• Szeto-Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that have demonstrated efficacy in treating a wide array of mitochondrial disorders, and are believed to target mitochondrial membranes due to their enrichment in the anionic phospholipid cardiolipin (CL). (biorxiv.org)
  • Recently, two additional essential functions of cyt c in apoptosis have been discovered that are carried out via its interactions with anionic phospholipids: a mitochondria specific phospholipid, cardiolipin (CL), and plasma membrane phosphatidylserine (PS). (cdc.gov)
  • The mitochondrial signature phospholipid cardiolipin shows a stabilizing function on Mic10 oligomers. (rug.nl)
  • This system constitutes a model to decipher the role of the above electrostatic interaction in the unfolding of cytochrome c at physiological pH upon interaction with the membrane component phospholipid cardiolipin in the early stages of the apoptosis cascade. (unimore.it)
  • BTHS is an X-linked genetic disease resulting from defects in the transacylase enzyme tafazzin, involved in biosynthetic remodeling of the mitochondrial phospholipid cardiolipin. (uconn.edu)
  • These changes can promote mitochondrial biogenesis and membrane dynamics that in turn support mitochondrial respiration. (nature.com)
  • Fig. 2: Transcriptional control of mitochondrial biogenesis through PGC1α. (nature.com)
  • Administration of chemical compounds, which modulate mitophagy and mitochondrial biogenesis, sustains energy metabolism leading subsequently to cellular and organismal survival. (atlasofscience.org)
  • [10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
  • cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells. (nacalaiusa.com)
  • Mitochondrial dysfunction includes heritable diseases, acquired pathologies, and age-related declines in health. (biorxiv.org)
  • MITO ), a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel therapies for diseases involving mitochondrial dysfunction, announced today the presentation of new SBT-272 preclinical data demonstrating functional improvement in upper motor neurons with TDP-43 pathology, which plays a significant role in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (stealthbt.com)
  • We designed SBT-272 to target mitochondrial dysfunction in the brain, which is known to precede and contribute to several neurodegenerative diseases, including ALS. (stealthbt.com)
  • We aim to develop SBT-272 for ALS and other neurological diseases of mitochondrial dysfunction. (stealthbt.com)
  • We are a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel therapies for diseases involving mitochondrial dysfunction. (stealthbt.com)
  • We believe our lead product candidate, elamipretide, has the potential to treat ophthalmic diseases entailing mitochondrial dysfunction, such as dry AMD, rare neuromuscular disorders, such as primary mitochondrial myopathy and Duchenne muscular dystrophy, and rare cardiomyopathies, such as Barth syndrome. (stealthbt.com)
  • Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)
  • Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. (frontiersin.org)
  • One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
  • Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
  • Initially these disorders were named according to symptoms (later the cause was found to be mitochondrial dysfunction and more specifically maternally inherited mitochondrial DNA variations). (medlink.com)
  • it was found that during apoptosis, cardiolipin in the outer membrane of the mitochondria increased from 10% to 30% saturation. (wikipedia.org)
  • Lee's study looked into the consequences of cardiolipin redistribution in the mitochondria and found that cardiolipin plays a critical role in proteins that are involved with oxidative respiration (such as ATP synthase), which in turn affects ATP production. (wikipedia.org)
  • Thus, when PLS3 flips cardiolipin across the inner to outer membrane of the mitochondria, the oxidative phosphorylation induced is greatly disturbed. (wikipedia.org)
  • Preclinical SBT-272 data have demonstrated mitochondria-protective and neuroprotective effects in models of ALS, FTD, alpha-synucleinopathy, a rare form of dementia that is similar to Parkinson's disease, Huntington's disease and ischemic stroke. (stealthbt.com)
  • Down-regulation of cardiolipins is due to a reduction of mitochondria, which is caused by an ATRA-dependent decrease in the expression of nuclear genes encoding mitochondrial proteins. (slub-dresden.de)
  • Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. (nature.com)
  • Gilkerson, R. W., Selker, J. M. L. & Capaldi, R. A. The cristal membrane of mitochondria is the principal site of oxidative phosphorylation. (nature.com)
  • Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. (frontiersin.org)
  • Programmed mitophagy: Mitophagic effects during retinal ganglion cell development (RGC), reverse differentiation towards pluripotency during somatic reprogramming, cardiomyocyte maturation, erythrocyte differentiation and sperm mitochondria elimination are depicted. (atlasofscience.org)
  • This five-year R01 for $2.5M is focused on investigating the molecular basis by which mitochondria-targeted peptide compounds interact with membranes and their downstream effects on membrane biophysical properties, protein complex structure and function, and mitochondrial physiology. (uconn.edu)
  • Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy . (wikipedia.org)
  • [5] The eukaryote Monocercomonoides is known to have completely lost its mitochondria, [6] and the multicellular organism Henneguya salminicola is known to have retained mitochondrion-related organelles in association with a complete loss of their mitochondrial genome. (wikipedia.org)
  • Carnitine palmitoyltransferase 1 (CPT1) is the enzyme in the outer mitochondrial membrane that converts long-chain acyl-CoA species to their corresponding long-chain acyl-carnitines for transport into the mitochondria (see Fig. Long‐Term Follow‐Up of Bezafibrate Treatment in Patients With the Myopathic Form of Carnitine Palmitoyltransferase 2 Deficiency. (siderac.com)
  • Like the other phospholipid scramblase family members (PLS1, PLS2, PLS4), PLS3 is a type II plasma membrane protein that is rich in proline and integral in apoptosis, or programmed cell death. (wikipedia.org)
  • Cardiolipin is a mitochondrion-specific phospholipid found in both the mitochondrial inner and outer membranes Many studies speculate that cardiolipin is a likely player in mitochondrial apoptosis. (wikipedia.org)
  • Finding that cardiolipin concentration in the outer mitochondrial membrane increased during apoptosis (as well as knowing the function that PLS3 plays in mitochondrial apoptotic effects) clued Lee in to the fact that PLS3 may have effects on this cardiolipin membrane redistribution. (wikipedia.org)
  • It was deduced experimentally that a lack of proper oxidative phosphorylation is directly linked with mitochondrial apoptosis. (wikipedia.org)
  • Thus, this PLS3-induced redistribution of cardiolipin during apoptosis has major effects on mitochondrial function. (wikipedia.org)
  • Since the (re)discovery of cytochrome c (cyt c) in the early 1920s and subsequent detailed characterization of its structure and function in mitochondrial electron transport, it took over 70 years to realize that cyt c plays a different, not less universal role in programmed cell death, apoptosis, by interacting with several proteins and forming apoptosomes. (cdc.gov)
  • Because antioxidant enhancements protect cells against apoptosis, ROS production was viewed not as a meaningless side effect of mitochondrial disintegration but rather playing some - as yet unidentified - role in apoptosis. (cdc.gov)
  • Redox catalysis of plasma membrane PS oxidation constitutes an important redox-dependent function of cyt c in apoptosis and phagocytosis. (cdc.gov)
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • How does mitochondrial Grx2 protect from doxorubicin toxicity, cardiolipin peroxidation and apoptosis? (mpg.de)
  • Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis. (nacalaiusa.com)
  • These are a special type of lipids that compose the cell membrane. (hellovaia.com)
  • ATRA perturbs the homeostasis of numerous lipids and the most relevant effects are observed on cardiolipins, which are located in the mitochondrial inner membranes and play a role in oxidative-phosphorylation. (slub-dresden.de)
  • FUNDC1, BNIP3, NIX, PHB2) or lipids (e.g. cardiolipin) that serve as mitophagy receptors in response to environmental and/or developmental stimuli. (atlasofscience.org)
  • The main biological functions of lipids include energy storage, acting as structural components of cell membranes , and participating as important signaling molecules . (wikidoc.org)
  • Lipids are a diverse group of compounds that have many key biological functions, such as acting as structural components of cell membranes, serving as energy storage sources and participating in signaling pathways. (wikidoc.org)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • These include the heat shock protein 70 in the endoplasmic reticulum and conserved nuclear membrane proteins. (preprints.org)
  • Here, we investigate the spatial distribution and regulation of mRNAs encoding these membrane and secretory proteins (termed "secretome" mRNAs) through live cell, single molecule tracking to directly monitor the position and translation states of secretome mRNAs on ER and their relationship to other organelles. (janelia.org)
  • Altogether, these findings uncover a novel coordination between ER and lysosomes, in which local release of amino acids and other factors from ER-associated lysosomes patterns and regulates translation of mRNAs encoding secretory and membrane proteins. (janelia.org)
  • Growth and division model proposes that peroxisomes form by fission from pre-existing ones and peroxisomal membrane proteins (PMPs) containing vesicles from the ER fuse with them to form functional peroxisomes which can grow further and divide [12]. (5dok.net)
  • Moreover, several studies have documented the existence of PINK1- and Parkin-independent signalling cascades revealing multiple mitochondrial proteins (e.g. (atlasofscience.org)
  • In addition to serving as a primary component of cellular membranes and binding sites for intra- and intercellular proteins, some glycerophospholipids in eukaryotic cells, such as phosphatidylinositols and phosphatidic acids are either precursors of, or are themselves, membrane-derived second messengers. (wikidoc.org)
  • [22] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . (wikipedia.org)
  • The structure and spontaneous curvature of clathrin lattices at the plasma membrane. (nih.gov)
  • On coupling control of mitochondrial respiration. (bioblast.at)
  • Fig. 3: Translational control of mitochondrial respiratory chain assembly. (nature.com)
  • The PINK1/Parkin pathway is the most well-studied molecular mechanism that regulates mitochondrial degradation upon stress. (atlasofscience.org)
  • The first, a grant from the National Institute on Aging, (R01AG065879), "First-in-class Peptide Therapeutics for Mitochondrial Disorders: Molecular Mechanism of Action and Optimization of Design. (uconn.edu)
  • Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. (oncotarget.com)
  • Through the explication and suggestion of information on the mechanism of toxic effects to safety assessment scientists, a subsidiary partnership system for risk assessment is ultimately to be a powerful tool that can indicate project-vector with data weight for the corresponding counterparts. (go.jp)
  • Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. (nih.gov)
  • In addition to the six recognized hallmarks of cancer, aerobic glycolysis or the Warburg effect is also a robust metabolic hallmark of most tumors. (plantbasedacademy.com)
  • Most of the metabolic energy of neurons is expended on maintaining ion gradients across the cell membrane. (benbest.com)
  • Compromised mitochondrial function results in the transformation of cellular powerhouses to "hotspots" of metabolic stress. (atlasofscience.org)
  • Hence, it is not surprising that mitochondrial damage is associated with a broad spectrum of pathological conditions, including premature ageing, myopathies, cardiovascular, metabolic and neurodegenerative diseases among others. (atlasofscience.org)
  • Metabolic rewiring and reformation of the entire mitochondrial population are mainly regulated by mitophagy during cardiomyocytes maturation, retinal ganglion cell (RGC) differentiation and macrophage polarization. (atlasofscience.org)
  • Carnitine palmitoyl transferase II deficiency, myopathic form Disease definition The myopathic form of carnitine palmitoyltransferase II (CPT II) deficiency, an inherited metabolic disorder that affects mitochondrial oxidation of long chain fatty acids (LCFA), is the most common and the least severe form of CPT II deficiency (see this term). (siderac.com)
  • On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. (frontiersin.org)
  • Starvation, hypoxia, heat, oxidative and mitochondrial stress are well-studied conditions known to potently induce mitophagy (Fig. 1b). (atlasofscience.org)
  • To elucidate the toxicological characteristics of NiNPs, we investigated their effects on the histopathology and oxidative states of zebrafish ( Danio rerio ) and compared the results with those of ionic nickel. (go.jp)
  • The multi-subunit mitochondrial contact site and cristae organizing system (MICOS) is a conserved protein complex of the inner mitochondrial membrane that is essential for maintenance of cristae architecture. (rug.nl)
  • These compartments or regions include the outer membrane, intermembrane space , inner membrane , cristae , and matrix . (wikipedia.org)
  • Quantification of mitochondrial fission and fusion rate through photoactivation in Glioblastoma Multiforme. (bioblast.at)
  • A hemi-fission intermediate links two mechanistically distinct stages of membrane fission. (nih.gov)
  • Membrane fission by dynamin: what we know and what we need to know. (nih.gov)
  • A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. (vdocuments.mx)
  • After reminding the reader of the basic concepts of mitochondrial genetics, she offers examples of disorders due to mutations in mitochondrial DNA and mutations in nuclear DNA. (medlink.com)
  • Mitochondrial disorders describe a broad range of disorders that have multiple genetic causes and variable symptoms and signs. (medlink.com)
  • In general, mitochondrial disorders are disorders of energy production. (medlink.com)
  • In this study, we have analyzed the interactions of the lead compound SS-31 (Elamipretide) with model and mitochondrial membranes using biophysical and computational approaches. (biorxiv.org)
  • Potassium ions rush out of the cell while sodium & chloride ions rush inward as the cell membranes depolarize. (benbest.com)
  • In Lee's experiment determining the effect of cardiolipin deprivation on cells, he studied an infected yeast mutant that lacked a cardiolipin creating enzyme, and found that although it was viable, the yeast was "moderately deficient in mitochondrial energy transforming machinery. (wikipedia.org)
  • Amphiphile monolayers as models to study polyelectrolyte coupling and enzyme reactions at membrane surfaces. (mpg.de)
  • To assess the effects of acylcarnitine accumulation on muscle insulin sensitivity, a model of muscle acylcarnitine accumulation was generated by deleting carnitine palmitoyltransferase 2 (CPT2) specifically from skeletal muscle (Cpt2 Sk−/− mice).CPT2 is an irreplaceable enzyme for mitochondrial long-chain fatty acid oxidation, converting matrix acylcarnitines to acyl-CoAs. (siderac.com)
  • Of note, investigating further the effects of cardiolipin deficiency or modification (oxidation/saturation) in the adaptive immune response is pivotal in the context of current (Tazpower) or future trials impacting cardiolipin remodeling and/or oxidation. (barthsyndrome.org)
  • Carnitine palmitoyltransferase II deficiency is an inherited disorder of mitochondrial long-chain fatty acid oxidation. (siderac.com)
  • Reducing equivalents produced in the Krebs cycle and in the beta-oxidation spirals are passed along a series of protein complexes embedded in the inner mitochondrial membrane (the electron transport chain). (medlink.com)
  • Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca 2+ homeostasis leading to neuroinflammation. (frontiersin.org)
  • Recent research has revealed important correlation of mitochondrial dynamics and the pathophysiology of brain diseases, as Alzheimer's. (frontiersin.org)
  • In this review of what is probably the most heterogeneous group of human diseases (the mitochondrial diseases including encephalomyopathies), the author tries to offer the clinician a rational diagnostic framework. (medlink.com)
  • A study of the effects of fructose feeding & exercise on SIRT 3 regulation in skeletal muscle. (bioblast.at)
  • Fig. 1: Regulation of mitochondrial respiratory capacity. (nature.com)
  • The core subunit Mic10 forms large oligomers that build a scaffold and induce membrane curvature. (rug.nl)
  • We report that Mic26 exerts a destabilizing effect on Mic10 oligomers and thus functions in an antagonistic manner to the stabilizing subunit Mic27. (rug.nl)
  • Cardiolipin promotes pore-forming activity of alpha-synuclein oligomers in mitochondrial membranes. (mpg.de)
  • Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. (plantbasedacademy.com)
  • Given that the consequences of defective mitochondrial function can be detrimental for cellular survival, redundant quality control mechanisms have been evolved to restore and sustain energy metabolism. (atlasofscience.org)
  • The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. (bioblast.at)
  • Fig. 4: Post-translational mechanisms governing respiratory control and the role of mitochondrial membrane dynamics. (nature.com)
  • Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how this could happen and whether this could exacerbate or worsen muscle condition in Barth syndrome patients will be the core of this project. (barthsyndrome.org)
  • Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. (nature.com)
  • Failure to properly carry out mitophagy deregulates mitochondrial function and causes progressive accumulation of defective organelles leading to the deterioration of biological systems, often culminating in tissue collapse. (atlasofscience.org)
  • Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
  • Additionally, molecular dynamics simulations were performed to estimate stability and flexibility of best complexes, while collagenase activity colorimetric assay was carried out to study the effects of (1), (2) and (3) on collagenase. (ijpsonline.com)
  • Recent molecular genetic analyses using Arabidopsis thaliana showed the conservation of nuclear membrane fusion machinery between plants and the budding yeast Saccharomyces cerevisiae. (preprints.org)
  • We have studied electrochemically the effects of urea-induced unfolding on the protein electrostatically immobilized on an electrode surface functionalized by means of a negatively charged molecular spacer. (unimore.it)
  • Mitochondrial molecular diagnostics in South Africa: Lessons from the past 20 years. (bioblast.at)
  • Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
  • Our findings indicate that tumor associated macrophages including Kupffer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects. (stanford.edu)
  • Molecular mechanics underlying flat-to-round membrane budding in live secretory cells. (nih.gov)
  • Metabolomics reveal altered mitochondrial metabolism associated with hypertension in a black South African male cohort: the SABPA study. (bioblast.at)
  • Bioactive sphingolipids in health and disease: lipidomic analysis, metabolism and roles in membrane signaling and autophagy. (sphingolipidclub.com)
  • Stress-induced mitophagy facilitates maximum mitochondrial quality control upon stress and supports adjustment of cellular metabolism to the external challenge. (atlasofscience.org)
  • Categorizing and describing a mitochondrial disorder is complicated in part because there are 3 ways to do so. (medlink.com)
  • Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. (atlasofscience.org)
  • The nuclear fusion process in plant reproduction is achieved by the sequential nuclear membrane fusion events. (preprints.org)
  • Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. (nih.gov)
  • Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
  • Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. (mpg.de)
  • Stress-induced mitophagy: Mitophagic effects during dissipation of mitochondrial membrane potential. (atlasofscience.org)
  • Although these homeostatic pathways may be sufficient to repair mitochondrial damage, uncontrolled and persistent defects trigger the removal of entire organelles through mitophagy. (atlasofscience.org)
  • Recent studies in nematodes, flies and rodents showed that most types of cells experience basal levels of mitophagy as part of their constant mitochondrial maintenance. (atlasofscience.org)
  • Furthermore, mitophagy removes total mitochondrial content during erythrocytes differentiation. (atlasofscience.org)
  • Identifying novel mitophagy modulators might establish novel therapeutic intervention strategies targeting a variety of mitochondrial-associated pathologies and provide critical insights with broad relevance to human health and quality of life (Fig. 2b). (atlasofscience.org)
  • Most notably, SS-31 modulates the surface electrostatic properties of model and mitochondrial membranes, which could play a significant role in the mitoprotective properties of this compound. (biorxiv.org)
  • Abstracts are listed here in the frame of the MiPMap for the 7th MiP school on Mitochondrial Physiology, 2015 Mar 24-28, Cape Town, ZA. (bioblast.at)
  • SBT-272 significantly improved mitochondrial structural integrity and motility in TDP-43 mutant (A315T)-expressing upper motor neurons. (stealthbt.com)
  • Structural comparisons revealed that the membrane structure at the base of the cilium and the microtubule organization differed between neurons and glia. (janelia.org)
  • Garab, G. (2014) Hierarchical organization and structural flexibility of thylakoid membranes. (brc.hu)
  • Poxviruses Encode a Reticulon-Like Protein that Promotes Membrane Curvature. (nih.gov)
  • For example, nickel nanoparticles (NiNPs) are used in electric capacitors, and their consumption is increasing, but there have been few reports of their toxicity and environmental effects. (go.jp)
  • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (nature.com)
  • these effects were not observed in mice with depletion of CD8+ T cells. (stanford.edu)
  • Loss of LHCB1 altered the thylakoid structure, with less membrane layers per grana stack and reduced grana width. (bvsalud.org)
  • Lambrev, P.H. and Akhtar, P. (2019) Macroorganisation and flexibility of thylakoid membranes. (brc.hu)
  • Mustárdy, L., Buttle, K., Steinbach, G. and Garab, G. (2008) The three-dimensional network of the thylakoid membranes in plants: quasihelical model of the granum-stroma assembly. (brc.hu)
  • 2014) The ultrastructure and flexibility of thylakoid membranes in leaves and isolated chloroplasts as revealed by small-angle neutron scattering. (brc.hu)
  • In addition, systemic effects of cardiolipin deficiency like neutropenia, T cell defects or other immune-related pathologies are important comorbidity factors in Barth syndrome patients in particular in respect to their higher susceptibility to recurrent infections. (barthsyndrome.org)
  • The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
  • Defects in the adaptive branch of immunity might also further deteriorate muscle function if inflammation is modulated by cardiolipin deficiency. (barthsyndrome.org)
  • Source-Omega ( www.source-omega.com ) today asserts the newest DHA omega-3 structure-function claim filed with the FDA to demonstrate how their exclusive product, SOURCE OIL® - Water Extracted Chromista Oil - best supports mitochondrial health and maintenance. (source-omega.com)
  • Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure. (bioblast.at)
  • Metallothioneins are involved in mitochondrial function and disease. (bioblast.at)
  • We aimed to identify the changes of mitochondrial function in rat livers when T2DM develops after NAFLD. (siderac.com)
  • Execution of apoptotic program in cells is accompanied by substantial and early mitochondrial production of reactive oxygen species (ROS). (cdc.gov)
  • Toxic effects of Dox include cardiomyocyte damage and apoptotic and necrotic cell death [ 5 ]. (oncotarget.com)
  • A primary cilium is a thin membrane-bound extension off a cell surface that contains receptors for perceiving and transmitting signals that modulate cell state and activity. (janelia.org)
  • Postsynaptic membranes contain several types of glutamate receptors, notably NMDA & AMPA receptors, which allow calcium ion entry. (benbest.com)
  • The notion that rubella wasonly a mild illness of children was dispelled in 1941, whenNorman Gregg, an Australian ophthalmic surgeon, reportedthe devastating teratogenic effects of the virus (47). (vdocuments.net)
  • These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
  • Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. (mpg.de)
  • My previous work started to shed light on the effects of cardiolipin deficiency in CD8+ T cell immune response (Corrado et al. (barthsyndrome.org)
  • Briefly, CD8+ T cells, responsible for fighting infections and safeguarding our organism from cancer, rely on the presence of cardiolipin and on its regulated synthesis and remodeling to properly activate, expand and eliminate pathogens or tumor cells. (barthsyndrome.org)
  • Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin. (nih.gov)
  • The resulting CDP-diacylglycerol can be utilized immediately for the synthesis of phosphatidylglycerol (PG), and thence cardiolipin (CL), and of phosphatidylinositol (PI). (ymdb.ca)
  • Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease. (frontiersin.org)
  • Examples of structures in this category are the digalactosyldiacylglycerols found in plant membranes and seminolipid from mammalian spermatazoa. (wikidoc.org)
  • Our results show that this polybasic peptide partitions into the membrane interfacial region with affinity and binding density that are directly related to surface charge. (biorxiv.org)