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  • fetal cardiac
  • Intrauterine growth restriction (IUGR) induces fetal cardiac remodelling and dysfunction, which persists postnatally and may explain the link between low birth weight and increased cardiovascular mortality in adulthood. (jove.com)
  • Then, after recovery at gestational age day 30 (full term), the same rabbit undergoes examination of fetal cardiac function. (jove.com)
  • Anesthesia is induced with ketamine and xylazine intramuscularly, then maintained by a continuous intravenous infusion of ketamine and xylazine to minimize iatrogenic effects on fetal cardiac function. (jove.com)
  • A repeat laparotomy is performed to expose each gestational sac and a microultrasound examination (VisualSonics VEVO 2100) of fetal cardiac function is performed. (jove.com)
  • analysis of cardiac
  • This approach allows simulations of LV dynamics that run faster than real time, and could be used to determine patient-specific parameters of LV performance on-line from clinically available measurements, with the eventual goal of real-time, patient-specific analysis of cardiac parameters. (deepdyve.com)
  • Here, we used a rabbit model of IUGR that allows analysis of cardiac function in a clinically relevant way. (jove.com)
  • vascular
  • In the subsequent sections we will review the information regarding cardiac morphological adaptations, signaling pathway of the cardiac cell, cardiac function and the vascular adaptation induced by RT using this animal model developed by Tamaki et al. (medsci.org)
  • Offline calculations determine standard M-mode cardiac variables, tricuspid and mitral annular plane systolic excursion, speckle tracking and strain analysis, modified myocardial performance index and vascular flow velocity waveforms of interest. (jove.com)
  • Abstract
  • In this extended abstract, we develop a two-component CGMD human RBC membrane model that explicitly comprises both the lipid bilayer and the cytoskeleton. (asme.org)
  • Measurement
  • Ultrasound imaging is based on the acoustic pulse-echo measurement: an ultrasound pulse is transmitted and echo signals are subsequently received. (onlinejacc.org)
  • Given the velocity of wave propagation in soft tissue (∼1,530 m/s) and the propagation distance for a typical cardiac examination (∼30 cm return-trip from the chest wall to the atrial roof), this measurement takes ∼200 μs, implying that, for transthoracic cardiac applications, ∼5,000 pulse-echo measurements can be made every second. (onlinejacc.org)
  • Dynamics
  • Although a number of coarse-grained molecular dynamics (CGMD) RBC membrane models have been developed in the past two decades, very few RBC membrane models have been used to study the disordered band 3 diffusion and membrane vesiculation in HS and HE. (asme.org)
  • We conclude that further investigation of the modelling of sheet dynamics is necessary to fully understand the impact of tissue structure on cardiac deformation. (jove.com)
  • dysfunction
  • Vulnerability among cardiac patients is multifactorial and may arise from myocardial interstitial disease (e.g., fibrosis or amyloidosis) or other derangements such as valve dysfunction, pulmonary hypertension, atherosclerosis, or dysrhythmia. (onlinejacc.org)
  • Mitochondria dysfunction is often described as a cause of cardiac impairment but its extent may depend on the type of experimental diabetes. (biomedcentral.com)
  • Mice fed with regular chow diet and injected with streptozotocin developed cardiac dysfunction without mitochondrial respiration defect. (biomedcentral.com)
  • While cardiac dysfunction was present in the three groups of mice, mitochondrial respiration impairment was only obvious in models reproducing features of type 2 diabetes. (biomedcentral.com)
  • functional
  • However, functional measurements of the right ventricle (RV) are also essential for fully understanding cardiac function. (biomedcentral.com)
  • Although these frame rates are adequate to assess cardiac morphology and certain functional aspects, they do not allow the resolution of all cardiac mechanical events, as some of them are very short-lived. (onlinejacc.org)
  • function
  • Guide point modeling of the left ventricle (LV) [ 1 ] can accurately obtain LV function parameters by interactively fitting a deformable LV finite element (FE) model to a few user-defined data points ("guide points") on MR images. (biomedcentral.com)
  • To develop interactive guide point modeling techniques for fast and efficient clinical evaluation of biventricular function. (biomedcentral.com)
  • This paper reviews current clinical applications and shows how torsion can give insights into LV mechanics and the influence of LV geometry and myocyte fiber architecture on cardiac function. (biomedsearch.com)
  • Increasingly, these imaging modalities are being employed clinically to examine cardiac function and assess wellbeing in utero , thereby guiding timing of birth decisions. (jove.com)
  • This small animal model of IUGR therefore affords examination of in utero cardiac function that is consistent with current clinical practice and is therefore useful in a translational research setting. (jove.com)
  • Tissue microstructure, in particular the alignment of myocytes (fibre direction) and their lateral organisation into sheets, is fundamental to cardiac function. (jove.com)
  • Patient-specific simulations of heart (dys)function aimed at personalizing cardiac therapy are hampered by the absence of in vivo imaging technology for clinically acquiring myocardial fiber orientations. (jove.com)
  • In all patients, cardiac function of the left ventricle (LV) improved significantly, as manifested by consistent reduction of the LV volume and wall stress. (jove.com)
  • Because cardiac magnetic resonance (CMR) is considered the gold standard for noninvasive assessment of myocardial function (12-14) and allows visualization and quantification of scarring using late gadolinium enhancement (LGE) (2,12,14-16) , we aimed to provide a review and meta-analysis to study the additional value of CMR in determining the prognosis in DCM. (onlinejacc.org)
  • Accepted students will spend 10 weeks working with faculty on a research project in a cardiovascular area of biomedical engineering, such as myocardial tissue engineering, artificial hearts, cardiac function modeling and imaging, or cardiovascular biomaterials. (regenerativemedicine.net)
  • Cardiac function was assessed ex vivo onto a Langendorff column. (biomedcentral.com)
  • It is thus obvious that defects in mitochondrial population quality may impair cardiac function. (biomedcentral.com)
  • hypertrophy
  • However, today it is surrounded by controversy if these models to induce skeletal muscle hypertrophy are similar to that promoted by RT in humans [ 1 - 3 ]. (medsci.org)
  • tissue
  • In some cases, the animals are given food as a reward [ 4 ] or movement is stimulated by an electrical shock in the tail or leg, but not directly in the muscle tissue as in the previous unconscious animal models [ 2 ]. (medsci.org)
  • Virtual monoenergetic images allow for an interactive optimization of iodine contrast relative to soft tissue, calcium, or stent material. (springer.com)
  • The ex vivo human placental perfusion model is one of few models providing reliable information about the transport behavior of xenobiotics at an important tissue barrier which delivers predictive and clinical relevant data. (jove.com)
  • This purpose may be served by measuring the magnetic resonance imaging (MRI)-derived parameter T2*, which varies inversely with tissue iron concentration but has limited availability. (onlinejacc.org)
  • The volume set obtained can be manipulated on a separate workstation in the interventional suite to generate a 3-dimensional (3D) angiographic image combined with CT-quality soft tissue imaging that can be used in real time during the procedure. (onlinejacc.org)
  • practice
  • It is the aim of this paper to provide an overview of the technical principles behind these new ultrasound imaging modalities, to review the current evidence of their potential clinical added value, and to forecast how they might influence daily clinical practice. (onlinejacc.org)
  • Established imaging measurements are often ignored in clinical practice or not used in the most beneficial way. (onlinejacc.org)
  • strains
  • Stress equilibrium is imposed in weak form and the resulting force balance equations are coupled to a lumped-parameter model of the circulation, leading to a system of differential-algebraic equations, whose numerical solution yields predictions of LV pressure and volume, together with spatial distributions of stresses and strains throughout the cardiac cycle. (deepdyve.com)
  • We also evaluated Lagrangian strains as local metrics of cardiac deformation. (jove.com)
  • advances
  • Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. (springer.com)
  • Several recent technical advances in cardiac ultrasound allow data to be acquired at a very high frame rate. (onlinejacc.org)
  • Recently, several technical advances have shown that 2D ultrasound imaging at a very high temporal resolution becomes possible through retrospective gating, plane wave/diverging wave imaging, and multiline transmit systems. (onlinejacc.org)
  • Early observations regarding the significance of interstitial fibrosis, including those by Weber and Brilla (1) in animal models, along with clinical advances in human cardiac imaging, have combined to focus attention on the entire range of myocardial fibrosis from focal to diffuse. (onlinejacc.org)
  • coronary
  • Besides the model of permanent ligation of the left anterior descending coronary artery, the technique of invasive hemodynamic measurements in mice is presented in detail. (jove.com)
  • (5) report on a study that prospectively evaluated cardiac sympathetic activity by m IBG scan and blood catecholamine levels in 32 patients with takotsubo cardiomyopathy and 20 control subjects in subacute (6 to 10 days after presentation with acute coronary syndrome) and recovery phases (4 months later). (onlinejacc.org)
  • (5) prospectively evaluated cardiac sympathetic activity by m IBG scan and blood catecholamine levels in subjects who presented with initial symptoms and signs closely mimicking those of takotsubo cardiomyopathy with suspicion of ST-segment elevation acute coronary syndrome. (onlinejacc.org)
  • visualization
  • For cardiovascular imaging, the main focus of Dual Energy CT is on the visualization and quantification of iodinated contrast media in vessels. (springer.com)
  • While some of the discussed applications are at the very early stage of feasibility studies, others, such as bone removal, virtual monoenergetic imaging, or visualization of iodine uptake in the lung parenchyma, are already now widely used. (springer.com)
  • humans
  • The lack of animal models with comparable protocols to the RT performed by humans hampers the knowledge. (medsci.org)
  • However, these models still have the challenge of training the animals to voluntarily perform the traditional exercises performed by humans. (medsci.org)
  • 2 ] created a model that mimics squat-training (figure 1 ) performed by humans, for rats and today it is the most common model used by many laboratories. (medsci.org)
  • examine
  • It is the aim of this paper to explain these developing technologies, review their potential benefits and current limitations, and examine how they might be applied to optimize cardiac diagnostics. (onlinejacc.org)
  • cross-sectional
  • Its cross-sectional images are used for diagnostic and therapeutic purposes in various medical disciplines. (wikipedia.org)
  • Background ACT provides cross-sectional CT images from a rotational angiography run using a C-arm mounted flat-panel detector in the interventional suite. (onlinejacc.org)
  • vivo
  • The objective of this project was to develop a methodology to estimate cardiac fiber orientations from in vivo images of patient heart geometries. (jove.com)
  • extent
  • However, to a lesser extent, other models are also employed to investigate the cardiovascular adaptations. (medsci.org)
  • Consequently, it is often unclear, or a matter for debate, the extent to which a CEP model can be trusted for a given application. (frontiersin.org)
  • In this latter model of ischemia/reperfusion injury, the initial extent of the infarct may be modulated by factors that affect myocardial salvage following reperfusion. (jove.com)