• Although several genes involved in mature conduction system function have been identified, their association with development of specific subcomponents of the cardiac conduction system remains challenging. (pcom.edu)
  • Several transcription factors, including homeodomain proteins and T-box proteins, are essential for cardiac conduction system morphogenesis and activation or repression of key regulatory genes. (pcom.edu)
  • In addition, several transcription factors modify expression of genes encoding the ion channel proteins that contribute to the electrophysiological properties of the conduction system and govern contraction of the surrounding myocardium. (pcom.edu)
  • A) Actual time PCR showed a considerable enhance in cardiac transcription element Nkx2.5, GATA4 and professional-angiogenic factor SDF-one, Ang-1 genes expression in left ventricle tissue at 3 days right after transplantation. (idhinhibitor.com)
  • Changes in some genes can cause atrial fibrillation on their own, while changes in other genes affect a person's risk of developing this condition in combination with a variety of environmental and lifestyle factors. (medlineplus.gov)
  • Some of these genes provide instructions for making cardiac transcription factors, which regulate the activity of certain genes involved in the formation and development of the heart before birth. (medlineplus.gov)
  • Other genes provide instructions for making parts of structural elements of cardiac muscle, such as sarcomeres. (medlineplus.gov)
  • Mutations in these non-ion channel genes have a variety of effects on the structure and function of cardiac muscle, all of which can lead to an abnormal heartbeat. (medlineplus.gov)
  • They then examined the mRNA expression pattern at a single cell level using so-called single-cell RNA sequencing analysis and found a subset of cardiac fibroblasts highly expressed genes activated by the transcription factor NF-kB and CCL2 mRNA. (kcl.ac.uk)
  • In response to tissue injury or stress, the resident cardiac fibroblasts undergo a transition to activated myofibroblasts, a highly synthetic cell type that induces the genes encoding smooth muscle α actin (ACTA2) and collagen. (kcl.ac.uk)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • We have previously shown that distal anterior wall ischemia/reperfusion induces gene expression changes in the proximal anterior myocardial area, involving genes responsible for cardiac remodeling. (oncotarget.com)
  • These studies are highly significant because it changes the paradigm that E2F mediated HCFC1 recruitment is critical for expression of cell cycle target genes, and raises the possibility that E2F participates in this process by recruiting factors other than HCFC1, thereby promoting new directions of research in this highly active field. (northwestern.edu)
  • PPARGC1A, a transcription factor regulating mitochondrial biogenesis and function and induced by oxidative stress, was increased and linked to many of the altered cardiac upstream regulators and genes associated with mitochondrial dysfunction. (cdc.gov)
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. (bvsalud.org)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
  • Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. (elsevierpure.com)
  • Isoforms with an intact T-box bound specifically to DNA sites resembling the consensus brachyury half site, although with less avidity compared with the related factor, Tbx5. (nih.gov)
  • The transcription factors TBX5 and Nkx2.5 both play central roles in cardiac development. (europa.eu)
  • A crystal that diffracted to 1.9 Å contained monomeric Tbx5 in the DNA-free form, which is the first structure of a DNA-free T-box transcription factor. (europa.eu)
  • The research reveals multiple subpopulations of cardiomyocytes expressing specific transcription factors (NR2F2, TBX5 and HEY2) - with different spatial and biological functions as observed in the heart. (azbio.org)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • The disease is due to mutations in the transcription factor TBX5 , which is important in the development of both the heart and upper limbs. (medscape.com)
  • Molecular genetic studies reveal that the disease is caused by mutations that inactivate the transcription factor TBX5 . (medscape.com)
  • The identification of the role of TBX5 in Holt-Oram syndrome suggests an important but as yet undefined role for TBX5 in human cardiac septation, isomerization, and upper limb development. (medscape.com)
  • Varela D, Conceição N, M. Cancela L . Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors . (ualg.pt)
  • In vivo visualization and molecular targeting of the cardiac conduction system. (stanford.edu)
  • Forced expression of these factors in dividing non-cardiomyocytes in mice reprograms these cells into functional cardiac-like myocytes, improves cardiac function and reduces adverse ventricular remodelling following myocardial infarction. (elsevierpure.com)
  • The important increases in HGF, bFGF and SDF-1 detected at an early phase (day 3) of transplantation unveiled their essential function in angiogenesis, anti-apoptosis and sparing of ruined cardiomyocytes in cardiac mend [40,forty one,42,43]. (idhinhibitor.com)
  • Our benefits are supported by the previous research in which sildenafil preconditioned adipose-derived stem cells (ASCs) expressed higher expansion factors such as bFGF, HGF and Ang-1 and ended up CPI-637 linked with considerable reduction in infarct dimensions, cardiomyocytes apoptosis and 6-MBOA improve heart function adhering to ischemia [32]. (idhinhibitor.com)
  • Conclusions Increased nuclear-localised RSK1 in cardiomyocytes promotes cardiac hypertrophy, but compromises the compensated hypertrophic response to PE. (bmj.com)
  • Feric, N. T. & Radisic, M. Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. (nature.com)
  • By profiling the transcriptome of ~24,000 nuclei, we identified major and rare cardiac cell types and revealed significant heterogeneity of cardiomyocytes, fibroblasts, and endothelial cells in postnatal developing hearts. (upenn.edu)
  • For instance, neurons rely on glycolysis and ensuing OxPhos but not FAO, while cardiomyocytes use OxPhos and FAO to generate most energy for cardiac contraction. (upenn.edu)
  • Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. (nih.gov)
  • We compared this data with existing murine and 3D cardiac organoid scRNA-seq data and confirmed the dominance of left ventricular cardiomyocytes (>90%) in our hiPSC-derived progeny. (stanford.edu)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • Herein, we introduce a cardiac-mimetic cell-culture system that resembles the microenvironment in the heart and provides interactions with cardiomyocytes and electrical cues to the cultured fibroblasts for direct cardiac reprogramming. (thno.org)
  • The cardiac-mimetic culture system may serve as an effective tool for producing a feasible number of reprogrammed cardiomyocytes from fibroblasts. (thno.org)
  • Loss of transcriptional regulation during cardiac development has detrimental effects on cardiogenesis that may lead to arrhythmias. (pcom.edu)
  • We report here analysis of Tbx20 expression during murine cardiac development and assessment of DNA-binding and transcriptional properties of Tbx20 isoforms. (nih.gov)
  • Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (jax.org)
  • When applied to a mouse model of pediatric mitochondrial cardiomyopathy, we uncovered profound cell type-specific modifications of the cardiac transcriptional landscape at single-nucleus resolution, including changes of subtype composition, maturation states, and functional remodeling of each cell type. (upenn.edu)
  • Varela T, Conceição N, Laizé V, Cancela ML . Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors . (ualg.pt)
  • Although exogenous transcriptional factors can induce direct cardiac reprogramming, the reprogramming efficiency is too low to be used clinically. (thno.org)
  • The cellular interactions and electric stimulation supplied by the culture system dramatically enhanced the cardiac reprogramming efficiency of cardiac-specific transcriptional factor-transfected fibroblasts. (thno.org)
  • Tbx20 physically interacted with cardiac transcription factors Nkx2-5, GATA4, and GATA5, collaborating to synergistically activate cardiac gene expression. (nih.gov)
  • This could lead to repression of chamber specific gene expression, a misbalance in cardiac cell types, and thereby to cardiac defects observed in rnf2 mutants. (knaw.nl)
  • ERK1/2 and RSKs phosphorylate transcription factors producing changes in gene expression. (bmj.com)
  • In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
  • A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. (unc.edu)
  • To demonstrate the power of devCellPy, we construct a murine cardiac developmental atlas from published datasets encompassing 104,199 cells from E6.5-E16.5 and train devCellPy to generate a cardiac prediction algorithm. (stanford.edu)
  • Diseases of the cardiovascular system that cause sudden cardiac deaths are often caused by lethal arrhythmias that originate from defects in the cardiac conduction system. (pcom.edu)
  • Overexpression of Gia in a transgenic fly model did not cause any cardiac defects. (wikipedia.org)
  • No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 -/- Mice. (jax.org)
  • They found that knockouts of specific transcription factors that were not previously linked to Digeorge were tied to distinctive combinations of facial muscle and cardiac defects resemble the congenital defects in babies. (scienceblogs.com)
  • Cardiac anomalies also may include cardiac conduction defects such as progressive atrioventricular block and atrial fibrillation . (medscape.com)
  • College of Wisconsin, current era from 28 patients with septal defects who factor HEY2 in formalin fixed tissue taken from a Milwaukee, Wisconsin, USA underwent cardiac surgery and who were enrolled in our collection of hearts with atrial septal defects congenital heart disease tissue bank. (cdc.gov)
  • Abnormalities in cardiac conduction can occur due to a variety of factors, including developmental and congenital defects, acquired injury or ischemia of portions of the conduction system, or less commonly due to inherited diseases that alter cardiac conduction system function. (medscape.com)
  • Cardiac fibrosis is a pathological manifestation of myocardial remodeling, which is characterized by increased fibroblast-to-myofibroblast conversion and excessive extracellular matrix (ECM) deposition within the myocardial interstitium, leading to myocardial stiffness, ventricular dilation, arrhythmias, and heart failure [ 1 , 2 ]. (hindawi.com)
  • Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. (jax.org)
  • Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
  • Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
  • The heart achieves the coordinated contraction of the atrial and ventricular chambers due to the precise timing of the cardiac conduction system (CCS), a specialized complex and heterogeneous network of cells that initiate and allow propagation of action potentials through the heart. (medscape.com)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodelling and susceptibility to arrhythmias. (elsevierpure.com)
  • Cardiac fibroblasts account for a majority of cells in the heart and represent a potential cellular source for restoration of cardiac function following injury through phenotypic reprogramming to a myocardial cell fate. (elsevierpure.com)
  • Our results suggest a strategy for cardiac repair through reprogramming fibroblasts resident in the heart with cardiogenic transcription factors or other molecules. (elsevierpure.com)
  • We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
  • Notably, transfection with miR-409-3p mimics promoted the proliferation of cardiac fibroblasts and fibroblast-to-myofibroblast differentiation, accompanied by upregulated expression of Col1a1, Col3a1, and α -SMA. (hindawi.com)
  • Gpd1 siRNA abolished the antifibrotic effect of miR-409-3p inhibitor in neonatal rat cardiac fibroblasts, suggesting that miR-409-3p promotes cardiac fibrosis at least partially through Gpd1. (hindawi.com)
  • A team of researchers, led by Professor Kinya Otsu, showcase how a distinct subset of cardiac fibroblasts become activated by pressure overload and attract monocytes to the heart. (kcl.ac.uk)
  • They found that cardiac fibroblasts can produce CCL2 and name the cells inflammatory fibroblasts. (kcl.ac.uk)
  • In the mouse which did not express the NF-kB activator IKKb in cardiac fibroblasts, pressure overload induced less monocyte recruitment and did not induce heart failure. (kcl.ac.uk)
  • The adult heart contains many resident cardiac fibroblasts, which play important roles in maintaining tissue architecture. (kcl.ac.uk)
  • Therefore, the aim of the present study was to identify a regulatory signaling pathway in cardiac inflammation based on the hypothesis that a distinct subset of inflammation-related activated fibroblasts plays crucial roles in the recruitment of inflammatory cells, especially monocytes/macrophages, and in the pathology of heart failure. (kcl.ac.uk)
  • To conclude, we found that a subset of cardiac fibroblasts involved in cardiac inflammation under stress. (kcl.ac.uk)
  • The direct cardiac reprogramming of fibroblasts could be a promising therapeutic option for these patients. (thno.org)
  • The human neonatal dermal fibroblasts containing cardiac transcription factors were plated on the membrane and cultured with the murine cardiomyocyte in the presence of the electric stimulus. (thno.org)
  • Direct cardiac reprogramming of fibroblasts is an attractive therapeutic strategy for treating cardiovascular diseases because the adult heart has a low regeneration capacity [ 1 ]. (thno.org)
  • This suggests that the natural cardiac milieu may be a critical factor for direct cardiac reprogramming [ 2 , 14 , 22 , 23 ], and delivery of cues in the cardiac microenvironment to fibroblasts may improve the efficiency of direct cardiac reprogramming in vitro . (thno.org)
  • Development of the cardiac conduction system is a complex biological process that can be wrought with problems. (pcom.edu)
  • Human genetic mutations in some of these transcription factors have been identified and are known to cause congenital heart diseases that include cardiac conduction system malformations. (pcom.edu)
  • In this review, we summarize the contributions of several key transcription factors to specification, patterning, maturation, and function of the cardiac conduction system. (pcom.edu)
  • The cardiac conduction system can be anatomically, developmentally, and molecularly distinguished from the working myocardium. (medscape.com)
  • This 'Molecular Perspectives' will highlight several diverse mechanisms of isolated conduction system disease as well as conduction system degeneration associated with other cardiac and non-cardiac disorders. (medscape.com)
  • Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
  • Cardiac fibrosis is a hallmark of numerous chronic cardiovascular diseases that leads to heart failure. (hindawi.com)
  • Dysregulation of microRNAs has been confirmed to be involved in cardiac fibrosis development. (hindawi.com)
  • This study was the first to highlight the role and molecular mechanism of miR-409-3p in cardiac fibrosis. (hindawi.com)
  • Furthermore, myocardial infarction surgery-induced cardiac fibrosis and dysfunction were attenuated by systemic delivery of miR-409-3p antagomir. (hindawi.com)
  • Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. (hindawi.com)
  • Finally, these findings suggest that modulating miR-409-3p could be a potential therapeutic method for cardiac fibrosis. (hindawi.com)
  • Understanding the molecular mechanisms underlying cardiac fibrosis is beneficial to the development of novel strategies for therapeutic intervention. (hindawi.com)
  • Inflammation, oxidative stress, and aging have been proven to contribute to cardiac fibrosis, which is regulated by multiple factors [ 7 - 9 ]. (hindawi.com)
  • Accumulating studies have revealed that miRNAs that participate in the myocardial fibrotic program, such as miR-18a-5p, attenuate cardiac fibrosis via regulating the Notch2 pathway [ 13 ], and miR-24-3p alleviates myocardial fibrosis through PHB2 [ 14 ]. (hindawi.com)
  • These observations demonstrated that miRNAs might be promising therapeutic targets for alleviating cardiac fibrosis. (hindawi.com)
  • For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
  • These cells acquire the capability to contract, migrate, proliferate, elaborate extracellular matrix and mediate the development of cardiac fibrosis. (kcl.ac.uk)
  • This work is highly influential because based on our work similar analysis in other diseases including liver, lung, kidney, breast and cardiac fibrosis will be carried out advancing our understanding of fibrotic diseases and opening up new therapeutic approaches. (northwestern.edu)
  • We are currently determining genome-wide epigenomic and transcription factor signatures that define uterine fibrosis. (northwestern.edu)
  • ErbB3(-/-) embryos survived until E13.5 exhibiting cardiac cushion abnormalities leading to blood reflux through defective valves. (nih.gov)
  • Fig. 6: Calcium transient abnormalities on MYBPC3 -/- cardiac microtissues. (nature.com)
  • At higher levels of exposure in humans, lead produces cardiac lesions and electrocardiographic abnormalities. (cdc.gov)
  • Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)
  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)
  • BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)
  • According to another study, predictors for reoperation include postoperative MR, presence of major associated cardiac malformations, associated left atrioventricular valve malformations, partial or absent left atrioventricular valve cleft closure, and a weight of less than 5 kg. (medscape.com)
  • Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
  • The prognosis of Holt-Oram syndrome is generally good, but it depends on the severity of the cardiac malformations. (medscape.com)
  • Among cardiac GATA factors, there was preferential synergy with GATA5, implicated in endocardial differentiation. (nih.gov)
  • Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation. (xenbase.org)
  • We recently discovered that Growth Differentiation Factor 15 (GDF15) is a new heart-derived hormone. (upenn.edu)
  • Together, our work provides the scientific community with a powerful new genetic lineage tracing approach as well as a single cell transcriptomic atlas of hiPSCs undergoing cardiac differentiation. (stanford.edu)
  • The first clinical manifestation of the disease may be heart failure, cardiac arrhythmias (including heart block), or infective endocarditis. (medscape.com)
  • In addition, elevated expression of cardiac transcription elements Nkx2.5 and GATA-four was detected both in vitro and in vivo by genuine-time PCR. (idhinhibitor.com)
  • We show that expression of the cardiac transcription factor Nkx2.5 marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. (elifesciences.org)
  • Extra-cardiac Nkx2.5 lineage progenitors migrate into the embryo and contribute to clusters of CD41 + /CD45 + and RUNX1 + cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. (elifesciences.org)
  • Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. (nature.com)
  • This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. (nih.gov)
  • The secondary heart field (SHF) is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the cardiac arterial pole. (duke.edu)
  • Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. (jax.org)
  • The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. (nature.com)
  • In vitro cardiac tissue models: current status and future prospects. (nature.com)
  • However, cardiac reprogramming efficiency is lower in vitro than in vivo [ 4 , 5 , 20 , 21 ]. (thno.org)
  • After identifying a number of relevant transcription factors, Tzahor, Harel and their collaborators around the world spent months developing and testing knockout mice that would reveal, in detail, the functions of these regulatory proteins in the development of the heart and face progenitors. (scienceblogs.com)
  • During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. (stanford.edu)
  • Methuselah-like 5 is a G protein coupled receptor (GPCR) that is essential for cardiac development in Drosophila. (wikipedia.org)
  • Deletion of this gene interferes with cardioblast junction proteins, resulting in a broken hearted phenotype similar to other heterotrimeric cardiac G protein mutants. (wikipedia.org)
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
  • Transcription factor protein interactomes reveal genetic determinants in heart disease. (rndsystems.com)
  • Understanding on a molecular level the underlying regulatory pathways and the synergistic action of transcription factors is of broad interest for cardiovascular biologist, as it opens the perspective to influence cardiac growth and stimulate cardiac regeneration. (europa.eu)
  • Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
  • Our results provide insight into the mechanisms underlying cardiac inflammation and fibroblast-mediated inflammatory responses that could be therapeutically targeted to treat heart failure. (kcl.ac.uk)
  • The cardiac fibroblast might therefore be a therapeutic target to treat patients with heart failure. (kcl.ac.uk)
  • To address some of the limitations of these models, here we used two complementary ex vivo models based on Xenopus embryos: pluripotent animal cap explants expressing Gata4 transcription factor and conjugates of gastrula -stage AE with animal caps (AC). (xenbase.org)
  • During gastrulation anterior endoderm (AE) provides cardiogenic signals that act on adjacent mesoderm , resulting in induction of cardiac precursors. (xenbase.org)
  • Cdx2 specifically is the gene responsible for normal expression of certain cardiogenic transcription factors which regulate cardiac and blood development during embryogenesis. (pvillage.org)
  • Echocardiography was used to assess cardiac function/dimensions at baseline and following treatment. (bmj.com)
  • Echocardiography is considered the most reliable noninvasive test to establish the diagnosis, assess cardiac function, and exclude associated structural heart disease. (medscape.com)
  • Malignant hyperthermia-like manifestations in a two-month-old child with Holt-Oram syndrome undergoing cardiac surgery. (medscape.com)
  • Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • In addition to these common genetic variations, risk factors for atrial fibrillation include high blood pressure ( hypertension ), diabetes mellitus, a previous stroke, or an accumulation of fatty deposits and scar-like tissue in the lining of the arteries ( atherosclerosis ). (medlineplus.gov)
  • An immunologically identical cardiac tissue can be produced by direct reprogramming from the patients' tissue without the potential risk of tumorigenesis that occurs with induced pluripotent stem cells [ 2 ] and the ethical issue using embryonic stem cells. (thno.org)
  • 42 pathologic cardiac tissue samples frequency and are aetiologic in cardiac malforma- were sequenced. (cdc.gov)
  • Abnormal samples can increase risk for poor data quality,15 we cardiac development appears to occur through a were interested in replicating these experiments process that is heterogeneous and complex, with using fresh frozen cardiac tissue instead of formalin both environmental and genetic risk factors.1 fixed tissue after decades of storage. (cdc.gov)
  • Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
  • GATA4 molecular screening and assessment of environmental risk factors in a Moroccan cohort with tetralogy of Fallot. (cdc.gov)
  • Utilizing the upstream regulator (i.e. transcription factors, cytokines, growth factors) analysis, the lung had 285, blood cells 30, aorta 39, and heart 32 significantly altered mediators 4 h post-exposure. (cdc.gov)
  • We detected the most pronounced differences at 3 dpf, including upregulation of heart transcription factors, such as tbx2a, tbx2b, and tbx3a. (knaw.nl)
  • of heart (cardiac) muscle cells. (medlineplus.gov)
  • More importantly, we are using proximity labeling in vivo to identify and understand new heart-derived hormones in physiology and disease, a new area of research of cardiac endocrinology. (upenn.edu)
  • Cardiac Endocrinology: Heart-derived hormones in physiology and disease. (upenn.edu)
  • miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
  • Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
  • His son presented with cardiac conduction disturbance with no congenital heart or skeletal defect. (medscape.com)
  • Nano-thin and nano-porous membranes and heart like electric stimulus were used in the cardiac-mimetic cell-culture system. (thno.org)
  • Although in vivo direct cardiac reprogramming has shown positive effects on the in situ repair of the heart in diseased animal models [ 14 ], several obstacles remain for clinical translation. (thno.org)
  • Intronic Polymorphisms in Gene of Second Heart Field as Risk Factors for Human Congenital Heart Disease in a Chinese Population. (cdc.gov)
  • The normal cardiac impulse of the vertebrate heart originates in the pacemaker cells of the sinoatrial node, located in the right atrium. (medscape.com)
  • HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. (jax.org)
  • Patients with Holt-Oram syndrome may require dietary modification because of their specific cardiac abnormality. (medscape.com)
  • No activity restrictions are required unless a specific cardiac abnormality indicates otherwise. (medscape.com)
  • Based on our findings and literature we postulate that loss of Rnf2-mediated repression results in upregulation and ectopic expression of tbx2/3, whose expression is normally restricted to the cardiac conductive system. (knaw.nl)
  • A) RT-PCR showing expression of cardiac fate marker myl7 , liver fate marker nr1h5 and control marker odc1 in Gata4 mRNA-injected ACs , control ACs and stage 33 sibling control embryo . (xenbase.org)
  • Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. (jax.org)
  • miR-146a targets Fos expression in human cardiac cells. (jefferson.edu)
  • Furthermore, the in vivo viral delivery of reprogramming factors may not be safe for clinical translation. (thno.org)
  • Tzahor and his student, Itamar Harel began looking for the answer in transcription factors -- the proteins that initially control genetic activity. (scienceblogs.com)
  • One of Chakravarti's major research interests is to determine the mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription. (northwestern.edu)
  • Tbx20 is a member of the T-box transcription factor family expressed in the forming hearts of vertebrate and invertebrate embryos. (nih.gov)
  • Even more challenging was the creation of double-knock out embryos, missing two of the transcription factors. (scienceblogs.com)
  • The main goal of this study consisted of studying new roles of miR-146a in cardiac pathological processes caused by the pro-inflammatory cytokine TNF-α. (jefferson.edu)
  • Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole. (duke.edu)
  • This is in contrast to (B), where injection of cer1 or hhex MOs in AE leads to downregulation of both cardiac and liver marker gene mRNA levels in conjugates. (xenbase.org)
  • Interestingly, AP-1 inhibition was accompanied by a reduction in matrix metalloproteinase (MMP)-9 mRNA levels in human cardiac cells. (jefferson.edu)
  • Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
  • Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated nuclear factor- κ B, nuclear factor- κ B, and SMAD signaling pathways, respectively. (aspetjournals.org)
  • These persons should receive targeted interventions including or J12.82 [pneumonia due to coronavirus disease 2019] during March 2020- chronic disease management, precautions to reduce exposure, October 2021), or SARS-CoV-2 reverse transcription-polymerase chain additional primary and booster vaccine doses, and effective reaction (RT-PCR) positivity. (cdc.gov)
  • Regular follow-up is essential for both cardiac and skeletal conditions. (medscape.com)
  • This indicated the involvement of epigenetic modulators in the regulation of GATA-dependent transcription. (biomedcentral.com)
  • Silva IAL, Varela D, M. Cancela L, Conceição N . Zebrafish optineurin: genomic organization and transcription regulation . (ualg.pt)
  • Approximately 75% of patients have some cardiac abnormality. (medscape.com)
  • Drosophila have a cardiac structure called the dorsal vessel that comprises a tubular structure with a cardioaortic valve and aortic-like outflow. (wikipedia.org)