Cardiac tissue cell cardiac. Medical search. Frequent questions

Mammals have the ability to complete small amounts of cardiac regeneration during development. (wikipedia.org)
This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
Cardiac regeneration of the injured heart, however, is not achieved. (nih.gov)
Currently, numerous alternative treatment approaches aiming at cardiac regeneration are under investigation. (nih.gov)
For this we utilise cardiac tissue engineering and animal models and combine these with chemo- and optogenetic tools to dissect out mechanisms in cardiac regeneration. (cnic.es)
equipment offers 7 specific settings to promote different levels of tissue healing and regeneration. (nutrimedical.com)
Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. (wjgnet.com)
Notch signaling is highly conserved cell signaling pathway, which is involved in diverse embryonic organs or tissue development as well as regeneration ( 1 - 10 ). (frontiersin.org)
The system promotes myocardial regeneration after a cardiac event. (techbriefs.com)
In APL Bioengineering, researchers from Pohang University of Science and Technology in South Korea take stock of stem cell-laden 3D bioprinted cardiac patch technologies and their efficacy as a therapeutic and regenerative approach for ischemic cardiomyopathy in reversing scar formation and promoting myocardial regeneration. (techbriefs.com)
As enthusiasm for cardiac regeneration charges and science continues to advance, 3D bioprinted cardiac patches will soon become an increasingly feasible, viable, and functional option, unblocking the barriers to achieve cardiomyocytes properties. (techbriefs.com)
He is developing a treatment strategy for abdominal aortic aneurysms by delivering mesenchymal stem cells or their secreted products to the periadventitial side of the aneurysm to inhibit the matrix degradation commonly seen in the disease progression and promote its regeneration. (pitt.edu)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

Interestingly, although psychomotor retardation is a major manifestation of this disease, the pathologic findings in CNS tissue are not as striking as in other organs. (medscape.com)
Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
Cells Tissues Organs (2008) 188 (1-2): 139-149. (karger.com)
Cells Tissues Organs (2008) 187 (3): 186-198. (karger.com)
Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
Cells Tissues Organs (2005) 180 (4): 195-203. (karger.com)
During the last decades, research has focused on the cell-type-specific properties of these cells in culture, which then led to an immunocentric view of their role in disease like if they were primed like T cells to infiltrate target organs to cause tissue damage and drive progressive scaring [ 2 , 3 ]. (hindawi.com)
In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
All solid organs and most other tissues harbor a network of DC or macrophages (Table 1 ). (hindawi.com)
This diagnostic test uses invisible electromagnetic energy beams to produce images of internal tissues, bones and organs on film. (hopkinsmedicine.org)
The research in Dr. Vorp's lab focuses on the biomechanics, "mechanopathobiology," regenerative medicine, and tissue engineering of tubular tissues and organs, predominantly the vasculature. (pitt.edu)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. (elsevierpure.com)
however, significant vacuolization is present in the heart's connective tissue cells of the heart valves. (medscape.com)
Contractions in cardiac muscle tissue are due to a myogenic response of the heart's pacemaker cells. (wikipedia.org)
Using this technique in animals, the researchers have observed an increase in physiological functions such as the cardiac ejection fraction - a measure of the efficacy of the heart's contraction - and an improvement of cardiac chamber volumes following the placement of these tissue structures on the surface of the animal's damaged hearts. (derstandard.at)
May 12, 2022 Following a heart attack, the human body is incapable of repairing lost tissue due to the heart's inability to generate new muscle. (sciencedaily.com)
While cardiac sarcoma may cause changes in the heart's rhythm, EKG changes may indicate other heart problems. (hopkinsmedicine.org)
The rhythmic contraction of cardiac muscle is regulated by the sinoatrial node, the heart's pacemaker. (britannica.com)
Concordantly in this same region, the heart's local microstructural tissue helicity is also selectively increased in exercised mice. (researchgate.net)
Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
In the new study, inducing the expression of LAV-BPIFB4 in aged mice led to improvements in cardiac function that, translated to the human context, would be equivalent to a reduction in the heart's biological age by 10 years. (medicalnewstoday.com)

Transplantation of pluripotent stem cell-derived cardiomyocytes represents one regenerative therapeutic concept that aims at adding new myocytes to the injured heart. (cnic.es)

The propagation of these signals is facilitated by the electrical excitability of the cardiomyocytes (cardiac muscle cells): The increase of the transmembrane potential of a cell beyond threshold triggers an action potential which in turn leads to an increase of the transmembrane potentials of adjacent cells. (ptb.de)
Therefore, therapeutic or regenerative approaches should be planned to target both of them concurrently to achieve a successful cardiac repair, because the heart has very little ability to regenerate cardiomyocytes or heart cells by itself. (techbriefs.com)
These iPS cells differentiate into beating cardiomyocytes. (ca.gov)
Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. (bvsalud.org)

While individual fibroblastic cells interface with a greater number of cells, inflammatory cells have the largest contact area suggesting a role in establishing intercellular electrical connections in scar tissue. (edu.sa)
The impaired cardiac cells die, leading to a buildup of scar tissue (fibrosis) over time that worsens the heart block. (medlineplus.gov)
By increasing collagen production less scar tissue is formed at the damaged site. (nutrimedical.com)
Fibroblasts in scar tissue elicit myocyte excitation and promote arrhythmia in mouse hearts. (bvsalud.org)
Myocardial damage is caused by vasculitis, leading to coronary occlusion due to the release of toxic mediators by activated eosinophils causing direct myocardial damage, or by replacement of the myocardium with granulomas and scar tissue. (medscape.com)

1 Department of Regenerative Medicine and Advanced Cardiac Therapeutics, 2 Cardiology Division, Department of Internal Medicine, 3 Department of Cardiovascular Surgery, 4 Division of Diagnostic Pathology, 5 Department of Pathology, Keio University School of Medicine, Tokyo, Japan. (jci.org)
Address correspondence to: Keiichi Fukuda, Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. (jci.org)
Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. (mdpi.com)
The incidences of various esophageal diseases (e.g., congenital esophageal stenosis, tracheoesophageal fistula, esophageal atresia, esophageal cancer) are increasing, but esophageal tissue is difficult to be recovered because of its weak regenerative capability. (nature.com)
The researchers explore various types of candidate stem cells that possess cardiac regenerative potential, explaining their applications and limitations. (techbriefs.com)

These phases include the inflammatory response, the activation, differentiation, and fusion of satellite cells, and the maturation and remodeling of newly formed myofibrils. (wikipedia.org)
These macrophages can also facilitate the proliferation and differentiation of satellite cells. (wikipedia.org)
For this reason, our group has recently described and patented a method to obtain cardiac stem cells (CSCs) from small biopsies of myocardium and grow them through several generations in the laboratory without losing differentiation potential. (derstandard.at)
Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells are also involved in Notch signaling including regulation of blood vessel sprouting, branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells ( 4 , 6 , 7 , 21 - 23 ). (frontiersin.org)
The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)

Our group is specifically focusing on two aspects: i) low cell engraftment and ii) engraftment-induced arrhythmias. (cnic.es)
The clinical picture is usually dominated by severe cardiac arrhythmias, and sudden death may occur. (nih.gov)

Adult humans cannot regenerate cardiac muscle tissue after an injury, which can lead to scarring and thus heart failure. (wikipedia.org)
Other vertebrates can regenerate cardiac muscle tissue throughout their entire life span. (wikipedia.org)
Skeletal muscle is able to regenerate far better than cardiac muscle due to satellite cells, which are dormant in all healthy skeletal muscle tissue. (wikipedia.org)
These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)

We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
These cells acquire the capability to contract, migrate, proliferate, elaborate extracellular matrix and mediate the development of cardiac fibrosis. (kcl.ac.uk)
Other major sources of electrophysiological heterogeneity are blood vessels, cardiac fibrosis, and irregular invaginations on the interior of ventricles. (ptb.de)

In humans the muscle systems are classified by gross appearance and location of cells. (britannica.com)
Unfortunately, cardiac physiology in animal models (rabbits and dogs) differs from that in humans, and hamster cells lack many key features of human heart cells. (ca.gov)

Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
When co-cultured with human mesenchymal stem cells (hMSCs), the NMs exhibit excellent bioactivity in encouraging hMSCs adhesion. (jove.com)
When co-cultured with human mesenchymal stem cells, the nano-matrix exhibited excellent bioactivity in encouraging cell adhesion. (jove.com)
Here he also utilizes mesenchymal stem cells or their products incorporated in a biodegradable scaffold that undergoes substantial in vivo remodeling to develop a native-like blood vessel. (pitt.edu)

Fibroblasts are present in connective tissue and are capable of forming collagen fibers. (nutrimedical.com)
Stimulate tissue granulation and connective tissue projections, which are part of the healing process of wounds, ulcers or inflamed tissue. (nutrimedical.com)
In the case of bone healing, different types of tissue, such as connective tissue and cartilage, are involved in the repair process. (proprofs.com)

Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. (mdpi.com)

This condition alters the normal beating of the heart and can lead to fainting (syncope) or sudden cardiac arrest and death. (medlineplus.gov)
An article by Hjalmarson (1997) claims that there is no other therapy that has such a well-documented effect on sudden cardiac death. (cms.gov)
Nearly 500,000 people in the US die of sudden cardiac death each year, and long QT syndrome (LQTS) is a major form of sudden cardiac death. (ca.gov)

Gap junctions facilitate ion diffusion in adjacent cells and thus electrical wave propagation. (ptb.de)
For instance, re-entries, i.e., circulating excitation waves, develop preferentially in the vicinity of fibrotic regions of cardiac tissue where the electrical wave propagation is degraded. (ptb.de)
The heterogeneity of tissue is also crucial for the medical control of electrical wave propagation, particularly during defibrillation. (ptb.de)

The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. (nature.com)
Electrospinning was considered a promising technology because it can recapitulate microstructures mimicking the environment of the extracellular matrix (ECM) in native tissue. (nature.com)

Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality. (elsevierpure.com)
There are two types of striated muscle: Cardiac muscle (heart muscle) Skeletal muscle (muscle attached to the skeleton) Striated muscle tissue contains T-tubules which enables the release of calcium ions from the sarcoplasmic reticulum. (wikipedia.org)
Cardiac muscle lies between the epicardium and the endocardium in the heart. (wikipedia.org)
These cells respond to signals from the autonomic nervous system to either increase or decrease the heart rate. (wikipedia.org)
According to the lab's findings, the ultrasonic system-on-patch allows continuous tracking of physiological signals from tissues as deep as 164?mm, continuously measuring central blood pressure, heart rate, cardiac output, and other physiological signals for up to twelve hours at a time. (innovationtoronto.com)
Abnormal values of blood pressure and cardiac output, at rest or during exercise, are hallmarks of heart failure. (innovationtoronto.com)
The sodium channels containing proteins produced from the SCN5A gene are abundant in heart (cardiac) muscle cells and play key roles in these cells' ability to generate and transmit electrical signals. (medlineplus.gov)
This condition affects the function of the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. (medlineplus.gov)
The question for us at University of Rome "Sapienza" in Italy is: Why not use stem cells to repair the human heart? (derstandard.at)
Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
So we decided to use these stem cells in association with an artificial, netlike matrix to support formation of functional tissue-like structures that can be used in a new therapeutic approach to repair the heart. (derstandard.at)
Our aim is to develop (stem-cell based) strategies to remuscularize the failing heart. (cnic.es)
Combining tissue engineering and stem cell biology allows us to generate three-dimensional human tissue constructs (engineered heart tissue) with organotypic function that structurally resemble native myocardium. (cnic.es)
We use engineered heart tissue to simulate myocardial injury and study human (patho-) physiology in a dish to identify new drug targets. (cnic.es)
Cardiac sarcoma is a rare type of primary malignant (cancerous) tumor that occurs in the heart. (hopkinsmedicine.org)
A primary cardiac tumor is one that starts in the heart. (hopkinsmedicine.org)
A secondary cardiac tumor starts somewhere else in the body and then spreads to the heart. (hopkinsmedicine.org)
Tumors of the heart may occur on the outside surface of the heart, within one or more chambers of the heart (intracavitary) or within the muscle tissue of the heart. (hopkinsmedicine.org)
Cardiac angiosarcomas that occur on the pericardium (the thin sac that surrounds the heart) can cause increased fluid inside the sac. (hopkinsmedicine.org)
Therefore, other diagnostic tools are needed to make a definitive diagnosis of cardiac sarcoma or any other type of heart tumor. (hopkinsmedicine.org)
In response to pressure overload such as hypertension, monocytes (a type of white blood cell) enter the heart and become inflammatory macrophages. (kcl.ac.uk)
The heart consists of many kinds of cells, such as heart cells, fibroblasts, and smooth muscle cells. (kcl.ac.uk)
However, we currently do not know which type of cells in the heart produce CCL and attract monocytes in blood to the heart. (kcl.ac.uk)
A team of researchers, led by Professor Kinya Otsu, showcase how a distinct subset of cardiac fibroblasts become activated by pressure overload and attract monocytes to the heart. (kcl.ac.uk)
In the mouse which did not express the NF-kB activator IKKb in cardiac fibroblasts, pressure overload induced less monocyte recruitment and did not induce heart failure. (kcl.ac.uk)
The adult heart contains many resident cardiac fibroblasts, which play important roles in maintaining tissue architecture. (kcl.ac.uk)
Therefore, the aim of the present study was to identify a regulatory signaling pathway in cardiac inflammation based on the hypothesis that a distinct subset of inflammation-related activated fibroblasts plays crucial roles in the recruitment of inflammatory cells, especially monocytes/macrophages, and in the pathology of heart failure. (kcl.ac.uk)
Our results provide insight into the mechanisms underlying cardiac inflammation and fibroblast-mediated inflammatory responses that could be therapeutically targeted to treat heart failure. (kcl.ac.uk)
The cardiac fibroblast might therefore be a therapeutic target to treat patients with heart failure. (kcl.ac.uk)
Bronchoalveolar lavage (BAL) was performed and BAL cells as welt as lung and heart tissues were retained for RNA isolation and Northern analysis. (cdc.gov)
Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
Myocardial infarction, or heart attacks, play a large part in heart diseases and the necrosis of cardiac tissue after blood supply is decreased or stopped. (techbriefs.com)
The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)
Another change associated with aging involves the dysfunction of endothelial cells , which form the inner lining of blood vessels and the heart. (medicalnewstoday.com)
Thus, endothelial cell dysfunction can lead to a reduction in the blood supply to the heart muscle by coronary arteries, thus increasing the risk of a heart attack or myocardial infarction. (medicalnewstoday.com)
However, there are genetic forms of LQTS that should allow us to make iPS cell-derived heart cells that have the key features of LQTS. (ca.gov)
The standard tests for LQTS use animal models or hamster cells that express human heart genes at high levels. (ca.gov)
Human embryonic stem cells (hESCs) can be differentiated into heart cells, but we do not know the culture conditions that would make the assay most similar to LQTS in a living person. (ca.gov)
These problems could be solved if we had a method to grow human heart cells from people with genetic LQTS mutations, so that we know the exact test conditions that would reflect the human disease. (ca.gov)
Living heart slices have recently emerged as a powerful experimental model for fundamental cardiac research. (bvsalud.org)
By retaining the structure and function of the native myocardium while maintaining the simplicity of cell culture models, heart slices can be easily employed in electrophysiological, pharmacological, biochemical, and structural investigations. (bvsalud.org)
Our group has pioneered the living heart slice preparation, an ex-vivo platform that maintains native cardiac tissue architecture and physiological electrical and contractile properties. (bvsalud.org)
Here, we evaluated the cardiotoxic effect of HCQ and AZM applied alone or in combination on cardiac contractility by measuring contractile force and contraction kinetics in heart slices prepared from porcine hearts. (bvsalud.org)
Autopsy revealed necrotizing vasculitis involving pericardial and intramyocardial vessels, as well as eosinophilic and giant cell inflammation of the heart and lungs, supporting the diagnosis of CSS. (medscape.com)
Involvement of the heart usually occurs in the third phase as vasculitic lesions in myocardium and the coronary vessels, causing (peri)myocarditis, heart failure, cardiac tamponade , myocardial infarction , or pericardial effusion , as in our patient. (medscape.com)

This means that they are not functionally programmed to work as cardiac cells in conjuction with the other resident cardiac cells. (derstandard.at)
In response to tissue injury or stress, the resident cardiac fibroblasts undergo a transition to activated myofibroblasts, a highly synthetic cell type that induces the genes encoding smooth muscle α actin (ACTA2) and collagen. (kcl.ac.uk)

The contribution of inflammatory cells to the electrophysiological properties of injured myocardium is unknown. (edu.sa)
The cost of surgery and the time of hospitalization would be reduced, and the standard use of life-long immune suppression medications would be unnecessary in the case of an engineered myocardium using a patient's own tissue. (derstandard.at)
Myocardial tissue engineering strategies follow the idea of in vitro generation of myocardium-like structures for epicardial transplantation. (nih.gov)
When this decrease in perfusion occurs and is not alleviated, that section of myocardium progresses to permanent damage and cell death. (cms.gov)
Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. (bvsalud.org)

The precise B cell subsets, mechanisms, and factors that facilitate the maintenance of latency and prevent reactivation are not fully understood. (nature.com)
These mechanisms, in addition to increased cell death and turnover, are thought to lead to steatosis and carcinogenesis [Palmer and Phillips 2007]. (cdc.gov)

Cardiac pathologies associated with arrhythmic activity are often accompanied by inflammation. (edu.sa)
There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
To conclude, we found that a subset of cardiac fibroblasts involved in cardiac inflammation under stress. (kcl.ac.uk)
These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)

A new study shows that LAV-BPIFB4 may exert its cardioprotective effects by promoting the formation of new blood vessels and reducing the number of blood vessel cells that have become senescent and stopped multiplying. (medicalnewstoday.com)
Endothelial cells also play an important role in angiogenesis, the process of formation of new blood vessels from preexisting ones. (medicalnewstoday.com)
Endothelial dysfunction during aging is also associated with the reduction in the density of capillaries , the small blood vessels that transport oxygen and nutrients to tissues. (medicalnewstoday.com)
Pericytes interact with endothelial cells to play an important role in the formation of new blood vessels and the maintenance of blood vessels. (medicalnewstoday.com)
Whilst the evidence is mixed, some studies have suggested that aging is associated with a decline in the coverage of endothelial cells by pericytes, resulting in increased permeability of blood vessels. (medicalnewstoday.com)

Echocardiography has become the most useful tool in the diagnosis of cardiac sarcoma, allowing the doctor to see the exact size and location of the tumor. (hopkinsmedicine.org)

B) immunostaining for YF antigens in Kuppfer cells and inflammatory cells in the portal tract. (cdc.gov)
F) YF antigens detected in the cytoplasm of meningeal inflammatory cells. (cdc.gov)
J) detectable YF antigens in the inflammatory cells. (cdc.gov)
Three distinct cell populations were identified: inflammatory, fibroblastic and endocardial cells. (edu.sa)
Together these data demonstrate inflammatory cells significantly contribute to scar electrophysiology through coupling mediated at least partially by connexin43 expression. (edu.sa)
MIF was identified as a major regulator of atherogenesis by promoting the recruitment of mononuclear cells, activating inflammatory signaling pathways, and transdifferentiating macrophages into foam cells in the vessel wall as well as by enhancing collagenase expression and matrix degradation, the latter contributing to plaque destabilization [ 18 - 20 ]. (hindawi.com)
They found that cardiac fibroblasts can produce CCL2 and name the cells inflammatory fibroblasts. (kcl.ac.uk)
Next steps for this research is to identify the marker for the inflammatory fibroblasts to isolate the cell population and examine the characteristics of the cells to regulate their activity. (kcl.ac.uk)
Eotaxin-3, a chemokine highly secreted by endothelial and inflammatory cells in CSS patients' damaged tissues, seems to directly target eosinophils toward affected tissues. (medscape.com)

A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
This role is partly mediated by CSS patients' T cells, which predominantly exhibit an activated Th2 phenotype, resulting in the secretion of high levels of interleukin (IL)-4, IL-13, and IL-5. (medscape.com)

We show that primary human umbilical vein endothelial cells (HUVECs) readily uptake the nanoparticles with and without specific antibody targets. (frontiersin.org)
Endothelial cells regulate the blood flow as well as the exchange of fluids and molecules between the blood and the tissue. (medicalnewstoday.com)
The dysfunction of endothelial cells results in the narrowing of arteries and can increase the risk of cardiovascular diseases. (medicalnewstoday.com)
Pericytes or perivascular cells are cells that are embedded at intervals along the walls of capillaries and wrap around endothelial cells. (medicalnewstoday.com)
Thus, in addition to endothelial cells, impaired pericyte function may contribute to cardiovascular diseases. (medicalnewstoday.com)
The manipulation of endothelial cells to secrete protective factors could enhance cardioprotection. (mdpi.com)

Stem cell therapies already exist in medical practice. (derstandard.at)
Currently applied patch-based stem cell therapies have shown advanced efficacy, rather than using single-component therapies, by providing a tissue-friendly environment during the time of host-graft integration. (techbriefs.com)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Mononuclear phagocytes contributions to tissue pathologies relate to their central roles in orchestrating all stages of host defense and wound healing, which often become maladaptive processes, especially in sterile and/or diffuse tissue injuries. (hindawi.com)
Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)

They share updates on the challenging implementation of the state-of-the-art 3D bioprinting approach to fabricate a cardiac patch and highlight different strategies to implement vascularization and augment cardiac functional properties with respect to electrophysiological similarities to native tissue. (techbriefs.com)

This provides the first in-depth investigation into how human myofibroblasts modulate hiPSC-CMs function, identifying interleukin-6 and connexin43 as paracrine- and contact-mediators respectively, and highlighting their potential as targets for reducing arrhythmic risk in cardiac cell therapy. (bvsalud.org)

Histiocytoid cardiomyopathy is a rare cardiac disorder of infancy and childhood that predominantly affects girls under the age of 2 years. (nih.gov)

We aim to develop a cell culture platform to automatically differentiate human induced pluripotent stem cells (hiPSCs) for lab-on-a chip applications. (dim-elicit.fr)
They then leave the cell cycle to self-renew or differentiate as myoblasts. (wikipedia.org)
Stem cells are characterised by their unique ability to constantly renew themselves and differentiate into a diverse range of other specialised cell types. (derstandard.at)
They multiply and differentiate into specific cell types that contribute to the formation of new bone. (proprofs.com)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

In addition, autologous CSCs can be employed without the ethical and immunological problems associated with the use of embryonic stem cells. (derstandard.at)
In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)

Unlike skeletal muscle, cardiac muscle cells are unicellular. (wikipedia.org)
Both smooth muscle cells and cardiac muscle cells have a single nucleus, and skeletal muscle cells have many nuclei. (wikipedia.org)

Visible and infrared light have been shown to affect positive therapeutic benefits to living tissues and organisms on a cellular level. (nutrimedical.com)
Although there are still inherent limitations for the clinical study, the suggested stem cell delivery platform technology provides a practical therapeutic perspective for various tissue engineering applications," said author Hyoryung Nam. (techbriefs.com)
Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)

Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts. (elsevierpure.com)
As in many of the lysosomal storage diseases, the functional deficiency of lysosomal enzymes results in abnormal cell architecture. (medscape.com)
Striated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres. (wikipedia.org)

The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)

that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)

Based on this suggested technique, we developed a bioprinted 3D esophageal structure with multi-layered features and converged with biochemical microenvironmental cues of esophageal tissue by using decellularizedbioinks from mucosal and muscular layers of native esophageal tissues. (nature.com)
Human esophageal tissue consists of the mucosa, submucosa, and muscular layers. (nature.com)
The correct answer is muscle cell - muscle tissue - biceps muscle - muscular system. (proprofs.com)
This list represents a system organized from least to most complex because it starts with the smallest unit, the muscle cell, then progresses to the next level of organization, the muscle tissue, followed by the biceps muscle, and finally culminating in the muscular system, which is the most complex level of organization as it includes all the muscles in the body. (proprofs.com)

The presence of sarcomeres manifests as a series of bands visible along the muscle fibers, which is responsible for the striated appearance observed in microscopic images of this tissue. (wikipedia.org)
Each muscle cell contains myofibrils composed of actin and myosin myofilaments repeated as a sarcomere. (wikipedia.org)
Many nuclei are present in each muscle cell placed at regular intervals beneath the sarcolemma. (wikipedia.org)
Cardiac muscle cells generally only contain one nucleus, located in the central region. (wikipedia.org)
Unlike skeletal and cardiac muscle tissue, smooth muscle tissue is not striated since there are no sarcomeres present. (wikipedia.org)
Striated muscle tissue has more mitochondria than smooth muscle. (wikipedia.org)
The main function of striated muscle tissue is to create force and contract. (wikipedia.org)
These contractions in cardiac muscle will pump blood throughout the body. (wikipedia.org)
Because of the gap junctions, the pacemaker cells transfer the depolarization to other cardiac muscle fibers, in order to contract in unison. (wikipedia.org)
These mutations alter the structure of ion channels made with the SCN5A protein and disrupt the flow of sodium ions into cardiac muscle cells. (medlineplus.gov)
In individuals with this condition the cardiac muscle takes longer than usual to recharge between beats. (medlineplus.gov)
Channels made with these altered SCN5A proteins stay open longer than usual, which allows sodium ions to continue flowing into cardiac muscle cells abnormally. (medlineplus.gov)
muscle , contractile tissue found in animals , the function of which is to produce motion . (britannica.com)
The innervation of muscle cells, or fibres, permits an animal to carry out the normal activities of life. (britannica.com)
Muscle cells fuel their actions by converting chemical energy in the form of adenosine triphosphate (ATP), which is derived from the metabolism of food, into mechanical energy . (britannica.com)
Muscle is contractile tissue grouped into coordinated systems for greater efficiency . (britannica.com)
Striated muscle is almost exclusively attached to the skeleton and constitutes the bulk of the body's muscle tissue. (britannica.com)

Our objective is to produce a cell-based test for LQTS with induced pluripotent stem (iPS) cell technology, which allows adult cells to be "reprogrammed" to be stem cell-like cells. (ca.gov)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

Early enzymologic studies showed that cultured fibroblasts from patients with I-cell disease were deficient in numerous lysosomal enzymes. (medscape.com)
I-cell disease fibroblasts were subsequently discovered to be able to internalize and use lysosomal enzymes produced by normal cells, whereas normal or other lysosomal disease fibroblasts were incapable of internalizing lysosomal enzymes secreted by the I-cell disease fibroblasts. (medscape.com)
These are observed in cells of mesenchymal origin, especially fibroblasts. (medscape.com)
Other sites of abnormal cell vacuolization include the renal glomerular podocytes and in the fibroblasts of the liver's periportal spaces. (medscape.com)
They then examined the mRNA expression pattern at a single cell level using so-called single-cell RNA sequencing analysis and found a subset of cardiac fibroblasts highly expressed genes activated by the transcription factor NF-kB and CCL2 mRNA. (kcl.ac.uk)

Macrophages induce phagocytosis of the cell debris. (wikipedia.org)
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)

In fatal cases, autopsies reveal permanent damage to nerve cells, with focal areas of fatty degeneration and necrosis [Stevens et al. (cdc.gov)

Histological findings include sharply demarcated groups and sheets of cells with abundant foamy or granular cytoplasm, justifying the use of the term "histiocytoid" cardiomyopathy. (nih.gov)

Using a hybrid therapy that incorporates tissue engineering, we seeded a biodegradable mesh with cardiac stem cells. (derstandard.at)

Vacuolization of peripheral Schwann cells is minimal but not enough to impair normal myelination. (medscape.com)

Title : Tissue cultures of KB epithelial cells for poliomyelitis virus tests Personal Author(s) : Luoto, Lauri;Pickens, Edgar G. (cdc.gov)

Induce a thermal like effect in the tissue. (nutrimedical.com)

Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. (bvsalud.org)

Notch signaling regulates cell-fate determination during activation by signal sending and receiving, affected through ligand-receptor crosstalk. (frontiersin.org)

A tissue-centric view assumes that changing tissue microenvironments shape the phenotypes of their resident and infiltrating mononuclear phagocytes to fulfill the tissue's need to maintain or regain homeostasis. (hindawi.com)
Due to their considerable plasticity and heterogeneity, the tissue-based DC and macrophage populations have been defined as mononuclear phagocytes [ 1 , 6 , 7 ]. (hindawi.com)

But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
Timm Schroeder Hematopoietic stem cell research has made tremendous progress over the last decades, and blood has become one of the best understood mammalian stem cell systems. (karger.com)

An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
This slightly different perspective may somewhat shape our understanding of macrophage heterogeneity and tissue pathology but certainly also raise new questions for future research. (hindawi.com)

After injecting these cells into the hearts of animals with damaged myocardial tissue, my colleagues and I have observed an improvement in physiological functions. (derstandard.at)
These cells provide several important physiological functions during homeostasis (Figure 1 ). (hindawi.com)

Blocking interleukin-6 reduced the effects of myofibroblasts only in the absence of physical contact between cell-types. (bvsalud.org)

Anatomy46

Organisms14

Diseases40

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Phenomena and Processes44

Disciplines and Occupations6

Technology, Industry, Agriculture3

Information Science4

Health Care11

Regeneration15

Organs15

Heart's11

Myocytes1

Cardiomyocytes5

Scar Tissue5

Regenerative5

Differentiation9

Vascular3

Arrhythmias2

Regenerate4

Fibrosis3

Humans2

Mesenchymal Stem4

Connective tissue3

Native tissues1

Sudden3

Electrical wave propagation3

Extracellular matrix2

Heart47

Resident cardiac2

Myocardium5

Mechanisms2

Inflammation4

Blood vessels5

Tumor1

Inflammatory9

Phenotype2

Endothelial cells6

Therapies3

Pathologies2

Electrophysiological1

Arrhythmic1

Predominantly1

Differentiate5

Embryonic2

Skeletal muscle2

Therapeutic3

Functional3

Morphologically1

Generate1

Muscular4

Muscle17

Adult2

Fibroblasts5

Macrophages3

Necrosis1

Abundant1

Biodegradable1

Peripheral1

Epithelial cells1

Induce1

Electrophysiology1

Regulates1

Mononuclear2

Stem cell res2

Pathology2

Physiological functions2

Myofibroblasts1