Renal denervationFibrillationMyocardialElectrophysiologyConductionInnervationCoronary ArteryAutonomicAllograft vasculopathyClinicalEctopySyncopeRefractoryPatientsDiastolicConclusionControl of cardiacElectrophysiologistNervousPlexusSubstrateNeurohormonalRatsMechanismsNerveCardiomyopathyCardiovascular eventsLeftSympathectomyNervesAcuteGeneticsChildrenJournalCenterCommonData
Renal denervation3
- For instance, clinical trials of vagal stimulation and spinal cord stimulation in the treatment of heart failure are currently underway, and renal denervation has been studied recently in the treatment of resistant hypertension. (aerjournal.com)
- Similarly, renal denervation may play a role in the treatment of atrial fibrillation, as well as in controlling refractory ventricular arrhythmias. (aerjournal.com)
- Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. (jocms.org)
Fibrillation11
- Following myocardial infarction (MI), the myocardium is prone to calcium-driven alternans, which typically precedes ventricular tachycardia and fibrillation. (frontiersin.org)
- Rushil conducted translational research centered on advancements in Cardiac Magnetic Resonance Imaging, VT Ablation, Atrial Fibrillation, Cardiac Sarcoidosis, Cardiac Sympathetic Denervation and Hypothermia Induction in the animal experiment lab at Johns Hopkins under the supervision of Harikrishna Tandri, MD, FACC. (stanford.edu)
- Observational studies and inferences from typical electrophysiology studies were initially focused on ventricular ectopy triggering ventricular tachycardia (VT), which, in turn, can degenerate into ventricular fibrillation, as a mechanisms for sudden cardiac death. (medscape.com)
- Renal artery denervation (RDN) can treat hypertension and paroxysmal atrial fibrillation (PAF). (hindawi.com)
- With further study, RDN has been found to have significant therapeutic effects on other cardiovascular diseases, such as atrial fibrillation (AF), heart failure, and ventricular arrhythmia [ 4 - 9 ]. (hindawi.com)
- Similar to persistent AF, paroxysmal atrial fibrillation (PAF) could also have a significant impact on cardiac diastolic function. (hindawi.com)
- CARL pioneered computational mapping of 'chaotic' heart rhythm disturbances (arrhythmias), targeting mechanistic drivers for atrial and ventricular fibrillation (AF, VF) using machine learning and computational models. (stanford.edu)
- These changes in turn can lead to the development of left ventricular hypertrophy (LVH), coronary artery disease (CAD), various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, complications that manifest clinically as angina or myocardial infarction, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure (CHF). (medscape.com)
- Dr. Olgin's basic research lab is interested in atrial and ventricular remodeling and how these processes occur to develop a substrate for atrial fibrillation and ventricular tachycardia. (ucsf.edu)
- He also has active studies in understanding the remodeling that occurs in the ventricle in the setting of heart failure and myocardial infarction to create the substrate for sudden death and ventricular tachycardia and fibrillation. (ucsf.edu)
- Dr. Olgin's clinical research has focused on atrial fibrillation and sudden cardiac death mechanisms, epidemiology, genetics and interventions. (ucsf.edu)
Myocardial1
- Abnormal neuronal function is often seen in various heart diseases, such as heart failure (HF), myocardial ischemia, infarction, and arrhythmias. (slideshare.net)
Electrophysiology7
- Rushil recently completed another three-year long Post-Doctoral Research Fellowship in Cardiac Electrophysiology at Johns Hopkins Medical Institutions, Baltimore, MD, United States. (stanford.edu)
- Notably, autonomic stimulation is also a potent modulator of cardiac electrophysiology. (aerjournal.com)
- In this review, we present the current experimental and clinical data on the effect of these therapeutic modalities on cardiac electrophysiology and their potential role in arrhythmia management. (aerjournal.com)
- The interplay between the central nervous system and cardiac electrophysiology is fundamental, and becomes obvious each time one's pulse quickens in response to stress. (aerjournal.com)
- 1 Therefore, it is no surprise that neurohormonal regulation of cardiac electrophysiology is an area of active investigation for its potential antiarrhythmic effects. (aerjournal.com)
- A new mouse cardiac electrophysiology method was used to study mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+), which results in histological and hemodynamic abnormalities characteristic of familial hypertrophic cardiomyopathy (FHC) and sudden death of uncertain etiology during exercise. (jci.org)
- Wild-type animals had completely normal cardiac electrophysiology. (jci.org)
Conduction2
- Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
- While high levels of overall cardiac sympathetic drive are a negative prognostic indicator of mortality following MI and during heart failure, β-adrenergic receptor stimulation in the infarct border zone reduced spatially heterogeneous alternans, and prevented conduction block and propagation of extrasystoles. (frontiersin.org)
Innervation1
- MI is also associated with remodeling of the sympathetic innervation in the infarct border zone, although how this influences arrhythmogenesis is controversial. (frontiersin.org)
Coronary Artery2
- Genetic Variations Within METTL16 and Susceptibility to Sudden Cardiac Death in Chinese Populations With Coronary Artery Disease. (cdc.gov)
- Thus, hypertensive heart disease is a term applied generally to heart diseases, such as LVH (seen in the images below), coronary artery disease, cardiac arrhythmias, and CHF, that are caused by the direct or indirect effects of elevated BP. (medscape.com)
Autonomic4
- Manipulating the autonomic nervous system in studies designed to treat heart failure and hypertension have revealed that autonomic modulation may have a role in the treatment of common atrial and ventricular arrhythmias as well. (aerjournal.com)
- Normally, cardiac neurohormonal regulation is accomplished through the balanced effects of sympathetic and parasympathetic autonomic stimulation, along with the hormonal regulation of the renin-angiotensinaldosterone system (RAAS). (aerjournal.com)
- Role of the autonomic nervous system in the genesis of cardiac arrhythmias: pathophysiology and therapy implications. (jocms.org)
- Franciosi S, Perry FKG, Roston TM, Armstrong KR, Claydon VE, Sanatani S. The role of the autonomic nervous system in arrhythmias and sudden cardiac death. (jocms.org)
Allograft vasculopathy2
- Munagala M, Phancao A. Cardiac Allograft Vasculopathy: A Review of Risk Factors and Pathogenesis. (lidsen.com)
- Long term survival of heart transplant recipients is limited by chronic rejection, cardiac allograft vasculopathy (CAV), and malignancy. (lidsen.com)
Clinical7
- This may help explain recent clinical imaging studies using meta-iodobenzylguanidine (MIBG) and 11C-meta-hydroxyephedrine positron emission tomography (PET) which demonstrate that border zone denervation is strongly associated with a high risk of future arrhythmia. (frontiersin.org)
- Up until now they were working on developing a Shared Decision-Making Tool for AF Stroke Prevention as part of the ENHANCE-AF trial under Paul J. Wang, MD. Dr. Shah's other projects are focused on pulsed field ablation of the heart and delineating clinical applications of Magneto-Cardiography in patients with cardiac arrhythmias. (stanford.edu)
- Clinical and Genetic Features of Korean Inherited Arrhythmia Probands. (cdc.gov)
- Clinical proportion plexus contain diastolic amino protoplasm, explanted sympathetic plan heart by test, contractile heart, Recent heart, and sexual Coronary point. (augenta.net)
- To recover failure alkali in mortality artery, we will test the water that the robot of the clinical g failure function measure to issues of ventricular exposure presence is in ectopic and reducing alpha-adrenergic arthritis. (augenta.net)
- Introduction and aim of the study: Long QT syndrome is a life threatening genetic arrhythmia syndrome which is characterized by ventricular arrhythmias with few children often having their initial clinical presentation as sudden cardiac arrest. (authorea.com)
- CLINICAL INTERESTS: Dr. Olgin is a Cardiologist and a Cardiac Electrophysiologist. (ucsf.edu)
Ectopy1
- and (c) inducible ventricular ectopy. (jci.org)
Syncope2
- A prolonged QT interval on the electrocardiogram is associated with an increased risk of the torsades de pointes form of ventricular arrhythmia resulting in syncope, sudden cardiac arrest or death, or misdiagnosis as a seizure disorder. (bvsalud.org)
- Results: All four children are asymptomatic since hospital discharge with no episodes of syncope or presyncope, or device-detected ventricular tachyarrhythmia till to-date. (authorea.com)
Refractory2
- Left cardiac sympathetic denervation in children with Jervell Lange-Nielsen syndrome and drug refractory torsades - A case series. (cdc.gov)
- The study aimed to evaluate the effect of RDN on cardiac diastolic function in patients with refractory hypertension and PAF. (hindawi.com)
Patients9
- The Cardiac Arrhythmia Suppression Trial (CAST) and other arrhythmia suppression studies have demonstrated that eliminating VPCs with available antiarrhythmic drugs increases the risk of death to patients without providing any measurable benefit. (medscape.com)
- VPCs also are common in patients with hypertension, ventricular hypertrophy, cardiomyopathy, and mitral valve prolapse. (medscape.com)
- Theoretically, the RDN also has a certain effect on cardiac diastolic function in these patients. (hindawi.com)
- In this case-control study, cardiac and neurohormonal parameters were compared between fifty-one patients with acute coronary syndrome admitted to the cardiac center in Azadi teaching Hospital in Duhok-Iraq, and thirty comparable gender and age-healthy subjects. (jocms.org)
- Meanwhile, cardiac troponin was significantly elevated in those patients compared to healthy subjects (0.17 vs. 4.82 ng/ml, respectively). (jocms.org)
- The PR Interval Predicted Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention: 3 Years Follow-up Results/Primer Perkütan Koroner Girisim Uygulanan Akut Koroner Sendrom Hastalarinda PR Mesafesi Majör Istenmeyen Olaylari Öngörmüstür: 3 Yillik Takip Sonuçlari. (jocms.org)
- In subject inflammation-induced people, we recommend implanted that senile pressure-flow apparatus is cardiac, minute model in peaceful patients of both bad and nervous ec-coupling Aspirin as Below particularly in sympathetic phenyl presence. (augenta.net)
- The book Компоненты further backs to water-soluble proteins avoiding cardiac patients and approaches for using Adrenergic congestive changes. (augenta.net)
- Cardiac transplant is a widely accepted therapy for select patients with end stage cardiovascular disease. (lidsen.com)
Diastolic4
- Hypertension and PAF can affect cardiac diastolic function. (hindawi.com)
- Before RDN, the indices about cardiac diastolic function were out of the normal range. (hindawi.com)
- AF could lead to the loss of atrial systolic function and ventricular irregular contraction and then promote the decline of cardiac diastolic function. (hindawi.com)
- Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. (jci.org)
Conclusion1
- Conclusion: Left cardiac sympathetic denervation is an underutilized simple surgical procedure, for Long QT syndrome. (authorea.com)
Control of cardiac1
- Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function. (jocms.org)
Electrophysiologist1
- Rushil aspires to complete his cardiology training and become a cardiac electrophysiologist here in the United States. (stanford.edu)
Nervous5
- 4 In reality, the intrinsic cardiac nervous system, composed of several ganglia located primarily posterior to the atria, likely acts as a 'little brain' of the heart - it provides efferent input to the myocardium, collects afferent signals on a beat-to-beat basis and performs some integrative functions on its own, all under the tonic modulation of extrinsic sympathetic and parasympathetic input (see Figure 1 ). (aerjournal.com)
- Sympathectomy physically destroys relevant nerves anywhere in either of the two sympathetic trunks, which are long chains of nerve ganglia located bilaterally along the vertebral column (a localisation which entails a low risk of injury) responsible for various important aspects of the peripheral nervous system (PNS). (wikipedia.org)
- ETS involves dissection of the main sympathetic trunk in the upper thoracic region of the sympathetic nervous system, irreparably disrupting neural messages that ordinarily would travel to many different organs, glands and muscles. (wikipedia.org)
- By blocking the afferent and efferent nervous connections between the kidney and cerebra, the sympathetic nerve activity is inhibited and the hypotensive effect is achieved. (hindawi.com)
- We considered it likely that the QT prolongation was triggered by thiamylal and increased sympathetic nervous system activity. (bvsalud.org)
Plexus1
- originates from the right and left stellate ganglia, which provide the sympathetic nerves to form the cardiac plexus of the heart. (slideshare.net)
Substrate1
- Infarcted hearts undergo considerable remodeling, providing a substrate for arrhythmia via multiple mechanisms. (frontiersin.org)
Neurohormonal1
- Elevated BP leads to adverse changes in cardiac structure and function in 2 ways: directly, by increased afterload, and indirectly, by associated neurohormonal and vascular changes. (medscape.com)
Rats1
- 0.05) dilation of the left ventricle, and reduction in ejection fraction compared to sham operated rats ( n = 4) on 7 T cardiac magnetic resonance imaging. (frontiersin.org)
Mechanisms1
- In animal models, focal mechanisms without evidence of macro-reentry play a major role in the origin of ventricular arrhythmia associated with ischemic cardiomyopathy. (medscape.com)
Nerve6
- the ability of sympathetic nerve terminals to take up catecholamine is a more sensitive index of nerve function and viability than the catecholamine content. (slideshare.net)
- Experimental data on vagal nerve and spinal cord stimulation suggest that each technique may reduce ventricular arrhythmias. (aerjournal.com)
- Endoscopic thoracic sympathectomy (ETS) is a surgical procedure in which a portion of the sympathetic nerve trunk in the thoracic region is destroyed. (wikipedia.org)
- The operation is accomplished by dissecting the nerve tissue of the main sympathetic chain. (wikipedia.org)
- citation needed] Another technique, the clamping method, also referred to as 'endoscopic sympathetic blockade' (ESB) employs titanium clamps around the nerve tissue, and was developed as an alternative to older methods in an unsuccessful attempt to make the procedure reversible. (wikipedia.org)
- Exact results of ETS are impossible to predict, because of considerable anatomic variation in nerve function from one patient to the next, and also because of variations in surgical technique. (wikipedia.org)
Cardiomyopathy3
- DiscoVari: A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes. (cdc.gov)
- We report the case of an 8-year-old boy with left ventricular noncompaction cardiomyopathy (LVNC) and QT prolongation who experienced further prolongation of the QTc during general anesthesia for extraction of a maxillary mesiodens. (bvsalud.org)
- Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice. (jci.org)
Cardiovascular events1
- Two of the major goals in the treatment of this condition include reducing progression or recurrence of the arrhythmia and decreasing the risk of cardiovascular events, thereby improving quality of life and decreasing morbidity. (romanianjournalcardiology.ro)
Left5
- originates from the medulla and passes through the right and left vagal nerves, which further divide into the superior and inferior cardiac nerves. (slideshare.net)
- Left cardiac sympathetic denervation and device implantation in congenital long QT sy. (authorea.com)
- Materials and methods: We present a series of four children suffering from Long QT syndrome, who were successfully managed with left cardiac sympathetic denervation (LCSD) combined with device implantation (permanent pacemaker implantation in two children and implantable loop recorder in one child). (authorea.com)
- Two-dimensional echocardiogram (parasternal long axis view) from a 70-year-old woman showing concentric left ventricular hypertrophy and left atrial enlargement. (medscape.com)
- Gross specimen of the heart with concentric left ventricular hypertrophy. (medscape.com)
Sympathectomy2
- The most common area targeted in sympathectomy is the upper thoracic region, that part of the sympathetic chain lying between the first and fifth thoracic vertebrae. (wikipedia.org)
- No reliable operation exists for foot sweating except lumbar sympathectomy, at the opposite end of the sympathetic chain. (wikipedia.org)
Nerves1
- the endoscopic sympathetic block (ESB) procedure and those procedures that affect fewer nerves have lower risks. (wikipedia.org)
Acute1
- Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. (jocms.org)
Genetics1
- Our increasing ability (using genetics and epigenetics) to predict who will get what disease, allowing us to intervene and prolong healthy life. (myhealthspecialist.com)
Children2
- Children with catecholaminergic polymorphic ventricular tachycardia (CPVT) are at risk for sudden death, and a risk stratification tool does not exist. (nih.gov)
- During general anesthesia for children with LVNC and QT prolongation, it is necessary to monitor intraoperative hemodynamic fluctuations and prepare for the possible occurrence of arrhythmias. (bvsalud.org)
Journal1
- Journal of Cardiac Failure. (elsevierpure.com)
Center1
- Sanjiv Narayan is Professor of Medicine, Director of the Stanford NIH T32 CHIP (Computational medicine in the Heart: Integrated Program HL166155), and is Co-Founder of the Stanford Arrhythmia Center. (stanford.edu)
Common1
- VPCs are the most common ventricular arrhythmia. (medscape.com)
Data1
- Narayan directs the Computational Arrhythmia Research Lab (CARL), that operates at the intersection of cardiovascular medicine, bioengineering, and data science. (stanford.edu)