Mahmood Mohammed M, Dakhel M. Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning. (mosuljournals.com)

The altered profile of mitochondrial CL in the liver was explored using a targeted metabolomics strategy by ultra-high-pressure liquid chromatography MS/MS coupled with quadrupole time-of-flight mass spectrometry. (myjournals.org)

Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca 2+ homeostasis leading to neuroinflammation. (frontiersin.org)

This study provides new insights into the mitochondrial mechanisms underlying DR intervention in obesity. (myjournals.org)
Our findings indicate that the Mic10 core machinery of MICOS is regulated by several mechanisms, including interaction with cardiolipin and antagonistic actions of Mic26 and Mic27. (rug.nl)
To learn about basic mitochondrial and cellular biology, understand mechanisms of disease, and develop drugs, cell culture is indispensable. (brocku.ca)
A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. (vdocuments.mx)

Combining image analysis using supervised machine learning to quantify mitochondrial morphology defects and high-throughput genetic screening of 1,531 nuclear-encoded mitochondrial genes (called the mitome), Tim Wai and his colleagues analysed fibroblasts from both healthy individuals and patients suffering from DOA+. (pasteur.fr)
Many of the mitochondrial phenomena we investigate exert effects on these processes and thus manifest as changes in mitochondrial network morphology. (brocku.ca)
Measuring mitochondrial network morphology in mitochondrial disease. (brocku.ca)

Biochemical and histopathological analyses were performed to evaluate the ameliorative effects of DR on obese mice. (myjournals.org)
We generated mice with cardiac-specific lipin 1 KO (cs-Lpin1 -/- ) to examine the intrinsic effects of lipin 1 in the myocardium. (bioblast.at)
these effects were not observed in mice with depletion of CD8+ T cells. (stanford.edu)

We report that Mic26 exerts a destabilizing effect on Mic10 oligomers and thus functions in an antagonistic manner to the stabilizing subunit Mic27. (rug.nl)

Mitochondrial Oxygen Toxicity. (brocku.ca)
Mitochondrial zinc toxicity. (brocku.ca)
is associated with limited-use adverse effects specifically accumulative and dose-dependent heart toxicity which is the underlying cause for increasing the risk of mortality in cancer patients that use this kind of anticancer. (mosuljournals.com)

Of note, investigating further the effects of cardiolipin deficiency or modification (oxidation/saturation) in the adaptive immune response is pivotal in the context of current (Tazpower) or future trials impacting cardiolipin remodeling and/or oxidation. (barthsyndrome.org)

Toxic effects of Dox include cardiomyocyte damage and apoptotic and necrotic cell death [ 5 ]. (oncotarget.com)

This study shows mitochondrial defects linked to OPA1 deficiency in DOA patients are also modulated by the action of other mitochondrial genes in a more intricate fashion, with clinical implications for diagnosis. (pasteur.fr)

Notably, the former does not require oxygen, whereas mitochondrial energy production is dependent on oxygen. (nature.com)

Severe side effects such as cardiotoxicity, however, limit Dox application. (oncotarget.com)
Therefore, targeting this alteration using bee propolis has shown strong protective effects against the cardiotoxicity of Dox. (mosuljournals.com)

Disse opgørelser er endnu ikke publiceret, men udkommer som en NOVANA rapport i efteråret 2020. (gylle.dk)

The Barth Syndrome (BTHS) is caused by the loss of the mitochondrial acyltransferase tafazzin, which is involved in the remodeling process of the hallmark mitochondrial glycerophospholipid cardiolipin. (uni-goettingen.de)
In addition to the six recognized hallmarks of cancer, aerobic glycolysis or the Warburg effect is also a robust metabolic hallmark of most tumors. (plantbasedacademy.com)

In Lee's experiment determining the effect of cardiolipin deprivation on cells, he studied an infected yeast mutant that lacked a cardiolipin creating enzyme, and found that although it was viable, the yeast was "moderately deficient in mitochondrial energy transforming machinery. (wikipedia.org)

Cycling and small-sided games similarly stimulates mitochondrial gene expression and signalling in middle-aged sedentary men. (bioblast.at)

Recent research has revealed important correlation of mitochondrial dynamics and the pathophysiology of brain diseases, as Alzheimer's. (frontiersin.org)

The notion that rubella wasonly a mild illness of children was dispelled in 1941, whenNorman Gregg, an Australian ophthalmic surgeon, reportedthe devastating teratogenic effects of the virus (47). (vdocuments.net)

My previous work started to shed light on the effects of cardiolipin deficiency in CD8+ T cell immune response (Corrado et al. (barthsyndrome.org)

The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. (bioblast.at)

While 2DG has pleiotropic effects on cell metabolism in cultured cells it is not known which of these manifests in vivo. (nature.com)
However, inhibition of glycolysis is merely the most prominent of a number of pleiotropic effects of 2DG on cell metabolism. (nature.com)
Metabolomics reveal altered mitochondrial metabolism associated with hypertension in a black South African male cohort: the SABPA study. (bioblast.at)

Crocin has been reported to have therapeutic effects on multiple cancers including colon cancer, but its specific mechanism is still ambiguous and needs to be further explored. (bvsalud.org)
Mitochondrial-targeted therapeutic approaches for manipulating cardiolipin. (brocku.ca)

Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. (oncotarget.com)

Briefly, CD8+ T cells, responsible for fighting infections and safeguarding our organism from cancer, rely on the presence of cardiolipin and on its regulated synthesis and remodeling to properly activate, expand and eliminate pathogens or tumor cells. (barthsyndrome.org)
Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin. (nih.gov)
The resulting CDP-diacylglycerol can be utilized immediately for the synthesis of phosphatidylglycerol (PG), and thence cardiolipin (CL), and of phosphatidylinositol (PI). (ymdb.ca)

The increase in the heart respiratory chain proteome suggests an increase in mitochondrial oxidative capacity, which could compensate for the energy deficit caused by the inhibition of glycolysis. (nature.com)

cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells. (nacalaiusa.com)

To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)
Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)

ATRA reduces the amounts of cardiolipins and the effect is associated with the growth-inhibitory activity of the retinoid. (slub-dresden.de)

Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease. (frontiersin.org)
Mitochondrial dynamics in health and disease. (brocku.ca)

SBT-272 significantly improved mitochondrial structural integrity and motility in TDP-43 mutant (A315T)-expressing upper motor neurons. (stealthbt.com)
Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. (nacalaiusa.com)

The new findings presented today further strengthen the importance of improving mitochondrial health with respect to TDP-43 pathology in ALS and lay a strong foundation for the clinical development of SBT-272 for ALS patients. (stealthbt.com)
Advances in methods to analyse cardiolipin and their clinical applications. (ucl.ac.uk)

As 2DG achieves both these effects in cultured cells 12 we sought to determine whether this occurred in vivo in the heart, which could explain its reported anti-SARS.CoV-2 effects. (nature.com)
To facilitate this we developed the Mitochondrial Network Analysis (MiNA) toolset as a simple set of macros making use of existing ImageJ plug-ins that allows a semi-automated analysis of mitochondrial networks in cultured mammalian cells. (brocku.ca)
111) infected African green monkey kidneycells with throat washings from patients with rubella and indi-rectly demonstrated the presence of RV by resistance to chal-lenge with an echovirus, while Weller and Neva (154) detectedcytopathic effects in human amnion cells infected with RVfrom blood and urine specimens. (vdocuments.net)
The origin of the Warburg effect in tumor cells has been controversial. (plantbasedacademy.com)
However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)

A study of the effects of fructose feeding & exercise on SIRT 3 regulation in skeletal muscle. (bioblast.at)

In this study, MRI was applied to observe whether resveratrol could intensify the anti-GBM tumor effect by enhancing antitumor immunity during radiotherapy. (bvsalud.org)
Stuart JA, Moradi F. Resveratrol effects on skeletal muscle. (brocku.ca)

On the other hand, it is known that 2DG given continuously can have severe detrimental effects on the rodent heart. (nature.com)
Deciphering 2DG's effects in vivo is important to understand how it might restrict viral infections, such as SARS-CoV-2, and any complications that might segue, especially those affecting the heart where 2DG has been reported to have serious detrimental effects in rodents 7 . (nature.com)

My research in cell physiology focuses on mitochondrial biology in the context of health, aging, and disease. (brocku.ca)

Ubiquitylation of histones regulates chromatin-templated processes through a combination of structural and functional effects. (uni-goettingen.de)

Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how this could happen and whether this could exacerbate or worsen muscle condition in Barth syndrome patients will be the core of this project. (barthsyndrome.org)

These enhancements in mitochondrial health were associated with improved axon outgrowth, a key indicator of improved neuronal health. (stealthbt.com)

Patients with low-ROS genotypes had an increased frequency of positivity for antiphospholipid antibodies anti-β2 glycoprotein I and anti-cardiolipin, related to the severe comorbidity antiphospholipid syndrome (APS). (bmj.com)

Chemicals and Drugs4

Phenomena and Processes1

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Named Groups1

Health Care1

Geographicals1

Regulating mitochondrial function1

Mitochondria15

Phospholipid cardiolipin3

Apoptosis10

Membrane10

Respiration3

Membranes4

Dysfunction10

Fission2

Bioenergetics1

Biosynthesis1

Reactive oxygen1

Systemic2

Function11

Molecular6

Doxorubicin-induced2

Oxidative stress3

Targeted metabolomics1

Homeostasis1

Mechanisms4

Morphology3

Mice3

Oligomers1

Toxicity3

Saturation1

Apoptotic1

Implications1

Dependent1

Cardiotoxicity2

20201

Hallmark2

Enzyme1

Stimulates1

Diseases1

Ophthalmic1

Deficiency1

Electron1

Metabolism3

Therapeutic2

Cellular1

Synthesis3

Respiratory1

Promotes1

Gene expression2

Reduces1

Dynamics2

Integrity2

Clinical2

Cells5

Regulation1

Resveratrol2

Detrimental effects2

Context1

Structural1

Reduction1

Enhancements1

Severe1