Cardiac toxicity. Medical search. Frequent questions

Cardiac toxicity can cause arrhythmias or heart failure. (moleculardevices.com)
Although the first-generation BTK inhibitor ibrutinib has shown significant efficacy in the treatment of patients with CLL, it is associated with notable cardiac toxicity, including cardiac arrhythmias, cardiac failure, and sudden death. (oncnursingnews.com)
In response, international regulatory agreements were developed that mandate testing of all new drugs, both cardiac and non-cardiac, for cardiac liability, including drug-induced long QT interval (LQT) and risk for development of life-threatening arrhythmias, such as Torsade de Pointes (TdP) 5 . (nature.com)
Increased quinidine levels can increase the risk of quinidine toxicity and cardiac arrhythmias. (medicinenet.com)
Phenothiazines such as thioridazine (Mellaril), an antipsychotic drug, and tricyclic antidepressants such as amitriptyline ( Elavil , Endep ) should not be used with quinidine since they can cause cardiac arrhythmias, and their use with quinidine increases the risk of cardiac arrhythmias. (medicinenet.com)

It added: "Sampling established recent cocaine use, causing cocaine toxicity and resulting cardiac arrhythmia. (nme.com)

The development of highly predictive in vitro assays suitable for high-throughput screening is critical to improving the inefficiencies and high costs associated with cardiac safety compound failure. (moleculardevices.com)
The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. (europa.eu)

Cocaine may induce miscarriage, premature labor, placental abruption, or fetal toxicity, and modifications may be necessary for acute management. (medscape.com)

Overdoses of immediate-release CCBs are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest, while overdoses of extended-release formulations can result in delayed onset of dysrhythmias, shock, sudden cardiac collapse, and bowel ischemia. (medscape.com)
Overdoses of immediate-release CCBs are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest. (medscape.com)
In 2011, the 14-year-old from Hagerstown went into cardiac arrest and died after drinking two 24 ounce cans of Monster in two days. (cbsnews.com)
Jamal Edwards died of a cardiac arrest after taking cocaine, a coroner has ruled. (nme.com)
He had seizure activity and was in cardiac arrest by the time paramedics arrived, the medical examiner's report said. (latimes.com)
Vasopressin offers considerable theoretical advantage over epinephrine in cardiac arrest due to cocaine toxicity. (medscape.com)
Epinephrine has been the drug of choice for the treatment of cardiac arrest, primarily for its alpha-adrenergic effects. (medscape.com)

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling. (jcvi.org)
Minimizing Cardiac Toxicity in Children with Acute Myeloid Leukemia in the It Takes a Village: Maximizing Supportive Care and Minimizing Toxicity During Childhood Leukemia Therapy - Live Q&A ASH session on Saturday. (healthtree.org)
Withhold or permanently discontinue fluorouracil in patients with evidence of acute early-onset or unusually severe toxicity, which may indicate near complete or total absence of dipyrimidine dehydrogenase (DPD) activity. (nih.gov)
Clinical effects of arsenic toxicity depend on the chronicity of exposure (eg, acute, chronic) and the chemical form involved, which may be inorganic arsenic (pentavalent arsenic and trivalent arsenic), organic arsenicals, or arsine gas. (medscape.com)
Treatment of acute arsenic toxicity is supportive. (medscape.com)
Clozapine is relatively contraindicated in patients with severe cardiac or renal disorders, or a history of neutropenia, bone-marrow disorders, paralytic ileus, acute substance-induced psychosis or intoxication, circulatory collapse or epilepsy. (bpac.org.nz)
Thus, there is concern primarily about use of epinephrine, lidocaine, and beta-blockers in the setting of acute cocaine toxicity. (medscape.com)

These features are important to better understand in vitro cardiomyocyte function and the impact of toxic compounds that induce cardiac abnormalities such as hERG blocking potassium channels. (moleculardevices.com)
In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia. (jcvi.org)

Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)

Serum concentrations might be detectable after an exposure to plant-derived cardiac glycosides, some of which can cross-react with the various hospital laboratory assays used. (cdc.gov)
Cardiac glycosides. (cdc.gov)
Typical pulmonary edema therapy (eg, vasodilators, cardiac glycosides) is not necessary, and diuretics actually may contribute to severe hypotension. (medscape.com)

As an industry leader in testing services for clinical trials, BioTel Research combines the expert medical imaging of VirtualScopics and the cardiac core lab leadership of Cardiocore. (xtalks.com)
The advice is based on clinical trials that revealed a link between cardiac damage and Herceptin use. (bbc.co.uk)

This is critical to reduce the inefficiencies and high costs associated with compounds that fail during cardiac safety assessment. (moleculardevices.com)
In collaboration with Eurofins, we discuss the assessment of potential cardiotoxicity of compounds with CiPA initiative, the new cardiac safety testing paradigm that includes in vitro assays using hiPSC-CM. (moleculardevices.com)
In this longitudinal review, investigators conducted a comprehensive assessment of cardiac outcomes with acalabrutinib vs active comparator drugs, such as ibrutinib in patients with and without cardiovascular disorders at baseline. (oncnursingnews.com)
Each patient was given a cardiac assessment and they were then followed for 32 months. (bbc.co.uk)
Current NICE guidelines outline that, before using the drug, all women should receive cardiac assessment and be monitored throughout their treatment to minimise the risk. (bbc.co.uk)

Monitor cardiac function, including left ventricular ejection fraction, at baseline and during treatment. (nih.gov)

La plateforme consistera en un modèle in vitro tridimensionnel qui imite le tissu cardiaque humain, associé à un système de surveillance fiable à haut débit reposant sur des analyses multi-omiques et intégré à un outil d'évaluation des risques par apprentissage automatique. (europa.eu)
By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs. (europa.eu)

FDA notified healthcare professionals that Xanodyne Pharmaceuticals has agreed to withdraw propoxyphene, an opioid pain reliever used to treat mild to moderate pain, from the U.S. market at the request of the FDA, due to new data showing that the drug can cause serious toxicity to the heart, even when used at therapeutic doses. (implantsutra.com)

Correction of acid-base disturbances and electrolyte abnormalities is also important, to optimize cardiac function. (medscape.com)

Using mouse models and human biospecimens, the investigators found that activation of cytosolic cyclic GMP-AMP synthase (cGAS)- and stimulator of interferon genes (STING)-dependent type 1 interferon signaling (cGAS-STING pathway) induced delayed cardiac inflammation after radiation and anthracycline chemotherapy. (mskcc.org)
In order to do this, treatment regimens should include primary cardioprotection using Dexrazoxane concurrently with chemotherapy and regular cardiac monitoring. (healthtree.org)
Contrast enhanced cardiac magnetic resonance imaging (ce-CMR) may offer a stronger screening approach, especially since it can assess the right ventricle (RV) and detect early changes in response to chemotherapy. (biomedcentral.com)

Therefore, cardiac monitoring with echocardiography and other cardiac imaging modalities are needed. (healthtree.org)

This analysis does not suggest an increased risk of cardiac treatment-emergent adverse effects [TEAEs] and outcomes in acalabrutinib-treated patients, regardless of the presence of baseline cardiovascular disorders," Rupal O'Quinn, MD, of Perelman School of Medicine, and colleagues wrote in a poster presentation on the data. (oncnursingnews.com)
The primary care team can improve safety through monitoring and management of constipation, neutropenia, metabolic effects and cardiac toxicity, and being aware of medicines which may interact with clozapine or exacerbate its adverse effects. (bpac.org.nz)
3 However, due to the risk of serious adverse effects, e.g. significant constipation, blood dyscrasias, metabolic and cardiac toxicity, clozapine is limited to treatment-resistant patients and the initiating prescriber needs to ensure that careful monitoring occurs. (bpac.org.nz)
It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. (bvsalud.org)

Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. (qxmd.com)
Local anesthetic toxicity was suspected and a dose of 200 mL of a 20% lipid emulsion was infused. (qxmd.com)
Symptoms of central nervous system and cardiac toxicity disappeared within 5 and 15 min after the first lipid injection, respectively. (qxmd.com)

Patients taking clozapine should be monitored for symptoms and signs of cardiac toxicity and neutropenia. (bpac.org.nz)

Cardiotoxicity or cardiac toxicity is a term used to define chemicals that are toxic to the heart, causing muscle damage or heart electrophysiology dysfunction. (moleculardevices.com)
However, high-dose anthracyclines are associated with an increased risk of cardiac toxicity, including Left Ventricular Systolic Dysfunction (LVSD). (healthtree.org)

Their results, published in the Journal of Experimental Medicine on March 6, 2023, identify a targetable mechanism for one of the most challenging treatment-related late toxicities in cancer survivors. (mskcc.org)

Ingestion of ethylene glycol leads to systemic toxicity beginning with CNS effects, followed by cardiopulmonary effects, and finally renal failure. (cdc.gov)

After completion of this educational activity, the reader should be able to discuss the major exposure routes for trichloroethylene, describe two potential environmental and occupational sources of exposure to trichloroethylene, state two reasons why trichloroethylene is a health hazard, describe factors contributing to trichloroethylene toxicity, identify evaluation and treatment protocols for persons exposed to trichloroethylene, and list two sources of information on trichloroethylene. (cdc.gov)

It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process. (europa.eu)
effects/100 person-months) of cardiac disorder events observed were consistently lower in the acalabrutinib arm vs the comparator arms across the 3 individual trials regardless of grade. (oncnursingnews.com)
How frequently should childhood cancer survivors be screened for effects of cardiac toxicities? (cancertherapyadvisor.com)
In fact, it appears that the frequency of most side effects, including serious toxicities, were equal in both arms of the study. (sciencedaily.com)
In the last 40 years, over 20% of drugs discontinued at all phases of development, including discovery, preclinical and clinical evaluation, and post-market surveillance has been due to cardiac toxicity, where unintended interactions with cardiac ion channels result in pro-arrhythmic effects 4 . (nature.com)
Effects of antimony on mitochondrial function and protein thiol and adenine nucleotide status in cultured cardiac myocytes. (cdc.gov)
If the cardiac side-effects of Herceptin treatment can be managed, the drug is safe to use. (bbc.co.uk)
Appropriate cardiorespiratory monitoring should be initiated until the effects of opioid toxicity subside. (medscape.com)

Here we show, computationally and experimentally, the limits of all-optical electrophysiology when applied to drug testing, then implement and validate OptoDyCE, a fully automated system for all-optical cardiac electrophysiology. (nature.com)
The coroner ruled her death was caused by multiple drug toxicity, citing use of Ecstasy and amphetamines. (latimes.com)
Lead author Francisco Esteva, an associate professor at the MD Anderson Cancer Center, said: "The drug substantially prolongs survival and while we found substantial cardiac toxicity, we also discovered that this side-effect can be successfully treated, which was not clearly known before this study. (bbc.co.uk)

Mechanical movement and calcium fluxes of the cardiac spheroid can be observed from the stacks of the time-lapse acquisition images. (moleculardevices.com)
It is possible to identify toxicity in these compounds using both measurement of calcium flux, and high content imaging. (moleculardevices.com)
Spontaneous calcium oscillation acquired with FLIPR Calcium Assay Kit and the FLIPR system from iPSC cardiomyocytes or 3D cardiac spheroids can be paired with cytotoxicity and mitochondrial integrity data from the ImageXpress confocal system for comprehensive phenotypic analysis and bioactivity profiling of both pharmaceutical and environmental compounds. (moleculardevices.com)
Antimony alters kinetics of calcium transients of neonatal rat cardiac myocytes. (cdc.gov)

Basic supportive care is the first, and possibly most important, mode of management for CCB toxicity: Stabilize airway, breathing, and circulation (ABCs). (medscape.com)
Patients with cocaine toxicity should receive initial evaluation and stabilization, including attention to ABCs, oxygen, intravenous access, and cardiac and pulse oximetry monitoring. (medscape.com)

If there is significant cardiotoxicity, other cardioprotective measures may be needed such as cardiac remodeling medications, anthracycline treatment interruption and/or modifications made to the current regimen. (healthtree.org)

Signs of toxicity resolved and the patient underwent the scheduled surgical procedure uneventfully under brachial plexus blockade. (qxmd.com)

Given that the CLL patient population is inherently at higher risk for cardiac events due to factors like advanced age, polypharmacy, substantial comorbidities, and pre-existing cardiac conditions, a comprehensive evaluation of cardiac toxicities associated with CLL therapies is imperative. (oncnursingnews.com)

Cimetidine ( Tagamet ) increases quinidine levels by decreasing the elimination of quinidine giving rise to elevated quinidine serum levels that may lead to quinidine toxicity. (medicinenet.com)

Up to one-third of patients hospitalized with pneumococcal pneumonia experience major adverse cardiac events (MACE) during or after pneumonia. (jcvi.org)
Patients with chronic lymphocytic leukemia (CLL) who received acalabrutinib (Calquence) reported a fewer number of cardiac toxicities than patients receiving other treatments such as ibrutinib (Imbruvica), according to findings from a longitudinal study. (oncnursingnews.com)
EAIRs were reported for system organ class (SOC) "cardiac disorders" among all patients and stratified by the count of baseline cardiovascular disorders in each individual trial. (oncnursingnews.com)
EAIRs for SOC cardiac disorders were also reported pre- and post-crossover for patients who switched from comparator arms to acalabrutinib monotherapy in ELEVATE-TN and ASCEND. (oncnursingnews.com)
The guidelines for non-invasive cardiac imaging to screen for DRC show limitations in early identification of patients at risk, currently relying on left ventricular (LV) ejection fraction (EF) for establishing high risk. (biomedcentral.com)
Patients with cocaine toxicity may be combative, aggressive, and disoriented, and have delusions of persecution or hallucinations. (medscape.com)
Perform routine pregnancy testing for appropriate patients as physiologic changes in pregnancy may increase cocaine toxicity. (medscape.com)
[ 45 ] The American College of Cardiology Foundation/American Heart Association (ACCF/AHA) 2014 recommendations for treatment of patients with cocaine toxicity are based on class C evidence (ie, consensus opinion of experts, case studies, or standard of care). (medscape.com)

Cardiomyocytes are the cells that make up the cardiac muscles and are responsible for the heart's contractile function. (moleculardevices.com)

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) has received a $6 million grant from the National Institutes of Health (NIH) for a consortium to develop a new technological methodology for mapping the molecular pathways of toxicity within cells. (invitrojobs.com)

It is essential to utilize cardioprotective measures as well as cardiac monitoring in order to lower the risk of cardiotoxicity. (healthtree.org)

The long infusion of daunorubicin is used to minimize the risk for cardiac toxicity. (cancercentrum.se)

Cardioactive compounds are used in clinical treatment of heart failure, arrhythmia, or other cardiac diseases. (moleculardevices.com)
At MSK, radiation oncologists, medical oncologists, and cardiologists are dedicated to finding new ways to prevent, detect, and treat long-term cardiac disease resulting from cancer treatment," says radiation oncologist Adam Schmitt, MD , senior author of the paper. (mskcc.org)
NCT02475681) demonstrated a lower EAIR of any-grade cardiac disorder events during the post-crossover period with acalabrutinib vs the pre-crossover period with comparator treatment. (oncnursingnews.com)

In the pooled comparator group (n = 585), EAIRs of any grade of cardiac disorder events were approximately twice as high vs the pooled acalabrutinib group (n = 599). (oncnursingnews.com)

This can give rise to intoxication with digoxin, and it is important to reduce the dose of digoxin to prevent toxicity. (medicinenet.com)

Memorial Sloan Kettering Cancer Center (MSK) researchers have discovered that innate immune signaling drives late cardiac toxicity after DNA-damaging cancer therapies. (mskcc.org)
Crystal S. Denlinger, MD, of Fox Chase Cancer Center, discusses cardiac toxicities in cancer survivors, a new topic for the NCCN Survivorship Guidelines this year, and the need for more research on this important side effect, including prevention and surveillance. (ascopost.com)

For the third analysis group, EAIRs were also reported for SOC "cardiac disorders" overall and by number of baseline disorders for pooled acalabrutinib monotherapy and pooled comparator groups across the 3 randomized controlled trials. (oncnursingnews.com)

Thus, the patient who is asymptomatic following heroin overdose and has not demonstrated recrudescent toxicity during a 6-hour period of observation may be discharged safely. (medscape.com)

The researchers also identified the chemokine CXCL10 in circulating blood as a novel biomarker for radiation-induced cardiac toxicity. (mskcc.org)

Further, they found that suppressing this signaling pathway with an experimental STING antagonist effectively prevented cardiac toxicity in mouse models. (mskcc.org)

however, there is some increase in lower gastrointestinal toxicity and some increase in myelosuppression, but fortunately, no increase in cardiac adverse events with the addition of this second-generation HER2 antibody that disrupts HER2/HER3 heterodimer signaling. (cancernetwork.com)

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Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment73

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